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Entry version 4 (19 Jan 2022)
Sequence version 1 (07 Apr 2021)
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Protein
Submitted name:

Sorbin and SH3 domain containing 2

Gene

mMyoMyo1_018129

Organism
Myotis myotis (Greater mouse-eared bat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sorbin and SH3 domain containing 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:mMyoMyo1_018129Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMyotis myotis (Greater mouse-eared bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51298 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraVespertilionidaeMyotis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000527355 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini143 – 207SoHoInterPro annotationAdd BLAST65
Domaini1025 – 1084SH3InterPro annotationAdd BLAST60
Domaini1100 – 1161SH3InterPro annotationAdd BLAST62
Domaini1204 – 1263SH3InterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 71DisorderedSequence analysisAdd BLAST47
Regioni193 – 344DisorderedSequence analysisAdd BLAST152
Regioni371 – 473DisorderedSequence analysisAdd BLAST103
Regioni834 – 855DisorderedSequence analysisAdd BLAST22
Regioni973 – 1027DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 46Polar residuesSequence analysisAdd BLAST22
Compositional biasi54 – 71Polar residuesSequence analysisAdd BLAST18
Compositional biasi193 – 223Polar residuesSequence analysisAdd BLAST31
Compositional biasi226 – 244Pro residuesSequence analysisAdd BLAST19
Compositional biasi245 – 275Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi290 – 308Pro residuesSequence analysisAdd BLAST19
Compositional biasi317 – 337Pro residuesSequence analysisAdd BLAST21
Compositional biasi385 – 408Polar residuesSequence analysisAdd BLAST24
Compositional biasi443 – 468Polar residuesSequence analysisAdd BLAST26
Compositional biasi1013 – 1027Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR14167:SF56, PTHR14167:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

A0A7J7Z8Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTDSGGCAR KRAAMSVTLT SVKRVQSSPN LLAAGRDSQS PDSAKGFRSV
60 70 80 90 100
RPNLQEKRSP TQSQVTVNGN SGGAVSPMSY YQRPFSPSAY SLPGSLNSSI
110 120 130 140 150
IMPHGRSLDS TEAYAQHAQS LDGPVGSSIP LYRSSEEEKR VTVIKAPHYP
160 170 180 190 200
GIGPVDESGI PTAIRTTVDR PKDWYKTMFK QIHMVHKPGL YNSPYSAQSH
210 220 230 240 250
PAAKTQTYRP LSKSHSDNGT DTFKDATPPA PPPHVPPPVP PLRPRDRSST
260 270 280 290 300
EKHDWDPPDR KVDTRRFRSE PRSIFEYEPG KSSILQHERP PPLPTTPTPV
310 320 330 340 350
PREPSRKPIP MSPYGEVTGS PSPPPRSGLP TPSPSTPALS PIWTDRIHPD
360 370 380 390 400
DVELENEPWY KFFSELEFGR PPPKKALDYV QDHSPGVSNE ASLYQSSIDR
410 420 430 440 450
SLERPSSSAG LASDFRKRRK SEPAVGQPRG LGDPRASRTS PGRADLPGSS
460 470 480 490 500
ATLTQSFISS SPSSPSRAKG GDDSKMCAPL CSCSGPRGRP CQEVDDCPPY
510 520 530 540 550
RQHLDVPRDS QRALAFKNGW QMARQNAEVW SSTEEAVSPK IKSRSCDDLL
560 570 580 590 600
NDDCGGFPDP KAKSESMGSL LCEEDAQEGC PVPWASSFLQ ETRATGRSRL
610 620 630 640 650
RHGSAHNAPG FLKMYKKMHR INRKDLLNSE VMCSVRSRVL QYEQEPHAPG
660 670 680 690 700
LLHGWSQSSA DEVPRDMVPT RISEFEKLIQ KSKSMPNLGE EMLSPAVLEP
710 720 730 740 750
QHHGLGPTRR FSIESLLEED NPGRHPCPGP RSCTSKTLVP IHIEVTSEEP
760 770 780 790 800
PRTHLELSDS DQDGVVSEHS DCMHVEGSSF CSESDFDHFS FTSSESFYGS
810 820 830 840 850
SHHHHHHHHH HHRHLVSSCK GRCPASYTRF TTMRKHERAK HEPPEEPRRH
860 870 880 890 900
DPDAGLSKLA FLVSPVPFRR KKHSPPQKQT EKATCNTAVF EALDSALKDI
910 920 930 940 950
CDQIKAEKRR GSLPDNSILH RLISELLPDV PERNSSLRAL RRSPMPQPCH
960 970 980 990 1000
PLPQDGATHC PWYQNGCGRM PHSASLQDMD TNSNYHPDHD SALGLPDRES
1010 1020 1030 1040 1050
PRSYASTVAD LGRNAPRDRR GTPEKEKLPA KAVYDFKAQT SKELSFKKGD
1060 1070 1080 1090 1100
TVYILRKIDQ NWYEGEHHGR VGIFPISYVE KLSPPEKAQP ARPPPPAQPG
1110 1120 1130 1140 1150
EIGEAIAKYN FNADTNVELS LRKGDRVILL KRVDQNWYEG KIPGTNRQGI
1160 1170 1180 1190 1200
FPVSYVEVVK RNTAKGAEDY PDPPIPHSYS SDRIHSLSSN KPQRPVFTHE
1210 1220 1230 1240 1250
NIQGGGEPFQ ALYNYTPRNE DELELRESDV IDVMEKCDDG WFVGTSRRTK
1260
FFGTFPGNYV KRL
Length:1,263
Mass (Da):140,608
Last modified:April 7, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D1DD8315EE9CF1D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7J7Z8N6A0A7J7Z8N6_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
643Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z8P5A0A7J7Z8P5_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
489Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z8T9A0A7J7Z8T9_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
1,163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z8U8A0A7J7Z8U8_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
1,132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z8Z7A0A7J7Z8Z7_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
1,220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z942A0A7J7Z942_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z971A0A7J7Z971_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z979A0A7J7Z979_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
848Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z983A0A7J7Z983_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
620Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7J7Z987A0A7J7Z987_MYOMY
Sorbin and SH3 domain containing 2
mMyoMyo1_018129
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JABWUV010000003 Genomic DNA Translation: KAF6370653.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JABWUV010000003 Genomic DNA Translation: KAF6370653.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type
PANTHERiPTHR14167:SF56, PTHR14167:SF56, 1 hit
PfamiView protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7J7Z8Q0_MYOMY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7J7Z8Q0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 7, 2021
Last sequence update: April 7, 2021
Last modified: January 19, 2022
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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