UniProtKB - A0A7I2V6E0 (A0A7I2V6E0_HUMAN)
Hepatocyte growth factor-regulated tyrosine kinase substrate
HGS
Functioni
Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
UniRule annotationGO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol binding Source: InterPro
- protein domain specific binding Source: UniProtKB-UniRule
- ubiquitin binding Source: InterPro
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | KinaseImported, Transferase |
Biological process | Protein transportUniRule annotation, Transport |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Hepatocyte growth factor-regulated tyrosine kinase substrateUniRule annotationARBA annotation |
Gene namesi | Name:HGSImported ORF Names:hCG_1987560Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4897, HGS |
Subcellular locationi
Endosome
- Early endosome membrane UniRule annotationARBA annotation; Peripheral membrane protein UniRule annotationARBA annotation; Cytoplasmic side UniRule annotationARBA annotation
- multivesicular body membrane UniRule annotation; Peripheral membrane protein UniRule annotation
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Cytosol
- cytosol Source: UniProtKB-UniRule
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- multivesicular body membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotation, EndosomeUniRule annotation, MembraneUniRule annotationInteractioni
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB-UniRule
- ubiquitin binding Source: InterPro
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 76 | VHSInterPro annotationAdd BLAST | 76 | |
Domaini | 93 – 153 | FYVE-typeInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 252 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 271 – 339 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 651 – 710 | DisorderedSequence analysisAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 403 – 445 | Sequence analysisAdd BLAST | 43 | |
Coiled coili | 466 – 486 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 185 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 218 – 249 | Polar residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 651 – 679 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 694 – 710 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158297 |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR024641, HRS_helical IPR017073, Ubi-bd_Hrs_VPS27 IPR003903, UIM_dom IPR002014, VHS_dom IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF12210, Hrs_helical, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036956, Hrs_Vps27, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50330, UIM, 1 hit PS50179, VHS, 1 hit PS50178, ZF_FYVE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 63 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MESVVKNCGQ TVHDEVANKQ TMEELKDLLK RQVEVNVRNK ILYLIQAWAH
60 70 80 90 100
AFRNEPKYKV VQDTYQIMKV EGHVFPEFKE SDAMFAAERA PDWVDAEECH
110 120 130 140 150
RCRVQFGVMT RKHHCRACGQ IFCGKCSSKY STIPKFGIEK EVRVCEPCYE
160 170 180 190 200
QLNRKAEGKA TSTTELPPEY LTSPLSQQSQ LPPKRDETAL QEEEELQLAL
210 220 230 240 250
ALSQSEAEEK ERLRQKSTYT SYPKAEPMPS ASSAPPASSL YSSPVNSSAP
260 270 280 290 300
LAEDIDPELA RYLNRNYWEK KQEEARKSPT PSAPVPLTEP AAQPGEGHAA
310 320 330 340 350
PTNVVENPLP ETDSQPIPPS GGPFSEPQFH NGESEESHEQ FLKALQNAVT
360 370 380 390 400
TFVNRMKSNH MRGRSITNDS AVLSLFQSIN GMHPQLLELL NQLDERRLYY
410 420 430 440 450
EGLQDKLAQI RDARGALSAL REEHREKLRR AAEEAERQRQ IQLAQKLEIM
460 470 480 490 500
RQKKQEYLEV QRQLAIQRLQ EQEKERQMRL EQQKQTVQMR AQMPAFPLPY
510 520 530 540 550
AQLQAMPAAG GVLYQPSGPA SFPSTFSPAG SVEGSPMHGV YMSQPAPAAG
560 570 580 590 600
PYPSMPSTAA DPSMVSAYMY PAGATGAQAA PQAQAGPTAS PAYSSYQPTP
610 620 630 640 650
TAGYQNVASQ APQSLPAISQ PPQSSTMGYM GSQSVSMGYQ PYNMQNLMTT
660 670 680 690 700
LPSQDASLPP QQPYIAGQQP MYQQMAPSGG PPQQQPPVAQ QPQAQGPPAQ
710
GSEAQLISFD
Computationally mapped potential isoform sequencesi
There are 63 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14964 | HGS_HUMAN | Hepatocyte growth factor-regulated ... | HGS HRS | 777 | Annotation score: | ||
I3L1P5 | I3L1P5_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 536 | Annotation score: | ||
A0A7I2V2W5 | A0A7I2V2W5_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 768 | Annotation score: | ||
A0A7I2V3J3 | A0A7I2V3J3_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 777 | Annotation score: | ||
A0A7I2V2D8 | A0A7I2V2D8_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 767 | Annotation score: | ||
A0A7I2V2K2 | A0A7I2V2K2_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 737 | Annotation score: | ||
A0A7I2V2R9 | A0A7I2V2R9_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 768 | Annotation score: | ||
A0A7I2V307 | A0A7I2V307_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 783 | Annotation score: | ||
A0A7I2V3F9 | A0A7I2V3F9_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 765 | Annotation score: | ||
A0A7I2V3Z1 | A0A7I2V3Z1_HUMAN | Hepatocyte growth factor-regulated ... | HGS | 690 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC139530 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89677.1 |
Genome annotation databases
Ensembli | ENST00000678105; ENSP00000504789; ENSG00000185359 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC139530 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89677.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENST00000678105; ENSP00000504789; ENSG00000185359 |
Organism-specific databases
HGNCi | HGNC:4897, HGS |
OpenTargetsi | ENSG00000185359 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158297 |
Family and domain databases
Gene3Di | 1.25.40.90, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR008942, ENTH_VHS IPR024641, HRS_helical IPR017073, Ubi-bd_Hrs_VPS27 IPR003903, UIM_dom IPR002014, VHS_dom IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit PF12210, Hrs_helical, 1 hit PF00790, VHS, 1 hit |
PIRSFi | PIRSF036956, Hrs_Vps27, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit SM00288, VHS, 1 hit |
SUPFAMi | SSF48464, SSF48464, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50330, UIM, 1 hit PS50179, VHS, 1 hit PS50178, ZF_FYVE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A7I2V6E0_HUMAN | |
Accessioni | A0A7I2V6E0Primary (citable) accession number: A0A7I2V6E0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 7, 2021 |
Last sequence update: | April 7, 2021 | |
Last modified: | January 19, 2022 | |
This is version 4 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |