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UniProtKB - A0A7I2V4L2 (A0A7I2V4L2_HUMAN)

Entry version 4 (19 Jan 2022)
Sequence version 1 (07 Apr 2021)
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Protein
Submitted name:

Centrosome and spindle pole-associated protein 1

Gene

CSPP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosome and spindle pole-associated protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSPP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26193, CSPP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000104218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A7I2V4L2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 173DisorderedSequence analysisAdd BLAST64
Regioni310 – 332DisorderedSequence analysisAdd BLAST23
Regioni664 – 686DisorderedSequence analysisAdd BLAST23
Regioni742 – 782DisorderedSequence analysisAdd BLAST41
Regioni842 – 861DisorderedSequence analysisAdd BLAST20
Regioni1043 – 1076DisorderedSequence analysisAdd BLAST34
Regioni1163 – 1185DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2 – 26Sequence analysisAdd BLAST25
Coiled coili176 – 196Sequence analysisAdd BLAST21
Coiled coili347 – 374Sequence analysisAdd BLAST28
Coiled coili555 – 596Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi110 – 143Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi147 – 164Polar residuesSequence analysisAdd BLAST18
Compositional biasi310 – 330Polar residuesSequence analysisAdd BLAST21
Compositional biasi664 – 680Polar residuesSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000015084

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026708, CSPP1

The PANTHER Classification System

More...PANTHERi		PTHR21616, PTHR21616, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 47 potential isoforms that are computationally mapped.Show allAlign All

A0A7I2V4L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADNLDEFIE EQKARLAEDK AELESDPPYM EMKGKLSAKL SENSKILISM 
        60         70         80         90        100
AKENIPPNSQ QTRGSLGIDY GLSLPLGEDY ERKKHKLKEE LRQDYRRYLT 
       110        120        130        140        150
QERLKLERNK EYNQFLRGKE ESSEKFRQVE KSTEPKSQRN KKPIGQVKPD 
       160        170        180        190        200
LTSQIQTSCE NSEGPRKDVL TPSEAYEELL NQRRLEEDRY RQLDDEIELR 
       210        220        230        240        250
NRRIIKKANE EVGISNLKHQ RFASKAGIPD RRFHRFNEDR VFDRRYHRPD 
       260        270        280        290        300
QDPEVSEEMD ERFRYESDFD RRLSRVYTND RMHRNKRGNM PPMEHDGDVI 
       310        320        330        340        350
EQSNIRISSA ENKSAPDNET SKSANQDTCS PFAGMLFGGE DRELIQRRKE 
       360        370        380        390        400
KYRLELLEQM AEQQRNKRRE KDLELRVAAS GAQDPEKSPD RLKQFSVAPR 
       410        420        430        440        450
HFEEMIPPER PRIAFQTPLP PLSAPSVPPI PSVHPVPSQN EDLRSGLSSA 
       460        470        480        490        500
LGEMVSPRIA PLPPPPLLPP LATNYRTPYD DAYYFYGSRN TFDPSLAYYG 
       510        520        530        540        550
SGMMGVQPAA YVSAPVTHQL AQPVVNTVGQ NELKITSDQV INSGLIFEDK 
       560        570        580        590        600
PKPSKQSLQS YQEALQQQIR EREERRKKER EEKEEYEAKL EAEMRTYNPW 
       610        620        630        640        650
GKGGGGAPLR DAKGNLITDL NRMHRQNIDA YHNPDARTYE DKRAVVSLDP 
       660        670        680        690        700
NLATSNAENL EDAANKSSGH MQTQSSPFAR GNVFGEPPTE LQIKQQELYK 
       710        720        730        740        750
NFLRFQIEEK KQREEAERER LRIAEEKEER RLAEQRARIQ QEYEEEQEKK 
       760        770        780        790        800
REKEEEQRLK NEEHIRLAEE RQKEAERKKK EEEEKYNLQL QHYCERDNLI 
       810        820        830        840        850
GEETKHMRQP SPIVPALQNK IASKLQRPPS VDSIIRSFIH ESSMSRAQSP 
       860        870        880        890        900
PVPARKNQLR AEEEKKNVIM ELSEMRKQLR SEERRLQERL LHMDSDDEIP 
       910        920        930        940        950
IRKKERNPMD IFDMARHRLQ APVRRQSPKG LDAATFQNVH DFNELKDRDS 
       960        970        980        990       1000
ETRVDLKFMY LDPPRDHHTL EIQQQALLRE QQKRLNRIKM QEGAKVDLDA 
      1010       1020       1030       1040       1050
IPSAKVREQR MPRDDTSDFL KNSLLESDSA FIGAYGETYP AIEDDVLPPP 
      1060       1070       1080       1090       1100
SQLPSARERR RNKWKGLDID SSRPNVAPDG LSLKSISSVN VDELRVRNEE 
      1110       1120       1130       1140       1150
RMRRLNEFHN KPINTDDESS LVDPDDIMKH IGDDGSNSVA TEPWLRPGTS 
      1160       1170       1180 
ETLKRFMAEQ LNQEQQQIPG KPGTFTWQGL STAHG
Length:1,185
Mass (Da):137,830
Last modified:April 7, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC495527B74B89932
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 47 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1MSJ5CSPP1_HUMAN
Centrosome and spindle pole-associa...
CSPP1 CSPP
1,256Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2M5F2Z2M5_HUMAN
Centrosome and spindle pole-associa...
CSPP1
404Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5W3A0A7I2V5W3_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,226Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V5G7A0A7I2V5G7_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,008Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF96A0A6Q8PF96_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PGS3A0A6Q8PGS3_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PF61A0A6Q8PF61_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6Q8PHN8A0A6Q8PHN8_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2PHE7A0A7I2PHE7_HUMAN
Centrosome and spindle pole-associa...
CSPP1
1,248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V2I3A0A7I2V2I3_HUMAN
Centrosome and spindle pole-associa...
CSPP1
669Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC087359 Genomic DNA No translation available.
AC109335 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_016869340.1, XM_017013851.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000678645; ENSP00000504031; ENSG00000104218

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79848

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087359 Genomic DNA No translation available.
AC109335 Genomic DNA No translation available.
RefSeqiXP_016869340.1, XM_017013851.1

3D structure databases

SMRiA0A7I2V4L2
ModBaseiSearch...

Genome annotation databases

EnsembliENST00000678645; ENSP00000504031; ENSG00000104218
GeneIDi79848

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79848
HGNCiHGNC:26193, CSPP1
OpenTargetsiENSG00000104218

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00390000015084

Family and domain databases

InterProiView protein in InterPro
IPR026708, CSPP1
PANTHERiPTHR21616, PTHR21616, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7I2V4L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7I2V4L2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 7, 2021
Last sequence update: April 7, 2021
Last modified: January 19, 2022
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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