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UniProtKB - A0A7I2V3H7 (A0A7I2V3H7_HUMAN)

Entry version 4 (19 Jan 2022)
Sequence version 1 (07 Apr 2021)
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Protein
Submitted name:

GRB10-interacting GYF protein 2

Gene

GIGYF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GRB10-interacting GYF protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIGYF2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11960, GIGYF2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000204120

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini285 – 333GYFInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 38DisorderedSequence analysisAdd BLAST20
Regioni63 – 184DisorderedSequence analysisAdd BLAST122
Regioni485 – 545DisorderedSequence analysisAdd BLAST61
Regioni597 – 618DisorderedSequence analysisAdd BLAST22
Regioni624 – 643DisorderedSequence analysisAdd BLAST20
Regioni669 – 688DisorderedSequence analysisAdd BLAST20
Regioni709 – 749DisorderedSequence analysisAdd BLAST41
Regioni761 – 800DisorderedSequence analysisAdd BLAST40
Regioni836 – 864DisorderedSequence analysisAdd BLAST29
Regioni947 – 982DisorderedSequence analysisAdd BLAST36
Regioni999 – 1023DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi19 – 36Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi65 – 117Basic and acidic residuesSequence analysisAdd BLAST53
Compositional biasi118 – 141Polar residuesSequence analysisAdd BLAST24
Compositional biasi142 – 168Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi723 – 749Polar residuesSequence analysisAdd BLAST27
Compositional biasi840 – 861Polar residuesSequence analysisAdd BLAST22

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156108

Family and domain databases

Conserved Domains Database

More...CDDi		cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 18 potential isoforms that are computationally mapped.Show allAlign All

A0A7I2V3H7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERRRRFEFD FRDRDDERGY RRVRSGSGSI DDDRDSLPEW CLEDAEEEMG 
        60         70         80         90        100
TFDSSGAFLS LKKVQKEPIP EEQEMDFRPV DEGEECSDSE GSHNEEAKEP 
       110        120        130        140        150
DKTNKKEGEK TDRVGVEASE ETPQTSSSSA RPGTPSDHQS QEASQFERKD 
       160        170        180        190        200
EPKTEQTEKA EEETRMENSL PAKVPSRGDE MVADVQQPLS QIPSDTASPL 
       210        220        230        240        250
LILPPPVPNP SPTLRPVETP VVGAPGMGSV STEPDDEEGL KHLEQQAEKM 
       260        270        280        290        300
VAYLQDSALD DERLASKLQE HRAKGVSIPL MHEAMQKWYY KDPQGEIQGP 
       310        320        330        340        350
FNNQEMAEWF QAGYFTMSLL VKRACDESFQ PLGDIMKMWG RVPFSPGPAP 
       360        370        380        390        400
PPHMGELDQE RLTRQQELTA LYQMQHLQYQ QFLIQQQYAQ VLAQQQKAAL 
       410        420        430        440        450
SSQQQQQLAL LLQQFQTLKM RISDQNIIPS VTRSVSVPDT GSIWELQPTA 
       460        470        480        490        500
SQPTVWEGGS VWDLPLDTTT PGPALEQLQQ LEKAKAAKLE QERREAEMRA 
       510        520        530        540        550
KREEEERKRQ EELRRQQEEI LRRQQEEERK RREEEELARR KQEEALRRQR 
       560        570        580        590        600
EQEIALRRQR EEEERQQQEE ALRRLEERRR EEEERRKQEE LLRKQEEEAA 
       610        620        630        640        650
KWAREEEEAQ RRLEENRLRM EEEAARLRHE EEERKRKELE VQRQKELMRQ 
       660        670        680        690        700
RQQQQEALRR LQQQQQQQQL AQMKLPSSST WGQQSNTTAC QSQATLSLAE 
       710        720        730        740        750
IQKLEEERER QLREEQRRQQ RELMKALQQQ QQQQQQKLSG WGNVSKPSGT 
       760        770        780        790        800
TKSLLEIQQE EARQMQKQQQ QQQQHQQPNR ARNNTHSNLH TSIGNSVWGS 
       810        820        830        840        850
INTGPPNQWA SDLVSSIWSN ADTKNSNMGF WDDAVKEVGP RNSTNKNKNN 
       860        870        880        890        900
ASLSKSVGVS NRQNKKVEEE EKLLKLFQGV NKAQDGFTQW CEQMLHALNT 
       910        920        930        940        950
ANNLDVPTFV SFLKEVESPY EVHDYIRAYL GDTSEAKEFA KQFLERRAKQ 
       960        970        980        990       1000
KANQQRQQQQ LPQQQQQQPP QQPPQQPQQQ DSVWGMNHST LHSVFQTNQS 
      1010       1020       1030       1040       1050
NNQQSNFEAV QSGKKKKKQK MVRADPSLLG FSVNASSERL NMGEIETLDD 

Y
Length:1,051
Mass (Da):122,200
Last modified:April 7, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE7E6641E17EBF8A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6Y7W6GGYF2_HUMAN
GRB10-interacting GYF protein 2
GIGYF2 KIAA0642, PERQ2, TNRC15
1,299Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ESB6E7ESB6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
836Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHW1C9JHW1_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
720Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I1E4Y6I1E4Y6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
1,321Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBF1F8WBF1_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V361A0A7I2V361_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
1,081Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3H0A0A7I2V3H0_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
1,126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V516A0A7I2V516_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
1,130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JPV7C9JPV7_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J0V6C9J0V6_HUMAN
GRB10-interacting GYF protein 2
GIGYF2
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC016692 Genomic DNA No translation available.
AC064852 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000677591; ENSP00000503061; ENSG00000204120
ENST00000678339; ENSP00000503437; ENSG00000204120
ENST00000678466; ENSP00000504219; ENSG00000204120
ENST00000678885; ENSP00000503563; ENSG00000204120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016692 Genomic DNA No translation available.
AC064852 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENST00000677591; ENSP00000503061; ENSG00000204120
ENST00000678339; ENSP00000503437; ENSG00000204120
ENST00000678466; ENSP00000504219; ENSG00000204120
ENST00000678885; ENSP00000503563; ENSG00000204120

Organism-specific databases

HGNCiHGNC:11960, GIGYF2
OpenTargetsiENSG00000204120

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000156108

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7I2V3H7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7I2V3H7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 7, 2021
Last sequence update: April 7, 2021
Last modified: January 19, 2022
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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