The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - A0A7I2V365 (A0A7I2V365_HUMAN)
Protein
Submitted name:
Citron Rho-interacting kinase
Gene
CIT
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Citron Rho-interacting kinase |
Gene namesi | Name:CIT |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1985, CIT |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 943 – 992 | Phorbol-ester/DAG-typeInterPro annotationAdd BLAST | 50 | |
Domaini | 1101 – 1391 | CNHInterPro annotationAdd BLAST | 291 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 871 – 932 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 1415 – 1522 | DisorderedSequence analysisAdd BLAST | 108 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 12 – 142 | Sequence analysisAdd BLAST | 131 | |
Coiled coili | 150 – 170 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 178 – 302 | Sequence analysisAdd BLAST | 125 | |
Coiled coili | 321 – 390 | Sequence analysisAdd BLAST | 70 | |
Coiled coili | 412 – 439 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 447 – 638 | Sequence analysisAdd BLAST | 192 | |
Coiled coili | 650 – 677 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 689 – 765 | Sequence analysisAdd BLAST | 77 | |
Coiled coili | 773 – 793 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1423 – 1437 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1461 – 1509 | Basic and acidic residuesSequence analysisAdd BLAST | 49 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT01030000234517 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR046349, C1-like_sf IPR017405, Citron_Rho-interacting_kinase IPR001180, CNH_dom IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf |
PANTHERi | PTHR22988:SF26, PTHR22988:SF26, 2 hits |
Pfami | View protein in Pfam PF00780, CNH, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit |
SUPFAMi | SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All
A0A7I2V365-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKKLLIKSK ELQDSQDKCH KMEQEMTRLH RRVSEVEAVL SQKEVELKAS
60 70 80 90 100
ETQRSLLEQD LATYITECSS LKRSLEQARM EVSQEDDKAL QLLHDIREQS
110 120 130 140 150
RKLQEIKEQE YQAQVEEMRL MMNQLEEDLV SARRRSDLYE SELRESRLAA
160 170 180 190 200
EEFKRKATEC QHKLLKAKDQ GKPEVGEYAK LEKINAEQQL KIQELQEKLE
210 220 230 240 250
KAVKASTEAT ELLQNIRQAK ERAERELEKL QNREDSSEGI RKKLVEAEER
260 270 280 290 300
RHSLENKVKR LETMERRENR LKDDIQTKSQ QIQQMADKIL ELEEKHREAQ
310 320 330 340 350
VSAQHLEVHL KQKEQHYEEK IKVLDNQIKK DLADKETLEN MMQRHEEEAH
360 370 380 390 400
EKGKILSEQK AMINAMDSKI RSLEQRIVEL SEANKLAANS SLFTQRNMKA
410 420 430 440 450
QEEMISELRQ QKFYLETQAG KLEAQNRKLE EQLEKISHQD HSDKNRLLEL
460 470 480 490 500
ETRLREVSLE HEEQKLELKR QLTELQLSLQ ERESQLTALQ AARAALESQL
510 520 530 540 550
RQAKTELEET TAEAEEEIQA LTAHRDEIQR KFDALRNSCT VITDLEEQLN
560 570 580 590 600
QLTEDNAELN NQNFYLSKQL DEASGANDEI VQLRSEVDHL RREITEREMQ
610 620 630 640 650
LTSQKQTMEA LKTTCTMLEE QVMDLEALND ELLEKERQWE AWRSVLGDEK
660 670 680 690 700
SQFECRVREL QRMLDTEKQS RARADQRITE SRQVVELAVK EHKAEILALQ
710 720 730 740 750
QALKEQKLKA ESLSDKLNDL EKKHAMLEMN ARSLQQKLET ERELKQRLLE
760 770 780 790 800
EQAKLQQQMD LQKNHIFRLT QGLQEALDRA DLLKTERSDL EYQLENIQVL
810 820 830 840 850
YSHEKVKMEG TISQQTKLID FLQAKMDQPA KKKKVPLQYN ELKLALEKEK
860 870 880 890 900
ARCAELEEAL QKTRIELRSA REEAAHRKAT DHPHPSTPAT ARQQIAMSAI
910 920 930 940 950
VRSPEHQPSA MSLLAPPSSR RKESSTPEEF SRRLKERMHH NIPHRFNVGL
960 970 980 990 1000
NMRATKCAVC LDTVHFGRQA SKCLECQVMC HPKCSTCLPA TCGLPAEYAT
1010 1020 1030 1040 1050
HFTEAFCRDK MNSPGLQTKE PSSSLHLEGW MKVPRNNKRG QQGWDRKYIV
1060 1070 1080 1090 1100
LEGSKVLIYD NERWVTALES VVAGGRVSRE KAEADAKLLG NSLLKLEGDD
1110 1120 1130 1140 1150
RLDMNCTLPF SDQVVLVGTE EGLYALNVLK NSLTHVPGIG AVFQIYIIKD
1160 1170 1180 1190 1200
LEKLLMIAGE ERALCLVDVK KVKQSLAQSH LPAQPDISPN IFEAVKGCHL
1210 1220 1230 1240 1250
FGAGKIENGL CICAAMPSKV VILRYNENLS KYCIRKEIET SEPCSCIHFT
1260 1270 1280 1290 1300
NYSILIGTNK FYEIDMKQYT LEEFLDKNDH SLAPAVFAAS SNSFPVSIVQ
1310 1320 1330 1340 1350
VNSAGQREEY LLCFHEFGVF VDSYGRRSRT DDLKWSRLPL AFAYREPYLF
1360 1370 1380 1390 1400
VTHFNSLEVI EIQARSSAGT PARAYLDIPN PRYLGPAISS GAIYLASSYQ
1410 1420 1430 1440 1450
DKLRVICCKG NLVKESGTEH HRGPSTSRSS PNKRGPPTYN EHITKRVASS
1460 1470 1480 1490 1500
PAPPEGPSHP REPSTPHRYR EGRTELRRDK SPGRPLEREK SPGRMLSTRR
1510 1520 1530
ERSPGRLFED SSRGRLPAGA VRTPLSQVNK VWDQSSV
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14578 | CTRO_HUMAN | Citron Rho-interacting kinase | CIT CRIK, KIAA0949, STK21 | 2,027 | Annotation score: | ||
H7BYJ3 | H7BYJ3_HUMAN | Non-specific serine/threonine prote... | CIT | 1,640 | Annotation score: | ||
A0A7I2V4A6 | A0A7I2V4A6_HUMAN | Citron Rho-interacting kinase | CIT | 1,566 | Annotation score: | ||
A0A7I2V4H7 | A0A7I2V4H7_HUMAN | Citron Rho-interacting kinase | CIT | 1,617 | Annotation score: | ||
A0A7I2V4I0 | A0A7I2V4I0_HUMAN | Citron Rho-interacting kinase | CIT | 1,603 | Annotation score: | ||
A0A7I2V692 | A0A7I2V692_HUMAN | Citron Rho-interacting kinase | CIT | 1,608 | Annotation score: | ||
H0YGG8 | H0YGG8_HUMAN | Citron Rho-interacting kinase | CIT | 109 | Annotation score: | ||
F5H4K4 | F5H4K4_HUMAN | Citron Rho-interacting kinase | CIT | 104 | Annotation score: | ||
A0A7I2V2G7 | A0A7I2V2G7_HUMAN | Citron Rho-interacting kinase | CIT | 206 | Annotation score: | ||
A0A7I2YQJ8 | A0A7I2YQJ8_HUMAN | Citron Rho-interacting kinase | CIT | 507 | Annotation score: | ||
There is more potential isoformShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002563 Genomic DNA No translation available. AC004813 Genomic DNA No translation available. AC079317 Genomic DNA No translation available. KF511174 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000678677.1; ENSP00000503253.1; ENSG00000122966.17 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC002563 Genomic DNA No translation available. AC004813 Genomic DNA No translation available. AC079317 Genomic DNA No translation available. KF511174 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A7I2V365 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A7I2V365 |
Genome annotation databases
Ensembli | ENST00000678677.1; ENSP00000503253.1; ENSG00000122966.17 |
Organism-specific databases
HGNCi | HGNC:1985, CIT |
OpenTargetsi | ENSG00000122966 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01030000234517 |
Family and domain databases
CDDi | cd00029, C1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR046349, C1-like_sf IPR017405, Citron_Rho-interacting_kinase IPR001180, CNH_dom IPR002219, PE/DAG-bd IPR011993, PH-like_dom_sf |
PANTHERi | PTHR22988:SF26, PTHR22988:SF26, 2 hits |
Pfami | View protein in Pfam PF00780, CNH, 1 hit |
SMARTi | View protein in SMART SM00109, C1, 1 hit SM00036, CNH, 1 hit |
SUPFAMi | SSF57889, SSF57889, 1 hit |
PROSITEi | View protein in PROSITE PS50219, CNH, 1 hit PS00479, ZF_DAG_PE_1, 1 hit PS50081, ZF_DAG_PE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A7I2V365_HUMAN | |
Accessioni | A0A7I2V365Primary (citable) accession number: A0A7I2V365 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 7, 2021 |
Last sequence update: | April 7, 2021 | |
Last modified: | May 25, 2022 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |