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Entry version 2 (07 Apr 2021)
Sequence version 1 (10 Feb 2021)
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Protein
Submitted name:

AF4/FMR2 family member 1 isoform X1

Gene

AFF1

Organism
Phyllostomus discolor (pale spear-nosed bat)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyllostomus discolor (pale spear-nosed bat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri89673 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMicrochiropteraPhyllostomidaePhyllostominaePhyllostomus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000504628 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini983 – 1237AF-4_CInterPro annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 57DisorderedSequence analysisAdd BLAST32
Regioni79 – 364DisorderedSequence analysisAdd BLAST286
Regioni381 – 748DisorderedSequence analysisAdd BLAST368
Regioni796 – 991DisorderedSequence analysisAdd BLAST196
Regioni1121 – 1152DisorderedSequence analysisAdd BLAST32

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili997 – 1017Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi79 – 93PolyampholyteSequence analysisAdd BLAST15
Compositional biasi109 – 132PolarSequence analysisAdd BLAST24
Compositional biasi175 – 198PolyampholyteSequence analysisAdd BLAST24
Compositional biasi221 – 249PolarSequence analysisAdd BLAST29
Compositional biasi326 – 348PolyampholyteSequence analysisAdd BLAST23
Compositional biasi386 – 438PolarSequence analysisAdd BLAST53
Compositional biasi481 – 508PolarSequence analysisAdd BLAST28
Compositional biasi562 – 589PolyampholyteSequence analysisAdd BLAST28
Compositional biasi608 – 630PolarSequence analysisAdd BLAST23
Compositional biasi657 – 698PolyampholyteSequence analysisAdd BLAST42
Compositional biasi726 – 743PolarSequence analysisAdd BLAST18
Compositional biasi805 – 857PolyampholyteSequence analysisAdd BLAST53
Compositional biasi889 – 913PolarSequence analysisAdd BLAST25
Compositional biasi935 – 958PolyampholyteSequence analysisAdd BLAST24
Compositional biasi959 – 978PolarSequence analysisAdd BLAST20

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

A0A7E6DU64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTERVNSS SNSLYNEDRN LLRIREKERR NQEAHQEKEA FPEKIPLFGE
60 70 80 90 100
PYKTEKGDEL SSRIQNMLGN YEEVKELLST KSHTHRLDAP ESRLGKPRYP
110 120 130 140 150
LFPEKGSKIP SHSFNTSVRH QPISTPASGP LPAGNISHNP KMAQPRMESM
160 170 180 190 200
PSLHVKSYAP PDSQHLAQDR LGQEGYSSGH HKNGDRRADG DHCSSMTDSA
210 220 230 240 250
PERRLSPLLS SLPSPVPPLS PVHSNQQNLP RTQGSNKVHS SNNNNKGYCP
260 270 280 290 300
AKSPKDLAVK VRDKETPQDS LVAVSSLGVV PPQPPSQSFP PPSLPSKSVA
310 320 330 340 350
MQQKPTAYVR PMDGQDQAPS ESPELKPPPE DYRQQTFEKT DLKVPAKSKL
360 370 380 390 400
TKLKMPSQSV EQTYSSEVHC VEEILKEMTH SWPPPLTAIH TPSTAEPTKF
410 420 430 440 450
PFPTKDSQHI SSATQNQKQY DTTSKTHPNS QQGTSVCVPA RFSMLEDDLQ
460 470 480 490 500
LSDSEDSEIE QTPEKPPSAS APPSAPQSLP EAAASAHSSG AESESTSDSD
510 520 530 540 550
SSSDSESESS SSDSEENEPH EPPAPEPEPP TTNKWQLDNW LTKVSQPAVP
560 570 580 590 600
PEALGTAEPP PQHPDEKGKG GDGSTTSHEH SESKDPPPKG SGRAPRVPPE
610 620 630 640 650
GHHTGKRSCQ KSPAQQELPQ RQTVGTKQPK NPIKASAPAD SRASLQVESE
660 670 680 690 700
PGPPHGSKDQ PSKEKPKVKT KGRPRAGDGR EPKPAVPTPS EKKKHRGGPP
710 720 730 740 750
APSKVLLGPE PTNDNVEDRS PEHLALVPLT QSQGPTHDSG ISGRTSGCRR
760 770 780 790 800
AVVVQEDRRK GKLPVPLKDT KLLSPLRDTP PPQSLMVKIT LDLLSWVPQP
810 820 830 840 850
PGKGSHQKKP EDKQPSAGKK LDSEKKSSDN SSKLAKKRKG EAERDHESKK
860 870 880 890 900
VRLEKDTKSQ SSSSSSHKES SKTKTPRPSS EPSKKEMLPP TLVSSSSSTS
910 920 930 940 950
SSSSSSSSQK PAKPAQKRPR REAHPCGQDP PKSASNTKDN HKDSPAPRRR
960 970 980 990 1000
KTEGKGSGSS TEHKGSSGDT ANPFPVPSLP NGNSKPGKPQ VKFDRQADLH
1010 1020 1030 1040 1050
MKEAKKLKQR AELMTDKVGK AFKYLEAALS LIECGIAMES ESPASKSAYS
1060 1070 1080 1090 1100
VYSETEDLIK FIMSLKPFTD PTGSTQEKIF AILCMRCQSV LNMAMFRCKK
1110 1120 1130 1140 1150
DRAIKYSRTL NEHFQSSSKV TQAPSPCIAR STGTPSPLSP MPSSASCAGS
1160 1170 1180 1190 1200
QSSAGSVGSS GMPAAIQNMT SSYITITSHI FTAFDLWEQA EILTRKNKEF
1210 1220 1230
FAQLSTSACT LALNSSLVDL VHYTRQGFQW LKQGTKTP
Length:1,238
Mass (Da):134,554
Last modified:February 10, 2021 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84BD6DAA75137D28
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6J2LDM2A0A6J2LDM2_9CHIR
AF4/FMR2 family member 1 isoform X5
AFF1
1,223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DU29A0A7E6DU29_9CHIR
AF4/FMR2 family member 1 isoform X4
AFF1
1,230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DU38A0A7E6DU38_9CHIR
AF4/FMR2 family member 1 isoform X6
AFF1
1,209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DU74A0A7E6DU74_9CHIR
AF4/FMR2 family member 1 isoform X3
AFF1
1,231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DU89A0A7E6DU89_9CHIR
AF4/FMR2 family member 1 isoform X8
AFF1
1,201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DUQ8A0A7E6DUQ8_9CHIR
AF4/FMR2 family member 1 isoform X9
AFF1
1,199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DV15A0A7E6DV15_9CHIR
AF4/FMR2 family member 1 isoform X7
AFF1
1,208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DVC3A0A7E6DVC3_9CHIR
AF4/FMR2 family member 1 isoform X2
AFF1
1,237Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7E6DVG6A0A7E6DVG6_9CHIR
AF4/FMR2 family member 1 isoform X1...
AFF1
1,170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_035882701.1, XM_036026808.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_035882701.1, XM_036026808.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A7E6DU64_9CHIR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A7E6DU64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2021
Last sequence update: February 10, 2021
Last modified: April 7, 2021
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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