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UniProtKB - A0A6Q8PFE3 (A0A6Q8PFE3_HUMAN)
Protein
Submitted name:
Tripartite motif-containing protein 2
Gene
TRIM2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Tripartite motif-containing protein 2Imported |
Gene namesi | Name:TRIM2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15974, TRIM2 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 123 – 224 | FilaminPROSITE-ProRule annotationAdd BLAST | 102 | |
Repeati | 276 – 319 | NHLPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 323 – 366 | NHLPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 367 – 408 | NHLPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 412 – 455 | NHLPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 459 – 502 | NHLPROSITE-ProRule annotationAdd BLAST | 44 | |
Repeati | 503 – 546 | NHLPROSITE-ProRule annotationAdd BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 265 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.ARBA annotation
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155905 |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001258, NHL_repeat IPR013017, NHL_repeat_subgr |
Pfami | View protein in Pfam PF00630, Filamin, 1 hit PF01436, NHL, 6 hits |
SMARTi | View protein in SMART SM00557, IG_FLMN, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50194, FILAMIN_REPEAT, 1 hit PS51125, NHL, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 38 potential isoforms that are computationally mapped.Show allAlign All
A0A6Q8PFE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVLQRTPGS NAEESSILET VTAVAAGKPL SCPNHDGNVL QSQLDTLLQG
60 70 80 90 100
QESIKSCSNF TAQALNHGTE TEVLLVKKQM SEKLNELADQ DFPLHPREND
110 120 130 140 150
QLDFIVETEG LKKSIHNLGT ILTTNAVASE TVATGEGLRQ TIIGQPMSVT
160 170 180 190 200
ITTKDKDGEL CKTGNAYLTA ELSTPDGSVA DGEILDNKNG TYEFLYTVQK
210 220 230 240 250
EGDFTLSLRL YDQHIRGSPF KLKVIRSADV SPTTEGVKRR VKSPGSGHVK
260 270 280 290 300
QKAVKRPASM YSTGKRKENP IEDDLIFRVG TKGRNKGEFT NLQGVAASTN
310 320 330 340 350
GKILIADSNN QCVQIFSNDG QFKSRFGIRG RSPGQLQRPT GVAVHPSGDI
360 370 380 390 400
IIADYDNKWV SIFSSDGKFK TKIGSGKLMG PKGVSVDRNG HIIVVDNKAC
410 420 430 440 450
CVFIFQPNGK IVTRFGSRGN GDRQFAGPHF AAVNSNNEII ITDFHNHSVK
460 470 480 490 500
VFNQEGEFML KFGSNGEGNG QFNAPTGVAV DSNGNIIVAD WGNSRIQVFD
510 520 530 540
GSGSFLSYIN TSADPLYGPQ GLALTSDGHV VVADSGNHCF KVYRYLQ
Computationally mapped potential isoform sequencesi
There are 38 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9C040 | TRIM2_HUMAN | Tripartite motif-containing protein... | TRIM2 KIAA0517, RNF86 | 744 | Annotation score: | ||
A0A6Q8PGE9 | A0A6Q8PGE9_HUMAN | Tripartite motif-containing protein... | TRIM2 | 743 | Annotation score: | ||
A0A6Q8PGL5 | A0A6Q8PGL5_HUMAN | Tripartite motif-containing protein... | TRIM2 | 742 | Annotation score: | ||
A0A6Q8PFV0 | A0A6Q8PFV0_HUMAN | Tripartite motif-containing protein... | TRIM2 | 725 | Annotation score: | ||
A0A0J9YX34 | A0A0J9YX34_HUMAN | Tripartite motif-containing protein... | TRIM2 | 681 | Annotation score: | ||
A0A6Q8PF63 | A0A6Q8PF63_HUMAN | Tripartite motif-containing protein... | TRIM2 | 762 | Annotation score: | ||
A0A6Q8PFB0 | A0A6Q8PFB0_HUMAN | Tripartite motif-containing protein... | TRIM2 | 761 | Annotation score: | ||
A0A6Q8PG16 | A0A6Q8PG16_HUMAN | Tripartite motif-containing protein... | TRIM2 | 748 | Annotation score: | ||
A0A6Q8PF74 | A0A6Q8PF74_HUMAN | Tripartite motif-containing protein... | TRIM2 | 766 | Annotation score: | ||
A0A6Q8PGG4 | A0A6Q8PGG4_HUMAN | Tripartite motif-containing protein... | TRIM2 | 765 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013477 Genomic DNA No translation available. AC114791 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000675146; ENSP00000501760; ENSG00000109654 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013477 Genomic DNA No translation available. AC114791 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A6Q8PFE3 |
ModBasei | Search... |
Genome annotation databases
Ensembli | ENST00000675146; ENSP00000501760; ENSG00000109654 |
Organism-specific databases
HGNCi | HGNC:15974, TRIM2 |
OpenTargetsi | ENSG00000109654 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155905 |
Family and domain databases
Gene3Di | 2.120.10.30, 2 hits 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR011042, 6-blade_b-propeller_TolB-like IPR017868, Filamin/ABP280_repeat-like IPR001298, Filamin/ABP280_rpt IPR013783, Ig-like_fold IPR014756, Ig_E-set IPR001258, NHL_repeat IPR013017, NHL_repeat_subgr |
Pfami | View protein in Pfam PF00630, Filamin, 1 hit PF01436, NHL, 6 hits |
SMARTi | View protein in SMART SM00557, IG_FLMN, 1 hit |
SUPFAMi | SSF81296, SSF81296, 1 hit |
PROSITEi | View protein in PROSITE PS50194, FILAMIN_REPEAT, 1 hit PS51125, NHL, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A6Q8PFE3_HUMAN | |
Accessioni | A0A6Q8PFE3Primary (citable) accession number: A0A6Q8PFE3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 2, 2020 |
Last sequence update: | December 2, 2020 | |
Last modified: | January 19, 2022 | |
This is version 6 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |