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Entry version 5 (19 Jan 2022)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

LOW QUALITY PROTEIN: nesprin-1

Gene

SYNE1

Organism
Zalophus californianus (California sealion)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LOW QUALITY PROTEIN: nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZalophus californianus (California sealion)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9704 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOtariidaeZalophus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515165 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8777CytoplasmicPROSITE-ProRule annotationAdd BLAST8777
Topological domaini8799 – 8828Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8769 – 8828KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5867 – 5895DisorderedSequence analysisAdd BLAST29
Regioni6198 – 6227DisorderedSequence analysisAdd BLAST30
Regioni6266 – 6296DisorderedSequence analysisAdd BLAST31
Regioni8252 – 8289DisorderedSequence analysisAdd BLAST38
Regioni8702 – 8763DisorderedSequence analysisAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili334 – 354Sequence analysisAdd BLAST21
Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili632 – 656Sequence analysisAdd BLAST25
Coiled coili782 – 802Sequence analysisAdd BLAST21
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1341Sequence analysisAdd BLAST21
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1493 – 1513Sequence analysisAdd BLAST21
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2281 – 2301Sequence analysisAdd BLAST21
Coiled coili2349 – 2376Sequence analysisAdd BLAST28
Coiled coili2489 – 2509Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3473 – 3493Sequence analysisAdd BLAST21
Coiled coili3579 – 3599Sequence analysisAdd BLAST21
Coiled coili3607 – 3627Sequence analysisAdd BLAST21
Coiled coili3655 – 3675Sequence analysisAdd BLAST21
Coiled coili3697 – 3717Sequence analysisAdd BLAST21
Coiled coili3790 – 3810Sequence analysisAdd BLAST21
Coiled coili3973 – 3993Sequence analysisAdd BLAST21
Coiled coili4115 – 4135Sequence analysisAdd BLAST21
Coiled coili4153 – 4173Sequence analysisAdd BLAST21
Coiled coili4282 – 4312Sequence analysisAdd BLAST31
Coiled coili4780 – 4814Sequence analysisAdd BLAST35
Coiled coili4858 – 4878Sequence analysisAdd BLAST21
Coiled coili5075 – 5095Sequence analysisAdd BLAST21
Coiled coili5113 – 5133Sequence analysisAdd BLAST21
Coiled coili5220 – 5240Sequence analysisAdd BLAST21
Coiled coili5364 – 5391Sequence analysisAdd BLAST28
Coiled coili5421 – 5441Sequence analysisAdd BLAST21
Coiled coili5520 – 5540Sequence analysisAdd BLAST21
Coiled coili5581 – 5601Sequence analysisAdd BLAST21
Coiled coili5607 – 5627Sequence analysisAdd BLAST21
Coiled coili5635 – 5662Sequence analysisAdd BLAST28
Coiled coili5741 – 5768Sequence analysisAdd BLAST28
Coiled coili5779 – 5816Sequence analysisAdd BLAST38
Coiled coili6011 – 6031Sequence analysisAdd BLAST21
Coiled coili6066 – 6093Sequence analysisAdd BLAST28
Coiled coili6235 – 6262Sequence analysisAdd BLAST28
Coiled coili6534 – 6554Sequence analysisAdd BLAST21
Coiled coili7065 – 7092Sequence analysisAdd BLAST28
Coiled coili7171 – 7201Sequence analysisAdd BLAST31
Coiled coili7820 – 7847Sequence analysisAdd BLAST28
Coiled coili8499 – 8519Sequence analysisAdd BLAST21
Coiled coili8677 – 8697Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5870 – 5895Polar residuesSequence analysisAdd BLAST26
Compositional biasi6212 – 6227Polar residuesSequence analysisAdd BLAST16
Compositional biasi8255 – 8275Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 44 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P9FLC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRMASRS PRDIANVMQR LQDEQELVQK RTFTKWINSH LAKRKPPLVV
60 70 80 90 100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKSMYRGSP IKLVNINSTD IADGRPSIVL GLVWTIILYF QIEELTSNLP
160 170 180 190 200
QLQSLSGSTS SVDSMVSAET ASPPSKRKVA TKIQGNAKKA LLKWVQYTVA
210 220 230 240 250
KQMGIEVKDF GRSWRSGIAF HSIIHAIRPE LVDLERVKGR PNRENLEEAF
260 270 280 290 300
TIAETELGIP RLLDPEDVDV DKPDEKSVMT YVAQFLNHYP DIHNTGTDGQ
310 320 330 340 350
ENDEILPGFP SFANSIQNFK REDRLILKET KVWIEQFERD LTRAQMTESN
360 370 380 390 400
LQDKYQSFKH FRVQYEIKRK QIEHLIQPVH RNGKLSLDQA LVKQSWDRVS
410 420 430 440 450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITIQQ VHEETANTIQ
460 470 480 490 500
RKREQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS
510 520 530 540 550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR ESVELLLQNY
560 570 580 590 600
ISFIENTKFF EQYEVTYQIL KQTAEMYVQA DGSVEEAENV MKFMNETTAQ
610 620 630 640 650
WRNLSVEVRS VRSMLEEVIA NWDRYDNTVA SLQAWLEDAE KMLNQSEHAK
660 670 680 690 700
KDFFRNLPHW IQQHAAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL
710 720 730 740 750
FMEVKQYARA DETDRMKKEY TDCVTVLSDF ATEAHKKLSE PLEVSFLNVK
760 770 780 790 800
LLIQDLEDIE QRVPVMDAQY KMITKTAHLI TKESSQEEAN EMFATMSRLK
810 820 830 840 850
EQLTKVKECH PPLLYESRQL LIPLEELEKQ MTLFYDSLGK INEILTVLEH
860 870 880 890 900
EAQSSALFKQ KQQELSACQE SCKKTMTQIE KGSQSVQKFV TLSSLLKHFD
910 920 930 940 950
QTKLHRQIAD VHGAFQNMVK KIGDWKKHVE TNSRLMKKFE ESRAELEKVL
960 970 980 990 1000
RIAQEGLEEK GNPEDLLKRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE
1010 1020 1030 1040 1050
QQGLQEAVRK LHKQWKDLQG EAPYHLLHLK IDVEKNRFLA SVEECRTELD
1060 1070 1080 1090 1100
RETKLVPQEG SEKIIKEHRI FFSDKGPHHL CEKRLQLIEE LCLKLPVRDP
1110 1120 1130 1140 1150
VRNTPETCHA TLKELRATIG TTYMKLMEDP DKWKDYTSRI SEFSSWISAK
1160 1170 1180 1190 1200
ETQLKGFKSE PFNTANHGEI KCAVEEIRNG VTTKGETLNW LKSRLKILIE
1210 1220 1230 1240 1250
VSSENEAQKQ GDELAKLSSS FKALVALLSE VEKMLSNFGD CVQYKEIVKS
1260 1270 1280 1290 1300
SLEELISGSK EVQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ
1310 1320 1330 1340 1350
QQIAQAQQGE VGLPGQVREE LRKLESTLDG MEHSREKQER RIQVTLRKWE
1360 1370 1380 1390 1400
RFDTNKETVV RYLFQTGSSH ERFLSFSSLE SLSSELEQTK EFSKRTEGIA
1410 1420 1430 1440 1450
VQAENLVKEA SEIPLGPKNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM
1460 1470 1480 1490 1500
VKNKWDHFGN NFETLSVWIT EKEKELNALE TSSSAMDMQI HQIKVAIQEI
1510 1520 1530 1540 1550
ESKISSITEL EEEAQSFAQF VTTGESARIK AKLTQIRRYW EELREHAQCL
1560 1570 1580 1590 1600
EGTILGHLSQ QQKFEETLRK IQKSVSEFED KLADPIKICS SATETYKVLQ
1610 1620 1630 1640 1650
EHMDLCQALE ALSSAVATIS ASAQKVANRG SSIQRAAALQ LRYEETGTRA
1660 1670 1680 1690 1700
KERQTVLENL LTHWQRLEKE LSTFLTWLER CEAIASSPEM DISADRVKVE
1710 1720 1730 1740 1750
SELQSIQALQ NEVVSQASIY SNLLQMKESL FSVASNDDVK MMKVHLEQLD
1760 1770 1780 1790 1800
ERWRDLPQII SKRITFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE
1810 1820 1830 1840 1850
ISITDHQAAF TRHKDHVAEI ESKKGELQSL QDHLVKLGAL GQAENLHLLQ
1860 1870 1880 1890 1900
GKAEDCFQLL EEASQVVERR QLALSQLAEF LQSHASLSGV LHRLRHTVEA
1910 1920 1930 1940 1950
TDSMNRKQTD LLEKDLNHAI QDAKTLESAA ISLDSILAKA QYHLKSGSSE
1960 1970 1980 1990 2000
QRTSCRTTAD HLCSELERIQ NLLGMKQSEA DALAVLKKAF QDQKEELLKS
2010 2020 2030 2040 2050
IEDIEERTDK ERLKELTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK
2060 2070 2080 2090 2100
QIAQKDVAFA SEIDREVNRL EVTWDDTKRL IHENQGQCCG LIDLMREYQN
2110 2120 2130 2140 2150
FKLAVSKVLE NASNVIATRT TIKDQEDLKW ALSKHETAKN EMCNKQKELD
2160 2170 2180 2190 2200
NFTSKGKQLL SELKKIHSSD FILVKTDMES TVDRWLDISE KIEENMDKLR
2210 2220 2230 2240 2250
ISLTIWADVL SSKDEIDGWS NSSVPQLTES ISNLNNSLRA EEFLKEFESE
2260 2270 2280 2290 2300
VKNKALRLEE LHCKVNDLKE LTKNPETPPD LQFIEADLRQ KLEHAKEITE
2310 2320 2330 2340 2350
EAKGTLRDFT AQSTQVEKFI SDITSWLTKV EESLKNCAQT ETWEGLKKVK
2360 2370 2380 2390 2400
EIQKELQSQQ SNISSTQENL NSLCRKYHSV ELEGLGSALT GLIKNHEAVT
2410 2420 2430 2440 2450
QLCSKTQASL QDSLEKHFNE SMQEFQEWFS GIKAAAKESS DRTGDSKVLE
2460 2470 2480 2490 2500
AKLHDLQNIL DSISDGQSKL DAVTQEGQIL YAHVSKQIVS SIQEQITKAN
2510 2520 2530 2540 2550
EEFQAFLKQC LKDKQALQDC ALELGSFEDQ HRKLNLWIHE MDERLSTENL
2560 2570 2580 2590 2600
GESKRHIPEK KNEVHKVEMF LGELLAARES LDKLSQRGQL LSEEGHGAGK
2610 2620 2630 2640 2650
EGRLCSQLLT NYQNLLRMTK ERLRSCQVAL HEHEALEEAL QSMWSWVKGI
2660 2670 2680 2690 2700
QDRLTAAEST VGSKDTLEKR LLQIQDILLM KGEGEVKLNM AIGKGEQALR
2710 2720 2730 2740 2750
SSNKQGQKVI QTQLQTLKDV WADIMSSSVR AQSTLESVIS KWNDYLEWKN
2760 2770 2780 2790 2800
QLEQWMESVD QKVEHPLQLQ PGLKEKFSLL DHFQSILSEA EDHARVLQSL
2810 2820 2830 2840 2850
TSKSRELYQK TEDESFKETA QEELKTQFND IITVSKEKMR KVEEIVKDHL
2860 2870 2880 2890 2900
MYLDAVQEFT DWLHSAKEEL HRWSDMSGDS SATQKKLSKI KELMDSREIG
2910 2920 2930 2940 2950
ASRRGRVESL APAVKQNTSA SGCELVDAEM QALRADWKQW EDSVLQTQTS
2960 2970 2980 2990 3000
LENLVSQMAL SEQEFSGQVA HLEQALDQFS ALLITWAQQL ALLEGKNTDK
3010 3020 3030 3040 3050
EIVECWQKGQ EILDALQKAE PKTEDLKSQL NELCRFSRDL STYSGKVSGL
3060 3070 3080 3090 3100
IKEYNCLCLQ ASKGCQNREQ ILQQRFRRAF KDFQQWLVNA KITTAKCFDI
3110 3120 3130 3140 3150
PQNINEVSTS LQKIQEFLSE SENGQHKLNM MLSKGELLST LLTKEKADGI
3160 3170 3180 3190 3200
QAKVATAKED WKNFHSNLHQ KESALENLKI QMKDFEVSAE PVQDWLSKTE
3210 3220 3230 3240 3250
KLVQESSNRL YDLPAKRREQ QKLQSVLEEV NCYEPQLNRL REKAQQLWEG
3260 3270 3280 3290 3300
QAASKSFMHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ
3310 3320 3330 3340 3350
DWLTDAVHML DSYCHPTSDK SVLDSRMLKL EALLSVKQEK EIQMKMIVTR
3360 3370 3380 3390 3400
GESVLQNTSP EGIPAIQQQL QSVKDMWASL LSAAIRCKSQ LEGALSKWTS
3410 3420 3430 3440 3450
YQDDVRQFSS WMDSVEGSLN ESERPYAELR EKTTALGKAK LLSEEVLSYS
3460 3470 3480 3490 3500
SLLETIELKG AGMTEHYVTQ LEFQDLQERY RAIKERAKEA VTKSEKLVRL
3510 3520 3530 3540 3550
HQEYQRDLKA FEVWLGQEQE KLDQHSVLEG DAHTHETTLR DLQELQVHCA
3560 3570 3580 3590 3600
EGQALLNSVL HTREEVIPSG IPQTEDRALE SLRQDWQAYQ QRLSETRTQF
3610 3620 3630 3640 3650
NNVVNKLRLM EQKYQQVDEW LKTLENKVSV KTGRQSSRAT KQIQLHQMKK
3660 3670 3680 3690 3700
WHEEVTAYKD EVEEVGARVQ EMLDENHVSS RMGCQATQLT SRYQALLLQV
3710 3720 3730 3740 3750
LEQIKFLEEE IQSLEESELS LSSYSDWYNS THKNFKNVAT KIDRVDKVMM
3760 3770 3780 3790 3800
GKKMKMLESL LKDMEKGHSL LKSAREKGER ALKYLEDSEA ETLRKEIQEH
3810 3820 3830 3840 3850
VEQLKELTSI VRKEHMTLEK GLLLAKEFSD KYKALTQWIS EYQEILHTPE
3860 3870 3880 3890 3900
EPKMELYEKK AQLSKYKSLQ QMVLSHEPSV RSVREKGEAL LEVVQDVTLK
3910 3920 3930 3940 3950
DEIDKLQSDY KDLCGAGKEH VCSLEAKVKD HEDYNSDLQK VEKWLLQMSG
3960 3970 3980 3990 4000
RLVVPDLMET SSLETITQQL AHHKAMMEEI AGFEDRLNNL KIKGDNLISQ
4010 4020 4030 4040 4050
CADHLQAKLK QNVHAHLQGT KDSYSAICST AQRVYQSLEH ELQKHVSRQD
4060 4070 4080 4090 4100
TLQQCQAWLC AVQPDLKPSQ HPPLSRAEAM KQVKHFRALQ EQARTYLDLL
4110 4120 4130 4140 4150
CSMCDLSNSS VKTTAKDIQQ TEQMIEQRLA QAQNLTQGWG EIKHMKAELW
4160 4170 4180 4190 4200
IYLQDADQQL QNMKRRHSEL ELNIAQNMVS QVKDFVKKLQ CKQASVTAIT
4210 4220 4230 4240 4250
ERVNKLTKKQ ESPEHKEISH LNDQWLDLCL QSNNLCLQRE EDLQRTRDYH
4260 4270 4280 4290 4300
DCMNVVEVFL EKFTTEWDNL ARSDAESTAV HLEALKKLAL ALQERKQAIE
4310 4320 4330 4340 4350
DLKDQKQKMI EHLNLDDKEL VKEQTSHLEQ RWFQLEDLVK RKIQVSVTNM
4360 4370 4380 4390 4400
EELNVVRSRF QELMEWAEEQ QPNVAEALKQ SPPPDMAQNL LMDHLAICSE
4410 4420 4430 4440 4450
LEAKQMLLKS LIKDADRVMA DLGLNERQII QKALSDAQRH VNCLSDLVGQ
4460 4470 4480 4490 4500
RRKYLNKALS EKSQFLMAVF QATSQIQQHE RKIMFREHIC LLPDDVSKQV
4510 4520 4530 4540 4550
KTCKSAQASL KTYQNEVTGL WAQGRELMKG AAEQEKSEVL GKLQELQSVY
4560 4570 4580 4590 4600
DTVLQKCSHR LQELEKNLVS RKHFKEDFDK ACHWLKQADI ITFPEINLMN
4610 4620 4630 4640 4650
ESSELHTQLA KYQHILEQSP EYENLLLTLQ RTGQAILPSL NEVDHSYLNE
4660 4670 4680 4690 4700
KLNALPLQFN VIVALAKDKF YKVQEAILTR KEYASLIELT VQSLSELEDQ
4710 4720 4730 4740 4750
FLKMSKVPAD LRVEEALSLQ EGCRALLGEV AGLGEAVDEL NQKKESFRST
4760 4770 4780 4790 4800
GQPWQPDKML QLVTLYHRLK RQTEQRVSLL EDITSAYQEH EKMCQQLEKQ
4810 4820 4830 4840 4850
LEAVKTEQSK VNEETLPAEE KLKIYHSLAG SLQDSGIVLK QVTVHLEDLV
4860 4870 4880 4890 4900
PHLDPLAYEK AKQQIQSWQE ELKLLTSAIG TTVTECESRM VQSIDFQTEL
4910 4920 4930 4940 4950
SRSLEWLRSV KAELSGPECL DLSLQDIQEE IRKIQIHQEE VQSSLRIMNA
4960 4970 4980 4990 5000
LSNKEKEKFT KAKELISADL QHTLAELSEL DGDVQEALRT RQAALTQIYS
5010 5020 5030 5040 5050
QCQRYYQVSQ AANDWLEDAH EMLQLAGNGL DVENAEENLK SHMEFFSTED
5060 5070 5080 5090 5100
QFHSNLEELQ GLVASLDPLL KPTAKEDLAQ KMASLEEKSQ RIIQDSHAQL
5110 5120 5130 5140 5150
DLLQRCAAQW QDYQKAREEV IELMNDAEKK LSEFSLSKTS SSHEAEEKLS
5160 5170 5180 5190 5200
EHKSLVSVVN SFHEKVVALE DKTSQLEKTG NDASKAALSR SMTTVWQRWT
5210 5220 5230 5240 5250
RLRAVAQDQE KILEDAVDEW KSLNTKVTKA KEMIDQLRDK LPDSSAEKAS
5260 5270 5280 5290 5300
KSELFTLLDH HDTLVLELDQ QQLALGLLRQ QALSMLQDGA TLSHGEEPSI
5310 5320 5330 5340 5350
VQEITAMQDR CLNMQDKVKS NGKVVKQELK EREVVETQIN SVKSWFQETK
5360 5370 5380 5390 5400
EYLGNPTIEI DAQLEELQIL LTEATNHRQN IEKMTEEQKN KYLGLYSILP
5410 5420 5430 5440 5450
PELSLQFAEV ALDLGTIHDQ IQDKVREVEQ SKAMSQELSR QIQKIAKDLT
5460 5470 5480 5490 5500
TILSKLRTKT DNLAQAKTDQ KVLGEELDGC HLKLMELDAA VQKFAEQNGQ
5510 5520 5530 5540 5550
LGKPLAKKIG KLTELHQQTI RQAENRLSKL GQAASHLEEY NEMLEFILKW
5560 5570 5580 5590 5600
IEKAKVLVHG KITWNSAHQL REQYILHQTM LEESEEIHSN LEAMIEKLQY
5610 5620 5630 5640 5650
LASVYSTEKM SQQVAELGRE SEELRQMIKI RLQNLQDAAK DMKKFETELK
5660 5670 5680 5690 5700
NLQVALEQAQ TTLTSAEVGR LSLKEQLSHR LHLLSEMESL KPKVHAVQIC
5710 5720 5730 5740 5750
QSALRIPEEV VTSLPLCHAA LHLQEEASRL QHTAIQQCNL MQEAVVQYEQ
5760 5770 5780 5790 5800
YEQEMQHLQE LIEGAHREIE DKPVATSNIQ ELQAQISRHE ELAQKIKGYQ
5810 5820 5830 5840 5850
EQIASLNSKC KMLTMKAKHA TMLLTVTEVE GLAEGTDDLD GELLPRPXGP
5860 5870 5880 5890 5900
PSVVMMTAGR CHTLLSPVTE ESGEEGTGSE ISSPPACRSP SPVANTDASV
5910 5920 5930 5940 5950
NQDIAYYQAL SPERLQTNAS RIHPSTLPSQ EFYEPGLEPS ATAKLDDLQR
5960 5970 5980 5990 6000
SWETLKNVIS EKQRTLYEAL ERQQKYQDSL QSISTKMEAI EMKLSESLEH
6010 6020 6030 6040 6050
SRSPESQMAE HQALMDEILM LQDEISELQS SLAEELVSES PESDPAEQLA
6060 6070 6080 6090 6100
LQSTLTVLAE RMSTIKMKAS GKRQLLEEKL NDQLEEQRQE QALQRYRCEA
6110 6120 6130 6140 6150
DELDHWLLST KATLDTALGT AKEPMDMEAQ LVDCQNMLVE IEQKVVALSE
6160 6170 6180 6190 6200
LSVHNENLLL EGKAHTKEEA ELLAVKLRTL KGSLLELQRA LHDKQLDIQG
6210 6220 6230 6240 6250
TAQEKEESHA DLTSSQSPGV QDWLAQARTM WTHQRQSSLQ QQKELEQELA
6260 6270 6280 6290 6300
EQKSLLRSVA SRGEEILTQH SAAETSGGAG EKPDVLSQEL GMEGEKSAAE
6310 6320 6330 6340 6350
DQMRMKWESL HQEFSTKQKL LQNVLEQEQE QVLYSRPNRL LSGVPLYKGD
6360 6370 6380 6390 6400
GQTQDKSAVT SLLDGLNQAF EEVSSQGGGT KRQNIHLEQK LYDGVSATST
6410 6420 6430 6440 6450
WLDDVEERLF VATALLPEET EACLFNQETL AKDIKEMSEE MDKNRNLFSQ
6460 6470 6480 6490 6500
AFPENGDNRD VIEDTLGCLL GRLSLLDSVV NQRCHQMKER LQQILNFQND
6510 6520 6530 6540 6550
LKVLCTSLAD NKYIILQKLA NVFEQPVAEQ IEAIQEAEDG LKELDAGITE
6560 6570 6580 6590 6600
LKKRGDTLQI EQPSMQELSK LQDMYDELMM TIGSRRSGLN QNLALKGQYE
6610 6620 6630 6640 6650
RALHDLADVV ETGQDKMAGD QKIIVSSKED IQQLLDKHKE YFQGLESHMI
6660 6670 6680 6690 6700
LTETLFRKII SFAVLQETQF HTELMVQASA VLKRAHKRGV ELEYILETWS
6710 6720 6730 6740 6750
HLDEDHQELS RQLEAVESSI PSVGLVEESE ERLIDRITLY QHLKSSLNEY
6760 6770 6780 6790 6800
QPKLYQVLDD GKRLLISISC SDLESQLNQL GEHWLNNTNK VSKELHRLET
6810 6820 6830 6840 6850
VLKHWTRYQS ESAELIHWLQ SAKDRLEFWT QQSVTVPQEL EMVRDHLNAF
6860 6870 6880 6890 6900
LEFSKEVDAK SSLKSSVLST GNQLLRLKKV DTAALRSELS QIDSQWTDLL
6910 6920 6930 6940 6950
TNIPTVQEKL HQLQMDKLPS RHAISEVMTW ISLMENVIQK DEENIKNSIG
6960 6970 6980 6990 7000
YKAIHEYLQK YKGFKIDINC KQLTVDFVNQ SVLQISSQDV ESKRSDKTDF
7010 7020 7030 7040 7050
AEQLGAMNKS WQILQGLVTE KIQLLEGLLE SWSEYENNVQ SLKTWYETQE
7060 7070 7080 7090 7100
NRLKQQHRIG DQASVQNAMK DCQDLEDLIR AKEKEVEKIE QNGLALIQNK
7110 7120 7130 7140 7150
KEEVSGVVMS TLRELNQTWA NLDHMVGQLK ILLKSVFDQW NNHKVAFDEI
7160 7170 7180 7190 7200
NSYLMEARYS LSRFRLLTGS LEAVQVQVDN LQNLQDDLEK QEKNLQRFGS
7210 7220 7230 7240 7250
VTNQLLKECH PPVTETLTNT LKDVNMRWNN LLEEIAEQLY SSKALLQLWQ
7260 7270 7280 7290 7300
RYKDYSKQCA STVQQQEDQT NELLKAATNK DIADDEVATW IQDCNDLLKG
7310 7320 7330 7340 7350
LGTVKDSLFV LHELGEQLKQ QVDASAASAI QSDQLSLSQH LCALEQALCK
7360 7370 7380 7390 7400
QQTMLQAGVL DYETFTKSLE ALEAWVVEAE EILQGQDPSR SSDLSTIQER
7410 7420 7430 7440 7450
MEELKGQMLK FSSMAPDLDR LNELGYRLPL NDKEIKRMQN LNRHWSLISS
7460 7470 7480 7490 7500
QTTERFSKLQ SFLLQHQTFL EKCETWMEFL VQTEQKLAVE ISGNYQHLLE
7510 7520 7530 7540 7550
QQRAHELFQA EMFSRQQILH SIIIDGQRLL EQGQVDDRDE FNLKLTLLSN
7560 7570 7580 7590 7600
QWQGVIRRAQ QRRGIIDSQI RQWQRYREMA EKLRKWLVEV SYLPVSALGS
7610 7620 7630 7640 7650
VLIPLQQART LFDEVQFKEK VCLRQQGSYI LTVEAGKQLL LSADSGAEAA
7660 7670 7680 7690 7700
LQAELTEIQD KWKSASVRLE EQKKKLAFLL KDWEKCENGI ADSLEKLRTF
7710 7720 7730 7740 7750
KKKLSQPLPN HHEELHAEQM RCKELENAAG SWKDDLAQLT LLKDTLCAYI
7760 7770 7780 7790 7800
SADDISILNE RMELLQRQWE ELCHQLSLRR QQVSERLNEW AVFNEKNKEL
7810 7820 7830 7840 7850
CEWLTQMESK VSQNGDILIE EMIEKLKKDY QEEIAVAQEN KIQLQQMGER
7860 7870 7880 7890 7900
LARASHESKA SEIEYKLGKV NDRWQHLLDL TAARVKKLKE TLVAVQQLDK
7910 7920 7930 7940 7950
NMSSLRTWLA HIESELAKPI VYDSCDSDEI QKKLTEQQEL QRDIEKHSTG
7960 7970 7980 7990 8000
VASVLNLCEV LLHDCDACAT DAECDSIQQA TRNLDRRWRN ICAMSMERRL
8010 8020 8030 8040 8050
KIEETWRLWQ KFLDDYSRFE DWLKISERTA AFPSSSGVLY TVAKEELKKF
8060 8070 8080 8090 8100
EAFQRQVHES LTQLELINKQ YRRLARENRT DSTCSLKQMV HEGNQRWDNL
8110 8120 8130 8140 8150
QKRVTSILRR LKHFIGQREE FETARDSILV WLTEMDLQLT NIEHFSECDV
8160 8170 8180 8190 8200
QAKIKQLKAF QQEISLNHNK IEQIIAQGEQ LIEKSEPLDA AVIEEELDEL
8210 8220 8230 8240 8250
RRYCQEVFGR VERYHKKLIR LPLPDDEHDL SDRELELDDS AALSDLHWRD
8260 8270 8280 8290 8300
TSVDGVLSPQ PSSNPSLSLA QPLRSERSGR DTPASVDSIP LEWDHDYDLS
8310 8320 8330 8340 8350
RDLESAVSRT LPSEDEEGQD DKDFYLSGAV GLSDVMIPES PEAYVKLTES
8360 8370 8380 8390 8400
AIRNTSGAPS AFESQIRQLD KALDESRFQM QQTENIIRSK TPTGPELDSS
8410 8420 8430 8440 8450
YRGYMKLLSE CSGSIDSVKR LEHKLKEEEE NFPGFVNLNT TETQTAGVID
8460 8470 8480 8490 8500
RWELIQAQAL SKELRMKQNL QKWQQFHTDL NNIWTWLGEM EQELEQLRHL
8510 8520 8530 8540 8550
DLSTDIQAIE LQIKKLKELQ KAVDHRKAII LSINLCSNEF TQPGSEKSQD
8560 8570 8580 8590 8600
LQDRLSQMNG RWDRVCSLLE EWRGLLQDAL MQCQDFHEMS HGLLLMLENI
8610 8620 8630 8640 8650
DRRKNEIVPI DSNQDAETLQ DHHKQLMQIR HELLESQLRV ASLQDMSCQL
8660 8670 8680 8690 8700
LVNAEGTDCL EAKEKVHVIG NRLRLLLKEV SHHIKELEKL LDMASSQQDL
8710 8720 8730 8740 8750
SSWSSADELD TSGSVSPASG RSTPNRQRTP RGKCSLSQPG PSVNSPHSRS
8760 8770 8780 8790 8800
IKGGSDSSLS EPRPTRSGRA FLFRVLRAAL PLQLLLLLLI GLACLVPMSE
8810 8820
EDYSCALSNN FARSFHPMLR YTNGPPPL
Length:8,828
Mass (Da):1,014,514
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44B9FFE9072AED46
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_035584483.1, XM_035728590.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_035584483.1, XM_035728590.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 12 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 44 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P9FLC4_ZALCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P9FLC4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: January 19, 2022
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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