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Entry version 2 (10 Feb 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

zinc metalloproteinase-disintegrin-like batroxstatin-1

Gene

LOC105889875

Organism
Clupea harengus (Atlantic herring)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
zinc metalloproteinase-disintegrin-like batroxstatin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC105889875Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiClupea harengus (Atlantic herring)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7950 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiClupeiClupeiformesClupeoideiClupeidaeClupea
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515152 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei664 – 687HelicalSequence analysisAdd BLAST24

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502823496723 – 765Sequence analysisAdd BLAST743

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi459 ↔ 479PROSITE-ProRule annotation
    Disulfide bondi623 ↔ 633PROSITE-ProRule annotation
    Disulfide bondi641 ↔ 650PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bondPROSITE-ProRule annotationARBA annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 393Peptidase M12BInterPro annotationAdd BLAST196
    Domaini401 – 487DisintegrinInterPro annotationAdd BLAST87
    Domaini619 – 651EGF-likeInterPro annotationAdd BLAST33

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni693 – 765DisorderedSequence analysisAdd BLAST73

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi693 – 726PolarSequence analysisAdd BLAST34
    Compositional biasi727 – 742Pro-richSequence analysisAdd BLAST16

    Keywords - Domaini

    EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04269, ZnMc_adamalysin_II_like, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.390.10, 1 hit
    4.10.70.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR006586, ADAM_Cys-rich
    IPR018358, Disintegrin_CS
    IPR001762, Disintegrin_dom
    IPR036436, Disintegrin_dom_sf
    IPR000742, EGF-like_dom
    IPR024079, MetalloPept_cat_dom_sf
    IPR001590, Peptidase_M12B
    IPR002870, Peptidase_M12B_N
    IPR034027, Reprolysin_adamalysin

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08516, ADAM_CR, 1 hit
    PF00200, Disintegrin, 1 hit
    PF01562, Pep_M12B_propep, 1 hit
    PF01421, Reprolysin, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00289, DISINTEGRIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00608, ACR, 1 hit
    SM00050, DISIN, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF57552, SSF57552, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50215, ADAM_MEPRO, 1 hit
    PS00427, DISINTEGRIN_1, 1 hit
    PS50214, DISINTEGRIN_2, 1 hit
    PS01186, EGF_2, 1 hit
    PS50026, EGF_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A6P8FCS5-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTRKPLLFWI FALAASLDPS VCHGPELDGV EVYDVVRPIR LHSLNKRDVE
    60 70 80 90 100
    SSRPEVLKYG MTIRGRDIEL NLERNQDILT KEYSETYYTE DGTPVTYSPE
    110 120 130 140 150
    DLDHCYYRGS VVNDSESMIS VSTCDGLRGY VRTAEQRFLI EPMSEDKDGD
    160 170 180 190 200
    HAVLKFEDVP DKPMTCGVTN TSWDPEYPLR TSRSRSRAAG PSLLQQQKYI
    210 220 230 240 250
    ELYLVADNRE YIRMNKDPAA VRKRIFEIIN FVNAVYKPLN TFIALTGLEI
    260 270 280 290 300
    WTDSDKISVT SPAGATLDSF TKWRNSDLRK RKRHDNAHLI TAIDFDGSTV
    310 320 330 340 350
    GLAFIGTLCS EHSTGVVQDH NHRAIAVAAT LSHEMGHNLG MSHDTSSCAC
    360 370 380 390 400
    PDGSCIMAAA LSYNIPRKFS SCSSNGYGDF LNNRNPECVL NKPDYMELVA
    410 420 430 440 450
    EPVCQNGFLE RGEQCDCGTT EECNNPCCNA TTCRLVDGAQ CAAGECCENC
    460 470 480 490 500
    KIMSPARECR TKRDDCDLAE YCTGKSPECP EDVFAVNSLP CENGKSYCYN
    510 520 530 540 550
    GRCPQKEEQC VRMWGATARV ARQYCYDQNT RGIYYGFCKR PSSDQYLPCQ
    560 570 580 590 600
    RADVMCGKLY CHDGNASPNY GRLVEFSDCK ATFYGDYEND HGQVDTGTKC
    610 620 630 640 650
    GEGKVCSQNE CVDLETAYRA TNCSAKCQGR GVCNHRSECQ CEPGWLQPHC
    660 670 680 690 700
    DTQDPSMQLP RGSVIAIAVT LSLLGLIVVI GASVFLLKRR QSTSRMAGLP
    710 720 730 740 750
    TQKSQPVSNP VFGRQQLKTP RQNPETTQRP RAPPPPPPSA SGRSRPLQTS
    760
    FMAARQALRP PPPRV
    Length:765
    Mass (Da):85,128
    Last modified:December 2, 2020 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03D15B6112541186
    GO

    Sequence databases

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_031426298.1, XM_031570438.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    RefSeqiXP_031426298.1, XM_031570438.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    CDDicd04269, ZnMc_adamalysin_II_like, 1 hit
    Gene3Di3.40.390.10, 1 hit
    4.10.70.10, 1 hit
    InterProiView protein in InterPro
    IPR006586, ADAM_Cys-rich
    IPR018358, Disintegrin_CS
    IPR001762, Disintegrin_dom
    IPR036436, Disintegrin_dom_sf
    IPR000742, EGF-like_dom
    IPR024079, MetalloPept_cat_dom_sf
    IPR001590, Peptidase_M12B
    IPR002870, Peptidase_M12B_N
    IPR034027, Reprolysin_adamalysin
    PfamiView protein in Pfam
    PF08516, ADAM_CR, 1 hit
    PF00200, Disintegrin, 1 hit
    PF01562, Pep_M12B_propep, 1 hit
    PF01421, Reprolysin, 1 hit
    PRINTSiPR00289, DISINTEGRIN
    SMARTiView protein in SMART
    SM00608, ACR, 1 hit
    SM00050, DISIN, 1 hit
    SUPFAMiSSF57552, SSF57552, 1 hit
    PROSITEiView protein in PROSITE
    PS50215, ADAM_MEPRO, 1 hit
    PS00427, DISINTEGRIN_1, 1 hit
    PS50214, DISINTEGRIN_2, 1 hit
    PS01186, EGF_2, 1 hit
    PS50026, EGF_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P8FCS5_CLUHA
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P8FCS5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
    Last sequence update: December 2, 2020
    Last modified: February 10, 2021
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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