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Entry version 3 (07 Apr 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

AF4/FMR2 family member 1 isoform X1

Gene

Aff1

Organism
Mus caroli (Ryukyu mouse) (Ricefield mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aff1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus caroli (Ryukyu mouse) (Ricefield mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10089 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515126 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini966 – 1226AF-4_CInterPro annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 60DisorderedSequence analysisAdd BLAST33
Regioni76 – 227DisorderedSequence analysisAdd BLAST152
Regioni239 – 326DisorderedSequence analysisAdd BLAST88
Regioni362 – 741DisorderedSequence analysisAdd BLAST380
Regioni785 – 982DisorderedSequence analysisAdd BLAST198
Regioni1106 – 1136DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 45PolyampholyteSequence analysisAdd BLAST18
Compositional biasi76 – 101PolyampholyteSequence analysisAdd BLAST26
Compositional biasi110 – 140PolarSequence analysisAdd BLAST31
Compositional biasi168 – 186PolyampholyteSequence analysisAdd BLAST19
Compositional biasi210 – 227PolarSequence analysisAdd BLAST18
Compositional biasi264 – 279Pro-richSequence analysisAdd BLAST16
Compositional biasi389 – 421PolarSequence analysisAdd BLAST33
Compositional biasi438 – 452Pro-richSequence analysisAdd BLAST15
Compositional biasi454 – 480PolarSequence analysisAdd BLAST27
Compositional biasi481 – 496AcidicSequence analysisAdd BLAST16
Compositional biasi505 – 550PolarSequence analysisAdd BLAST46
Compositional biasi658 – 676Pro-richSequence analysisAdd BLAST19
Compositional biasi713 – 741PolarSequence analysisAdd BLAST29
Compositional biasi797 – 848PolyampholyteSequence analysisAdd BLAST52
Compositional biasi849 – 898PolarSequence analysisAdd BLAST50
Compositional biasi912 – 927PolarSequence analysisAdd BLAST16
Compositional biasi928 – 942PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P7R3M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRIRPGES GGACLYNEDR NLLRIKEKER RNQEAHQEKE AFPEKAPLFP
60 70 80 90 100
EPYKTAKGDE LSSRIQTMLG DYEEMKEFLS SKSHPHRLDG SEDRPGKPRY
110 120 130 140 150
PLGHDRGNGA ASSSLRTHVY HQPIHTSAPG SRSVGNISHS PKMAQPRMEP
160 170 180 190 200
SLHAKIYDGP RLTQDHLSQG HCSRKCDRRA EGDASSAPER KLSPLITSLP
210 220 230 240 250
SPVPPLSPVH SRLQGTSKAH SSGVSSKSCC VAKSSKDLVA KAQDKETPHD
260 270 280 290 300
SLVAVTSLGA APPQPPCQTF PPPPLPSKSA AMQQKPTAYV RPMDGQDQAP
310 320 330 340 350
SESPELKPPL EDYGQQSFEK PDLKVPAKAK LTRLRMPSQS VEQPYSNEVH
360 370 380 390 400
CVEEILKEMT HSWPPPLTAI HTPSTAEPSR FPFPTKDPLH VSSATQSQKQ
410 420 430 440 450
YDTPSKTHPN PQQGTSTLED DLQLSDSEDS DTEQATEKPP SPPAPPSAPQ
460 470 480 490 500
TLPEPVASAH SSSGESESSE SDSSSDSESE SSSSDSEEEE NEPLETPAPE
510 520 530 540 550
PEPPTTNNKW QLDNWLTKVN QPSVPLDGRG STESPQWRQE SKSVAEGSSD
560 570 580 590 600
QQHPDSKDPP PKSSSKTLRG PSEGPQPGKR GCPKSPAQQE PPPRQTVGSK
610 620 630 640 650
LPRKPAKGSG QAEPQASSQV ESEAGPLPYG SKEQTSKDRP KVKTKGRPRA
660 670 680 690 700
VGSREPKPEV PAPTPQAAVP RPKPPVPTPS EKRKHKSSTA PSKAPSAPQP
710 720 730 740 750
PKDSAGDRNP EHSALVSMTQ SQGPSHSGRG SSGSIRTSGC RQAVIAQEDG
760 770 780 790 800
CKDKLLLPLR DTKLLSPLRD SPPPTSLVVK ITLDLLTRIP QPLGKGSRPR
810 820 830 840 850
KAEDRQLSAG KKQDSETKSC DSSSRVTKKR KGDPEKEHSN KRHKPDKSQT
860 870 880 890 900
TSSSSSHTES SKTKAPRSSS ENSRKETLPP ASVSSVSSSS SSQKPSRPAQ
910 920 930 940 950
KRPRPDEDTC SQEPPRSASS TKNSSTDPPA PKHRKVQARG SEHKGSSGDA
960 970 980 990 1000
ANAANPFPVP SLPNGNAKPG KPQVKSDRQQ ADFHMKEAKK LKCKAETMVD
1010 1020 1030 1040 1050
KAGKAFKYLE AVLSFIECGM ATESESSAKS AYTVYSETVD LVRYVMSLKC
1060 1070 1080 1090 1100
FSDNTMPAQE KIFAVLCLRC QSLLNMAMFR CKKDTVMKYS RTLSEHFKST
1110 1120 1130 1140 1150
SKVAQAPSPC TARSTGVPSP LSPMPSPASS VGSQSSAGSS VGSVGVTATV
1160 1170 1180 1190 1200
STPVSIQNMT SSYVTITSHV LTAFSLWDQA EALTRKNKEF FAQLSTKVRV
1210 1220
LALNSSLVDL VHYTRQGLQR LKQSPKAP
Length:1,228
Mass (Da):132,576
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i272BF8A25C138229
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_029333879.1, XM_029478019.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_029333879.1, XM_029478019.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P7R3M0_MUSCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P7R3M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: April 7, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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