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UniProtKB - A0A6P7R3M0 (A0A6P7R3M0_MUSCR)

Entry version 3 (07 Apr 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

AF4/FMR2 family member 1 isoform X1

Gene

Aff1

Organism
Mus caroli (Ryukyu mouse) (Ricefield mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aff1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus caroli (Ryukyu mouse) (Ricefield mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10089 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515126 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini966 – 1226AF-4_CInterPro annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 60DisorderedSequence analysisAdd BLAST33
Regioni76 – 227DisorderedSequence analysisAdd BLAST152
Regioni239 – 326DisorderedSequence analysisAdd BLAST88
Regioni362 – 741DisorderedSequence analysisAdd BLAST380
Regioni785 – 982DisorderedSequence analysisAdd BLAST198
Regioni1106 – 1136DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 45PolyampholyteSequence analysisAdd BLAST18
Compositional biasi76 – 101PolyampholyteSequence analysisAdd BLAST26
Compositional biasi110 – 140PolarSequence analysisAdd BLAST31
Compositional biasi168 – 186PolyampholyteSequence analysisAdd BLAST19
Compositional biasi210 – 227PolarSequence analysisAdd BLAST18
Compositional biasi264 – 279Pro-richSequence analysisAdd BLAST16
Compositional biasi389 – 421PolarSequence analysisAdd BLAST33
Compositional biasi438 – 452Pro-richSequence analysisAdd BLAST15
Compositional biasi454 – 480PolarSequence analysisAdd BLAST27
Compositional biasi481 – 496AcidicSequence analysisAdd BLAST16
Compositional biasi505 – 550PolarSequence analysisAdd BLAST46
Compositional biasi658 – 676Pro-richSequence analysisAdd BLAST19
Compositional biasi713 – 741PolarSequence analysisAdd BLAST29
Compositional biasi797 – 848PolyampholyteSequence analysisAdd BLAST52
Compositional biasi849 – 898PolarSequence analysisAdd BLAST50
Compositional biasi912 – 927PolarSequence analysisAdd BLAST16
Compositional biasi928 – 942PolyampholyteSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...PANTHERi		PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P7R3M0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METRIRPGES GGACLYNEDR NLLRIKEKER RNQEAHQEKE AFPEKAPLFP 
        60         70         80         90        100
EPYKTAKGDE LSSRIQTMLG DYEEMKEFLS SKSHPHRLDG SEDRPGKPRY 
       110        120        130        140        150
PLGHDRGNGA ASSSLRTHVY HQPIHTSAPG SRSVGNISHS PKMAQPRMEP 
       160        170        180        190        200
SLHAKIYDGP RLTQDHLSQG HCSRKCDRRA EGDASSAPER KLSPLITSLP 
       210        220        230        240        250
SPVPPLSPVH SRLQGTSKAH SSGVSSKSCC VAKSSKDLVA KAQDKETPHD 
       260        270        280        290        300
SLVAVTSLGA APPQPPCQTF PPPPLPSKSA AMQQKPTAYV RPMDGQDQAP 
       310        320        330        340        350
SESPELKPPL EDYGQQSFEK PDLKVPAKAK LTRLRMPSQS VEQPYSNEVH 
       360        370        380        390        400
CVEEILKEMT HSWPPPLTAI HTPSTAEPSR FPFPTKDPLH VSSATQSQKQ 
       410        420        430        440        450
YDTPSKTHPN PQQGTSTLED DLQLSDSEDS DTEQATEKPP SPPAPPSAPQ 
       460        470        480        490        500
TLPEPVASAH SSSGESESSE SDSSSDSESE SSSSDSEEEE NEPLETPAPE 
       510        520        530        540        550
PEPPTTNNKW QLDNWLTKVN QPSVPLDGRG STESPQWRQE SKSVAEGSSD 
       560        570        580        590        600
QQHPDSKDPP PKSSSKTLRG PSEGPQPGKR GCPKSPAQQE PPPRQTVGSK 
       610        620        630        640        650
LPRKPAKGSG QAEPQASSQV ESEAGPLPYG SKEQTSKDRP KVKTKGRPRA 
       660        670        680        690        700
VGSREPKPEV PAPTPQAAVP RPKPPVPTPS EKRKHKSSTA PSKAPSAPQP 
       710        720        730        740        750
PKDSAGDRNP EHSALVSMTQ SQGPSHSGRG SSGSIRTSGC RQAVIAQEDG 
       760        770        780        790        800
CKDKLLLPLR DTKLLSPLRD SPPPTSLVVK ITLDLLTRIP QPLGKGSRPR 
       810        820        830        840        850
KAEDRQLSAG KKQDSETKSC DSSSRVTKKR KGDPEKEHSN KRHKPDKSQT 
       860        870        880        890        900
TSSSSSHTES SKTKAPRSSS ENSRKETLPP ASVSSVSSSS SSQKPSRPAQ 
       910        920        930        940        950
KRPRPDEDTC SQEPPRSASS TKNSSTDPPA PKHRKVQARG SEHKGSSGDA 
       960        970        980        990       1000
ANAANPFPVP SLPNGNAKPG KPQVKSDRQQ ADFHMKEAKK LKCKAETMVD 
      1010       1020       1030       1040       1050
KAGKAFKYLE AVLSFIECGM ATESESSAKS AYTVYSETVD LVRYVMSLKC 
      1060       1070       1080       1090       1100
FSDNTMPAQE KIFAVLCLRC QSLLNMAMFR CKKDTVMKYS RTLSEHFKST 
      1110       1120       1130       1140       1150
SKVAQAPSPC TARSTGVPSP LSPMPSPASS VGSQSSAGSS VGSVGVTATV 
      1160       1170       1180       1190       1200
STPVSIQNMT SSYVTITSHV LTAFSLWDQA EALTRKNKEF FAQLSTKVRV 
      1210       1220 
LALNSSLVDL VHYTRQGLQR LKQSPKAP
Length:1,228
Mass (Da):132,576
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i272BF8A25C138229
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_029333879.1, XM_029478019.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_029333879.1, XM_029478019.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P7R3M0_MUSCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P7R3M0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: April 7, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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