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Entry version 6 (19 Jan 2022)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

nesprin-1 isoform X1

Gene

SYNE1

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8781CytoplasmicPROSITE-ProRule annotationAdd BLAST8781
Topological domaini8803 – 8832Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8773 – 8832KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5867 – 5894DisorderedSequence analysisAdd BLAST28
Regioni8254 – 8293DisorderedSequence analysisAdd BLAST40
Regioni8706 – 8768DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili632 – 656Sequence analysisAdd BLAST25
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1341Sequence analysisAdd BLAST21
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1909 – 1929Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2091 – 2111Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2281 – 2301Sequence analysisAdd BLAST21
Coiled coili2349 – 2369Sequence analysisAdd BLAST21
Coiled coili2969 – 2989Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3412 – 3439Sequence analysisAdd BLAST28
Coiled coili3501 – 3521Sequence analysisAdd BLAST21
Coiled coili3579 – 3599Sequence analysisAdd BLAST21
Coiled coili3697 – 3717Sequence analysisAdd BLAST21
Coiled coili3790 – 3810Sequence analysisAdd BLAST21
Coiled coili3973 – 3993Sequence analysisAdd BLAST21
Coiled coili4115 – 4135Sequence analysisAdd BLAST21
Coiled coili4153 – 4173Sequence analysisAdd BLAST21
Coiled coili4282 – 4319Sequence analysisAdd BLAST38
Coiled coili4730 – 4750Sequence analysisAdd BLAST21
Coiled coili4780 – 4814Sequence analysisAdd BLAST35
Coiled coili4858 – 4878Sequence analysisAdd BLAST21
Coiled coili4970 – 4990Sequence analysisAdd BLAST21
Coiled coili5075 – 5095Sequence analysisAdd BLAST21
Coiled coili5110 – 5133Sequence analysisAdd BLAST24
Coiled coili5159 – 5179Sequence analysisAdd BLAST21
Coiled coili5364 – 5391Sequence analysisAdd BLAST28
Coiled coili5513 – 5543Sequence analysisAdd BLAST31
Coiled coili5635 – 5662Sequence analysisAdd BLAST28
Coiled coili5741 – 5768Sequence analysisAdd BLAST28
Coiled coili5779 – 5816Sequence analysisAdd BLAST38
Coiled coili6070 – 6097Sequence analysisAdd BLAST28
Coiled coili6240 – 6267Sequence analysisAdd BLAST28
Coiled coili6539 – 6566Sequence analysisAdd BLAST28
Coiled coili6597 – 6621Sequence analysisAdd BLAST25
Coiled coili7070 – 7097Sequence analysisAdd BLAST28
Coiled coili7176 – 7206Sequence analysisAdd BLAST31
Coiled coili7825 – 7852Sequence analysisAdd BLAST28
Coiled coili7932 – 7952Sequence analysisAdd BLAST21
Coiled coili8677 – 8701Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5870 – 5894Polar residuesSequence analysisAdd BLAST25
Compositional biasi8259 – 8279Polar residuesSequence analysisAdd BLAST21
Compositional biasi8706 – 8766Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWTSFRQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P7EDS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSRAASRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV
60 70 80 90 100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKSMYRGSP IKLVNINSTD IADGRPSIVL GLMWTIILYF QIEELTSNLP
160 170 180 190 200
QLQALSSSAS SMDSMVSSET ASPPSKRKVA TKIQGNAKKA LLKWVQYTVT
210 220 230 240 250
KQSGIEVKDF GRSWRSGVAF HSVIHAIRPE LVDLEKVKGR PNRENLEEAF
260 270 280 290 300
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKQYP DVHSTGSDGQ
310 320 330 340 350
EIDEILPSFP SFTNSIQILK REDRLILKEM KVWIEQFERD LTRAQMTDSS
360 370 380 390 400
LQDKYQSFKH FRVQYEMKRK QIEHLLQPLH RDGKLSLDQA LVKQAWDRVS
410 420 430 440 450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITIQQ VHEETANTIQ
460 470 480 490 500
RKREQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS
510 520 530 540 550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGGR DSVELLLQNY
560 570 580 590 600
ISFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ
610 620 630 640 650
WRNLSVEVRS VRSMLEEVIA NWDRYGNTVA SLQAWLEDAE KMLNQSEHAK
660 670 680 690 700
KDFFRNLPHW IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL
710 720 730 740 750
FMEVKQYARA DELDRMKKEY NDCVTVLSDF ATEAHRKLSE PLEVSFINVK
760 770 780 790 800
LLIQDLEDIE QRVPVMDAQY KMITKTAHLI TKEISQEEAN EMFATMSGLK
810 820 830 840 850
EQLTKVKDCY SPLLSESQQL LVPLEELEKQ MTAFYDSLGK IDEIMTVLEH
860 870 880 890 900
EAQSSPLFKQ KHQELLACQE SCKKAMTQIE KGSQSVQKFV TLSNVLKHFD
910 920 930 940 950
QTKLQRKIAD MHVAFQNMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL
960 970 980 990 1000
RVAQEGLEEK GDPEDLLKRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE
1010 1020 1030 1040 1050
QRGLQEAVRK LHKQWKDLQA EAPYHLLHLK IEVEKNRFLA SVEECRAELD
1060 1070 1080 1090 1100
RETKLVPQEG SEKIIKEHRI FFSDKGPHHL CEKRLQLIEE LCLKLPVRDA
1110 1120 1130 1140 1150
VRNTPETCHV TLKELRAAID CTYVKLVGDP DKWKDYTSRI SEFSSWISAK
1160 1170 1180 1190 1200
ETQLKGIKNE TIDTANQGKV KRALEEIRSG ITKKGETLSW LKSRLKILIE
1210 1220 1230 1240 1250
VSSEDEAQKQ GDELAKLSSS FKALGTLLSE VEKMLSNFGD CVQYKEIVKS
1260 1270 1280 1290 1300
SLEELITGSK EVQEEAEKIL DTENLFEAQQ LLLHHQQKTK RINAKKKDVQ
1310 1320 1330 1340 1350
QQIAQAQQGE GGLPGRVQEE LQKLESTLDS VEHSREKQER RIQVTLRKWE
1360 1370 1380 1390 1400
RFETNKETVV RYLFQTGSSH ERFLSFSSLE SLSSELEQTK EFSKRTEGIA
1410 1420 1430 1440 1450
VQAENLVKEA SEIPLGPKNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM
1460 1470 1480 1490 1500
VKNKWDHFGT NFETLSIWIT EKEKELNALE TSSSAMDTQI NQIKVMIKEI
1510 1520 1530 1540 1550
ESKISSITGL EEEAQSFAQF ITTGESARIK AKLTQIRRYW EELREHAQSL
1560 1570 1580 1590 1600
QGIILGHLSQ QQKFEENLKK IQQSVSEFED KLADPVKICS SATETYKVLQ
1610 1620 1630 1640 1650
EHMDLCQALE SLTSMVAALS ASARKVSNRD ASIQEAATMQ RSYEGLLGRA
1660 1670 1680 1690 1700
KERQTELEKL LACWQRLEKE LSTFLTWLER CEAIASSPEA DISADRVKVE
1710 1720 1730 1740 1750
SELQSIQVLQ NEVVSQASIY SNLLQLKESL FSVASKDDVK MMKLQLEQLD
1760 1770 1780 1790 1800
ERWRDLPQII SKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE
1810 1820 1830 1840 1850
ISIVDHQAAL TRHKDHVAEV ESKKGELQSL QGHLAKLGAL SRAEDLHLLQ
1860 1870 1880 1890 1900
GKAEDCLQLF EEASQVVERR QHALSQLAKF LQSHASLSES LHQLRQTVEA
1910 1920 1930 1940 1950
THSMNKKQSD LLERDLNDAI RNVKTLESAA ISLDGLLTKA QYHLKSGGSE
1960 1970 1980 1990 2000
QRTSCRATSD HLSVELERIQ NLLGTKQSEA DALAVLKKAF RDQKEELLKS
2010 2020 2030 2040 2050
IEDIEERTDR ERLKDLTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK
2060 2070 2080 2090 2100
QIAQKDVAFA PEVDKEINRL EVTWDDTKKL IHENQGQCCG LIDLMREYQN
2110 2120 2130 2140 2150
LKSAITKVLE NASNVIATKT TVKDQEDLKW ALSKHEAAKN EMCNKQKDLD
2160 2170 2180 2190 2200
NFTSKGKQLL SELKKIHSGD FIVVKTDLES TVDKWLDISE KIEESMDRLR
2210 2220 2230 2240 2250
VSLSIWDDVL TSKDEIDGWS NHSVPQMTES ISNLNDSLRA EEFLKEFESE
2260 2270 2280 2290 2300
VKKKTLRLEE LRSKVNDLKE LTKNPETPPD LQFIEADLRQ KLEHAKEITE
2310 2320 2330 2340 2350
EAKGTLKEFT TQSAQVEKFI NDTATWLTKL EESLMNCAQT ETCEALKKVK
2360 2370 2380 2390 2400
DIQKELQSQQ SNISTTQENL NSLCRKYHSV ELGSLGSAMT GLIKRHEAVS
2410 2420 2430 2440 2450
QSCSKTQASL QDSLEKHFNE SMQEFQEWFS GIKAAAKESS DRTGDSKVLE
2460 2470 2480 2490 2500
AKLHDLQNIL DSVSDGQSKL DAVTREGQTL YAHLSKQIVS SIQEQVTKAN
2510 2520 2530 2540 2550
EEFQAFLKQC LKDKQALQDC ALELGSFEDQ HRKLNLWIHE MEGRLSTENL
2560 2570 2580 2590 2600
GESKQHIPEK KNEVHKIEMF LGELLAARES LDKLSQRGQL LSEEGHGAGK
2610 2620 2630 2640 2650
ESRLCSQLLT SYQNLLRMTK EKLRSCQVAL QEHEALEEAL QSMWSWVKDM
2660 2670 2680 2690 2700
QDRLASAEGT VGSKDALERR LLQVQEILLM KGEGEVKLNM AIGKGEQALR
2710 2720 2730 2740 2750
SSNKEGQKVI QTQLQTLKDV WGNIMGSSVH AQSTLESVIS QWNDYLEWKN
2760 2770 2780 2790 2800
QLEQWMESVD QKVEHPLQLQ PGLKEKFSLL DHFQSIVSEA EDHAGALQRL
2810 2820 2830 2840 2850
TAKARELYQK TEDEAFTDTA QEELKTQFND ILTVSKEKMR KVEEIVKDHL
2860 2870 2880 2890 2900
VYLDAVQEFT DWLHSAKEEL HRWSDMSGDS PATQKKLSKI KELMDSREIG
2910 2920 2930 2940 2950
ASRLSRVESL APAVKQNTTA SGCELLHTEM QALRADWKQW EDSVFQTQTS
2960 2970 2980 2990 3000
LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLTSWTQQL ALLEGKNTDK
3010 3020 3030 3040 3050
ELVECWQKGR EILDALQKAE PQTENLKSQL NELCRFSGDL STYSGKVSGL
3060 3070 3080 3090 3100
IKEYNCLCLQ ASKGCQNKEQ ILQQRFLRAF KDFQQWLVNA KITTAKCFDI
3110 3120 3130 3140 3150
PQNINEVSMS LQKIQEFFSE SENGQHKLNM MLSKGELLCT LLTKEKASSI
3160 3170 3180 3190 3200
QAKIATAKED WKNFHSNLHQ KESALENLKI QMKDFEVSAE PVQDWLSKTE
3210 3220 3230 3240 3250
KMVHESSNRL YDLPAKRREQ QKLQSVLEEI NCYEPQLRRL KEKAQQLWEG
3260 3270 3280 3290 3300
QAASRSFMHR VSQLSSQYLA LSNVTKEKVS RLDRIVAEHN QFSLGIKDLQ
3310 3320 3330 3340 3350
DWMTDTVHML DSYCHPTSDK SVLDSRMLKL EALLSVKQEK EIQMKMIVTR
3360 3370 3380 3390 3400
GESVLQNTSP EGVPAIQQQL ASVKDMWASL LSAAIRCKSQ LEGALSKWTS
3410 3420 3430 3440 3450
YQDDVRQFSS WMDGMEASLN ESERQHAELR EKTAALGKAK LLNEEVLSHG
3460 3470 3480 3490 3500
SLLETIEVKG AGMTEHYVTQ LEFQDLQERY RAIRERTKEA VTKSEKLVRL
3510 3520 3530 3540 3550
HQEYQRDLKA FEAWLEKEQE KLDRYSVLEG DAHTHETALR DLQELQVRCA
3560 3570 3580 3590 3600
EGQALLNSAL HTREEVIPSG IPQTEDRALE SLRQDWQAYQ QRLSETRTQF
3610 3620 3630 3640 3650
NNVVNKLRLV EQKFQQVDEW LKTMEEKVNP RTGRQSSRAA KEMQLHQMKK
3660 3670 3680 3690 3700
WHEEITAYRD EVEEVGARAQ EILDESHVSS RMGCQATQLT SRYQALLLQV
3710 3720 3730 3740 3750
LEQIKFLEEE IQSLEESELS LSSYSDWYSS THKNFKNVAA KIDKVDKVMM
3760 3770 3780 3790 3800
GKKMKMLEGL LKDMEKGQSL LKSTREKGER ALKYLEDGEA ETLRKEIHDH
3810 3820 3830 3840 3850
MEQLKELTGT VRKEHMTLEK GLHLTKEFSD KYKALTQWIA EYRDILHGPE
3860 3870 3880 3890 3900
EPKMELYEKK AQLSKYKSLQ QTVLSHEPSV KSVREKGEAL LELVQDVTLK
3910 3920 3930 3940 3950
DKIDQLQSDY QDLCSAAKEH VYSLEAKVKD HEDYNSELQE VEKWLLQMSG
3960 3970 3980 3990 4000
RLVAPDLMET SSLETITQQL ARHKAMMEEI AGFEDRLNDL KTKGDNLISQ
4010 4020 4030 4040 4050
CADHLQAKLK QNVHAHLQGT KDSYSAICST AQRVYQSLEH ELQKHVSRQD
4060 4070 4080 4090 4100
TLQQCQAWLS AVQPDLKPSV NPPLSRAEAV KQVKHFRALQ EQARTYLDLL
4110 4120 4130 4140 4150
CSMCDLSNSS VKTTAKDIQQ TEQMIEQRLA QAQNLTQGWE EIKHMKAELW
4160 4170 4180 4190 4200
SYLQDADQQL QNMKRRHSEL ELNIAQNMVS QVKDFVKKLQ CKQASVTTIT
4210 4220 4230 4240 4250
EKVDELTKKQ ESPEHKEISH LNDQWLDLCL HSNNLCLQRE EDLQRTRDYH
4260 4270 4280 4290 4300
DRMNVVEGFL EKFTTEWDNL ARSDAESTAV HLEALKKLAL ALQERKKAIE
4310 4320 4330 4340 4350
DLKEQKQKMI EHLNLDDKEL VKEQTSHLEQ RWFQLEDLVK RKIQVSITNL
4360 4370 4380 4390 4400
EELSVVRSRF QELMEWAEEQ QPNIAEALKQ SPPPDMAQNL LMDHLAICSE
4410 4420 4430 4440 4450
LEAKQMLLKS LTKDADRVMA DLGLNERQII QKALSDAQRH VSSLSDLVGQ
4460 4470 4480 4490 4500
RRKYLNKALS EKTQFLMAVF QATSQIQQHE RKIMFREHIC LLPDDVSKQV
4510 4520 4530 4540 4550
KTCKSAQASL KTYQNEVTGL WAQGRELMKG VTEQEKSEVL GKLQELQSVY
4560 4570 4580 4590 4600
DTVLQKCSHR LQELEKNLVS RKHFKEDFDK ACHWLKQADI VTFPEINLMN
4610 4620 4630 4640 4650
ETAELHTQLA KYQHILEQSP EYENLLLSLQ RTGQAILPTL NEVDHSYLDE
4660 4670 4680 4690 4700
KLHALPLQFN VIIDLAKDKF YKVQEAMLAR KEYASLIELT SQSLHDLENQ
4710 4720 4730 4740 4750
FSRMSQIPGH LSVEEALSLQ DSWRALGGEV AGLTEAMDEL NQKKESFRST
4760 4770 4780 4790 4800
GQPWQPDKMP QLVTLYHRLK RQTEQRVSFL EDTTSAYQEH ERMCLQLEKQ
4810 4820 4830 4840 4850
LEAVRMEQSK VNEETLPAEE KLKVYHSLAG SLQNSGILLK RVTRHLEDLV
4860 4870 4880 4890 4900
SHLDPAAYEK AKHQLQAWQE ELKLLTSAIG ATVTECESRM VQSRDFQTEL
4910 4920 4930 4940 4950
SRSLDWLRSV EAALSGPLCL DPNLRDIQEE IRKVQIHQEE VQSSLRIMNA
4960 4970 4980 4990 5000
LSNKEQEKFM RAKELISADL QRTLAELSEL DGALQEALRT RQTTLTQIYS
5010 5020 5030 5040 5050
QCQRYYQVFQ AANDWLEDAH EMLQLTGNGL DVESAEESLK SHMEFFSAED
5060 5070 5080 5090 5100
QFHSNLEELQ GLVANLDPLI KPTGKEDLAQ KMASLEEKSQ TIIQDSHAQL
5110 5120 5130 5140 5150
ELLQRCAAQW QDYQKAREEV IELMNEAEKK LSEFSLLKTS SSHEAEEKLS
5160 5170 5180 5190 5200
EHKALVSVIN SFHEKIVALE GEASELERTG NDASKAAISR STTAVWQRWT
5210 5220 5230 5240 5250
RLRAVAQDQE KLLEDAVDEW TSFNNKVKKA SEMIDQLQDK LPGSSAEKAS
5260 5270 5280 5290 5300
KAELVTLLEY HDTFTLELER QQSALGMLRQ QALSMLQDGA TPSPGGEPPT
5310 5320 5330 5340 5350
VQEITAMQDR CLNMQEKVKK NGKMVKQELK EREVVETQIS SVKSWVQETK
5360 5370 5380 5390 5400
EYLGNPTIEI DAQLEELKIL LTEAINHRQN VEKMAEEQKN KYLGLYTILP
5410 5420 5430 5440 5450
SELSLQLAEV ALELGTIHDQ IQDKVKEVEQ SKTMSQEFSQ QIQKIARDIT
5460 5470 5480 5490 5500
TILTKLRAKT DNLVQAKTDQ KVLGEELDGC HLKLMELDKA VQKFSEQNGQ
5510 5520 5530 5540 5550
LGKPLAKKIG KLTELHQQTI RQAENQLSKL NQAASHLEEY NEMLELILRW
5560 5570 5580 5590 5600
IEKTKILVHG KIAWNSASQL REQYISHQTM LEESEDIYND LEAMTEKLQY
5610 5620 5630 5640 5650
LDSVYHTEIM SQQVADLGRE TEELRQVIKI RLQSLHDAAK DMKKFEAELR
5660 5670 5680 5690 5700
NLQVALEQAQ TTLTSPEVGR LSLKEQLSHR QHLLSEMESL KPKVHAVQVC
5710 5720 5730 5740 5750
QSALRIPEDV VTSLPLCHAA LHLQEEASRL QHTAIQQCNI MQEAVVQYEQ
5760 5770 5780 5790 5800
YEQEMQHLQE LIEGAHREIE DKPVATSNIQ ELQAQISRHE ELAQKIKGYQ
5810 5820 5830 5840 5850
EQIASLNSKC KMLTVKAKHA TMLLTVTEVE GLAEGTEDLA GELLPATSAH
5860 5870 5880 5890 5900
PSVVMMTAGR CHTLLSPVTE ESGEEGTNSE ISSPPACRSP SPVANTDASV
5910 5920 5930 5940 5950
NQDIAYYQAL SPERLQTDAA KVPPSTLPPQ ELYEPGLEPS ATAKLDDLQR
5960 5970 5980 5990 6000
SWETLKNVIS EKQRTLYEAL ERQQKYQDSL QSISTKMEAI EMKLSESLEQ
6010 6020 6030 6040 6050
GRSPESQMAE HQSFPQALMD EILMLQEEIS ELQSALADEL VSESPESEPA
6060 6070 6080 6090 6100
EQLALQSTLT VLAERMSTIK MKASGKRQLL EEKLNDQLEE QRQEQALHRY
6110 6120 6130 6140 6150
RCEADQLDHW LLSTKATLDI ALGSPKEPMD MEAQLVDCQN MLVEIEQKVV
6160 6170 6180 6190 6200
ALSELSVHNE NLLLEGKAHT KDEAEQLAVK LRTLKGSLLE LQRALQDRQL
6210 6220 6230 6240 6250
HIQQGTAQEK EESDADLAAT QSPGVQEWLA QARSTWTHQR QSSLQQQKEL
6260 6270 6280 6290 6300
EQELAEQKSL LQSVASLGEE ILTQHSAPEP SGGVGEKPDV LSQELGMEGE
6310 6320 6330 6340 6350
KSPAEDQMRM KWESLHQEFS TKQKLLQNVL EQEQEQVLYS RPNRLLSGVP
6360 6370 6380 6390 6400
LYKGDGQAQD KSAVTSLLDG LNQVFEEVSS QGGGTKKQSV DLERKLYDGV
6410 6420 6430 6440 6450
SATSTWLDDV EERLFVATAL LAEEPETCIF NQETLAKDIK EMSEEMDKNK
6460 6470 6480 6490 6500
NLFSQAFPEN GDNRDVIEDT LGCLLGRLSL LDSVVNQRCH QMKERLQQIL
6510 6520 6530 6540 6550
NFQNDLKVLV TSLADHKYII LQKLAKMFEQ PVAEQIEAIQ QAEDGLKELD
6560 6570 6580 6590 6600
AGIIELKRRA DKLQIEQPSM QELSKLQDMY DELLMTIGSR RSGLNQNLAL
6610 6620 6630 6640 6650
KSQYERALQD LADLLETGQE KTAGDQKIIV SSKEEIQQLL DKHKEYFQGL
6660 6670 6680 6690 6700
ESHMILTETL FRKIISFAVP RETQFHTDLM AQASAVLKGA HKRGVELEYI
6710 6720 6730 6740 6750
LETWSQLEKE HWELSRQLEV VEGSTPSVGL VEESEDRLID RIALYQHLKS
6760 6770 6780 6790 6800
SLNEYQPKLY QVIDDGKRLL ISVSCPDLES QLNQLGEHWL NDTNKVSKEL
6810 6820 6830 6840 6850
HRLETILKHW TRYQSESADL IHWLQSAKDR LEFWTQQSVT VPQELEMVRD
6860 6870 6880 6890 6900
HLNGFLEFSK EVDAKSTLKS SVLSTGNQLL RLKKVDTAAL RSELSHIDGQ
6910 6920 6930 6940 6950
WNDLLTNIPA VQEKLHQLQM DKLPSRHAIS EVMTWISLME SVIQKDEENI
6960 6970 6980 6990 7000
KNSIGYKTIH EYLQKYKGFQ IDINCKQLTV DFVNQSVLQI SSQDVESKRS
7010 7020 7030 7040 7050
DKTDFAERLG AMNKSWQILQ GLVTEKIQLL EGLLESWSEY ENNVQCLKTW
7060 7070 7080 7090 7100
FETQEERLKQ QHRIGDQASV QNAMKDCQDL EDLIKAKEKE VEKIEQNGLA
7110 7120 7130 7140 7150
LVQNKKEEVS GTVRSTLQEL NQTWANLDHM VGQLKILLKS VLDQWSHHKV
7160 7170 7180 7190 7200
AFDEINSCLM EARYSLSRFC LLTGSLEAVQ IQVDSLQNLQ DDLEKQEKSL
7210 7220 7230 7240 7250
QKFGSVTSQL LKECHPPVTE TLTNTLKEVN MRWNNLLEEI AEQLRASKAL
7260 7270 7280 7290 7300
LQLWQRYKDY FKQCAATVQQ QEGRTNEFLK AATDKDIGDD EVATWIQDCN
7310 7320 7330 7340 7350
DLLKGLGPIQ DSLVVLHELG GQLKQQVDAS AASAIQSDWL SLKQQSHALE
7360 7370 7380 7390 7400
QALCKQQTVL QAGVLDYETF TKSLEALETW IVEAEEILQG QDPSHSSDLS
7410 7420 7430 7440 7450
TIQERMEELK GQMLKFSSMV PDLDRLNELG YRLPLNDKEI KRVQNLNRHW
7460 7470 7480 7490 7500
ALISSQTTER FSKLQSFLLQ HQTFLEKCET WMEFLVQTEQ KLAVEISGNY
7510 7520 7530 7540 7550
QHLLEQQRAH ELFQAEMFSC QQILHSIIFD GQHLLEQGQV DDRDEFNLKL
7560 7570 7580 7590 7600
TLLSNQWQGV IRRAQQRRGI IDSQIRQWQR YREMAEKLRK WLVEVSCLPV
7610 7620 7630 7640 7650
SGLGSVRIPL QQARALFDQV QFKEKVFLRQ QGSYILTVEA GKQLLLSADS
7660 7670 7680 7690 7700
GAEATLQAEL AEIQEKWKSA SVCLEEQKKK LAGLLQDWEK CENGIADSLE
7710 7720 7730 7740 7750
KLRTFKKRLS QPLPDHHEEL HAEQMCCKEL ENAVGSWTDD LAQLTVLKKA
7760 7770 7780 7790 7800
LCAYISADDI SILNERMELL QRQWEELCHQ LSLRRQQVSE RLNEWAVFSE
7810 7820 7830 7840 7850
KNKELCEWLT QMESKVSQNG DILIEEMIEK LRKDYQEEIA VAQENKIQLQ
7860 7870 7880 7890 7900
QMGERLARAS HESKASEIEY KLGKINDRWQ HLLDLMAARV KKLKETLVAV
7910 7920 7930 7940 7950
QQLDKNMSSL RTWLAHIESE LAKPIVYDSC DSEEIQKKLN EQQELQRDIE
7960 7970 7980 7990 8000
KHSTGVASVL NLCEVLLHDC DACATDAECD SIQQATRNLD RRWRNICAMS
8010 8020 8030 8040 8050
MERRLKIEET WRLWQKFLDD FSHFEDWLKI SERTAAFPSS SGVLYTVAKE
8060 8070 8080 8090 8100
ELKKFEAFQR QVHESLTQLE LINKQYRRLA RENRTDAAGS LKQMVHKGNQ
8110 8120 8130 8140 8150
RWDNLQKRVT SILRRLKHFI GQREEFETAR DSILVWLTEM DLQLTNIEHF
8160 8170 8180 8190 8200
SECDVQAKIK QLKAFQQEIS LNHNKIEQII AQGEQLIEKS EPLDAAVIEE
8210 8220 8230 8240 8250
ELDELRRYCQ EVFGRVDRYH KKLMRLPLPD DEHDLSDREL ELDEAGALSD
8260 8270 8280 8290 8300
LRWRDTTDGV LSPQPSSNPS LSLAQPLRSE RSGRDTPASV DSIPLEWDHD
8310 8320 8330 8340 8350
YDLSRDLESA VSRTLPSEDE EGPEDKDFYL RGAVGLSDVV IPESPEAYVK
8360 8370 8380 8390 8400
LTESAIRNSS GDRGALESQI RQLGKALDDS HFQMQQTENI IHSKTPTGPE
8410 8420 8430 8440 8450
LDSGYRGYMK LLGECSGSID SVKRLEHKLT EEEDHFPGFV NLNSTETQTA
8460 8470 8480 8490 8500
GVIDRWELIQ AEALSKELRM KQKPQRRQQL DSDLNSVLTW LRETEGDLEQ
8510 8520 8530 8540 8550
LQRLQLSTDI QSIALQIQKL KELQKAVDQR KAIILSIHLC SSEFTQTGQE
8560 8570 8580 8590 8600
ESQDLQDRLS QMNGRWDRVC SLLEEWRGLL QDALMQCQDF HEMSHSLLLM
8610 8620 8630 8640 8650
LENIDRRKNE IVPIDSNLDA EILQDHHKQL KQIRHELLES QLKVASLQDM
8660 8670 8680 8690 8700
SCQLLVNAEG TDCLEAKEKV HVIGNRLKLL LKEVSRHIKE LEKLLDMSSS
8710 8720 8730 8740 8750
QQDLSSWSSA DELDTSGSVS PTSGRSTPNR QKTPRGKCSL SQPGPSVNSP
8760 8770 8780 8790 8800
HSRSIKGGSD SSLSEPRPAR SGRAFLFRVL RAALPLQLLL LLLIGLACLV
8810 8820 8830
PMSEEDYSCA LSNNFARSFH PMLRYTNGPP PL
Length:8,832
Mass (Da):1,013,044
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7941B938784AD7D6
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014952960.2, XM_015097474.2
XP_027828365.1, XM_027972564.1
XP_027828366.1, XM_027972565.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
oas:101106269

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014952960.2, XM_015097474.2
XP_027828365.1, XM_027972564.1
XP_027828366.1, XM_027972565.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGioas:101106269

Phylogenomic databases

OMAiLWTSFRQ

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 13 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P7EDS4_SHEEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P7EDS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: January 19, 2022
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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