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UniProtKB - A0A6P7EDS4 (A0A6P7EDS4_SHEEP)

Entry version 6 (19 Jan 2022)
Sequence version 1 (02 Dec 2020)
Previous versions | rss
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Protein
Submitted name:

nesprin-1 isoform X1

Gene

SYNE1

Organism
Ovis aries (Sheep)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOvis aries (Sheep)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9940 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515149 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8781CytoplasmicPROSITE-ProRule annotationAdd BLAST8781
Topological domaini8803 – 8832Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8773 – 8832KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5867 – 5894DisorderedSequence analysisAdd BLAST28
Regioni8254 – 8293DisorderedSequence analysisAdd BLAST40
Regioni8706 – 8768DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili632 – 656Sequence analysisAdd BLAST25
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1341Sequence analysisAdd BLAST21
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1909 – 1929Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2091 – 2111Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2281 – 2301Sequence analysisAdd BLAST21
Coiled coili2349 – 2369Sequence analysisAdd BLAST21
Coiled coili2969 – 2989Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3412 – 3439Sequence analysisAdd BLAST28
Coiled coili3501 – 3521Sequence analysisAdd BLAST21
Coiled coili3579 – 3599Sequence analysisAdd BLAST21
Coiled coili3697 – 3717Sequence analysisAdd BLAST21
Coiled coili3790 – 3810Sequence analysisAdd BLAST21
Coiled coili3973 – 3993Sequence analysisAdd BLAST21
Coiled coili4115 – 4135Sequence analysisAdd BLAST21
Coiled coili4153 – 4173Sequence analysisAdd BLAST21
Coiled coili4282 – 4319Sequence analysisAdd BLAST38
Coiled coili4730 – 4750Sequence analysisAdd BLAST21
Coiled coili4780 – 4814Sequence analysisAdd BLAST35
Coiled coili4858 – 4878Sequence analysisAdd BLAST21
Coiled coili4970 – 4990Sequence analysisAdd BLAST21
Coiled coili5075 – 5095Sequence analysisAdd BLAST21
Coiled coili5110 – 5133Sequence analysisAdd BLAST24
Coiled coili5159 – 5179Sequence analysisAdd BLAST21
Coiled coili5364 – 5391Sequence analysisAdd BLAST28
Coiled coili5513 – 5543Sequence analysisAdd BLAST31
Coiled coili5635 – 5662Sequence analysisAdd BLAST28
Coiled coili5741 – 5768Sequence analysisAdd BLAST28
Coiled coili5779 – 5816Sequence analysisAdd BLAST38
Coiled coili6070 – 6097Sequence analysisAdd BLAST28
Coiled coili6240 – 6267Sequence analysisAdd BLAST28
Coiled coili6539 – 6566Sequence analysisAdd BLAST28
Coiled coili6597 – 6621Sequence analysisAdd BLAST25
Coiled coili7070 – 7097Sequence analysisAdd BLAST28
Coiled coili7176 – 7206Sequence analysisAdd BLAST31
Coiled coili7825 – 7852Sequence analysisAdd BLAST28
Coiled coili7932 – 7952Sequence analysisAdd BLAST21
Coiled coili8677 – 8701Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5870 – 5894Polar residuesSequence analysisAdd BLAST25
Compositional biasi8259 – 8279Polar residuesSequence analysisAdd BLAST21
Compositional biasi8706 – 8766Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		LWTSFRQ

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 13 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P7EDS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSRAASRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPMVV 
        60         70         80         90        100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE 
       110        120        130        140        150
GRKSMYRGSP IKLVNINSTD IADGRPSIVL GLMWTIILYF QIEELTSNLP 
       160        170        180        190        200
QLQALSSSAS SMDSMVSSET ASPPSKRKVA TKIQGNAKKA LLKWVQYTVT 
       210        220        230        240        250
KQSGIEVKDF GRSWRSGVAF HSVIHAIRPE LVDLEKVKGR PNRENLEEAF 
       260        270        280        290        300
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKQYP DVHSTGSDGQ 
       310        320        330        340        350
EIDEILPSFP SFTNSIQILK REDRLILKEM KVWIEQFERD LTRAQMTDSS 
       360        370        380        390        400
LQDKYQSFKH FRVQYEMKRK QIEHLLQPLH RDGKLSLDQA LVKQAWDRVS 
       410        420        430        440        450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITIQQ VHEETANTIQ 
       460        470        480        490        500
RKREQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS 
       510        520        530        540        550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGGR DSVELLLQNY 
       560        570        580        590        600
ISFIENSKFF EQYEVTYQIL KQTAEMYVKA DGSVEEAENV MKFMNETTAQ 
       610        620        630        640        650
WRNLSVEVRS VRSMLEEVIA NWDRYGNTVA SLQAWLEDAE KMLNQSEHAK 
       660        670        680        690        700
KDFFRNLPHW IQQHTAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL 
       710        720        730        740        750
FMEVKQYARA DELDRMKKEY NDCVTVLSDF ATEAHRKLSE PLEVSFINVK 
       760        770        780        790        800
LLIQDLEDIE QRVPVMDAQY KMITKTAHLI TKEISQEEAN EMFATMSGLK 
       810        820        830        840        850
EQLTKVKDCY SPLLSESQQL LVPLEELEKQ MTAFYDSLGK IDEIMTVLEH 
       860        870        880        890        900
EAQSSPLFKQ KHQELLACQE SCKKAMTQIE KGSQSVQKFV TLSNVLKHFD 
       910        920        930        940        950
QTKLQRKIAD MHVAFQNMVK KTGDWKKHVE TNSRLMKKFE ESRAELEKVL 
       960        970        980        990       1000
RVAQEGLEEK GDPEDLLKRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE 
      1010       1020       1030       1040       1050
QRGLQEAVRK LHKQWKDLQA EAPYHLLHLK IEVEKNRFLA SVEECRAELD 
      1060       1070       1080       1090       1100
RETKLVPQEG SEKIIKEHRI FFSDKGPHHL CEKRLQLIEE LCLKLPVRDA 
      1110       1120       1130       1140       1150
VRNTPETCHV TLKELRAAID CTYVKLVGDP DKWKDYTSRI SEFSSWISAK 
      1160       1170       1180       1190       1200
ETQLKGIKNE TIDTANQGKV KRALEEIRSG ITKKGETLSW LKSRLKILIE 
      1210       1220       1230       1240       1250
VSSEDEAQKQ GDELAKLSSS FKALGTLLSE VEKMLSNFGD CVQYKEIVKS 
      1260       1270       1280       1290       1300
SLEELITGSK EVQEEAEKIL DTENLFEAQQ LLLHHQQKTK RINAKKKDVQ 
      1310       1320       1330       1340       1350
QQIAQAQQGE GGLPGRVQEE LQKLESTLDS VEHSREKQER RIQVTLRKWE 
      1360       1370       1380       1390       1400
RFETNKETVV RYLFQTGSSH ERFLSFSSLE SLSSELEQTK EFSKRTEGIA 
      1410       1420       1430       1440       1450
VQAENLVKEA SEIPLGPKNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM 
      1460       1470       1480       1490       1500
VKNKWDHFGT NFETLSIWIT EKEKELNALE TSSSAMDTQI NQIKVMIKEI 
      1510       1520       1530       1540       1550
ESKISSITGL EEEAQSFAQF ITTGESARIK AKLTQIRRYW EELREHAQSL 
      1560       1570       1580       1590       1600
QGIILGHLSQ QQKFEENLKK IQQSVSEFED KLADPVKICS SATETYKVLQ 
      1610       1620       1630       1640       1650
EHMDLCQALE SLTSMVAALS ASARKVSNRD ASIQEAATMQ RSYEGLLGRA 
      1660       1670       1680       1690       1700
KERQTELEKL LACWQRLEKE LSTFLTWLER CEAIASSPEA DISADRVKVE 
      1710       1720       1730       1740       1750
SELQSIQVLQ NEVVSQASIY SNLLQLKESL FSVASKDDVK MMKLQLEQLD 
      1760       1770       1780       1790       1800
ERWRDLPQII SKRINFLQSV VAEHQQFDEL LLSFSVWIKL FLSELQTTSE 
      1810       1820       1830       1840       1850
ISIVDHQAAL TRHKDHVAEV ESKKGELQSL QGHLAKLGAL SRAEDLHLLQ 
      1860       1870       1880       1890       1900
GKAEDCLQLF EEASQVVERR QHALSQLAKF LQSHASLSES LHQLRQTVEA 
      1910       1920       1930       1940       1950
THSMNKKQSD LLERDLNDAI RNVKTLESAA ISLDGLLTKA QYHLKSGGSE 
      1960       1970       1980       1990       2000
QRTSCRATSD HLSVELERIQ NLLGTKQSEA DALAVLKKAF RDQKEELLKS 
      2010       2020       2030       2040       2050
IEDIEERTDR ERLKDLTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK 
      2060       2070       2080       2090       2100
QIAQKDVAFA PEVDKEINRL EVTWDDTKKL IHENQGQCCG LIDLMREYQN 
      2110       2120       2130       2140       2150
LKSAITKVLE NASNVIATKT TVKDQEDLKW ALSKHEAAKN EMCNKQKDLD 
      2160       2170       2180       2190       2200
NFTSKGKQLL SELKKIHSGD FIVVKTDLES TVDKWLDISE KIEESMDRLR 
      2210       2220       2230       2240       2250
VSLSIWDDVL TSKDEIDGWS NHSVPQMTES ISNLNDSLRA EEFLKEFESE 
      2260       2270       2280       2290       2300
VKKKTLRLEE LRSKVNDLKE LTKNPETPPD LQFIEADLRQ KLEHAKEITE 
      2310       2320       2330       2340       2350
EAKGTLKEFT TQSAQVEKFI NDTATWLTKL EESLMNCAQT ETCEALKKVK 
      2360       2370       2380       2390       2400
DIQKELQSQQ SNISTTQENL NSLCRKYHSV ELGSLGSAMT GLIKRHEAVS 
      2410       2420       2430       2440       2450
QSCSKTQASL QDSLEKHFNE SMQEFQEWFS GIKAAAKESS DRTGDSKVLE 
      2460       2470       2480       2490       2500
AKLHDLQNIL DSVSDGQSKL DAVTREGQTL YAHLSKQIVS SIQEQVTKAN 
      2510       2520       2530       2540       2550
EEFQAFLKQC LKDKQALQDC ALELGSFEDQ HRKLNLWIHE MEGRLSTENL 
      2560       2570       2580       2590       2600
GESKQHIPEK KNEVHKIEMF LGELLAARES LDKLSQRGQL LSEEGHGAGK 
      2610       2620       2630       2640       2650
ESRLCSQLLT SYQNLLRMTK EKLRSCQVAL QEHEALEEAL QSMWSWVKDM 
      2660       2670       2680       2690       2700
QDRLASAEGT VGSKDALERR LLQVQEILLM KGEGEVKLNM AIGKGEQALR 
      2710       2720       2730       2740       2750
SSNKEGQKVI QTQLQTLKDV WGNIMGSSVH AQSTLESVIS QWNDYLEWKN 
      2760       2770       2780       2790       2800
QLEQWMESVD QKVEHPLQLQ PGLKEKFSLL DHFQSIVSEA EDHAGALQRL 
      2810       2820       2830       2840       2850
TAKARELYQK TEDEAFTDTA QEELKTQFND ILTVSKEKMR KVEEIVKDHL 
      2860       2870       2880       2890       2900
VYLDAVQEFT DWLHSAKEEL HRWSDMSGDS PATQKKLSKI KELMDSREIG 
      2910       2920       2930       2940       2950
ASRLSRVESL APAVKQNTTA SGCELLHTEM QALRADWKQW EDSVFQTQTS 
      2960       2970       2980       2990       3000
LENLVSQMAL SEQEFSGQVA QLEQALEQFS ALLTSWTQQL ALLEGKNTDK 
      3010       3020       3030       3040       3050
ELVECWQKGR EILDALQKAE PQTENLKSQL NELCRFSGDL STYSGKVSGL 
      3060       3070       3080       3090       3100
IKEYNCLCLQ ASKGCQNKEQ ILQQRFLRAF KDFQQWLVNA KITTAKCFDI 
      3110       3120       3130       3140       3150
PQNINEVSMS LQKIQEFFSE SENGQHKLNM MLSKGELLCT LLTKEKASSI 
      3160       3170       3180       3190       3200
QAKIATAKED WKNFHSNLHQ KESALENLKI QMKDFEVSAE PVQDWLSKTE 
      3210       3220       3230       3240       3250
KMVHESSNRL YDLPAKRREQ QKLQSVLEEI NCYEPQLRRL KEKAQQLWEG 
      3260       3270       3280       3290       3300
QAASRSFMHR VSQLSSQYLA LSNVTKEKVS RLDRIVAEHN QFSLGIKDLQ 
      3310       3320       3330       3340       3350
DWMTDTVHML DSYCHPTSDK SVLDSRMLKL EALLSVKQEK EIQMKMIVTR 
      3360       3370       3380       3390       3400
GESVLQNTSP EGVPAIQQQL ASVKDMWASL LSAAIRCKSQ LEGALSKWTS 
      3410       3420       3430       3440       3450
YQDDVRQFSS WMDGMEASLN ESERQHAELR EKTAALGKAK LLNEEVLSHG 
      3460       3470       3480       3490       3500
SLLETIEVKG AGMTEHYVTQ LEFQDLQERY RAIRERTKEA VTKSEKLVRL 
      3510       3520       3530       3540       3550
HQEYQRDLKA FEAWLEKEQE KLDRYSVLEG DAHTHETALR DLQELQVRCA 
      3560       3570       3580       3590       3600
EGQALLNSAL HTREEVIPSG IPQTEDRALE SLRQDWQAYQ QRLSETRTQF 
      3610       3620       3630       3640       3650
NNVVNKLRLV EQKFQQVDEW LKTMEEKVNP RTGRQSSRAA KEMQLHQMKK 
      3660       3670       3680       3690       3700
WHEEITAYRD EVEEVGARAQ EILDESHVSS RMGCQATQLT SRYQALLLQV 
      3710       3720       3730       3740       3750
LEQIKFLEEE IQSLEESELS LSSYSDWYSS THKNFKNVAA KIDKVDKVMM 
      3760       3770       3780       3790       3800
GKKMKMLEGL LKDMEKGQSL LKSTREKGER ALKYLEDGEA ETLRKEIHDH 
      3810       3820       3830       3840       3850
MEQLKELTGT VRKEHMTLEK GLHLTKEFSD KYKALTQWIA EYRDILHGPE 
      3860       3870       3880       3890       3900
EPKMELYEKK AQLSKYKSLQ QTVLSHEPSV KSVREKGEAL LELVQDVTLK 
      3910       3920       3930       3940       3950
DKIDQLQSDY QDLCSAAKEH VYSLEAKVKD HEDYNSELQE VEKWLLQMSG 
      3960       3970       3980       3990       4000
RLVAPDLMET SSLETITQQL ARHKAMMEEI AGFEDRLNDL KTKGDNLISQ 
      4010       4020       4030       4040       4050
CADHLQAKLK QNVHAHLQGT KDSYSAICST AQRVYQSLEH ELQKHVSRQD 
      4060       4070       4080       4090       4100
TLQQCQAWLS AVQPDLKPSV NPPLSRAEAV KQVKHFRALQ EQARTYLDLL 
      4110       4120       4130       4140       4150
CSMCDLSNSS VKTTAKDIQQ TEQMIEQRLA QAQNLTQGWE EIKHMKAELW 
      4160       4170       4180       4190       4200
SYLQDADQQL QNMKRRHSEL ELNIAQNMVS QVKDFVKKLQ CKQASVTTIT 
      4210       4220       4230       4240       4250
EKVDELTKKQ ESPEHKEISH LNDQWLDLCL HSNNLCLQRE EDLQRTRDYH 
      4260       4270       4280       4290       4300
DRMNVVEGFL EKFTTEWDNL ARSDAESTAV HLEALKKLAL ALQERKKAIE 
      4310       4320       4330       4340       4350
DLKEQKQKMI EHLNLDDKEL VKEQTSHLEQ RWFQLEDLVK RKIQVSITNL 
      4360       4370       4380       4390       4400
EELSVVRSRF QELMEWAEEQ QPNIAEALKQ SPPPDMAQNL LMDHLAICSE 
      4410       4420       4430       4440       4450
LEAKQMLLKS LTKDADRVMA DLGLNERQII QKALSDAQRH VSSLSDLVGQ 
      4460       4470       4480       4490       4500
RRKYLNKALS EKTQFLMAVF QATSQIQQHE RKIMFREHIC LLPDDVSKQV 
      4510       4520       4530       4540       4550
KTCKSAQASL KTYQNEVTGL WAQGRELMKG VTEQEKSEVL GKLQELQSVY 
      4560       4570       4580       4590       4600
DTVLQKCSHR LQELEKNLVS RKHFKEDFDK ACHWLKQADI VTFPEINLMN 
      4610       4620       4630       4640       4650
ETAELHTQLA KYQHILEQSP EYENLLLSLQ RTGQAILPTL NEVDHSYLDE 
      4660       4670       4680       4690       4700
KLHALPLQFN VIIDLAKDKF YKVQEAMLAR KEYASLIELT SQSLHDLENQ 
      4710       4720       4730       4740       4750
FSRMSQIPGH LSVEEALSLQ DSWRALGGEV AGLTEAMDEL NQKKESFRST 
      4760       4770       4780       4790       4800
GQPWQPDKMP QLVTLYHRLK RQTEQRVSFL EDTTSAYQEH ERMCLQLEKQ 
      4810       4820       4830       4840       4850
LEAVRMEQSK VNEETLPAEE KLKVYHSLAG SLQNSGILLK RVTRHLEDLV 
      4860       4870       4880       4890       4900
SHLDPAAYEK AKHQLQAWQE ELKLLTSAIG ATVTECESRM VQSRDFQTEL 
      4910       4920       4930       4940       4950
SRSLDWLRSV EAALSGPLCL DPNLRDIQEE IRKVQIHQEE VQSSLRIMNA 
      4960       4970       4980       4990       5000
LSNKEQEKFM RAKELISADL QRTLAELSEL DGALQEALRT RQTTLTQIYS 
      5010       5020       5030       5040       5050
QCQRYYQVFQ AANDWLEDAH EMLQLTGNGL DVESAEESLK SHMEFFSAED 
      5060       5070       5080       5090       5100
QFHSNLEELQ GLVANLDPLI KPTGKEDLAQ KMASLEEKSQ TIIQDSHAQL 
      5110       5120       5130       5140       5150
ELLQRCAAQW QDYQKAREEV IELMNEAEKK LSEFSLLKTS SSHEAEEKLS 
      5160       5170       5180       5190       5200
EHKALVSVIN SFHEKIVALE GEASELERTG NDASKAAISR STTAVWQRWT 
      5210       5220       5230       5240       5250
RLRAVAQDQE KLLEDAVDEW TSFNNKVKKA SEMIDQLQDK LPGSSAEKAS 
      5260       5270       5280       5290       5300
KAELVTLLEY HDTFTLELER QQSALGMLRQ QALSMLQDGA TPSPGGEPPT 
      5310       5320       5330       5340       5350
VQEITAMQDR CLNMQEKVKK NGKMVKQELK EREVVETQIS SVKSWVQETK 
      5360       5370       5380       5390       5400
EYLGNPTIEI DAQLEELKIL LTEAINHRQN VEKMAEEQKN KYLGLYTILP 
      5410       5420       5430       5440       5450
SELSLQLAEV ALELGTIHDQ IQDKVKEVEQ SKTMSQEFSQ QIQKIARDIT 
      5460       5470       5480       5490       5500
TILTKLRAKT DNLVQAKTDQ KVLGEELDGC HLKLMELDKA VQKFSEQNGQ 
      5510       5520       5530       5540       5550
LGKPLAKKIG KLTELHQQTI RQAENQLSKL NQAASHLEEY NEMLELILRW 
      5560       5570       5580       5590       5600
IEKTKILVHG KIAWNSASQL REQYISHQTM LEESEDIYND LEAMTEKLQY 
      5610       5620       5630       5640       5650
LDSVYHTEIM SQQVADLGRE TEELRQVIKI RLQSLHDAAK DMKKFEAELR 
      5660       5670       5680       5690       5700
NLQVALEQAQ TTLTSPEVGR LSLKEQLSHR QHLLSEMESL KPKVHAVQVC 
      5710       5720       5730       5740       5750
QSALRIPEDV VTSLPLCHAA LHLQEEASRL QHTAIQQCNI MQEAVVQYEQ 
      5760       5770       5780       5790       5800
YEQEMQHLQE LIEGAHREIE DKPVATSNIQ ELQAQISRHE ELAQKIKGYQ 
      5810       5820       5830       5840       5850
EQIASLNSKC KMLTVKAKHA TMLLTVTEVE GLAEGTEDLA GELLPATSAH 
      5860       5870       5880       5890       5900
PSVVMMTAGR CHTLLSPVTE ESGEEGTNSE ISSPPACRSP SPVANTDASV 
      5910       5920       5930       5940       5950
NQDIAYYQAL SPERLQTDAA KVPPSTLPPQ ELYEPGLEPS ATAKLDDLQR 
      5960       5970       5980       5990       6000
SWETLKNVIS EKQRTLYEAL ERQQKYQDSL QSISTKMEAI EMKLSESLEQ 
      6010       6020       6030       6040       6050
GRSPESQMAE HQSFPQALMD EILMLQEEIS ELQSALADEL VSESPESEPA 
      6060       6070       6080       6090       6100
EQLALQSTLT VLAERMSTIK MKASGKRQLL EEKLNDQLEE QRQEQALHRY 
      6110       6120       6130       6140       6150
RCEADQLDHW LLSTKATLDI ALGSPKEPMD MEAQLVDCQN MLVEIEQKVV 
      6160       6170       6180       6190       6200
ALSELSVHNE NLLLEGKAHT KDEAEQLAVK LRTLKGSLLE LQRALQDRQL 
      6210       6220       6230       6240       6250
HIQQGTAQEK EESDADLAAT QSPGVQEWLA QARSTWTHQR QSSLQQQKEL 
      6260       6270       6280       6290       6300
EQELAEQKSL LQSVASLGEE ILTQHSAPEP SGGVGEKPDV LSQELGMEGE 
      6310       6320       6330       6340       6350
KSPAEDQMRM KWESLHQEFS TKQKLLQNVL EQEQEQVLYS RPNRLLSGVP 
      6360       6370       6380       6390       6400
LYKGDGQAQD KSAVTSLLDG LNQVFEEVSS QGGGTKKQSV DLERKLYDGV 
      6410       6420       6430       6440       6450
SATSTWLDDV EERLFVATAL LAEEPETCIF NQETLAKDIK EMSEEMDKNK 
      6460       6470       6480       6490       6500
NLFSQAFPEN GDNRDVIEDT LGCLLGRLSL LDSVVNQRCH QMKERLQQIL 
      6510       6520       6530       6540       6550
NFQNDLKVLV TSLADHKYII LQKLAKMFEQ PVAEQIEAIQ QAEDGLKELD 
      6560       6570       6580       6590       6600
AGIIELKRRA DKLQIEQPSM QELSKLQDMY DELLMTIGSR RSGLNQNLAL 
      6610       6620       6630       6640       6650
KSQYERALQD LADLLETGQE KTAGDQKIIV SSKEEIQQLL DKHKEYFQGL 
      6660       6670       6680       6690       6700
ESHMILTETL FRKIISFAVP RETQFHTDLM AQASAVLKGA HKRGVELEYI 
      6710       6720       6730       6740       6750
LETWSQLEKE HWELSRQLEV VEGSTPSVGL VEESEDRLID RIALYQHLKS 
      6760       6770       6780       6790       6800
SLNEYQPKLY QVIDDGKRLL ISVSCPDLES QLNQLGEHWL NDTNKVSKEL 
      6810       6820       6830       6840       6850
HRLETILKHW TRYQSESADL IHWLQSAKDR LEFWTQQSVT VPQELEMVRD 
      6860       6870       6880       6890       6900
HLNGFLEFSK EVDAKSTLKS SVLSTGNQLL RLKKVDTAAL RSELSHIDGQ 
      6910       6920       6930       6940       6950
WNDLLTNIPA VQEKLHQLQM DKLPSRHAIS EVMTWISLME SVIQKDEENI 
      6960       6970       6980       6990       7000
KNSIGYKTIH EYLQKYKGFQ IDINCKQLTV DFVNQSVLQI SSQDVESKRS 
      7010       7020       7030       7040       7050
DKTDFAERLG AMNKSWQILQ GLVTEKIQLL EGLLESWSEY ENNVQCLKTW 
      7060       7070       7080       7090       7100
FETQEERLKQ QHRIGDQASV QNAMKDCQDL EDLIKAKEKE VEKIEQNGLA 
      7110       7120       7130       7140       7150
LVQNKKEEVS GTVRSTLQEL NQTWANLDHM VGQLKILLKS VLDQWSHHKV 
      7160       7170       7180       7190       7200
AFDEINSCLM EARYSLSRFC LLTGSLEAVQ IQVDSLQNLQ DDLEKQEKSL 
      7210       7220       7230       7240       7250
QKFGSVTSQL LKECHPPVTE TLTNTLKEVN MRWNNLLEEI AEQLRASKAL 
      7260       7270       7280       7290       7300
LQLWQRYKDY FKQCAATVQQ QEGRTNEFLK AATDKDIGDD EVATWIQDCN 
      7310       7320       7330       7340       7350
DLLKGLGPIQ DSLVVLHELG GQLKQQVDAS AASAIQSDWL SLKQQSHALE 
      7360       7370       7380       7390       7400
QALCKQQTVL QAGVLDYETF TKSLEALETW IVEAEEILQG QDPSHSSDLS 
      7410       7420       7430       7440       7450
TIQERMEELK GQMLKFSSMV PDLDRLNELG YRLPLNDKEI KRVQNLNRHW 
      7460       7470       7480       7490       7500
ALISSQTTER FSKLQSFLLQ HQTFLEKCET WMEFLVQTEQ KLAVEISGNY 
      7510       7520       7530       7540       7550
QHLLEQQRAH ELFQAEMFSC QQILHSIIFD GQHLLEQGQV DDRDEFNLKL 
      7560       7570       7580       7590       7600
TLLSNQWQGV IRRAQQRRGI IDSQIRQWQR YREMAEKLRK WLVEVSCLPV 
      7610       7620       7630       7640       7650
SGLGSVRIPL QQARALFDQV QFKEKVFLRQ QGSYILTVEA GKQLLLSADS 
      7660       7670       7680       7690       7700
GAEATLQAEL AEIQEKWKSA SVCLEEQKKK LAGLLQDWEK CENGIADSLE 
      7710       7720       7730       7740       7750
KLRTFKKRLS QPLPDHHEEL HAEQMCCKEL ENAVGSWTDD LAQLTVLKKA 
      7760       7770       7780       7790       7800
LCAYISADDI SILNERMELL QRQWEELCHQ LSLRRQQVSE RLNEWAVFSE 
      7810       7820       7830       7840       7850
KNKELCEWLT QMESKVSQNG DILIEEMIEK LRKDYQEEIA VAQENKIQLQ 
      7860       7870       7880       7890       7900
QMGERLARAS HESKASEIEY KLGKINDRWQ HLLDLMAARV KKLKETLVAV 
      7910       7920       7930       7940       7950
QQLDKNMSSL RTWLAHIESE LAKPIVYDSC DSEEIQKKLN EQQELQRDIE 
      7960       7970       7980       7990       8000
KHSTGVASVL NLCEVLLHDC DACATDAECD SIQQATRNLD RRWRNICAMS 
      8010       8020       8030       8040       8050
MERRLKIEET WRLWQKFLDD FSHFEDWLKI SERTAAFPSS SGVLYTVAKE 
      8060       8070       8080       8090       8100
ELKKFEAFQR QVHESLTQLE LINKQYRRLA RENRTDAAGS LKQMVHKGNQ 
      8110       8120       8130       8140       8150
RWDNLQKRVT SILRRLKHFI GQREEFETAR DSILVWLTEM DLQLTNIEHF 
      8160       8170       8180       8190       8200
SECDVQAKIK QLKAFQQEIS LNHNKIEQII AQGEQLIEKS EPLDAAVIEE 
      8210       8220       8230       8240       8250
ELDELRRYCQ EVFGRVDRYH KKLMRLPLPD DEHDLSDREL ELDEAGALSD 
      8260       8270       8280       8290       8300
LRWRDTTDGV LSPQPSSNPS LSLAQPLRSE RSGRDTPASV DSIPLEWDHD 
      8310       8320       8330       8340       8350
YDLSRDLESA VSRTLPSEDE EGPEDKDFYL RGAVGLSDVV IPESPEAYVK 
      8360       8370       8380       8390       8400
LTESAIRNSS GDRGALESQI RQLGKALDDS HFQMQQTENI IHSKTPTGPE 
      8410       8420       8430       8440       8450
LDSGYRGYMK LLGECSGSID SVKRLEHKLT EEEDHFPGFV NLNSTETQTA 
      8460       8470       8480       8490       8500
GVIDRWELIQ AEALSKELRM KQKPQRRQQL DSDLNSVLTW LRETEGDLEQ 
      8510       8520       8530       8540       8550
LQRLQLSTDI QSIALQIQKL KELQKAVDQR KAIILSIHLC SSEFTQTGQE 
      8560       8570       8580       8590       8600
ESQDLQDRLS QMNGRWDRVC SLLEEWRGLL QDALMQCQDF HEMSHSLLLM 
      8610       8620       8630       8640       8650
LENIDRRKNE IVPIDSNLDA EILQDHHKQL KQIRHELLES QLKVASLQDM 
      8660       8670       8680       8690       8700
SCQLLVNAEG TDCLEAKEKV HVIGNRLKLL LKEVSRHIKE LEKLLDMSSS 
      8710       8720       8730       8740       8750
QQDLSSWSSA DELDTSGSVS PTSGRSTPNR QKTPRGKCSL SQPGPSVNSP 
      8760       8770       8780       8790       8800
HSRSIKGGSD SSLSEPRPAR SGRAFLFRVL RAALPLQLLL LLLIGLACLV 
      8810       8820       8830 
PMSEEDYSCA LSNNFARSFH PMLRYTNGPP PL
Length:8,832
Mass (Da):1,013,044
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7941B938784AD7D6
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_014952960.2, XM_015097474.2
XP_027828365.1, XM_027972564.1
XP_027828366.1, XM_027972565.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		oas:101106269

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014952960.2, XM_015097474.2
XP_027828365.1, XM_027972564.1
XP_027828366.1, XM_027972565.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

KEGGioas:101106269

Phylogenomic databases

OMAiLWTSFRQ

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 13 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P7EDS4_SHEEP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P7EDS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: January 19, 2022
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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