Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 2 (10 Feb 2021)
Sequence version 1 (02 Dec 2020)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

afadin isoform X5

Gene

Afdn

Organism
Octodon degus (Degu) (Sciurus degus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
afadin isoform X5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AfdnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOctodon degus (Degu) (Sciurus degus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10160 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaOctodontidaeOctodon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515203 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 134Ras-associatingInterPro annotationAdd BLAST96
Domaini247 – 349Ras-associatingInterPro annotationAdd BLAST103
Domaini654 – 894DiluteInterPro annotationAdd BLAST241
Domaini993 – 1079PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 197DisorderedSequence analysisAdd BLAST68
Regioni355 – 376DisorderedSequence analysisAdd BLAST22
Regioni517 – 554DisorderedSequence analysisAdd BLAST38
Regioni1093 – 1209DisorderedSequence analysisAdd BLAST117
Regioni1222 – 1513DisorderedSequence analysisAdd BLAST292
Regioni1554 – 1709DisorderedSequence analysisAdd BLAST156
Regioni1727 – 1772DisorderedSequence analysisAdd BLAST46
Regioni1784 – 1888DisorderedSequence analysisAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1518 – 1545Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 197PolyampholyteSequence analysisAdd BLAST54
Compositional biasi355 – 370PolyampholyteSequence analysisAdd BLAST16
Compositional biasi530 – 554PolarSequence analysisAdd BLAST25
Compositional biasi1116 – 1131PolarSequence analysisAdd BLAST16
Compositional biasi1140 – 1155PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1157 – 1195PolarSequence analysisAdd BLAST39
Compositional biasi1222 – 1259PolarSequence analysisAdd BLAST38
Compositional biasi1260 – 1286PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1288 – 1326PolarSequence analysisAdd BLAST39
Compositional biasi1346 – 1361Pro-richSequence analysisAdd BLAST16
Compositional biasi1391 – 1427PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1447 – 1477PolarSequence analysisAdd BLAST31
Compositional biasi1499 – 1513PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1575 – 1677PolyampholyteSequence analysisAdd BLAST103
Compositional biasi1678 – 1702Pro-richSequence analysisAdd BLAST25
Compositional biasi1738 – 1757PolarSequence analysisAdd BLAST20
Compositional biasi1826 – 1840PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1870 – 1888PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P6DQE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGSRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
EERRLDIDEK PLVVQLNWNK DDREGRFVLK NENDAIPAKK AQSNGPEKQE
160 170 180 190 200
KEGVIQNFKR TLSKKEKKEK KKREKEALRQ TSEKEDRPSQ GDDSENSRLA
210 220 230 240 250
AEVYKDMPET SFTRTISNPE VVMKRRRQQK LEKRMQEFRS SDGRPDSGGT
260 270 280 290 300
LRIYADSLKP NIPYKTILLS TTDTADFAVA EALEKYGLEK ENPKDYCIAR
310 320 330 340 350
VMLPPGAQHS DERGAKEIIL DDDECPLQIF REWPSDKGIL VFQLKRRPLD
360 370 380 390 400
YIPKKTKKHS EGKPLKGKER ADVSGYGSAL PPEKLPYLVE LSPDGSDSRD
410 420 430 440 450
KPKLYRLQLS VTEVGTEKFD DNSIQLFGPG IQPHHCDLTN MDGVVTVTPR
460 470 480 490 500
SMDAETYVDG QRISETTMLQ SGMKVQFGAS HVFKFVDPSQ DHSLAKRSVD
510 520 530 540 550
GGLMVKGSRH KPGTVQETTF DLGGDVHSGT ALPTSRSTTR LDSDRVSSAS
560 570 580 590 600
STAERGMVKP MIRVDQQQDY RRQESRIQDA AGPELILPAS IEFRESSEDS
610 620 630 640 650
FLSAIINYTN SSTVHFKLSP TYVLYMACRY VLSSQHRPDL SPTERTHKVI
660 670 680 690 700
AVVNKMVSMM EGVIQKQKNI AGALAFWMAN ASELLNFIKQ DRDLSRITLD
710 720 730 740 750
AQDVLAHLVQ MAFKYLVHCL QSELNNYMPA FLDDPEENSL QRPKIDDVLH
760 770 780 790 800
TLTGAMSLLR RCRVNAALTI QLFSQLFHFI NMWLFNRLVT DPDSGLCSHY
810 820 830 840 850
WGAIIRQQLG HIEAWAEKQG LELAADCHLS RIVQATTLLT MDKYAPEDIP
860 870 880 890 900
NINSTCFKLN SLQLQALLQN YHCAPDEPFI PTDLIENVVA VAENTADELA
910 920 930 940 950
RSDGRDVQLE EDPDLQLPFL LPEDGYSCDV VRNIPNGLQE FLDPLCQRGF
960 970 980 990 1000
CRLIPHTRSP GTWTIYFEGA DYESHLMREN TELAQPLRKE PEIITVTLKK
1010 1020 1030 1040 1050
QNGMGLSIVA AKGAGQDKLG IYVKSVVKGG AADVDGRLAA GDQLLSVDGR
1060 1070 1080 1090 1100
SLVGLSQERA AELMTRTSSV VTLEVAKQGA IYHGLATLLN QPSPMMQRVS
1110 1120 1130 1140 1150
DRRGSGKPRP KSEGFELYNN SAQNGSPESP QLPWAEYSEP KKLPGDDRLM
1160 1170 1180 1190 1200
KNRADHRSSP NVANQPPSPG GKSTYTSGTT AKITSVSTGN LCTEEQTPPP
1210 1220 1230 1240 1250
RPEAYPIPTQ TYTREYFTFP ASKSQDRMAP PQNQWPNYED NPHMHTDSNH
1260 1270 1280 1290 1300
SSIAIQRVTR SQEELREDKA YQLERHRMEP IMDRKSDSDM WINQSSSVES
1310 1320 1330 1340 1350
STSSQEHLNH SSKSVTPAST LTKSGPGRWK TPAVVPPTPV AISQPIRTDL
1360 1370 1380 1390 1400
PPPPPPPPVH YASDFDGISM DLPLPPPPAN QVGPQSAQVA AAERKKREEH
1410 1420 1430 1440 1450
QRWYEKEKAR LEEERERKRR EQERKLGQMR TQSLNPAPFS PLAAQQAKPE
1460 1470 1480 1490 1500
KPSTLQRPQE TVIRELQPQQ QPRTIERRDL QYITISKEEL SSGDSLSPDP
1510 1520 1530 1540 1550
WKRDAREKLE KQQQMHIVDM LSKEIHDLQS KADRTAEESD RLRKLMLEWQ
1560 1570 1580 1590 1600
FQKRLQESKQ KDEDDEEEED DDVDTMLIMQ RLEAERRARV KGKNDLVDEE
1610 1620 1630 1640 1650
RRRQQQLEEM RKREAEDRAR QEEERRRQED ERVKRDAEEK RRQEEGYYNR
1660 1670 1680 1690 1700
LEAERRRQHD EVARRLLEPE EPGLCRPPLP RDYEPPVPSP VSSAPPPPPQ
1710 1720 1730 1740 1750
RNASYLKTQV LSPDSLFTAK FVAYNEEEED CSLEGQDKYA STRKSQGDLL
1760 1770 1780 1790 1800
SANLKPQQPP YQPRPASDGI FLSNSFQLPT TKANSMAHKM GHPPPPPKKP
1810 1820 1830 1840 1850
NFYHPGHYKG PHLYSGSAGT VTGTHDAARD LREKRARSQD ADLPGSSGAP
1860 1870 1880
ENLTFKERQR LFSQGQDVSD KVKASRKLTE LENELNTK
Length:1,888
Mass (Da):213,999
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB2A47359040EE65
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_023562272.1, XM_023706504.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023562272.1, XM_023706504.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P6DQE6_OCTDE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P6DQE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: February 10, 2021
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again