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Entry version 4 (02 Jun 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

nesprin-1

Gene

SYNE1

Organism
Pteropus vampyrus (Large flying fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPteropus vampyrus (Large flying fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri132908 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaChiropteraMegachiropteraPteropodidaePteropodinaePteropus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515202 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 146Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini190 – 295Calponin-homology (CH)InterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni162 – 184DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili322 – 342Sequence analysisAdd BLAST21
Coiled coili430 – 450Sequence analysisAdd BLAST21
Coiled coili620 – 644Sequence analysisAdd BLAST25
Coiled coili924 – 944Sequence analysisAdd BLAST21
Coiled coili1309 – 1336Sequence analysisAdd BLAST28
Coiled coili1498 – 1518Sequence analysisAdd BLAST21
Coiled coili1570 – 1590Sequence analysisAdd BLAST21
Coiled coili1924 – 1951Sequence analysisAdd BLAST28
Coiled coili1958 – 1978Sequence analysisAdd BLAST21
Coiled coili2028 – 2048Sequence analysisAdd BLAST21
Coiled coili2181 – 2208Sequence analysisAdd BLAST28
Coiled coili2218 – 2238Sequence analysisAdd BLAST21
Coiled coili2286 – 2306Sequence analysisAdd BLAST21
Coiled coili2426 – 2446Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P6CKE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLVLKCSF RFKDWLHEDG VSGRFQYPPS FRRADEQEIV QKRTFTKWIN
60 70 80 90 100
SHLSKRKPPM VVEDLFEDMK DGVKLLALLE VLSGQKLPCE QGRRMKRIHA
110 120 130 140 150
VANIGTALKF LEGRKIKLVN INSTDIADGR PSIVLGLMWT IILYFQIEEL
160 170 180 190 200
TSNLPQLQSL SSSTSSVDST VSSETASPPS KRKVATKIQG NAKKALLKWV
210 220 230 240 250
QYTAAKQTGI EVKDFGRSWR SGVAFHSVIH AIRPELVDLE RVKGRSNREN
260 270 280 290 300
LEEAFTIAET ELGIPRLLDP EDVDVDKPDE KSIMTYVAQF LKHYPDIHNT
310 320 330 340 350
STDMQETDRE DRLILKEMKV WIEQFERDLT RAQMTESNLQ DKYQSFRHFR
360 370 380 390 400
VQYEMKRKQI EHLIQPLYRD GKLSLDQALV KQSWDRVSSR LFDWHIQLDK
410 420 430 440 450
SLPAPLGTIG AWLYRAEVAL REEITIQQVH EETANTIQRK REQHKDLLQN
460 470 480 490 500
TDAHKRAFHE IYRTRSVNGI PVPHDQLEDM AERFHFVSST SELHLMKMEF
510 520 530 540 550
LELKYRLLSL LVLAESKLKS WIIKYGRRES VELLLQNYIA FIENSKFFEQ
560 570 580 590 600
YEVTYQILKE TAEMYVKADG SVEEAENVMK FMSETTAQWR NLSVEVRSVR
610 620 630 640 650
SMLEEVIASW DRYGDTVASL QAWLEDAEKM LNQSEHAKKD FFRNLPHWIQ
660 670 680 690 700
QHTAMNDAGN FLIETCDEVV SRDLKQQLLL LNGRWRELFM EVKQYARADE
710 720 730 740 750
MDRMKKEYTD CITTLSDFST EAHRKLSEPL EVSFMNVKLL IQELEDIEQR
760 770 780 790 800
VPVMDAQYKI ITKTAQLITK ESSQEEANEM FATMSGLKEQ LTEVKERYSP
810 820 830 840 850
LLYECQQLST PLEDLEKQMT FFYDSLGKIN EIMTILEHEA QSSALFKQKH
860 870 880 890 900
QELLACQESC KKTMTQIEKG SQSVQKFVTS SNVLKHFDQT KLQRQIADVH
910 920 930 940 950
VAFQNMVKKT GDWKKHVETN SRLMKKFEES RAELEKVLQM AREGLEEKGN
960 970 980 990 1000
PEDLLKKHTE FFSQLDQRVL NAFLKACDEL TDILPEQEQR GLQEAVRKLH
1010 1020 1030 1040 1050
KQWKDLQGEA PYHLLHLKIE VEKNRFLACV EECRAELDRE TKLVSQEGSE
1060 1070 1080 1090 1100
KLIKEHRIFF SDKGPHHLCE KRLQLIEELC LKLPVRDPGR NTPETCHTTL
1110 1120 1130 1140 1150
KELRAAIDST YAKLVDDPDK WKDYASRISE LSSWIAAQET QLKGVKSETI
1160 1170 1180 1190 1200
STANHGEFKR AVEEIRSGVT QKGETLGWLK SRLKILVEVS SEKEAQMQGD
1210 1220 1230 1240 1250
ELAKLSSSFK ALGTLLSEVE KMLSNVGDCV QYKESVQSSL EELISGSKEI
1260 1270 1280 1290 1300
QDQAEKILDT ENLFEAQQLL LHHQQKTKRI AAKKRDVQQQ IAQDRQGEGG
1310 1320 1330 1340 1350
LPGQVREELR KLESSLDSVE RSREKQERRI QVTLRKWERF ETNKETVVRY
1360 1370 1380 1390 1400
LFQTGSSHER FLSFSSLESL SSELEQTKVY HIKTMEMVKN KWDHFGNNFE
1410 1420 1430 1440 1450
TLSIWITEKE KELNALETSS SAMDVQISQI KVTIQEIESK ISSITGLEEE
1460 1470 1480 1490 1500
VQSFAQFLTT GESARMKAKL TQIRRYWEEL REHAQCLEGT ILGHISQQQK
1510 1520 1530 1540 1550
FEENLRKIQQ SVSEFEDKLA DPIKICSSAT ETYKALQEHM DLCQALESLN
1560 1570 1580 1590 1600
SSVAALSAGA QKVANRGRSI QDVETLQREY EGTLSQAKER QTVLESLLAT
1610 1620 1630 1640 1650
WQRLEKELST FLTWLERCEA IASSPEMDIS ADRAKVESEL QLIQALQSEV
1660 1670 1680 1690 1700
VSQAAIYSNL LQVKESLFSL ASKDDVKMMK LHLEQLDERW RDLPQIISKR
1710 1720 1730 1740 1750
INFLQSVATE HQQFDELLLS FSVWIKLFLS ELQTTSEISI TDHHAALIRH
1760 1770 1780 1790 1800
KDHAAEIESK KGELQSLQGH LAKLGALGRA EDLHLLQGKA EDCFQLFEEA
1810 1820 1830 1840 1850
SQVVERRQLA LSQVAEFVQS HVSLSGGLLR LRQTVEATNS MNKKQTDRLE
1860 1870 1880 1890 1900
KDLSDAIRDV KTFESTAIGL DGILTKAQYH LKSGSSEQRT SCRTIADHLC
1910 1920 1930 1940 1950
LELESIQNLL GTKQSEADAL AVLKKAFQDQ KEELLKSIED IEERTDKERL
1960 1970 1980 1990 2000
KEPTRQALQQ RLRVFNQLED ELNSHEHELC WLKDKAKQIA QKDVAFAPEV
2010 2020 2030 2040 2050
DREINRLEVT WDDTKKLIHE NQGQCCGLID LMREYQNLKS AVSKVLENAS
2060 2070 2080 2090 2100
NVIVTKTAIK DEEDLKWALS KHETARNEMC NKQKELDNFT SKGKQLLSEL
2110 2120 2130 2140 2150
KKIHSSDFIL VKTDMESTVD KWLDVSERIE ENMDRLRVSL SLWADVLSSK
2160 2170 2180 2190 2200
DEIEGWSNNS VPQLAESISN LNDSLRAGEF LKEFESEVKN KALKLEELHS
2210 2220 2230 2240 2250
KVKDLKELTK NLETPPDLQF IEADLRQRLE HAKELTEEAK GTLKDFTAQS
2260 2270 2280 2290 2300
TQVEKFVNDI TTWLTKLEES LMNCALTETC EGLKKVKEIQ KELQSQQSSI
2310 2320 2330 2340 2350
SSTQENLNSL CRRYHSAELA GLGSAMTGLI KKHEAVSQLC LKTQASLQES
2360 2370 2380 2390 2400
LEKHFNESMQ EFQEWFSGIK VAAKESSDRT GDSKVLEAKL HELQNVLDSV
2410 2420 2430 2440 2450
TDGQSKLDAV TQEGQTLYAH LSKQIVSSIQ EQITKANEEF QAFLKQCLKD
2460 2470 2480 2490 2500
KQALQDCALE LGSFEDQHRK LNLWIHEMDE RLSTENLGES KQHIPEKKNE
2510 2520 2530 2540 2550
VHKVEMFLGE LLAARESLDK LSQRGQLLSE EGHGVGKEGR LCSQLLTTYQ
2560 2570 2580 2590 2600
HLLRMTKEKL RSCQLALQEH EALEEALQSM WSWVKDAQDK LACAESTVGS
2610 2620 2630 2640 2650
KDTLEKRLLQ IQDILLMKGE GEVKLNMAIG KGEQAARSSN EEGQRVIQTQ
2660 2670 2680 2690 2700
LQTLADVWAN IMGSALRAQS NLESVISQWN DYLEWKNQLE QWMESVDQKV
2710 2720 2730 2740 2750
EHPLKLQPGL KEKFSLLDHF QSIVSEGEGH TGALHGLIAK SRELYQKTED
2760 2770 2780 2790 2800
ESFKETAQEE LKTQFNDIMT VAKEKMRKVE EIVKDHLMYL DAVQEFTDWL
2810 2820 2830 2840 2850
HSAKEELHRW SDMSGDSSAT QKKLSKIKEL MDSREIGASR LSRVELLAPA
2860 2870 2880 2890 2900
VTQNTTASGS ELMDTEMQAL RADWKQWEDS VCQTQTSLET LVSQMALSEQ
2910 2920 2930 2940 2950
EFTGQVAQLE QALEQLGVLL TTWAQQLSVL EGKNTDMEMV ECWQKGREIL
2960 2970 2980 2990
DALQKAEPKT EDLKSQLNDL CRFSRDLSTY SGKVSGLIKE YNW
Length:2,993
Mass (Da):344,067
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C0C17C6B9D5C679
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_023387932.1, XM_023532164.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023387932.1, XM_023532164.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P6CKE6_PTEVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P6CKE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: June 2, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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