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UniProtKB - A0A6P6CKE6 (A0A6P6CKE6_PTEVA)

Entry version 4 (02 Jun 2021)
Sequence version 1 (02 Dec 2020)
Previous versions | rss
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Protein
Submitted name:

nesprin-1

Gene

SYNE1

Organism
Pteropus vampyrus (Large flying fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPteropus vampyrus (Large flying fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri132908 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Chiroptera › Megachiroptera › Pteropodidae › Pteropodinae › Pteropus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515202 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 146Calponin-homology (CH)InterPro annotationAdd BLAST108
Domaini190 – 295Calponin-homology (CH)InterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni162 – 184DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili322 – 342Sequence analysisAdd BLAST21
Coiled coili430 – 450Sequence analysisAdd BLAST21
Coiled coili620 – 644Sequence analysisAdd BLAST25
Coiled coili924 – 944Sequence analysisAdd BLAST21
Coiled coili1309 – 1336Sequence analysisAdd BLAST28
Coiled coili1498 – 1518Sequence analysisAdd BLAST21
Coiled coili1570 – 1590Sequence analysisAdd BLAST21
Coiled coili1924 – 1951Sequence analysisAdd BLAST28
Coiled coili1958 – 1978Sequence analysisAdd BLAST21
Coiled coili2028 – 2048Sequence analysisAdd BLAST21
Coiled coili2181 – 2208Sequence analysisAdd BLAST28
Coiled coili2218 – 2238Sequence analysisAdd BLAST21
Coiled coili2286 – 2306Sequence analysisAdd BLAST21
Coiled coili2426 – 2446Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P6CKE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRLVLKCSF RFKDWLHEDG VSGRFQYPPS FRRADEQEIV QKRTFTKWIN 
        60         70         80         90        100
SHLSKRKPPM VVEDLFEDMK DGVKLLALLE VLSGQKLPCE QGRRMKRIHA 
       110        120        130        140        150
VANIGTALKF LEGRKIKLVN INSTDIADGR PSIVLGLMWT IILYFQIEEL 
       160        170        180        190        200
TSNLPQLQSL SSSTSSVDST VSSETASPPS KRKVATKIQG NAKKALLKWV 
       210        220        230        240        250
QYTAAKQTGI EVKDFGRSWR SGVAFHSVIH AIRPELVDLE RVKGRSNREN 
       260        270        280        290        300
LEEAFTIAET ELGIPRLLDP EDVDVDKPDE KSIMTYVAQF LKHYPDIHNT 
       310        320        330        340        350
STDMQETDRE DRLILKEMKV WIEQFERDLT RAQMTESNLQ DKYQSFRHFR 
       360        370        380        390        400
VQYEMKRKQI EHLIQPLYRD GKLSLDQALV KQSWDRVSSR LFDWHIQLDK 
       410        420        430        440        450
SLPAPLGTIG AWLYRAEVAL REEITIQQVH EETANTIQRK REQHKDLLQN 
       460        470        480        490        500
TDAHKRAFHE IYRTRSVNGI PVPHDQLEDM AERFHFVSST SELHLMKMEF 
       510        520        530        540        550
LELKYRLLSL LVLAESKLKS WIIKYGRRES VELLLQNYIA FIENSKFFEQ 
       560        570        580        590        600
YEVTYQILKE TAEMYVKADG SVEEAENVMK FMSETTAQWR NLSVEVRSVR 
       610        620        630        640        650
SMLEEVIASW DRYGDTVASL QAWLEDAEKM LNQSEHAKKD FFRNLPHWIQ 
       660        670        680        690        700
QHTAMNDAGN FLIETCDEVV SRDLKQQLLL LNGRWRELFM EVKQYARADE 
       710        720        730        740        750
MDRMKKEYTD CITTLSDFST EAHRKLSEPL EVSFMNVKLL IQELEDIEQR 
       760        770        780        790        800
VPVMDAQYKI ITKTAQLITK ESSQEEANEM FATMSGLKEQ LTEVKERYSP 
       810        820        830        840        850
LLYECQQLST PLEDLEKQMT FFYDSLGKIN EIMTILEHEA QSSALFKQKH 
       860        870        880        890        900
QELLACQESC KKTMTQIEKG SQSVQKFVTS SNVLKHFDQT KLQRQIADVH 
       910        920        930        940        950
VAFQNMVKKT GDWKKHVETN SRLMKKFEES RAELEKVLQM AREGLEEKGN 
       960        970        980        990       1000
PEDLLKKHTE FFSQLDQRVL NAFLKACDEL TDILPEQEQR GLQEAVRKLH 
      1010       1020       1030       1040       1050
KQWKDLQGEA PYHLLHLKIE VEKNRFLACV EECRAELDRE TKLVSQEGSE 
      1060       1070       1080       1090       1100
KLIKEHRIFF SDKGPHHLCE KRLQLIEELC LKLPVRDPGR NTPETCHTTL 
      1110       1120       1130       1140       1150
KELRAAIDST YAKLVDDPDK WKDYASRISE LSSWIAAQET QLKGVKSETI 
      1160       1170       1180       1190       1200
STANHGEFKR AVEEIRSGVT QKGETLGWLK SRLKILVEVS SEKEAQMQGD 
      1210       1220       1230       1240       1250
ELAKLSSSFK ALGTLLSEVE KMLSNVGDCV QYKESVQSSL EELISGSKEI 
      1260       1270       1280       1290       1300
QDQAEKILDT ENLFEAQQLL LHHQQKTKRI AAKKRDVQQQ IAQDRQGEGG 
      1310       1320       1330       1340       1350
LPGQVREELR KLESSLDSVE RSREKQERRI QVTLRKWERF ETNKETVVRY 
      1360       1370       1380       1390       1400
LFQTGSSHER FLSFSSLESL SSELEQTKVY HIKTMEMVKN KWDHFGNNFE 
      1410       1420       1430       1440       1450
TLSIWITEKE KELNALETSS SAMDVQISQI KVTIQEIESK ISSITGLEEE 
      1460       1470       1480       1490       1500
VQSFAQFLTT GESARMKAKL TQIRRYWEEL REHAQCLEGT ILGHISQQQK 
      1510       1520       1530       1540       1550
FEENLRKIQQ SVSEFEDKLA DPIKICSSAT ETYKALQEHM DLCQALESLN 
      1560       1570       1580       1590       1600
SSVAALSAGA QKVANRGRSI QDVETLQREY EGTLSQAKER QTVLESLLAT 
      1610       1620       1630       1640       1650
WQRLEKELST FLTWLERCEA IASSPEMDIS ADRAKVESEL QLIQALQSEV 
      1660       1670       1680       1690       1700
VSQAAIYSNL LQVKESLFSL ASKDDVKMMK LHLEQLDERW RDLPQIISKR 
      1710       1720       1730       1740       1750
INFLQSVATE HQQFDELLLS FSVWIKLFLS ELQTTSEISI TDHHAALIRH 
      1760       1770       1780       1790       1800
KDHAAEIESK KGELQSLQGH LAKLGALGRA EDLHLLQGKA EDCFQLFEEA 
      1810       1820       1830       1840       1850
SQVVERRQLA LSQVAEFVQS HVSLSGGLLR LRQTVEATNS MNKKQTDRLE 
      1860       1870       1880       1890       1900
KDLSDAIRDV KTFESTAIGL DGILTKAQYH LKSGSSEQRT SCRTIADHLC 
      1910       1920       1930       1940       1950
LELESIQNLL GTKQSEADAL AVLKKAFQDQ KEELLKSIED IEERTDKERL 
      1960       1970       1980       1990       2000
KEPTRQALQQ RLRVFNQLED ELNSHEHELC WLKDKAKQIA QKDVAFAPEV 
      2010       2020       2030       2040       2050
DREINRLEVT WDDTKKLIHE NQGQCCGLID LMREYQNLKS AVSKVLENAS 
      2060       2070       2080       2090       2100
NVIVTKTAIK DEEDLKWALS KHETARNEMC NKQKELDNFT SKGKQLLSEL 
      2110       2120       2130       2140       2150
KKIHSSDFIL VKTDMESTVD KWLDVSERIE ENMDRLRVSL SLWADVLSSK 
      2160       2170       2180       2190       2200
DEIEGWSNNS VPQLAESISN LNDSLRAGEF LKEFESEVKN KALKLEELHS 
      2210       2220       2230       2240       2250
KVKDLKELTK NLETPPDLQF IEADLRQRLE HAKELTEEAK GTLKDFTAQS 
      2260       2270       2280       2290       2300
TQVEKFVNDI TTWLTKLEES LMNCALTETC EGLKKVKEIQ KELQSQQSSI 
      2310       2320       2330       2340       2350
SSTQENLNSL CRRYHSAELA GLGSAMTGLI KKHEAVSQLC LKTQASLQES 
      2360       2370       2380       2390       2400
LEKHFNESMQ EFQEWFSGIK VAAKESSDRT GDSKVLEAKL HELQNVLDSV 
      2410       2420       2430       2440       2450
TDGQSKLDAV TQEGQTLYAH LSKQIVSSIQ EQITKANEEF QAFLKQCLKD 
      2460       2470       2480       2490       2500
KQALQDCALE LGSFEDQHRK LNLWIHEMDE RLSTENLGES KQHIPEKKNE 
      2510       2520       2530       2540       2550
VHKVEMFLGE LLAARESLDK LSQRGQLLSE EGHGVGKEGR LCSQLLTTYQ 
      2560       2570       2580       2590       2600
HLLRMTKEKL RSCQLALQEH EALEEALQSM WSWVKDAQDK LACAESTVGS 
      2610       2620       2630       2640       2650
KDTLEKRLLQ IQDILLMKGE GEVKLNMAIG KGEQAARSSN EEGQRVIQTQ 
      2660       2670       2680       2690       2700
LQTLADVWAN IMGSALRAQS NLESVISQWN DYLEWKNQLE QWMESVDQKV 
      2710       2720       2730       2740       2750
EHPLKLQPGL KEKFSLLDHF QSIVSEGEGH TGALHGLIAK SRELYQKTED 
      2760       2770       2780       2790       2800
ESFKETAQEE LKTQFNDIMT VAKEKMRKVE EIVKDHLMYL DAVQEFTDWL 
      2810       2820       2830       2840       2850
HSAKEELHRW SDMSGDSSAT QKKLSKIKEL MDSREIGASR LSRVELLAPA 
      2860       2870       2880       2890       2900
VTQNTTASGS ELMDTEMQAL RADWKQWEDS VCQTQTSLET LVSQMALSEQ 
      2910       2920       2930       2940       2950
EFTGQVAQLE QALEQLGVLL TTWAQQLSVL EGKNTDMEMV ECWQKGREIL 
      2960       2970       2980       2990 
DALQKAEPKT EDLKSQLNDL CRFSRDLSTY SGKVSGLIKE YNW
Length:2,993
Mass (Da):344,067
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C0C17C6B9D5C679
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_023387932.1, XM_023532164.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_023387932.1, XM_023532164.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00435, Spectrin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 10 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P6CKE6_PTEVA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P6CKE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: June 2, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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