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Entry version 6 (19 Jan 2022)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

unconventional myosin-X isoform X1

Gene

Myo10

Organism
Mus caroli (Ryukyu mouse) (Ricefield mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi157 – 164ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
unconventional myosin-X isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myo10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus caroli (Ryukyu mouse) (Ricefield mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10089 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515126 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 739Myosin motorInterPro annotationAdd BLAST677
Domaini1216 – 1314PHInterPro annotationAdd BLAST99
Domaini1396 – 1501PHInterPro annotationAdd BLAST106
Domaini1551 – 1699MyTH4InterPro annotationAdd BLAST149
Domaini1704 – 2048FERMInterPro annotationAdd BLAST345

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni619 – 641Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni822 – 845DisorderedSequence analysisAdd BLAST24
Regioni963 – 1041DisorderedSequence analysisAdd BLAST79
Regioni1065 – 1090DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1006 – 1035Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1065 – 1083Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13202, FERM_C_MyoX, 1 hit
cd14873, MYSc_Myo10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 4 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR031971, MYO10_CC
IPR001609, Myosin_head_motor_dom
IPR041797, MyoX_FERM_C
IPR040640, MyoX_N_SH3
IPR036124, MYSc_Myo10
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373, FERM_M, 1 hit
PF00612, IQ, 3 hits
PF16735, MYO10_CC, 1 hit
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 1 hit
PF00169, PH, 2 hits
PF18597, SH3_19, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 1 hit
SM00233, PH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 1 hit
PS50003, PH_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P5R3J9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSFFPEGAR VWLRENGQHF PSTVNSCAEG VVVFQTDYGQ VFTYKQSTIT
60 70 80 90 100
NQKVTAMHPL HEEGVDDMAS LAELHGGSIM YNLFQRYKRN QIYTYIGSII
110 120 130 140 150
ASVNPYQPIA GLYERATMEE YSRCHLGELP PHIFAIANEC YRCLWKRHDN
160 170 180 190 200
QCVLISGESG AGKTESTKLI LKFLSVISPQ TLDLGLQEKT SSVEQAILQS
210 220 230 240 250
SPIMEAFGNA KTVYNNNSSR FGKFVQLNIC QQGNIQGGRI VDYLLEKNRV
260 270 280 290 300
VRQNPGERNY HIFYALLAGL DQGEREEFYL SLPENYHYLN QSGCTEDKTI
310 320 330 340 350
SDQESFRQVI TAMEVMQFSK EEVREVLRLL AGILHLGNIE FITAGGAQIS
360 370 380 390 400
FKTALGRSAD LLGLDPTQLT DALTQRSMIL RGEEILTPLS VQQAIDSRDS
410 420 430 440 450
LAMALYARCF EWVIKKINSR IKGKDDFKSI GILDIFGFEN FEVNHFEQFN
460 470 480 490 500
INYANEKLQE YFNKHIFSLE QLEYSREGLV WEDIDWIDNG ECLDLIEKKL
510 520 530 540 550
GLLALINEES HFPQATDSTL LEKLHSQHAN NHFYVKPRVA VNNFGVKHYA
560 570 580 590 600
GEVQYDVRGI LEKNRDTFRD DLLNLLRESR FDFIYDLFEH VSSRNNQDTL
610 620 630 640 650
KCGSKHRRPT VSSQFKDSLH SLMATLSSSN PFFVRCIKPN TQKMPDQFDQ
660 670 680 690 700
VVVLNQLRYS GMLETVRIRK AGYAVRRPFQ DFYKRYKVLM RNLALPEDIR
710 720 730 740 750
GKCTVLLQVY DASNSEWQLG KTKVFLRESL EQKLEKRREE EIDRAAMVIR
760 770 780 790 800
AHILGYLARK QYRKVLCGVV TIQKNYRAFL ARKKFLHLKK AAIVFQKQLR
810 820 830 840 850
GQLARRVYRQ LLAEKRELEE RKRREEEKKR EEEERERERA QREADLLRAQ
860 870 880 890 900
QEAETRRQQE LEALQKRQRE ADLTRELEKQ RENKQVEEIL RLEKEIEDLQ
910 920 930 940 950
RMKEQQELSL TEASLQKLQQ LRDEELRRLE DEACRAAQEF LESLNFDEID
960 970 980 990 1000
ECVRNIERSL SVGSEISGEE LSELAESASG EKPNFNFSQP YPAEEEVDEG
1010 1020 1030 1040 1050
FEADDDAFKD SPNPSEHGHS DQRTSGIRTS DDSSEEDPYM NYTVVPTSPS
1060 1070 1080 1090 1100
ADSTVLLAAS MQDSASLHNS SSGESTYCMP QNNGDLPSPD GDYDYDQDDY
1110 1120 1130 1140 1150
EDGAITSGSS VTFSNSYGSQ WSPDYRYSVG TYNSSGAYRF SSEGAQSSFE
1160 1170 1180 1190 1200
DSEEDFDSRF DTDDELSYRR DSVYSCVTLP YFHSFLYMKG GLMNSWKRRW
1210 1220 1230 1240 1250
CVLKDETFLW FRSKQEALKQ GWLHKKGGGS STLSRRNWKK RWFVLRQSKL
1260 1270 1280 1290 1300
MYFENDSEEK LKGTVEVRTA KEIIDNTSKE NGIDIILADR TFHLIAESPE
1310 1320 1330 1340 1350
DASQWFSVLS QVHSSTDQEI REMHDEQANP QNAVGTLDVG LIDSVCASDS
1360 1370 1380 1390 1400
PDRPNSFVII TANRVLHCNA DTPEEMHHWI TLLQRSKGDT RVEGQEFIVR
1410 1420 1430 1440 1450
GWLHKEVKNS PKMSSLKLKK RWFVLTHNSL DYYKSSEKNA LKLGTLVLNS
1460 1470 1480 1490 1500
LCSVVPPDEK IFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSAIQNVT
1510 1520 1530 1540 1550
DTKAPIDTPT QQLIQDIKEN CLNSDVVEQI YKRNPILRYT HHPLHSPLLP
1560 1570 1580 1590 1600
LPYGDINLNL LKDKGYTTLQ DEAIKIFNSL QQLESMSDPI PIIQGILQTG
1610 1620 1630 1640 1650
HDLRPLRDEL YCQLIKQTNK VPHPGSVGNL YSWQILTCLS CTFLPSRGIL
1660 1670 1680 1690 1700
KYLKFHLKRI REQFPGTEME KYALFIYESL KKTKCREFVP SRDEIEALIH
1710 1720 1730 1740 1750
RQEMTSTVYC HGGGSCKITI NSHTTAGEVV EKLIRGLAME DSRNMFALFE
1760 1770 1780 1790 1800
YNGQVDKAIE SRTIVADVLA KFEKLAATSE AGDVPWKFYF KLYCFLDTDS
1810 1820 1830 1840 1850
MPKDSVEFAF MFEQAHEAVI HGHHPAPEES LQVLAALRLQ YLQGDYTPHT
1860 1870 1880 1890 1900
SIPPLEEVYS VQRLRARISQ STKTFTPYER LEKRRTSFLE GTLRRSFRTG
1910 1920 1930 1940 1950
SVVRQKVEEE QMLDMWIKEE VCSARTSIID KWKKLQGMNQ EQAMAKYMAL
1960 1970 1980 1990 2000
IKEWPGYGST LFDVECKEGG FPQELWLGVS ADAVSVYKRG EGKPLEVFQY
2010 2020 2030 2040 2050
EHILSFGAPL ANTYKIVVDE RELLFETSEV VDVAKLMKAY ISMIVKKRYS
2060
TTRSVSSQGS SR
Length:2,062
Mass (Da):237,426
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DB2FF942A1407B9
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_021039252.1, XM_021183593.2

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mcal:110310545

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_021039252.1, XM_021183593.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGimcal:110310545

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13202, FERM_C_MyoX, 1 hit
cd14873, MYSc_Myo10, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 4 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR031971, MYO10_CC
IPR001609, Myosin_head_motor_dom
IPR041797, MyoX_FERM_C
IPR040640, MyoX_N_SH3
IPR036124, MYSc_Myo10
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PfamiView protein in Pfam
PF00373, FERM_M, 1 hit
PF00612, IQ, 3 hits
PF16735, MYO10_CC, 1 hit
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 1 hit
PF00169, PH, 2 hits
PF18597, SH3_19, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00015, IQ, 3 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 1 hit
SM00233, PH, 2 hits
SUPFAMiSSF47031, SSF47031, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 1 hit
PS50003, PH_DOMAIN, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P5R3J9_MUSCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P5R3J9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: January 19, 2022
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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