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UniProtKB - A0A6P5P104 (A0A6P5P104_MUSCR)

Entry version 2 (10 Feb 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

insulin receptor substrate 4

Gene

Irs4

Organism
Mus caroli (Ryukyu mouse) (Ricefield mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
insulin receptor substrate 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Irs4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus caroli (Ryukyu mouse) (Ricefield mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10089 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515126 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 200PHInterPro annotationAdd BLAST122
Domaini232 – 336IRS-type PTBInterPro annotationAdd BLAST105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni399 – 661DisorderedSequence analysisAdd BLAST263
Regioni687 – 800DisorderedSequence analysisAdd BLAST114
Regioni823 – 890DisorderedSequence analysisAdd BLAST68
Regioni1169 – 1205DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi462 – 478PolyampholyteSequence analysisAdd BLAST17
Compositional biasi487 – 541PolarSequence analysisAdd BLAST55
Compositional biasi632 – 651PolyampholyteSequence analysisAdd BLAST20
Compositional biasi768 – 798PolarSequence analysisAdd BLAST31
Compositional biasi823 – 841PolarSequence analysisAdd BLAST19
Compositional biasi845 – 859PolyampholyteSequence analysisAdd BLAST15

Family and domain databases

Conserved Domains Database

More...CDDi		cd01204, PTB_IRS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR10614, PTHR10614, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02174, IRS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00628, INSULINRSI

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P5P104-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASCSFSGHQ ALRRLRASAA AAASAALAAV ATTPLLSSGT RTALIGTGSS 
        60         70         80         90        100
CPGAMWLSTA TGSRSDSESE EEDLPVGDEV CKRGYLRKQK HGHRRYFVLK 
       110        120        130        140        150
LETADAPARL EYYRNARKFR HSVRAAAAAA EAAASGAAVP ALIPPRRVII 
       160        170        180        190        200
LYQCFSVSQR ADARYRHLIA LFTQDEYFAM VAENESEQES WYLLLSRLIL 
       210        220        230        240        250
ESKRRRCGTL GALPDGEPAA LAAAAAAEPP FYKDVWQVVV KPRGLGHRKE 
       260        270        280        290        300
LSGVFRLCLT DEEVVFVRLN TEVASVVVQL LSIRRCGHSE QYFFLEVGRS 
       310        320        330        340        350
TVIGPGELWM QVDDSVVAQN MHELFLEKMR ALCADEYRAR CRSYSISIGA 
       360        370        380        390        400
HLLTLLSTRR HLGLLPLEPG GWLRRYGLEQ FCRLRAIRER EEMLFTRRFI 
       410        420        430        440        450
SPREPPPPFR RGTGHLPRAR RSRRAASVPP SLFRRSAPSP GRIPQPEDVP 
       460        470        480        490        500
NDRAREASGS SSGNTEEKDK EHEEGNRGDY IPMNNWGSGN GRGSGGGRGS 
       510        520        530        540        550
SGQGSSSQGS GGRQGSGGGQ GSGGQGAGGG NQCSGNGQGT AGGHGSGGGG 
       560        570        580        590        600
HGSGGGQRPG DGHGSGGGKN SGSGKNSDDG DRGKSVKKRS YFGKFTQSKQ 
       610        620        630        640        650
QQTLPPPPPP PPAAGATGGK GKSGGRFRLY FCADRGTKER KEAKEVRDME 
       660        670        680        690        700
TPGGVPRGAY RARAFDEDED DPYVPMRPGV AAPLACSSDY MPMAPQNSSA 
       710        720        730        740        750
STKRHSRSPF EDSRGYMMMF PRVSPPPPVP SAPKAPDTNK GDDSKDNDSD 
       760        770        780        790        800
SDYMFMAPGA GAIPKNPPNA QGGSSSKSWS SYFSLPSPIQ SSPLGQSDHS 
       810        820        830        840        850
EYVPMLPGKF LGSGLHKEAP FSLGTKTVSS KPSTEASFSK PEDKGSSAKP 
       860        870        880        890        900
SDDVTPMNKA KEPNHLPFIA KESQGKAKPL NPTQEQREAA SSRDYINIDF 
       910        920        930        940        950
IKRERLVLPS SAQGLPDMRG VITDPAPTAF SGYLNVEFGV PFPNPTIRLS 
       960        970        980        990       1000
DLLRVLPGAN SIPLAGTRWP FPGSAIGSIV EAGEYIEVIF NPAMTPAMSF 
      1010       1020       1030       1040       1050
ADSAICYDAQ TGQIYVVDPF SECCMDVSLS PGRCSEPPPV ARLRREEAQE 
      1060       1070       1080       1090       1100
RRRPQSRSQS LFASTGAAVS AFPTDSLDRD FPAASAVIAA PAEAPLLAVS 
      1110       1120       1130       1140       1150
RALAVVSALA AAPSIGDVFA GFRAAAGVDS ASARGFQPVA GAQAVREFQD 
      1160       1170       1180       1190       1200
LAAGWNPGAL NHEARGEDLA AGAAAPPPPP RQIWVLRPQE RADSEDDDDD 
      1210 
DDDIYVRMDF ARRDYRK
Length:1,217
Mass (Da):130,139
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD471D4595DA3D12A
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_021009754.1, XM_021154095.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_021009754.1, XM_021154095.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

CDDicd01204, PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039011, IRS
IPR002404, IRS_PTB
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PANTHERiPTHR10614, PTHR10614, 1 hit
PfamiView protein in Pfam
PF02174, IRS, 1 hit
PRINTSiPR00628, INSULINRSI
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00310, PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064, IRS_PTB, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P5P104_MUSCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P5P104
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: February 10, 2021
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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