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UniProtKB - A0A6P5LCS8 (A0A6P5LCS8_PHACI)

Entry version 2 (10 Feb 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

integrin alpha-IIb isoform X1

Gene

ITGA2B

Organism
Phascolarctos cinereus (Koala)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationImportedARBA annotation, ReceptorUniRule annotationARBA annotation
Biological processCell adhesionUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
integrin alpha-IIb isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ITGA2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhascolarctos cinereus (Koala)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri38626 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Diprotodontia › Phascolarctidae › Phascolarctos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1013 – 1034HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31UniRule annotationAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502851455832 – 1053UniRule annotationAdd BLAST1022

Keywords - PTMi

GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 96FG-GAPPROSITE-ProRule annotationAdd BLAST64
Repeati187 – 239FG-GAPPROSITE-ProRule annotationAdd BLAST53
Repeati251 – 306FG-GAPPROSITE-ProRule annotationAdd BLAST56
Repeati307 – 372FG-GAPPROSITE-ProRule annotationAdd BLAST66
Repeati373 – 432FG-GAPPROSITE-ProRule annotationAdd BLAST60
Repeati435 – 496FG-GAPPROSITE-ProRule annotationAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini481 – 935Integrin_alpha2InterPro annotationAdd BLAST455

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatARBA annotation, SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01185, INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00191, Int_alpha, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF69179, SSF69179, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51470, FG_GAP, 6 hits
PS00242, INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P5LCS8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRTQCLLPV LWLLRWIQLL LVPGGVPPAW ALNLDAAQPA LYVGPNGSYF 
        60         70         80         90        100
GFALDFYQDG YGGIGIAVGA PRALSPEGEE TGGVFLCPWA TQGTTCSPLT 
       110        120        130        140        150
FDLKDQTSRV GAITFKTFKT KQGLGASVVS WKDNIVACAP WQHWNALELT 
       160        170        180        190        200
EEAGKTPVGN CFVAHPKSGR RAEYAPCREN AMNPLYLGNY GYRRDLRYCE 
       210        220        230        240        250
IGFSSTITQS GELVLGAPGG YYFIGLLARA QLSDIMSSYT PSSLLWTVPS 
       260        270        280        290        300
QRLTKDVFTS EHRDAYRGYS VAVGEFNENP KDTEYVLGTP NWSTTLGAVE 
       310        320        330        340        350
IFYQNLSVLH VLQGEQVASY FGHTVAVTDI NRDGRDDLLV GAPLFMEHRA 
       360        370        380        390        400
NRKMAEVGRV YIYLQQRTQQ ILGNPRHLTG TELYGRFGSA IAPVGDLDQD 
       410        420        430        440        450
GYNDIAVGAP FGGPSGQGRV FIFRGQDEGL SPRPSQVLDS PFHQGFGFGF 
       460        470        480        490        500
ALKGAADIDA NGYPDLLVGA FGASQVAVYR AQPVVLATVR LLVPEVLNPA 
       510        520        530        540        550
VKNCEPPNPK TTVAVSCFNI QICMSITGHN IPEKLRINAE LQLDRLKPRQ 
       560        570        580        590        600
GRRVLFLSSL QSSTTLELEL ASGHVPVCHD AKAFLRDETE FRDKLSPIVL 
       610        620        630        640        650
GLNVSLKNEG ARGPLPLVLN GDTHVQEQTR IILDCGEDDL CVPQLQLTAS 
       660        670        680        690        700
MKGSPLFIGA DNVLEMQVSA SNEGEGAYEA ELAVHLPRGA HFMQALSDVK 
       710        720        730        740        750
NFEKLLCIQK KENESQLVLC ELGNPMKKDA RMRILMLVSV GNLEEAGDSV 
       760        770        780        790        800
SFMLQIKSKN SQNPNSEAFR LEVPVRAKAH VELFGNSFPA SVVLSPPPEG 
       810        820        830        840        850
TLGNEDPITV DRSTYKMEDI SKVEHAFELH NQGPGTVTGL RLQIGFPSHS 
       860        870        880        890        900
QTDDLLYVLD VQAQGGLQCS AQPPPNPLNL KVGQPTPAPS SAPTHPFQHE 
       910        920        930        940        950
REKRNVFIPE HLEPSELQEP IVLNCDTWPC TWVECELKQM ERGQRSMVTI 
       960        970        980        990       1000
STILWPPGLF KRPLEQFVLK SEAWFNVSGL PYDVPVESLP HGNVMVQTNL 
      1010       1020       1030       1040       1050
LRVLLEEREI PTWWVVVGVM GGLLLLALLI LVMWKVGFFK RNRPPLEEEE 

EEE
Length:1,053
Mass (Da):115,875
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03994F4E354ACE50
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_020853356.1, XM_020997697.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_020853356.1, XM_020997697.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517, FG-GAP
IPR013519, Int_alpha_beta-p
IPR000413, Integrin_alpha
IPR013649, Integrin_alpha-2
IPR018184, Integrin_alpha_C_CS
IPR028994, Integrin_alpha_N
IPR032695, Integrin_dom_sf
PfamiView protein in Pfam
PF01839, FG-GAP, 2 hits
PF00357, Integrin_alpha, 1 hit
PF08441, Integrin_alpha2, 1 hit
PRINTSiPR01185, INTEGRINA
SMARTiView protein in SMART
SM00191, Int_alpha, 5 hits
SUPFAMiSSF69179, SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470, FG_GAP, 6 hits
PS00242, INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P5LCS8_PHACI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P5LCS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: February 10, 2021
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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