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Entry version 3 (07 Apr 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1

Gene

ADAMTS13

Organism
Phascolarctos cinereus (Koala)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, IntegrinImported, MetalloproteaseARBA annotation, Protease
LigandMetal-bindingARBA annotation, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhascolarctos cinereus (Koala)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri38626 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaPhascolarctidaePhascolarctos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515140 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502868893220 – 1590Sequence analysisAdd BLAST1571

Keywords - PTMi

Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 412Peptidase M12BInterPro annotationAdd BLAST207

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 5 hits
2.60.120.290, 1 hit
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR035914, Sperma_CUB_dom_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 1 hit
SSF82895, SSF82895, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A6P5JTQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSTWVIFAS AFFFLGSFQL PDFQERFLMA LEPENIFFYF GAISTLEALE
60 70 80 90 100
FDVLQLSCAC EDHQISRLYC KTLHCSFQAL GELYTFQFPE ELSLLIPSFT
110 120 130 140 150
SQWVINSSLW LLKQYPDSCF TGGRVLLPPG AAAKITYCAG QLQGEVIVRG
160 170 180 190 200
EQLYIQPLKR EHWSLALDRS HAQPHLIHKI TQRASGTLQA HRLSPRISKR
210 220 230 240 250
ALGSVKHLEL LVVVGHDVYE YHKEDTERYV LTNLNIGAEL LRDVSVGAQF
260 270 280 290 300
RVHLIKMIIL TEPEADLSIT TNLTSSLLSV CEWSQRINPP DDTHPLHADL
310 320 330 340 350
VLYITRFDLE LSDGNKQVRG VTQLGGACSS SWSCLITEDT GFDLGVTIAH
360 370 380 390 400
EIGHSFGIDH DGADKNSCSS NDHIMALGGT PNSIGLTWSE CSREQFLHFV
410 420 430 440 450
STGKASCVND LPHLEGTIPQ AEPGLYYGAD EQCRVAFGSA AIACTFSRDD
460 470 480 490 500
VDMCQVLSCH TDPQDLTRCS RILIPLLDGT ECGVNKWCSK GHCRSLEELT
510 520 530 540 550
PVSLVHGQWS SWGPPSTCSR TCGGGVITRR RQCNNPRPAF GGLDCAGADL
560 570 580 590 600
KAELCNTQAC VKTQLEFMSE QCAATDGKPL YLTPGVPTFY SWKSAAQYSQ
610 620 630 640 650
GNDLCKHMCW ASGKNFIVSR GASFLDGTRC VPADHQAEGT ISVCVMGKCR
660 670 680 690 700
AFGCDGRMDS GHVKDVCQVC GGDNTTCSRV NGSYTGGRAQ EYVTFLTIPP
710 720 730 740 750
NFTTVHITNQ KPLFTHLAVK IRGQYVVSGK RSISLNTTYP SVLEDNQIEY
760 770 780 790 800
KVFLSKEKMP HLEEIHIRGP TQEDIEIQVY RKYGNEYGNL TSPEITFSYF
810 820 830 840 850
KPKQQQAWVW AVVHGACSVS CGEGLRQVSY SCFDQAQDKW TDDVYCGGTM
860 870 880 890 900
KPLSWEELCV PGPCPPHWAA GDFGPCSTTC GGGVRERTIS CVKVEGNLTL
910 920 930 940 950
MLPESYCKAS LQPVATETCN PQLCLARWKV SEPGPCSSVC GLGLAQRNVT
960 970 980 990 1000
CMQEGDGLEG PVDNRLCSME EKPSHFLPCV VTVCPLGWNT QEPGSFLEEA
1010 1020 1030 1040 1050
MDQLGASWKE NLTVHVWSPV AGECSVSCGT GIRELRYVCL DFASRKEVQE
1060 1070 1080 1090 1100
EKCSPVSQPA NQMMACHAAS CPPRWEIKAL APCPVTCGGG KVPLSVHCVR
1110 1120 1130 1140 1150
QNEGLTISLP HFKCGGMPRP SSYRDCSPEP CPARWRHKLA SCSVSCGGGV
1160 1170 1180 1190 1200
VQRILYCARA FGENEEEIVP DSQCQELPRP EEQEPCNLDP CPPRWKVVSS
1210 1220 1230 1240 1250
SSCSASCGLG IAMRSMICVQ LDHGEEAEVE EEACATLERP PASIPCIITD
1260 1270 1280 1290 1300
CTYQWHFSDW MECSASCGNG IQRRHDFCVR PHQTHAPVPA IFCQHIPKPV
1310 1320 1330 1340 1350
TVRGCSAGPC ERQVIPKPKA QEEATSAISR TTTAPALTFE SPQYRALAVP
1360 1370 1380 1390 1400
NHQLSSSIQP KESLKQDENT GTCGKQYLGP IGTINMTGMQ VAKCAVSIGR
1410 1420 1430 1440 1450
PLGEVVAFQV LESSLNCSVG EMLLFWGRLT WRKTCENLAG VTFVSKTNTL
1460 1470 1480 1490 1500
VVRQRLVFPE NGVVLQYWSQ VATENYHKEC DVQLFGPRGE IVSPPRKHNV
1510 1520 1530 1540 1550
RNQGGCRVFI NVAPEARIAI HALTIDLGTE ANQTSDSYIL IRDMHNMKIV
1560 1570 1580 1590
TFHGQQLFYW ESVGSQAEIE FSESFQEDHI SFRGQYWILK
Length:1,590
Mass (Da):175,377
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EB6E3BF775534D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6P5JUA6A0A6P5JUA6_PHACI
A disintegrin and metalloproteinase...
ADAMTS13
1,587Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6P5JXW4A0A6P5JXW4_PHACI
A disintegrin and metalloproteinase...
ADAMTS13
1,486Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6P5JTR1A0A6P5JTR1_PHACI
A disintegrin and metalloproteinase...
ADAMTS13
1,373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_020837622.1, XM_020981963.1
XP_020837623.1, XM_020981964.1
XP_020837624.1, XM_020981965.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pcw:110205378

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_020837622.1, XM_020981963.1
XP_020837623.1, XM_020981964.1
XP_020837624.1, XM_020981965.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGipcw:110205378

Family and domain databases

Gene3Di2.20.100.10, 5 hits
2.60.120.290, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR002870, Peptidase_M12B_N
IPR035914, Sperma_CUB_dom_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF01562, Pep_M12B_propep, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 9 hits
SUPFAMiSSF49854, SSF49854, 1 hit
SSF82895, SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P5JTQ6_PHACI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P5JTQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: April 7, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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