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Entry version 5 (29 Sep 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

adhesion G protein-coupled receptor L3 isoform X2

Gene

ADGRL3

Organism
Panthera pardus (Leopard) (Felis pardus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorARBA annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
adhesion G protein-coupled receptor L3 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRL3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPanthera pardus (Leopard) (Felis pardus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9691 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaePantherinaePanthera
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515130 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei942 – 965HelicalSequence analysisAdd BLAST24
Transmembranei977 – 995HelicalSequence analysisAdd BLAST19
Transmembranei1001 – 1023HelicalSequence analysisAdd BLAST23
Transmembranei1044 – 1064HelicalSequence analysisAdd BLAST21
Transmembranei1084 – 1107HelicalSequence analysisAdd BLAST24
Transmembranei1149 – 1171HelicalSequence analysisAdd BLAST23
Transmembranei1177 – 1200HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502821398320 – 1592Sequence analysisAdd BLAST1573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi198 ↔ 380PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 192SUEL-type lectinInterPro annotationAdd BLAST90
Domaini197 – 456Olfactomedin-likeInterPro annotationAdd BLAST260
Domaini561 – 617G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST57
Domaini878 – 929GPSInterPro annotationAdd BLAST52
Domaini940 – 1201G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST262

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni27 – 79DisorderedSequence analysisAdd BLAST53
Regioni489 – 535DisorderedSequence analysisAdd BLAST47
Regioni1220 – 1244DisorderedSequence analysisAdd BLAST25
Regioni1568 – 1592DisorderedSequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi494 – 535Polar residuesSequence analysisAdd BLAST42

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.740, 1 hit
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR003924, GPCR_2_latrophilin
IPR003334, GPCR_2_latrophilin_rcpt_C
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR015630, Latrophilin-3
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR003112, Olfac-like_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12011:SF60, PTHR12011:SF60, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF02354, Latrophilin, 1 hit
PF02191, OLF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00249, GPCRSECRETIN
PR01444, LATROPHILIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00284, OLF, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51132, OLF, 1 hit
PS50228, SUEL_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P4Y4X7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPSQLLVFM MLIAPIIQGG KHSERHPALA APLRHAERSP GGALPPRHLL
60 70 80 90 100
QQPAAERATA HRGQGPRGAT RGVRGPGAQG AQSAAQAFSR APIPMAVVRR
110 120 130 140 150
ELSCESYPIE LRCPGTDVIM IESANYGRTD DKICDSDPAQ MENIRCYLPD
160 170 180 190 200
AYKIMSQRCN NRTQCAVVAG PDVFPDPCPG TYKYLEVQYE CVPYIFLCPG
210 220 230 240 250
LLKGVYQSEH LFESDHQSGA WCKDPLQASD KIYYMPWTPY RTDTLTEYSS
260 270 280 290 300
KDDFIAGRPT TTYKLPHRVD GTGFVVYDGA LFFNKERTRN IVKFDLRTRI
310 320 330 340 350
KSGEAIIANA NYHDTSPYRW GGKSDIDLAV DENGLWVIYA TEQNNGKIVI
360 370 380 390 400
SQLNPYTLRI EGTWDTAYDK RSASNAFMIC GILYVVKSVY EDDDNEATGN
410 420 430 440 450
KIDYIYNTDQ SKDSLVDVPF PNSYQYIAAV DYNPRDNLLY VWNNYHVVKY
460 470 480 490 500
SLDFGPLDSR SGQAHHGQVS YISPPIHLDS ELERPPVREI STTGPLGMGS
510 520 530 540 550
TTTSTTLRTT TWSPGRSTTP SVSGRRNRST STPSPAVEVL DDITTHLPSA
560 570 580 590 600
ASQLPALEES CEAVEAREIM WFKTRQGQMA KQPCPAGTIG VSTYLCLAPD
610 620 630 640 650
GIWDPQGPDL SNCSSPWVNQ ITQKLKSGET AANIARELAE QTRNHLNAGD
660 670 680 690 700
ITYSVRAMDQ LVGLLDVQLR NLTPGGKDSA ARSLNKLQKR ERSCRAYVQA
710 720 730 740 750
MVETVNNLLQ PQASNAWRDL TTSDQLRAAT MLLDTVEESA FVLADNLLKT
760 770 780 790 800
DIVRENTDNI QLEVARLSTE GNLEDLKFPE NMGHGSTIQL SANTLKQNGR
810 820 830 840 850
NGEIRVAFVL YNNLGPYLST ENASMKLGTE AMSTNHSVIV NSPVITAAIN
860 870 880 890 900
KEFSNKVYLA DPVVFTVKHI KQSEENFNPN CSFWSYSKRT MTGYWSTQGC
910 920 930 940 950
RLLTTNKTHT TCSCNHLTNF AVLMAHVEVK HSDAVHDLLL DVITWVGILL
960 970 980 990 1000
SLVCLLICIF TFCFFRGLQS DRNTIHKNLC ISLFVAELLF LIGINRTDQP
1010 1020 1030 1040 1050
IACAVFAALL HFFFLAAFTW MFLEGVQLYI MLVEVFESEH SRRKYFYLVG
1060 1070 1080 1090 1100
YGMPALIVAV SAAVDYRSYG TDKVCWLRLD TYFIWSFIGP ATLIIMLNVI
1110 1120 1130 1140 1150
FLGIALYKMF HHTAILKPES GCLDNINASL GSIYWNLYYE DNRPFIKSWV
1160 1170 1180 1190 1200
IGAIALLCLL GLTWAFGLMY INESTVIMAY LFTIFNSLQG MFIFIFHCVL
1210 1220 1230 1240 1250
QKKVRKEYGK CLRTHCCSGK STESSIGSGK TSGSRTPGRY STGSQSRIRR
1260 1270 1280 1290 1300
MWNDTVRKQS ESSFITGDIN SSASLNRGAM ANHLISNALL RPHGTNNPYN
1310 1320 1330 1340 1350
TLLGEPAVCN NPSVSMYNAQ EPYRETKGLL NNARDTSVMD TLPLNGNHGN
1360 1370 1380 1390 1400
SYSIASGEYL SNCVQIIDRG YNHNETALEK KILKELTSNY IPSYLNNHER
1410 1420 1430 1440 1450
SSEQNRNLMN KLVNNLGSGS EDDAIVLDDA TSFNHEESLG LELIHEESDA
1460 1470 1480 1490 1500
PLLPPRVYST ENHQPHHYTR RRLPQDHSES FFPLLTNEHT EDLQSPHRDS
1510 1520 1530 1540 1550
LYTSMPALAG VPATESVTTS TQTEPPPAKC GDAEDVYYKS MPNLGSRNHV
1560 1570 1580 1590
HQLHTYYQLG RGSSDGFIVP PNKDGTPPEG SSKGPAHLVT SL
Length:1,592
Mass (Da):177,451
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA346A50ED030135F
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019324308.1, XM_019468763.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109278413

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019324308.1, XM_019468763.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi109278413

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23284

Family and domain databases

Gene3Di2.60.120.740, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471, GAIN_dom_N
IPR017981, GPCR_2-like
IPR036445, GPCR_2_extracell_dom_sf
IPR001879, GPCR_2_extracellular_dom
IPR003924, GPCR_2_latrophilin
IPR003334, GPCR_2_latrophilin_rcpt_C
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR015630, Latrophilin-3
IPR000922, Lectin_gal-bd_dom
IPR043159, Lectin_gal-bd_sf
IPR003112, Olfac-like_dom
PANTHERiPTHR12011:SF60, PTHR12011:SF60, 1 hit
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF16489, GAIN, 1 hit
PF02140, Gal_Lectin, 1 hit
PF01825, GPS, 1 hit
PF02793, HRM, 1 hit
PF02354, Latrophilin, 1 hit
PF02191, OLF, 1 hit
PRINTSiPR00249, GPCRSECRETIN
PR01444, LATROPHILIN
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00008, HormR, 1 hit
SM00284, OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50227, G_PROTEIN_RECEP_F2_3, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51132, OLF, 1 hit
PS50228, SUEL_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P4Y4X7_PANPR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P4Y4X7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: September 29, 2021
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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