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Entry version 2 (10 Feb 2021)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

transmembrane protein 94 isoform X1

Gene

TMEM94

Organism
Panthera pardus (Leopard) (Felis pardus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
transmembrane protein 94 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM94Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPanthera pardus (Leopard) (Felis pardus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9691 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaePantherinaePanthera
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515130 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei124 – 142HelicalSequence analysisAdd BLAST19
Transmembranei154 – 173HelicalSequence analysisAdd BLAST20
Transmembranei343 – 362HelicalSequence analysisAdd BLAST20
Transmembranei382 – 401HelicalSequence analysisAdd BLAST20
Transmembranei1157 – 1182HelicalSequence analysisAdd BLAST26
Transmembranei1188 – 1205HelicalSequence analysisAdd BLAST18
Transmembranei1231 – 1255HelicalSequence analysisAdd BLAST25
Transmembranei1299 – 1316HelicalSequence analysisAdd BLAST18
Transmembranei1328 – 1349HelicalSequence analysisAdd BLAST22
Transmembranei1369 – 1391HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni546 – 603DisorderedSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili181 – 201Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi549 – 567PolyampholyteSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023298, ATPase_P-typ_TM_dom_sf
IPR039720, TMEM94

The PANTHER Classification System

More...
PANTHERi
PTHR13219, PTHR13219, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81665, SSF81665, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P4XXX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGRSLPFGG DHIHLGMPAV LWAHGSEGEA RGLCPNLLSH VEYCWAPSLW
60 70 80 90 100
LEKSSPVRLQ TQLRNQLEGE PPLALGLSTR KALSILKEQL EAVLEGHLKE
110 120 130 140 150
RKKCLTWKEM WRSSFLHHSN RCSCFHWPGA SLMLLAVLLL LGCHGGQPAG
160 170 180 190 200
SHGAELVSAS ALCLLLLLNL ILIGRQDRLK RREVERRLRG IIDQIQDALR
210 220 230 240 250
DGKEIKWPDA MYPDLHMPFA PSWSLHWAYR DGHLVNLPVS LLVEGDIIAL
260 270 280 290 300
RPGQESFASL RGIKDDEHIV LEPGDLFPPF SPPPSPRGEV KKGPQNPQQH
310 320 330 340 350
RLFRVLETPV IDNIRWCLDM ALSRPVTALD NERFTVQSVM LHYAVPVVLA
360 370 380 390 400
GFLITNALRF MLNAPGVTSW QYTLLQLQVN GVLPVLPLLF PALWVLATAC
410 420 430 440 450
GEARVLAQMS KASPSSLLAK FSEDTLSSYT EAVSSQEMLR CIWGHFLRVI
460 470 480 490 500
QGTSPTLSHS SSLLHSLGSV TVLCCVDKQG ILSWPNPSPE TVLFFSGKVE
510 520 530 540 550
PPHSSHEDLT DDLSTRSFCH PEVEEEPHER DALLAGSLNT SLHLSNEQER
560 570 580 590 600
GDWPGDGPKP PEFYSHHKAH GRSKHPSGSN VSFSRDTEGG EEEPGKAQPG
610 620 630 640 650
LEGEPYEAED FVCDYHLEML SLSQDQQNPS CIQFDDSNWQ LHLTSLKPLG
660 670 680 690 700
LNVLLNLCNA SVTERLCRFS DHLCNIALQE SHSAVLPVHV PWGLCELARL
710 720 730 740 750
IGFTPGAKEL FKQENHLALY RLPSAEMVKE TSLGRLSSVT KRRPPLSHMI
760 770 780 790 800
SLFIKDTTTS TEQMLSHGTA DVVLEACTDF WDGADIYPLS GSDRKKVLDF
810 820 830 840 850
YQRACLSGYC SAFAYKPMSC ALSSQLNGKC IELVQAPGQS SIFTMCELPS
860 870 880 890 900
TVPIKLSTRR NSWSSDEGIG EVLEKEDCMQ ALSGQIFMGM VSSQYQARLD
910 920 930 940 950
IVRLIDGLVN ACIRFVYFSL EDELKSKVFA EKMGLETGWN CHISLTPNGD
960 970 980 990 1000
MPGSEIPPSS PSHAGSLHDD LNQVSRDDAE GLLLMEEEGH SDLISFQPTD
1010 1020 1030 1040 1050
SDLPSFLEDC NRAKLPRGIH QVRPHLQNID NVPLLVPLFT DCTPETMCEM
1060 1070 1080 1090 1100
IKIMQEYGEV TCCLGSSANL RNSCLFLQSD ISIALDPLYP SRCSWETFGY
1110 1120 1130 1140 1150
ATSTSMAQAS DGLSPLQLSG QLNSLPCSLT FRQEETISII RLIEQARHAT
1160 1170 1180 1190 1200
YGIRKCFLFL LQCQLTLVVI QFLSCLVQLP PLLSTTDILW LSCFCYPLLS
1210 1220 1230 1240 1250
ISLLGKPPHS SVMSMATGKN LQSIPRKTQH YFLLCFSLKF SLTVSSCLIC
1260 1270 1280 1290 1300
FGFTLQSFCD SSRARNLTNC SSIMLGSHAD TAPAWFDDFA NGLLTAQKLT
1310 1320 1330 1340 1350
AALTVLHTVF ISITHVHRTK PLWRKSPLTN LWWAVTVPVV LLGQVGQTAV
1360 1370 1380 1390 1400
DLQLWTHRDS RVHFGLEDVP LLTWLLGCLS LVLVVVTNEI VKLHEIRVRV
1410 1420
RYQKRQKLQF ETKLGMNSPF
Length:1,420
Mass (Da):157,983
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i38657F54E269C5CE
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019321778.1, XM_019466233.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109276937

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019321778.1, XM_019466233.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi109276937

Family and domain databases

InterProiView protein in InterPro
IPR023298, ATPase_P-typ_TM_dom_sf
IPR039720, TMEM94
PANTHERiPTHR13219, PTHR13219, 1 hit
SUPFAMiSSF81665, SSF81665, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P4XXX3_PANPR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P4XXX3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: February 10, 2021
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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