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Entry version 5 (19 Jan 2022)
Sequence version 1 (02 Dec 2020)
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Protein
Submitted name:

nesprin-1 isoform X8

Gene

SYNE1

Organism
Panthera pardus (Leopard) (Felis pardus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
nesprin-1 isoform X8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPanthera pardus (Leopard) (Felis pardus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9691 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaePantherinaePanthera
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515130 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8759CytoplasmicPROSITE-ProRule annotationAdd BLAST8759
Topological domaini8781 – 8810Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 140Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini184 – 289Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8751 – 8810KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5867 – 5894DisorderedSequence analysisAdd BLAST28
Regioni8257 – 8294DisorderedSequence analysisAdd BLAST38
Regioni8684 – 8746DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili333 – 353Sequence analysisAdd BLAST21
Coiled coili441 – 461Sequence analysisAdd BLAST21
Coiled coili631 – 655Sequence analysisAdd BLAST25
Coiled coili935 – 955Sequence analysisAdd BLAST21
Coiled coili1320 – 1347Sequence analysisAdd BLAST28
Coiled coili1419 – 1453Sequence analysisAdd BLAST35
Coiled coili1560 – 1580Sequence analysisAdd BLAST21
Coiled coili1633 – 1653Sequence analysisAdd BLAST21
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2244 – 2271Sequence analysisAdd BLAST28
Coiled coili2281 – 2301Sequence analysisAdd BLAST21
Coiled coili2349 – 2376Sequence analysisAdd BLAST28
Coiled coili2616 – 2636Sequence analysisAdd BLAST21
Coiled coili3168 – 3188Sequence analysisAdd BLAST21
Coiled coili3412 – 3439Sequence analysisAdd BLAST28
Coiled coili3473 – 3493Sequence analysisAdd BLAST21
Coiled coili3579 – 3599Sequence analysisAdd BLAST21
Coiled coili3697 – 3717Sequence analysisAdd BLAST21
Coiled coili3790 – 3810Sequence analysisAdd BLAST21
Coiled coili3973 – 3993Sequence analysisAdd BLAST21
Coiled coili4115 – 4135Sequence analysisAdd BLAST21
Coiled coili4153 – 4173Sequence analysisAdd BLAST21
Coiled coili4282 – 4312Sequence analysisAdd BLAST31
Coiled coili4350 – 4370Sequence analysisAdd BLAST21
Coiled coili4723 – 4750Sequence analysisAdd BLAST28
Coiled coili4780 – 4814Sequence analysisAdd BLAST35
Coiled coili4858 – 4878Sequence analysisAdd BLAST21
Coiled coili5075 – 5095Sequence analysisAdd BLAST21
Coiled coili5110 – 5133Sequence analysisAdd BLAST24
Coiled coili5364 – 5391Sequence analysisAdd BLAST28
Coiled coili5446 – 5466Sequence analysisAdd BLAST21
Coiled coili5513 – 5540Sequence analysisAdd BLAST28
Coiled coili5607 – 5627Sequence analysisAdd BLAST21
Coiled coili5635 – 5662Sequence analysisAdd BLAST28
Coiled coili5741 – 5768Sequence analysisAdd BLAST28
Coiled coili5779 – 5816Sequence analysisAdd BLAST38
Coiled coili6077 – 6097Sequence analysisAdd BLAST21
Coiled coili6240 – 6267Sequence analysisAdd BLAST28
Coiled coili6532 – 6566Sequence analysisAdd BLAST35
Coiled coili6597 – 6621Sequence analysisAdd BLAST25
Coiled coili7070 – 7104Sequence analysisAdd BLAST35
Coiled coili7176 – 7206Sequence analysisAdd BLAST31
Coiled coili7825 – 7852Sequence analysisAdd BLAST28
Coiled coili8481 – 8501Sequence analysisAdd BLAST21
Coiled coili8655 – 8679Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5870 – 5894Polar residuesSequence analysisAdd BLAST25
Compositional biasi8257 – 8280Polar residuesSequence analysisAdd BLAST24
Compositional biasi8684 – 8737Polar residuesSequence analysisAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 42 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P4UJL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRTSRSP RDIANVMQRL QDEQEIVQKR TFTKWINSHL TKRKPPLVVD
60 70 80 90 100
DLFEDMKDGV KLLALLEVLS GQKLPCEQGR RMKRIHAVAN IGTALKFLEG
110 120 130 140 150
RKSMYRGSPI KLVNINSTDI ADGRPSIVLG LMWTIILYFQ IEELTSNLPQ
160 170 180 190 200
LQSLPGSTSS VDSTVSAETA SPPSKRKVAT KIQGNAKKAL LKWVQYTVAK
210 220 230 240 250
QTGIDVKDFG RSWRSGVAFH SVIHAIRPEL VDLEKVKGRS NRENLEEAFT
260 270 280 290 300
IAESELGIPR LLDPEDVDVD KPDEKSIMTY VAQFLKHYPD IHNTGTDGQE
310 320 330 340 350
NDEILPGFPS FANSIQNFKR EDGLILKETK VWIKQFERDL TRAQMTESNL
360 370 380 390 400
QDKYQSFKHF RVQYEIKRKQ IEHLIQPIHR DGKLSLDQAL VKQSWDRVSS
410 420 430 440 450
RLFDWHIQLD KSLPAPLGTI GAWLYRAEVA LREEITIQQV HEETANTIQR
460 470 480 490 500
KREQHKDLLQ NTDAHKRAFH EIYRTRSVNG IPVPPDQLED MAERFHFVSS
510 520 530 540 550
TSELHLMKME FLELKYRLLS LLVLAESKLK SWIIKYGRRE SVELLLQNYI
560 570 580 590 600
SFIENSKFFE QYEVTYQILK QTAEMYVKAD GSVEEAENVM KFMNETTAQW
610 620 630 640 650
RNLSVEVRSV RSMLEEVIAN WDRYGNTVAS LQAWLEDAEK MLNQSEHAKK
660 670 680 690 700
DFFRNLPHWI QQHAAMNDAG NFLIETCDEM VSRDLKQQLL LLNGRWRELF
710 720 730 740 750
MEVKQYARAD EMDRMKKEYA DCITVLSDFA TEAHKKLSEP LEVSFINVKL
760 770 780 790 800
LIQDLEDIEQ RVPVMDAQYK MITKTAHLIT KESSQEEANE MFATMSGLKE
810 820 830 840 850
QLTKVKECCP PLLYESQQLL IPLEELEKQM TFFYDSLAKI HEIMAVLERE
860 870 880 890 900
AQSSALFKQK HQELSACQES CKKTMTQIEK GSQNVQKFVT LSSVLKHFDQ
910 920 930 940 950
TKLHRQIADA HGAFQNMVKK IGDWKKHVET NSRLMKKFEE SRAELEKVLR
960 970 980 990 1000
IAQEGLEEKG NPEDLLKKHT EFFSQLDQRV LNAFLKACDE LTDILPEQEQ
1010 1020 1030 1040 1050
QGLQEAVRKL HKQWKDLQGE APYHLLHLKI DVEKNRFLAS VEECRTELDR
1060 1070 1080 1090 1100
EITLVPQEGS EKIIKEHRIF FSDKGPHHLC EKRLQLIEEL CLKLPVRDPV
1110 1120 1130 1140 1150
RNTPETCHVT LKELRAAIDT TYMKLVEDQD KWKDYTRRIS EFSSWISAKE
1160 1170 1180 1190 1200
TQLKGFKNEP IDTANHGEIK HAVEEIRNGV TTKGETLNWL KSRLKILIEV
1210 1220 1230 1240 1250
SSENEAQKQG DELAKLSSSF KALIALLSEV EKMLSNFGDC VQYKEIVKSS
1260 1270 1280 1290 1300
LGELISDSKE VQEQAEKILD TENLFEAQQL LLHHQQKTKR ISAKKRDVQQ
1310 1320 1330 1340 1350
QIAQAQQGGG GMPGQVRDEL RKLESTLDSM EHSREKQERR IQVTLRKWER
1360 1370 1380 1390 1400
FETNKETVVR YLFQTGSSHE RFLSFSSLES LSSELEQTKE FSKRTEGIAV
1410 1420 1430 1440 1450
QAENLVKEAS EIPLGPKNKQ LLQQQAKTIK EQVKKLEDTL EEDIKTMEMV
1460 1470 1480 1490 1500
KNKWDHFGNN FETLSVWITE KEKELNALET SSSAMDMQIN QIKVIIQEIE
1510 1520 1530 1540 1550
SKIGCITELE EAAQSFAQFV TTGESARIKA KLTQIRRYWE ELREHAQCLE
1560 1570 1580 1590 1600
GTILGHLSQQ QKFEENLRKI QKSVSEFEDK LADPIKICSS ATETYKILQE
1610 1620 1630 1640 1650
HMDLCQALEA LNSAVTTVSA SAQKVANRGT SSVQEAAALQ QRYEETRSRA
1660 1670 1680 1690 1700
KERQAVLENL LAHWQRLEKE LSTFLTWLER CEAIASSPEM DISADRVKVE
1710 1720 1730 1740 1750
SELQSIQALQ NELVSQASVY SNLLQLKESL FSVASKDDVK MMKLHLEQLD
1760 1770 1780 1790 1800
ERWRDLPQII SKRINFLQSV VSEHQQFDEL LLSFSVWIKL FLSELQTTSE
1810 1820 1830 1840 1850
ISITDHQAAF ARHKDHEAEA ESKMGDLQSL RDHLAKLGAL GRAEDLHLLQ
1860 1870 1880 1890 1900
GKAEDCFQLF EEASQVVGRR QLALSQLAEF LQCHASLSGV LHRLRHTVET
1910 1920 1930 1940 1950
TDSMNKKQTD LLKKDLNRAI QDAKTLESTA VSLDGILAKA QYHLKSGSSE
1960 1970 1980 1990 2000
QRTSCRSTAD HLCFELERIQ NLLGTKQSEA DALAVLKKAF QDQKEELLKS
2010 2020 2030 2040 2050
IEDIEERTDK ERLKEPTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK
2060 2070 2080 2090 2100
QIAQKDVAFA SEVDREINRL EVTWDDTKKL IHENQGQCCG LIDLMRDYQN
2110 2120 2130 2140 2150
LKSVVSKVLE NANNVLATRT TIKDQEDLKW ALSKHESVKN EMCNKQKELD
2160 2170 2180 2190 2200
NFTSKGKQLL SELKKIHSGD FNLVKTDMES TVDRWLDVSE KIEENMDRLR
2210 2220 2230 2240 2250
ASLTIWGDVL SSKDEIDGWS NNSVPQLAES ISNLNNSVRA EEFLKEFESE
2260 2270 2280 2290 2300
VKNKALRLEE LHCKVNDLKE LTKNPETPPD LQFIEADLRQ KLEHAKEITE
2310 2320 2330 2340 2350
EAKGTLKEFT TQSTQVEKFI NDITSWLTRV EEALMNCAQT ETWEGLKKVK
2360 2370 2380 2390 2400
EIQKELQSQQ SNISSTQENL NSLCRKYHSI ELESLGSAMT GLIKNHEAVS
2410 2420 2430 2440 2450
QLCSKTQASL QDFLEKHFNE SMQEFQEWFS GIKAAAKKSS DRTGDSKVLE
2460 2470 2480 2490 2500
AKLHDLQNIL DSISDGQSKL DAVTQEGQTL YAHLSKQIVS SIQEQVTKAN
2510 2520 2530 2540 2550
EEFQAFLKQC LKDKQALQDC ALELGSFEDQ HRKLNLWIHE MDERLSTENF
2560 2570 2580 2590 2600
GESKQHIPEK KNEVHKVEMF LGELLAVRES LDKLSQRGQL LSEEGHGAGK
2610 2620 2630 2640 2650
EGRLCSQLLT NYQSLLRTTK EKLRNCQLAL QEHEALEEAV QSMWSWVKDI
2660 2670 2680 2690 2700
QDRLACAEST VGSKDTLEKR LLQIQDILLM KGEGEVKLNM AIGKGEQALR
2710 2720 2730 2740 2750
SSNKQGQKVI QTQLQNLKDV WADIMSSSLR AQSTLESVIS KWNDYLEWKN
2760 2770 2780 2790 2800
QLEQWMEFVD QKVEHPLQPQ PGLKEKFSLL DHFQSIVSEA EDHAGTLHRL
2810 2820 2830 2840 2850
ASKSRELYQK TEDESFKETA QEELKTQFND IITVSKEKMR KVEEIVKDHL
2860 2870 2880 2890 2900
MYLDAVQEFT DWLHSAKEEL HRWSDMSGDS SATQKKLSKI KELTDSRGIG
2910 2920 2930 2940 2950
ASRLSRVESL APAVRQNTSA SGCELVDAEM QALRADWKQW EDSVLQTQTS
2960 2970 2980 2990 3000
LENLVSRMAL SEQEFSGQVV QLEQALEEFG ALLTTCARQL ALLESKNTDK
3010 3020 3030 3040 3050
EIVECWRKGQ EILDALQKAE PKTEDLKSQL NELCRFSRDL STYSGKVSGL
3060 3070 3080 3090 3100
IKEYNCLCLQ ASKGCQTREQ ILQQRFQRAF KDFQQWLVNA KITTAKCFDI
3110 3120 3130 3140 3150
PQNISEVSTS LQKIQEFLSE SENGQHKLNV MVSKGELLST LLPKEKADGI
3160 3170 3180 3190 3200
QAKVATAKED WKKFHSNLHQ KESALENLKI QMKDFEVSAE PVQDWLSKTE
3210 3220 3230 3240 3250
KLVQESSNRL YDLPAKRREQ QKLQSVLEEI NCYEPQLNRL REKAQQLWEG
3260 3270 3280 3290 3300
QAASKSFMHR VSQLSSQYLA LSNLTKEKVS RLDRIVAEHN QFSLGIKELQ
3310 3320 3330 3340 3350
DWMTDAVHML DSYCHPISDK SVLDSRMLKL EALLSVKQEK EIQMKMIVTR
3360 3370 3380 3390 3400
GESVLQNTSP EGWPAIQQQL QSVKDMWASL LSAAIRCKSQ LEGALSKWTS
3410 3420 3430 3440 3450
YQDDVRQFSS WMDSVEASLN ESERQYAELR EKTASLGKAK LLSEEVLSYS
3460 3470 3480 3490 3500
SLLEAIELKG AGMTEHYVTQ LEFQDLQERY RAITERAKEA VTKSEKLVRL
3510 3520 3530 3540 3550
HQEYQRDLKA FEVWLGQEQE KLDRYSVLEG DAHTHETTLR DLQELQVHCA
3560 3570 3580 3590 3600
EGQVLLNSVL HTREEVIPSG IPQTEDRALE SLRQDWQAYQ QRLSETRTQF
3610 3620 3630 3640 3650
NNVVNKLRLM EQKYQQVDEW LKTLEDKVSL RTGRQSNRAA KEIQLHQMKK
3660 3670 3680 3690 3700
WHEEVIAYKD EVEDVGARAQ EMLDENHVSS SMGCQATQLT SRYQALLLQV
3710 3720 3730 3740 3750
LEQIQFLEEE IQSLEESELS LSSYSDWYSS THKNFKNVAT KIDRVDKATM
3760 3770 3780 3790 3800
GKKMKTLEGL LKDMEKGHSL LKSAREKGER ALKYLEDGEA EMLRKDIHEH
3810 3820 3830 3840 3850
VEQLKELTST VRKEHMTLEK GLLLAKEFSD KYKALTQWIS EYQEILHTPE
3860 3870 3880 3890 3900
EPKMELYEKK AQLSKYKSLQ QMVLSHEPSI KSVREKGEAL LELVQDVTLK
3910 3920 3930 3940 3950
DKMDKLQSDY QDLCGAGKEH VCSLETKVKD HEDYNSELQE VEKWLLQMSG
3960 3970 3980 3990 4000
RLVAPDLMET SSLETITQEL AHHKAMMEEI AGFEDRLNNL KSKGDNLISQ
4010 4020 4030 4040 4050
CADHLQAKLK QNVYAHLQGT KDSYSAVCST AQRVYQSLEH ELQKHVSRQD
4060 4070 4080 4090 4100
TLQQCQAWLS AVQPDLKPTQ HPPLSRAEAV KQVKHYRALQ EQARTYLDLL
4110 4120 4130 4140 4150
CSTCDLSSSS VKTTAKDIQE TEQMIEQRLV QAQNLTQGWG EIKHMKAELW
4160 4170 4180 4190 4200
IYLQDADQQL QNMKKRHSEL ELNIAQNMVS QVKDFVKKLQ CKQASVTAIT
4210 4220 4230 4240 4250
ERVNKLTKKQ ESPEHKEISH LNDQWLDLCL QANNLCLQRE EDLQRTRDYH
4260 4270 4280 4290 4300
DRMNVVEEFL EKFTTEWDNL ARSDAESTAV HLEALKKLAL ALQERKQAVE
4310 4320 4330 4340 4350
DLKDQKQKMI EHLNLDDKEL VKEQTSHLEQ RWFQLEDLVK RKLQASVTNL
4360 4370 4380 4390 4400
EELNVVRSRF QELMEWAEEQ QPNIAEALKQ SPPPDTAQNL LMDHLAICSE
4410 4420 4430 4440 4450
LEAKQMLLKS LIKDADRVMA DLGLNERQII QKALSDAQRH VNCLSDLVGQ
4460 4470 4480 4490 4500
RRKYLNKALS EKTQFLMAVF QATSQIQQHE RKIMFREHVC LLPDDVSKQV
4510 4520 4530 4540 4550
KTCKSAQASL KTYQNEVTGL WAQGRELMKG ATEQEKSEVL GKLQELQSVY
4560 4570 4580 4590 4600
DAVLQKCSHR LQELEKSLVS RKHFKEDFDK ACHWLKQADI ITFPEINLMN
4610 4620 4630 4640 4650
ESAELHAQLA KYQHILEQSP EYENLLLTLQ RTGQAILPSL NEVDHSYLNE
4660 4670 4680 4690 4700
KLNALPLQFN VIVALAKDKF YKVQETILAR KEYASLIDLT TQSLSELEDQ
4710 4720 4730 4740 4750
FLKMSKVPTD LRVEEAVSLQ EGCRALLGEV ARLGEAVDEL NQKKESFRST
4760 4770 4780 4790 4800
GQPWQPDKML HLVTLYHRLK RQTEQRVSLL EDTSSAYQEH EKMCHQLEKQ
4810 4820 4830 4840 4850
LQAVKTEQSK VNEETLPAEE KLKIYHSLAG SLQDSGIVLK RVTVHLEDLV
4860 4870 4880 4890 4900
PHLDPLAYEK AKQQIQSWQE ELKVLTSAIG ATVTECESRM VQSIDFQTEL
4910 4920 4930 4940 4950
SRSLDWLRSV KAELSGPVCL DLSLQDIQEE IRKTQIHQEE VQSSLRIMNA
4960 4970 4980 4990 5000
LSNKEKEKFT KAKELLSADF QHTLAELSEL DGDVQEALRT RQAALTQIYS
5010 5020 5030 5040 5050
QCQRYYQVFQ AANDWLEDAH EMLQLAGNGL DVESVEENLK SHVEFFSTED
5060 5070 5080 5090 5100
QFHSNLEELQ HLVASLDPLI KPTGKEHLAQ KMASLEEKSQ RIIQDSHAQL
5110 5120 5130 5140 5150
DLLQRCADQW QNYQKAREEV IELMNEAEKK LSEFSLLKTS SSHEAEEKLS
5160 5170 5180 5190 5200
EHKALASVVN SFHEKVVALE DKTSQLEKTG NDASKAAISR SMTTVWQRWT
5210 5220 5230 5240 5250
RLRAVAQDQE KILQDAVDEW TSFNNKVKKA TETTDQLQGK LPGGSAEKAS
5260 5270 5280 5290 5300
KAELLTLLDH HDALILELEQ QQLALGVLRQ QALGMLQDGA LQPPGEEPPT
5310 5320 5330 5340 5350
VQEITAMQDW CLNMQEKVKN TGKVVKQELK EREVVETQIN SVKSWVQETK
5360 5370 5380 5390 5400
EYLGNPTIEI DAQLEELQLL LTEATNHRQS IEKMAEEQKN KYLGLYSILP
5410 5420 5430 5440 5450
SELSLQLAEV ALDLGTIHDQ IQDKVREVEQ SKAMSQEFSR QIQKIAKDLT
5460 5470 5480 5490 5500
TILSKLRAKT DNLQQAKIDQ KVLGEELDGC NLKLMELDAA VQKFSEQNGQ
5510 5520 5530 5540 5550
LGKPLAKKVG KLMELHQQTI RQAENRLSKL SQAASHLEEY TEMLEFILKW
5560 5570 5580 5590 5600
IEKAKVLVHG KIAWNSANQL REQYIFHQTM LEESEEIPSN LEAMIEKLQC
5610 5620 5630 5640 5650
LASIYSTEKM SQQVADLGRE SEELRQTIRI RLQNLQDAAK DMKKFETELK
5660 5670 5680 5690 5700
NLQIALEQAQ TTLTSPEVGR LSLKEQLSHR QHLLSEMESL KPKVHAVQIC
5710 5720 5730 5740 5750
QSALRIPDDV VASLPLCHCA LHLQAEASRL QHTAIQQCNI MQEAVVQYEQ
5760 5770 5780 5790 5800
YEQEMQHLQE LIEGAHREIE DTPAATSNIQ ELQAQISRHE ELAQKIKGYQ
5810 5820 5830 5840 5850
EQIASLNSKC KMLTMKAKHA TMLLTVTEVE GLAEGTEDLD RELLPATSAH
5860 5870 5880 5890 5900
PSVVMMTAGR CHTLLSPVTE ESGEEGTNSE ISSPPACRSP SPVANTDASV
5910 5920 5930 5940 5950
NQDIAYYQAL SAERLQTDAA RIHPSTLPSP EFYELGLEPS ATAKLDDLQR
5960 5970 5980 5990 6000
SWETLKNVIS EKQRTLYEAL ERQQKYQDSL QSISTKMEAI EMKLSESLEH
6010 6020 6030 6040 6050
GRGPESQMAE HQSSPQALMD EILMLQEEIS ELQSSLAEEL VSQSPESDPA
6060 6070 6080 6090 6100
EQLALQSTLT VLAERMSTIK MMASGKRQLL EEKLNDQLEE QRQEQALQRY
6110 6120 6130 6140 6150
RCEADELDHW LLSTKATLDT ALGTAQEPMD MEAQLVDCQN MLVEIEQKVV
6160 6170 6180 6190 6200
ALSELSVHND NLLLEGKAHT KEEAEQLAVK LRTLKGSLLE LQRALHDKQL
6210 6220 6230 6240 6250
LMQQGTAQEK EESHADLTAS QSPGVQEWLA QARTAWAHQR QSSLQQQKEL
6260 6270 6280 6290 6300
EQELAEQKSL LRSVASRGEE ILTQHSAAET SAGIGEKPDV LSQELGMEGE
6310 6320 6330 6340 6350
KSASEDQMRM KWESLHQEFS TKQKLLQNVL EQEQEQVLYS RPNRLLSGVP
6360 6370 6380 6390 6400
LYKGDGQTQD RSAVTSLLDG LNQAFEEVSS QGGGTKRQNI HLEQKLYDGV
6410 6420 6430 6440 6450
SATSTWLDDV EERLFVATAL LPEETEACLF NQETLAKDIK EMSEEMDKNK
6460 6470 6480 6490 6500
NLFSQAFPEN GDNRDVIEDT LGCLLGRLSL LDSVVNQRCH QMKERLQQIL
6510 6520 6530 6540 6550
NFQNDLKVLC TSLADSKYII LQKLANVFEQ PVAEQIEAIQ QAEDGLKELD
6560 6570 6580 6590 6600
AEIIELKKRG DKLQIEQPSM QELSKLQDMY DELMMTIGSW RSSLNQNLAL
6610 6620 6630 6640 6650
KSQYERALQD LADLLETGQE KMAGDQKIIV SSKEEIQQLL DKHKEYFQGL
6660 6670 6680 6690 6700
ESHMILTETL FRKIINFAVL QETQFHTELM TQASAVLKRA HKRGVELEYI
6710 6720 6730 6740 6750
LETWSHLDED HQALSKQLEV VESSIPSVGL VEESEERLID RITLYQHLKS
6760 6770 6780 6790 6800
RLHEYQPKLY QVLDDGKRLL ISISCSDLES QLNQLGEQWL DNTNKVSKEL
6810 6820 6830 6840 6850
HRLETVLKHW TRYQSESAEL IHWLQSAKDR LEFWTQQSVT VPQELEMVRD
6860 6870 6880 6890 6900
HLNAFLEFSK EVDAKSSLKS SVLSIGNQLL RLKKVDTASL RSELSHIDSQ
6910 6920 6930 6940 6950
WTDLLTNIPT VQEKLHQLQM DKLPSRHAIS ELTTWISLME NVIQKDEENI
6960 6970 6980 6990 7000
KNSIGYKAIH EYLQKYKGFK IDINCKQLTV DFVNQSVLQI SSQDVESKRS
7010 7020 7030 7040 7050
DKTDFAEQLG AMNKSWQILQ GLVTEKIQLL EGLLESWSEY ENNVQSLKTW
7060 7070 7080 7090 7100
YETQENKLKQ QHRIGDQASV QSAMKDCQDL EDLIRAKEKE VEKMEQNGLA
7110 7120 7130 7140 7150
LIQNKKEEVS GVVMSTLREL KQTWANLDHM VGQFKILLKS VFDQWNNHKE
7160 7170 7180 7190 7200
AFDEINSYLM EARYSLSRFR LLTGSLEAVQ VQVDNLQNLQ DDLEKQEKNL
7210 7220 7230 7240 7250
QNFGSITNQL LKECHPPVTE TLTTTLKDVN MRWNNLLEEI AKQLCSSKAL
7260 7270 7280 7290 7300
LQLWQRYKDY SKQCASTVQQ QEDGASELLK AATNKDIADD EAATWIQDCN
7310 7320 7330 7340 7350
DLLKGLGTVK DSLFVLRELG EQLKQQVDAS AASTIQSDQL SLSQRLCALE
7360 7370 7380 7390 7400
QALCKQQTML QAGVLDYETF TKSLEALEAW IVEAEEILQG QDPGHSSDLS
7410 7420 7430 7440 7450
TIQQRMEELK GQMLKFSSMA PDLDRLNELG YRLPLNDKEI KRMQNLNRHW
7460 7470 7480 7490 7500
SLISSQTTER FSKLQSFLLQ HQTFLEKCET WMEFLVQTEQ KLAVEISGNY
7510 7520 7530 7540 7550
QHLLEQQRAH ELFQAEMFSR QQILHSIIID GQRLLEQGQV DDRDEFNLKL
7560 7570 7580 7590 7600
TLLSNQWQGV IRRAQQRRGI IDSQIRQWRR YREMAEKLRK WLVEVSYLPV
7610 7620 7630 7640 7650
SALGSVPIPL QQARTLFDEV QFKEKVFLRQ QGSYILTVEA GKQLLLSADS
7660 7670 7680 7690 7700
GAEAALQAEL AEIQEKWRSA SVRLEEQKKK LAFLLKDWEK CENGIADSLE
7710 7720 7730 7740 7750
KLRTFKKKLS PPLPDHHEEL HAEQMRCKEL ENAAGNWTDD LAQLALLKDT
7760 7770 7780 7790 7800
LCAYISADDI SILNERMELL QRQWEELCHQ LSLRRQQVSE RLNEWAVFSE
7810 7820 7830 7840 7850
KNKELCEWLT QMESKVSQNG DILIEEMIEK LKKDYQEEIA VAQENKIQLQ
7860 7870 7880 7890 7900
QMGERLARAS HESKASEIEY KLGKVNDRWQ HLLDLMAARV KKLKETLVAV
7910 7920 7930 7940 7950
QQLDKNMSSL RTWLAHIESE LAKPIVYDSC DSDEIQKKLT EQQELQRDIE
7960 7970 7980 7990 8000
KHSTGVASVL NLCEVLLHDC DACATDAECD SIQQATRNLD RRWRNICAMS
8010 8020 8030 8040 8050
MERRLRIEET WRLWQKFLDD YSRFEDWLKI SERTAAFPSS SGVLYTVAKE
8060 8070 8080 8090 8100
ELKKFEAFQR QVHESLTQLE LINKQYRRLA RENRTDSACS LKQMVHEGNQ
8110 8120 8130 8140 8150
RWDNLQKRVT SILRRLKHFI GQREEFETAR DSILVWLTEM DLQLTNIEHF
8160 8170 8180 8190 8200
SECDVQAKIK QLKAFQQEIS LNHNKIEQII SQGEQLIEKS EPLDAAVIEE
8210 8220 8230 8240 8250
ELDELRRYCQ EVFGRVERYH KKLIRLPLPD DEHDLSDREL ELDDSAALSD
8260 8270 8280 8290 8300
LHWRDTSADS VLSPQPSSNP SLSLAQPLRS ERSGRDTPAS VDSIPLEWDH
8310 8320 8330 8340 8350
DYDLSRDLES AVSRTLPSED EEVGDDKDFY LRGAVGLSGG PSALESQIRQ
8360 8370 8380 8390 8400
LDKALDESRF QMQQTENIIR SKTPTGPELD SSYRGYMKLL GECSGSIDSV
8410 8420 8430 8440 8450
RRLEHKLKEE EENFPGFVNL NSTETQTAGV IDRWELIQAQ ALSKELRMKQ
8460 8470 8480 8490 8500
NLQKWQQFNS DLNNIWTWLG ETEEELERLQ HLELSTDIQA IELQIKKLKE
8510 8520 8530 8540 8550
LQKAVDHRKA IILSINLCSP EFTQTGSEKS QDLQDRLSQM NGRWDRVCSL
8560 8570 8580 8590 8600
LDEWRGLLQD ALMQCQDFHE MSHGLLLMLE NIDRRKNEIV PIDSNQDAET
8610 8620 8630 8640 8650
LQDHHKQLMQ IRHELLESQL KVASLQDMSC QLLVNAEGTD CLEAKEKVHV
8660 8670 8680 8690 8700
IGNRLKLLLK EVSRHIKELE KLLDMSSSQQ DLSSWSSADE LDTSGSVSPT
8710 8720 8730 8740 8750
SGRSTPNRQR TPRGKCSLSQ PGPSVNSPHS RSIKGGCDSS LSEPRPARSG
8760 8770 8780 8790 8800
RAFLLRVLRA ALPLQLLLLL LIGLACLVPM SEEDYSCALS NNFARSFHPM
8810
LRYTNGPPPL
Length:8,810
Mass (Da):1,011,740
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB133B2D8D4B5B6F4
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_019287252.1, XM_019431707.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109256406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019287252.1, XM_019431707.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi109256406

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23345

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 12 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 42 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P4UJL8_PANPR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P4UJL8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: January 19, 2022
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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