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Entry version 6 (29 Sep 2021)
Sequence version 1 (07 Oct 2020)
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Protein

Nitrous-oxide reductase

Gene

nosZ

Organism
Bradyrhizobium sp. LCT2
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide.

UniRule annotationARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: nitrate reduction (denitrification)

This protein is involved in step 4 of the subpathway that synthesizes dinitrogen from nitrate.ARBA annotation This subpathway is part of the pathway nitrate reduction (denitrification), which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dinitrogen from nitrate, the pathway nitrate reduction (denitrification) and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi147Copper Z2UniRule annotation1
Metal bindingi148Copper Z3UniRule annotation1
Metal bindingi196Copper Z2UniRule annotation1
Metal bindingi273Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi276Calcium 2UniRule annotation1
Metal bindingi284Calcium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi290Calcium 2UniRule annotation1
Metal bindingi335Calcium 2UniRule annotation1
Metal bindingi337Copper Z1UniRule annotation1
Metal bindingi392Copper Z1UniRule annotation1
Metal bindingi443Copper Z3UniRule annotation1
Metal bindingi464Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi479Calcium 1UniRule annotation1
Metal bindingi504Copper Z4UniRule annotation1
Metal bindingi593Copper A1UniRule annotation1
Metal bindingi628Copper A1UniRule annotation1
Metal bindingi628Copper A2UniRule annotation1
Metal bindingi630Copper A2; via carbonyl oxygenUniRule annotation1
Metal bindingi632Copper A1UniRule annotation1
Metal bindingi632Copper A2UniRule annotation1
Metal bindingi636Copper A2UniRule annotation1
Metal bindingi639Copper A1UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationARBA annotation
LigandCalciumUniRule annotationARBA annotation, CopperUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00652;UER00709

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrous-oxide reductaseUniRule annotation (EC:1.7.2.4UniRule annotation)
Alternative name(s):
N(2)ORUniRule annotation
N2O reductaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nosZUniRule annotationImported
ORF Names:EI171_04135Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBradyrhizobium sp. LCT2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2493093 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaHyphomicrobialesBradyrhizobiaceaeBradyrhizobiumunclassified Bradyrhizobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000464041 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

PeriplasmUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.UniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A6P1R1H0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini549 – 650COX2_CUAInterPro annotationAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni552 – 650COX2-likeUniRule annotationAdd BLAST99

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NosZ family.UniRule annotationARBA annotation
In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalUniRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.420, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00716, NosZ, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002429, CcO_II-like_C
IPR008972, Cupredoxin
IPR028096, EfeO_Cupredoxin
IPR011045, N2O_reductase_N
IPR023644, NO_Rdtase
IPR041114, Nos_propeller
IPR041142, NOS_propeller_2
IPR006311, TAT_signal
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13473, Cupredoxin_1, 1 hit
PF18764, nos_propeller, 1 hit
PF18793, nos_propeller_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503, SSF49503, 1 hit
SSF50974, SSF50974, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04244, nitrous_NosZ_RR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50857, COX2_CUA, 1 hit
PS51318, TAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6P1R1H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSDNIKGV SRRTLLGTTA AAAGVGLAGG AVVTKDGAGF VSTADAQTKS
60 70 80 90 100
AAPKAPPARP AVQKTEVAPG ELDEYYVFFS SGQSGEMRII GLPSMRELMR
110 120 130 140 150
VPVFNRCSAT GWGQTNESLK VLTEGMQPAT REFLKNRGGT FMNGDLHHPH
160 170 180 190 200
VSFTDGTYDG RYAFMNDKAN SRVARVRLDV MKCDKIIELP NQHTVHGLRL
210 220 230 240 250
QKYPRTGYVF CNGEDGVPLP NDGKVLDNPK EYHSIFTALD GDTMKVAWQV
260 270 280 290 300
MVSGNLDNVD SDYQGKYCFS TCYNAEEGVT LAEMTANEQD WVVIFNLKRI
310 320 330 340 350
EEAVKKGDFK EMNGVPVIDG RKGSPYTRYV PVSNNPHGMN TAPDGIHIVA
360 370 380 390 400
AGKLSPTVTV MDVRLFDQLF DDKIKPRDVV VAEPELGLGP LHTAYDGKGN
410 420 430 440 450
AYTTLFLDSQ VVKWNIDLAK RAFKGEKVDP IIQKLDVHYQ PGHNHSSMGQ
460 470 480 490 500
TKEADGKWLI SLNKFSKDRF LNVGPLKPEN DQLIDISGDQ MKLVHDGPSF
510 520 530 540 550
AEPHDATIVH RSKINPISIW DRADPMFADA VKQAKADGIN LEADSKIIRD
560 570 580 590 600
GNKVRVYMTS TAPAFGLEQF QVKQGDQVTV YITNIDAVED LTHGFCIVNY
610 620 630 640 650
GIQMEVAPMA TASVSFSADK AGVYWYYCSW FCHAMHMEMK GRMFVEPKSV
Length:650
Mass (Da):71,674
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B6C547D90501C5B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP034432 Genomic DNA Translation: QHP66678.1

NCBI Reference Sequences

More...
RefSeqi
WP_011083147.1, NZ_CP034432.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
64020174

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP034432 Genomic DNA Translation: QHP66678.1
RefSeqiWP_011083147.1, NZ_CP034432.1

3D structure databases

SMRiA0A6P1R1H0
ModBaseiSearch...

Genome annotation databases

GeneIDi64020174

Enzyme and pathway databases

UniPathwayiUPA00652;UER00709

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.420, 1 hit
HAMAPiMF_00716, NosZ, 1 hit
InterProiView protein in InterPro
IPR002429, CcO_II-like_C
IPR008972, Cupredoxin
IPR028096, EfeO_Cupredoxin
IPR011045, N2O_reductase_N
IPR023644, NO_Rdtase
IPR041114, Nos_propeller
IPR041142, NOS_propeller_2
IPR006311, TAT_signal
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF13473, Cupredoxin_1, 1 hit
PF18764, nos_propeller, 1 hit
PF18793, nos_propeller_2, 1 hit
SUPFAMiSSF49503, SSF49503, 1 hit
SSF50974, SSF50974, 1 hit
TIGRFAMsiTIGR04244, nitrous_NosZ_RR, 1 hit
PROSITEiView protein in PROSITE
PS50857, COX2_CUA, 1 hit
PS51318, TAT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6P1R1H0_9BRAD
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6P1R1H0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: September 29, 2021
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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