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Entry version 2 (02 Dec 2020)
Sequence version 1 (07 Oct 2020)
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Protein

Receptor-type tyrosine-protein phosphatase

Gene

PTPRE

Organism
Sapajus apella (Brown-capped capuchin) (Cebus apella)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation, ReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPREImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSapajus apella (Brown-capped capuchin) (Cebus apella)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCebinaeSapajus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000504640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 42HelicalUniRule annotationAdd BLAST22
    Transmembranei91 – 113HelicalUniRule annotationAdd BLAST23

    Keywords - Cellular componenti

    Cell membraneARBA annotation, Membrane

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini179 – 438Tyrosine-protein phosphataseInterPro annotationAdd BLAST260
    Domaini358 – 429TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72
    Domaini470 – 733Tyrosine-protein phosphataseInterPro annotationAdd BLAST264
    Domaini649 – 724TYR_PHOSPHATASE_2InterPro annotationAdd BLAST76

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.UniRule annotationARBA annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotation

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.190.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029021, Prot-tyrosine_phosphatase-like
    IPR000242, PTPase_domain
    IPR016130, Tyr_Pase_AS
    IPR003595, Tyr_Pase_cat
    IPR016336, Tyr_Pase_rcpt_a/e-type
    IPR000387, TYR_PHOSPHATASE_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00102, Y_phosphatase, 2 hits

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF002006, PTPR_alpha_epsilon, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00700, PRTYPHPHTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00194, PTPc, 2 hits
    SM00404, PTPc_motif, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52799, SSF52799, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00383, TYR_PHOSPHATASE_1, 2 hits
    PS50056, TYR_PHOSPHATASE_2, 2 hits
    PS50055, TYR_PHOSPHATASE_PTP, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A6J3I7H8-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGYSTSAVPK EMARISSQLL LTRKLTFFFF FLFQTIAFTF PWSAMEPLCP
    60 70 80 90 100
    LLLAGFSLPL TRALQGNETA ADSNETTTTS GPPDPGGSQP LLAWLLLPLL
    110 120 130 140 150
    LLLLILLLAA YFFRFRKQRK AVVSASDKKM PNGILEEQEQ QRVMLLSRSP
    160 170 180 190 200
    SGPKKYFPIP VEHLEEEIRI RSADDCKQFR EEFNSLPSGH IQGTFELANK
    210 220 230 240 250
    EENREKNRYP NILPNDHSRV VLSQADGIPC SDYINASYID GYKEKNKFIA
    260 270 280 290 300
    AQGPKQETVN DFWRKIWEQK SATIVMLTNL KERKEEKCHQ YWPDQGCWTY
    310 320 330 340 350
    GNIRVCVEDC VVLVDYTIRK FCIQPQLPEG CKAPRLVSQL HFTSWPDFGV
    360 370 380 390 400
    PFTPIGMLKF LKKVKTLNPI HAGPIVVHCS AGVGRTGTFI VIDAMMAMMH
    410 420 430 440 450
    AEQKVDVFEF VSRIRNQRPQ MVQTDMQYTF IYQALLEYYL YGDTELDVSS
    460 470 480 490 500
    LEKHLHTLPG TSTHFDKIGL EEEFRKLTNV RIMKENMRTG NLPANMKKAR
    510 520 530 540 550
    VIQIIPYDFN RVILSMKRGQ EYTDYINASF IDGYRQKDYF IATQGPLAHT
    560 570 580 590 600
    VEDFWRMIWE WKSHTIVMLT EVQEREQDKC YQYWPTEGSV THGEMTVEIK
    610 620 630 640 650
    SDTLSEAISI RDFLVTFNQP QARQEEQVRV VRQFHFHGWP EIGIPAEGKG
    660 670 680 690 700
    MIDLIAAVQK QQQQTGNHPI TVHCSAGAGR TGTFIALSNI LERVKAEGLL
    710 720 730 740
    DVFQAVKSLR LQRPHMVQTL EQYEFCYKVV QDFIDIFSDY ANFK
    Length:744
    Mass (Da):85,597
    Last modified:October 7, 2020 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48EAEED4B4BAE45E
    GO

    Sequence databases

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_032137894.1, XM_032282003.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    RefSeqiXP_032137894.1, XM_032282003.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Family and domain databases

    Gene3Di3.90.190.10, 2 hits
    InterProiView protein in InterPro
    IPR029021, Prot-tyrosine_phosphatase-like
    IPR000242, PTPase_domain
    IPR016130, Tyr_Pase_AS
    IPR003595, Tyr_Pase_cat
    IPR016336, Tyr_Pase_rcpt_a/e-type
    IPR000387, TYR_PHOSPHATASE_dom
    PfamiView protein in Pfam
    PF00102, Y_phosphatase, 2 hits
    PIRSFiPIRSF002006, PTPR_alpha_epsilon, 1 hit
    PRINTSiPR00700, PRTYPHPHTASE
    SMARTiView protein in SMART
    SM00194, PTPc, 2 hits
    SM00404, PTPc_motif, 2 hits
    SUPFAMiSSF52799, SSF52799, 2 hits
    PROSITEiView protein in PROSITE
    PS00383, TYR_PHOSPHATASE_1, 2 hits
    PS50056, TYR_PHOSPHATASE_2, 2 hits
    PS50055, TYR_PHOSPHATASE_PTP, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6J3I7H8_SAPAP
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6J3I7H8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
    Last sequence update: October 7, 2020
    Last modified: December 2, 2020
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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