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Entry version 3 (10 Feb 2021)
Sequence version 1 (07 Oct 2020)
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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Sapajus apella (Brown-capped capuchin) (Cebus apella)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensin-converting enzymeUniRule annotation (EC:3.4.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACEImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSapajus apella (Brown-capped capuchin) (Cebus apella)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9515 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCebinaeSapajus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000504640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1262 – 1283HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502691610732 – 1308Angiotensin-converting enzymeSequence analysisAdd BLAST1277

Keywords - PTMi

GlycoproteinUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M2 family.UniRule annotationARBA annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06461, M2_ACE, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001548, Peptidase_M2

The PANTHER Classification System

More...
PANTHERi
PTHR10514, PTHR10514, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01401, Peptidase_M2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00791, PEPDIPTASEA

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A6J3GW96-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAASGHLGP GPPLPLLLLL LLLLPPPPAL ALDPGLQPGH FPADEAGAQH
60 70 80 90 100
FAQSYNSSAE QVLFQRIAAS WAHDTNITAE NARRQEEAAL LSQEFAEAWG
110 120 130 140 150
QKAKELYEPI WQNFTDPELR KIIGAVRTLG PANLPLAKRQ QYNILLSNMS
160 170 180 190 200
RTYSTAKVCF PNKTATCWSL DPELTNILAS SRSYAMLLFA WEGWHNAAGI
210 220 230 240 250
PLKPLYEDFT ALSNEAYKQD GFSDTGAYWR SWYNSPTFED DLEHLYHQLE
260 270 280 290 300
PLYLNLHAFV RRALYRRYGD RYINLRGPIP AHLLGDMWAQ SWDNIYDMVV
310 320 330 340 350
PFPDKPNLDV TSSMLQQGWN ATHMFRVAEE FFVSLGLSPM PPEFWAESML
360 370 380 390 400
EKPADGREVV CHASAWDFYN RKDFRIKQCT RVTMDQLSTV HHEMGHVQYY
410 420 430 440 450
LQYKDQPVSL REGANPGFHE AIGDVLALSV STPAHLYKIG LLDHVTNDTE
460 470 480 490 500
SDINYLLKMA LEKIAFLPFG YLVDQWRWGV FSGRTPPSRY NYDWWYLRTK
510 520 530 540 550
YQGICPPVTR NETHFDAGAK FHVPNVTPYI RYFVSFVLQF QFHQALCQEA
560 570 580 590 600
GYQGALHQCD IYQSTKAGAK LRKVLQAGSS RPWQEVLKEM VGSDALDAQP
610 620 630 640 650
LLDYFQPVTQ WLQEQNQKNG EVLGWPEYQW RPPLPDNYPE GIDLVTDEAE
660 670 680 690 700
ARKFVEEYDR TSQVVWNEYA EANWNYNTNI TKETSSILLQ KNMQIANYTL
710 720 730 740 750
QYGTQARRFD VSHFQNTTIK RILKKVQDLE RAALPAQELE EYNKILLDME
760 770 780 790 800
TTYSVATVCH TNGSCLQLEP DLTNVMATSR KYEELLWAWK GWRDKTGRTI
810 820 830 840 850
LQFYPKYVEF INKAARLNGY VDAGDSWRSM YETPSLEQDL ERLFQELQPL
860 870 880 890 900
YLNLHAYVRR ALHRHYGAQH INLEGPIPAH LLGNMWAQTW SNIYDLVAPF
910 920 930 940 950
PSATLMDTTE AMLKQGWTPR RMFKEADDFF TSLGLLPVPP EFWNKSMLEK
960 970 980 990 1000
PTDGREVVCH ASAWDFYNGK DFRIKQCTTV NLEDLVVAHH EMGHIQYFMQ
1010 1020 1030 1040 1050
YKDLPVALRD GANPGFHEAI GDVLALSVST PKHLHSLNLL SSEGDSFEHN
1060 1070 1080 1090 1100
INFLMKMALE KIAFIPFSYL VDQWRWRVFD GSITKENYNQ EWWSLRLKYQ
1110 1120 1130 1140 1150
GLCPPVPRTQ DDFDPGAKFH IPSSVPYIRY FVSFIIQFQF HEALCQVAGH
1160 1170 1180 1190 1200
TGPLHKCDIY QSKEAGQRLA AAMKLGFSQP WPEAMQLITG QPNMSASAML
1210 1220 1230 1240 1250
RYFKPLLDWL RAENELHGEK LGWPQYNWTP NSARSEGPLP ASGRVSFLGL
1260 1270 1280 1290 1300
DLEPQQARVG QWLLLFLGVA LLVATLGLSQ RLFSIRHHSL RQPHQGPQFG

SEVELRHS
Length:1,308
Mass (Da):150,192
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE31A64C87A1ADFE1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6J3GVX6A0A6J3GVX6_SAPAP
Angiotensin-converting enzyme
ACE
732Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_032121964.1, XM_032266073.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_032121964.1, XM_032266073.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd06461, M2_ACE, 2 hits
InterProiView protein in InterPro
IPR001548, Peptidase_M2
PANTHERiPTHR10514, PTHR10514, 2 hits
PfamiView protein in Pfam
PF01401, Peptidase_M2, 2 hits
PRINTSiPR00791, PEPDIPTASEA

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6J3GW96_SAPAP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6J3GW96
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: February 10, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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