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Entry version 3 (10 Feb 2021)
Sequence version 1 (07 Oct 2020)
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Protein
Submitted name:

trinucleotide repeat-containing gene 6A protein isoform X1

Gene

TNRC6A

Organism
Zalophus californianus (California sealion)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
trinucleotide repeat-containing gene 6A protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNRC6AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZalophus californianus (California sealion)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9704 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOtariidaeZalophus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515165 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1076 – 1202Ago_hookInterPro annotationAdd BLAST127
Domaini1506 – 1779TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 154DisorderedSequence analysisAdd BLAST154
Regioni169 – 293DisorderedSequence analysisAdd BLAST125
Regioni560 – 700DisorderedSequence analysisAdd BLAST141
Regioni715 – 1142DisorderedSequence analysisAdd BLAST428
Regioni1159 – 1198DisorderedSequence analysisAdd BLAST40
Regioni1250 – 1274DisorderedSequence analysisAdd BLAST25
Regioni1324 – 1371DisorderedSequence analysisAdd BLAST48
Regioni1425 – 1460DisorderedSequence analysisAdd BLAST36
Regioni1578 – 1636DisorderedSequence analysisAdd BLAST59
Regioni1725 – 1747DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 54PolyampholyteSequence analysisAdd BLAST54
Compositional biasi58 – 94PolarSequence analysisAdd BLAST37
Compositional biasi95 – 134Pro-richSequence analysisAdd BLAST40
Compositional biasi169 – 232PolarSequence analysisAdd BLAST64
Compositional biasi257 – 293PolarSequence analysisAdd BLAST37
Compositional biasi560 – 677PolarSequence analysisAdd BLAST118
Compositional biasi678 – 700PolyampholyteSequence analysisAdd BLAST23
Compositional biasi715 – 738PolarSequence analysisAdd BLAST24
Compositional biasi750 – 783PolarSequence analysisAdd BLAST34
Compositional biasi802 – 860PolarSequence analysisAdd BLAST59
Compositional biasi868 – 951PolarSequence analysisAdd BLAST84
Compositional biasi983 – 1005PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1012 – 1055PolarSequence analysisAdd BLAST44
Compositional biasi1094 – 1120PolarSequence analysisAdd BLAST27
Compositional biasi1159 – 1173PolarSequence analysisAdd BLAST15
Compositional biasi1324 – 1366PolarSequence analysisAdd BLAST43
Compositional biasi1727 – 1741Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6J2EFG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE
60 70 80 90 100
QKIKVPEQIK PSVSQPQPAN SNNGTSTATS TNNNAKRATA NNPQQPQPQP
110 120 130 140 150
QPPQQPQPQQ PQPQPPQPQP PQQPPQPAQA LPRYPREVPP RFRHQEHKQL
160 170 180 190 200
LKRGQHFPVI AANLGSAVKV LSSQSESSAL TNQQPQNNGE VQNSKNQSDI
210 220 230 240 250
NHNTSGSHYE NSQRGPVSSP SDSSTNCKNA VVNDSPEKEA WPSVPGSDPE
260 270 280 290 300
LASECMDADS ASSSESERNI AIMASGSTSG EKDGLRNSTG LGSQNKFVVG
310 320 330 340 350
SSSNNVGHGS STGPWGFSHG AIISTCQVSV DAPESKSESS NNRMNAWGTV
360 370 380 390 400
SSSSNGGLNP STLNSASNHG AWPVLDNNGL ALKGPVGSGS SGINIQCSTL
410 420 430 440 450
GQMPNNQSIN SKVGGSSTHG TWGSLQETCE SEVSGTQKVS FSGQPQNITT
460 470 480 490 500
EMTGPNNTTN FMTSSLPNSG SVQNNELPSN TGAWRVSTMN HPQIQAPSVM
510 520 530 540 550
NGTSLSHLSN GEPKSGGSYG TTWGAYGSNY SGDKCSSPNG QANGDTVNAT
560 570 580 590 600
LMQPGINGPM GTNFQVNTNK GGGVWESGAA NSQSASWGSG NGANSGGSRR
610 620 630 640 650
GWGTPAQNTG TNIPSVEWNK LPSNQHSNDS ANGNGKKFTN GWKSTEEEDQ
660 670 680 690 700
GSAASQTNEQ NSVWAKTGGT VESEGSTEST GRLEEKATGE NQSRDRRKID
710 720 730 740 750
QHTLLQSIVN RTDLDPRVLS NSGWGQTPIK QNTAWDTETS PRGERKTDNG
760 770 780 790 800
TEAWGSSATQ TFNSGACIDK TSPTSNDTSS VSGWGDPKPA LRWGDSKGSS
810 820 830 840 850
CQGGWEDDSA ATGMVKSNQW GNSKEEKSAW NDSQKSKQGW GDGQKSNQGW
860 870 880 890 900
SVSAGDNWGE TARSNHWGEA NKKSSSGGSD SDRSVSGWNE LGKTSSFTWG
910 920 930 940 950
NNINPNNSSG WDESSKPNPS QGWGDPPKSN QSLGWGDSSK PVSSPDWNKQ
960 970 980 990 1000
QDIVGSWGIP PATGKPPGTG WLGGPIPAPA KEEEPTGWEE PSPESIRRKM
1010 1020 1030 1040 1050
EIDDGTSAWG DPSKYNYKNV NMWNKNVPNG SSRSDQQAQV HQLLPSASAI
1060 1070 1080 1090 1100
SNKEAGSGSG WGEPWGEPST PATTVDNGTS AWGKPIDSGP SWGEPIATAS
1110 1120 1130 1140 1150
NTSTWGSSSV GPQALSKSGP KSMQDGWCGD DMPLPGSRPT GWEEEEDVEI
1160 1170 1180 1190 1200
GMWNSNSSQE LNSSLNWPPY TKKMSSKGLS GKKRRRERGT MKGGNKQEEA
1210 1220 1230 1240 1250
WINPFVKQFS NISFSRDSPE ENVQSNKMDL SGGMLQDKRM EIDKHSLNIG
1260 1270 1280 1290 1300
DYNRTVGKGP GSRPQISKES SMERSPYFDK DGIVADESQN MQFMSSQSMK
1310 1320 1330 1340 1350
LPPSNSALPN QALGSIAGLG MQNLNSVRQN GNPSMFGVGN TAAQPRGMQQ
1360 1370 1380 1390 1400
PPAQPLSSSQ PNLRAQVPPP LLSPQVPVSL LKYAPNNGGL NPLFGPQQVA
1410 1420 1430 1440 1450
MLNQLSQLNQ LSQISQLQRL LAQQQRAQSQ RSVPSGNRQQ QDQQGRPLSV
1460 1470 1480 1490 1500
QQQMMQQSRQ LDPSLLVKQQ TPPSQQQPLH QPAMKSFLEN VMPHTTPELQ
1510 1520 1530 1540 1550
KGPSPINAFS NFPIGLNSNL NVNMDMNSIK EPQSRLRKWT TVDSISVNTS
1560 1570 1580 1590 1600
LDQNSSKHGA ISSGFRLEES PFVPYDFMNS STSPASPPGS IGDGWPRAKS
1610 1620 1630 1640 1650
PNGSSSVNWP PEFRPGEPWK GYPNIDPETD PYVTPGSVIN NLSINTVREV
1660 1670 1680 1690 1700
DHLRDRNSGS SSSLNTTLPS TSAWSSIRAS NYNVPLSSTA QSTSARNSDS
1710 1720 1730 1740 1750
KLTWSPGSVT NTSLAHELWK VPLPPKNITA PSRPPPGLTG QKPPLSTWDN
1760 1770 1780 1790 1800
SPLRVGGGWG NSDARYTPGS SWGESSSGRI TNWLVLKNLT PQIDGSTLRT
1810 1820 1830 1840 1850
LCMQHGPLIT FHLNLPHGNA LVRYSSKEEV VKAQKSLHMC VLGNTTILAE
1860 1870 1880 1890 1900
FASEEEISRF FAQSQSLTPS PGWQSLGSSQ SRLGSLDCSH SFSSRTDLNH
1910 1920 1930 1940 1950
WNGAGLSGTH CGDLHGTSLW GTPHYSTSLW GPPSSSDPRG ISSPSPINAF
1960
LSVDHLGGGG ESM
Length:1,963
Mass (Da):210,079
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B92DDC8235DF1FD
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_027465622.1, XM_027609821.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_027465622.1, XM_027609821.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6J2EFG9_ZALCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6J2EFG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: February 10, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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