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UniProtKB - A0A6J2DSY3 (A0A6J2DSY3_ZALCA)

Entry version 3 (10 Feb 2021)
Sequence version 1 (07 Oct 2020)
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Protein
Submitted name:

afadin isoform X15

Gene

AFDN

Organism
Zalophus californianus (California sealion)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
afadin isoform X15Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiZalophus californianus (California sealion)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9704 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Otariidae › Zalophus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000515165 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 133Ras-associatingInterPro annotationAdd BLAST95
Domaini246 – 348Ras-associatingInterPro annotationAdd BLAST103
Domaini668 – 908DiluteInterPro annotationAdd BLAST241
Domaini1007 – 1093PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 196DisorderedSequence analysisAdd BLAST69
Regioni1107 – 1223DisorderedSequence analysisAdd BLAST117
Regioni1235 – 1527DisorderedSequence analysisAdd BLAST293
Regioni1569 – 1588DisorderedSequence analysisAdd BLAST20
Regioni1601 – 1821DisorderedSequence analysisAdd BLAST221

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 196PolyampholyteSequence analysisAdd BLAST54
Compositional biasi1154 – 1169PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1171 – 1209PolarSequence analysisAdd BLAST39
Compositional biasi1274 – 1304PolyampholyteSequence analysisAdd BLAST31
Compositional biasi1305 – 1340PolarSequence analysisAdd BLAST36
Compositional biasi1360 – 1376Pro-richSequence analysisAdd BLAST17
Compositional biasi1405 – 1441PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1468 – 1508PolarSequence analysisAdd BLAST41
Compositional biasi1513 – 1527PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1601 – 1678PolyampholyteSequence analysisAdd BLAST78
Compositional biasi1680 – 1709Pro-richSequence analysisAdd BLAST30
Compositional biasi1710 – 1724PolarSequence analysisAdd BLAST15
Compositional biasi1759 – 1773PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1790 – 1805PolarSequence analysisAdd BLAST16
Compositional biasi1806 – 1821PolyampholyteSequence analysisAdd BLAST16

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6J2DSY3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK 
        60         70         80         90        100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG 
       110        120        130        140        150
ERRLDIDEKP LVVQLNWNKD DREGRFVLKN ENDAVPPKKA QSNGPEKQEK 
       160        170        180        190        200
EGVIQNFKRT LSKKEKKEKK KREKEAVRQA SDKDDRPFQG DDIENSRLAA 
       210        220        230        240        250
EVYKDMPETS FTRTISNPEV VMKRRRQQKL ERRMQEFRSS DGRPDSGGTL 
       260        270        280        290        300
RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV 
       310        320        330        340        350
MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGVLV FQLKRRPPDY 
       360        370        380        390        400
IPKKTKKHVD GKLLKGKERA EGSGYGSALP PEKLPYLVEL SPGRRDRFAC 
       410        420        430        440        450
YNHHPYEDGS DSRDKPKLYR LQLSVTEVGT EKFDENSIQL FGSGIQPHHC 
       460        470        480        490        500
DLTNMDGVVT VTPRSMEAET YVEGQRISET TMLQSGMKVQ FGTSHVFKFV 
       510        520        530        540        550
DPSQDHALAK RSVDAGLTTK GPRHKPGIVQ ETTFDLGGDV HSGTALPTSK 
       560        570        580        590        600
STTRLDSDRV LSASSTVERG MVKPMIRGER QQDYRRQENR TQDAPGPELI 
       610        620        630        640        650
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSSQH 
       660        670        680        690        700
RPDVSPTERT HKVIAIVNRM VSMMEGVIQK QKNIAGALAF WMANASELLN 
       710        720        730        740        750
FIKQDRDLSR ITLDAQDVLA HLVQMAFKYL VHCLQSELNN YMPAFLDDPE 
       760        770        780        790        800
ENSLQRPKID DVLHTLTGAM SLLRRCRVNA ALTIQLFSQL FHFINMWLFN 
       810        820        830        840        850
RLVTDPESGL CSHYWGAIIR QQLGHVEAWA EKQGLELAAD CHLSRIVQAT 
       860        870        880        890        900
TLLTMDKYAP DDIPNINSTC FKLNSLQLQA LLQNYHCAPD EPFIPTDLIE 
       910        920        930        940        950
NVVAVAENTA DELARSDGRE VQLEEDPDLQ LPFLLPEDGY SCDVVRNIPN 
       960        970        980        990       1000
GLQEFLDPLC QRGFCRLIPH ARSPGTWTIF FEGADYESHL LRENTELAQP 
      1010       1020       1030       1040       1050
LRKEPEIITV TLKKQNGMGL SIVAAKGAGQ DKLGIYVKSV VKGGAADGDG 
      1060       1070       1080       1090       1100
RLAAGDQLLS VDGRSLVGLS QERAAELMTR TSSVVTLEVA KQGAIYHGLA 
      1110       1120       1130       1140       1150
TLLNQPSPMM QRISDRRGSG KPRPKSEGFE LYNNSAPNGS PESPQLPWAE 
      1160       1170       1180       1190       1200
YSEPKKLPGD DRLMKNRADH RSSPNVANQP PSPGGKSTYA PGTTAKITSV 
      1210       1220       1230       1240       1250
STGNLCTEEQ TPPPRPEAYP IPTQTYTREY FTFPASKSQD RMAPPQNQWP 
      1260       1270       1280       1290       1300
NYEEKPHMHA DSNHSSIAIQ RVTRSQEELR EDKAYQLERH RIEAVLDRKS 
      1310       1320       1330       1340       1350
DSDMWIHQSS SVGSSTSSQE HLDHSSKSGT PASTLTKSGP GRWKTPAAVQ 
      1360       1370       1380       1390       1400
PVPVAVSQPV QTDLPPPPPP PPTHYAGDFD GIPMDVPLPP PPAGQTGPVS 
      1410       1420       1430       1440       1450
AQAAAAERRK REEHQRWYEK EKARLEEERD RKRREQERKL GQMRSQSLNP 
      1460       1470       1480       1490       1500
APFSPVTVPH VKPEKPSTLQ RPQETVIREL QPQQQPRTIE RRDLQYITVS 
      1510       1520       1530       1540       1550
QEELSSGDSL SPDPWKRDAR EKLEKQQQMH IVDMLSREIQ ELQSKPERSA 
      1560       1570       1580       1590       1600
EESDRLRKLM LEWQFQKRLQ ESKQKDEEEE EEDDDVDAVL IVQRLEAERR 
      1610       1620       1630       1640       1650
ARLQDEERRR QQQLEEMRRR EAEDRARQEE ERRRQDEERA KRDAEEKRRQ 
      1660       1670       1680       1690       1700
EEGYYSRLEA ERRRQHAEAE RRLLEPEEPG LCRPPLPRGY ELPSPSPPAA 
      1710       1720       1730       1740       1750
APPPPPQRTA SSLQAQTLSP DSVYTARLVS YHEEEEEDRS LAGPNSYMGS 
      1760       1770       1780       1790       1800
SGTAVGAHDA YRDPRERLSK SHDADVPGSS GAPENLTFKE RQRLFSQGQD 
      1810       1820 
VSNKVKASRK LTELENELNT K
Length:1,821
Mass (Da):206,275
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i848EF41DF86CFDD8
GO

Sequence databases

NCBI Reference Sequences

More...RefSeqi		XP_027458876.1, XM_027603075.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_027458876.1, XM_027603075.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6J2DSY3_ZALCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6J2DSY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: February 10, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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