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Entry version 4 (07 Apr 2021)
Sequence version 1 (07 Oct 2020)
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Protein
Submitted name:

A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1

Gene

ADAMTS13

Organism
Geospiza fortis (Medium ground-finch)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, IntegrinImported, MetalloproteaseARBA annotation, Protease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAMTS13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGeospiza fortis (Medium ground-finch)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri48883 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesThraupidaeGeospiza
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000504602 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Extracellular matrixARBA annotation, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502666235819 – 1387Sequence analysisAdd BLAST1369

Keywords - PTMi

Cleavage on pair of basic residuesARBA annotation, Disulfide bondARBA annotation, GlycoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini203 – 397Peptidase M12BInterPro annotationAdd BLAST195

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 3 hits
2.60.120.290, 1 hit
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR035914, Sperma_CUB_dom_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 1 hit
SSF82895, SSF82895, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6I9Z8M1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVSLALRAL AVLPLGLCWL PEKFLGALDA GDVLSYFGTS SVADVPEFVV
60 70 80 90 100
AEPACPCQEE HFGLAPCRVQ RCSIQAWGQL YAFEFLEDHA LLSSSFVSSQ
110 120 130 140 150
VVNSSFVLLR RFPGSCFAGG KALQPPGASS RVTFCEGQLQ GVVTVGEEKI
160 170 180 190 200
HIRPVRSKDV ALLKDLGFSS PHILFKSAAR EAKPARAGWA PPRLHKRAEA
210 220 230 240 250
AVKHLELMVV AGPDVYLYHK EDTERYILAN LNIGAELLRD ASLGAHFRVH
260 270 280 290 300
LMQMLVLREP QAEVNITTNI TSSLISVCEW SKKVNPQNDS DPQHADIVLY
310 320 330 340 350
ITRFDLELPD GNKELRGVTQ LGGVCSSFWS CVITQDTGFD LGVTIAHEIG
360 370 380 390 400
HSLGIAHDGE GNLCSSSGYI MGSAPCSREQ FLALVSTGQT SCLNDLPDMD
410 420 430 440 450
GSIPGWKPGL YYGADEQCKI AFGSVATACT FADTNVDICK VLSCHVHPAD
460 470 480 490 500
KSSCTRLLVP LLDGTECGIN KWCSKGQCSS LEELNPMAVV HGHWSAWSPL
510 520 530 540 550
SPCSRSCGGG VVLRQRFCNN PRPAFGGQDC HGASVQAEMC NTQACLITQQ
560 570 580 590 600
DFMAEQCAAT NLKPLYLDVE TPSFYTWTSA VGFAKGDLLC KHMCRAVGKE
610 620 630 640 650
FMVSRRDNFL DGTRCEQDDT EHHGDLHVCV MGRCRAFGCD GQMGSRKAMD
660 670 680 690 700
PCKVCGGDNS TCTKVSGSYT EGKAEEYVTF LSLPYNTTSV HVTNRRPLFT
710 720 730 740 750
HLAVKVKGEY VVAGKGKISL NVTYPSVLED KQIKYQVFLT QDNLPSLEEI
760 770 780 790 800
HVDGPTQEEI EIQVYRRYTK KYGNATNPDI TFSYFVPRES LSYLWVPQQG
810 820 830 840 850
PCSVTCGEGV QPVAHVCFDQ TKNEVTEDQR CLELPQPLPE HKPCAMEPCL
860 870 880 890 900
YRWKMAQRDE CSAVCGTGVA QQNLTCVQFH DGLETVVDDS LCPAEEKPLS
910 920 930 940 950
LVPCVVNVCP LGWDKEEDAH LLQPLEPLGH VQLENQTVYV WSPVAGECSV
960 970 980 990 1000
SCGRGKTQLH YVCVAFDTKE EAQEENCQPV PKPESRVEVC ELNPCPPRWK
1010 1020 1030 1040 1050
VTPAGPCSSS CGLGLAVQLV TCVQTLHGQE VLQEEHLCPV AEKPLTSVPC
1060 1070 1080 1090 1100
VIRTCSYEWS FSEWSECSTS CGNGIQTRQD FCLSSLTHKP VNPLFCRHFP
1110 1120 1130 1140 1150
KAIVVRGCSA GPCPEQGGTQ SPGAQLQPVT PATHLPTAAA APEHRHKDLG
1160 1170 1180 1190 1200
VPLSAGPREQ TKPSGGVCGN LFLNATGIIN MTGVESRDCT VAIGRPLREE
1210 1220 1230 1240 1250
ISVTILESSL NCTAGEILLF SGRMMWRTGC RKLPLSLINS RTNTLIVKQR
1260 1270 1280 1290 1300
VVLPGNGVIL QYNSRTATKK YYQDCDQQLF GPQGEIVNPV QFPAERQGVV
1310 1320 1330 1340 1350
CRTFITVAPR QRISIRALNA DLGPEGNHTH FNYILVRDVS TMKTVVFRGK
1360 1370 1380
QQFLWQSTGS QAEIEFHENV KDHRTHFWAE YHAIEPK
Length:1,387
Mass (Da):152,122
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D748D16114C5700
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_014162643.1, XM_014307168.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102043124

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gfr:102043124

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_014162643.1, XM_014307168.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi102043124
KEGGigfr:102043124

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11093

Family and domain databases

Gene3Di2.20.100.10, 3 hits
2.60.120.290, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR041645, ADAM_CR_2
IPR010294, ADAM_spacer1
IPR013273, ADAMTS/ADAMTS-like
IPR024079, MetalloPept_cat_dom_sf
IPR001590, Peptidase_M12B
IPR035914, Sperma_CUB_dom_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF17771, ADAM_CR_2, 1 hit
PF05986, ADAM_spacer1, 1 hit
PF01421, Reprolysin, 1 hit
PF00090, TSP_1, 2 hits
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00209, TSP1, 5 hits
SUPFAMiSSF49854, SSF49854, 1 hit
SSF82895, SSF82895, 5 hits
PROSITEiView protein in PROSITE
PS50215, ADAM_MEPRO, 1 hit
PS50092, TSP1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6I9Z8M1_GEOFO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6I9Z8M1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: April 7, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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