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Entry version 3 (10 Feb 2021)
Sequence version 1 (07 Oct 2020)
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Protein
Submitted name:

trinucleotide repeat-containing gene 6A protein isoform X1

Gene

Tnrc6a

Organism
Peromyscus maniculatus bairdii (Prairie deer mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRNA-mediated gene silencingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
trinucleotide repeat-containing gene 6A protein isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnrc6aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPeromyscus maniculatus bairdii (Prairie deer mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri230844 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeNeotominaePeromyscus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000504601 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1084 – 1212Ago_hookInterPro annotationAdd BLAST129
Domaini1291 – 1490M_domainInterPro annotationAdd BLAST200
Domaini1515 – 1788TNRC6-PABC_bdgInterPro annotationAdd BLAST274

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 165DisorderedSequence analysisAdd BLAST165
Regioni184 – 278DisorderedSequence analysisAdd BLAST95
Regioni446 – 468DisorderedSequence analysisAdd BLAST23
Regioni574 – 711DisorderedSequence analysisAdd BLAST138
Regioni731 – 1152DisorderedSequence analysisAdd BLAST422
Regioni1169 – 1208DisorderedSequence analysisAdd BLAST40
Regioni1262 – 1283DisorderedSequence analysisAdd BLAST22
Regioni1334 – 1380DisorderedSequence analysisAdd BLAST47
Regioni1435 – 1470DisorderedSequence analysisAdd BLAST36
Regioni1587 – 1645DisorderedSequence analysisAdd BLAST59
Regioni1734 – 1756DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 79PolyampholyteSequence analysisAdd BLAST57
Compositional biasi83 – 142PolarSequence analysisAdd BLAST60
Compositional biasi184 – 241PolarSequence analysisAdd BLAST58
Compositional biasi574 – 685PolarSequence analysisAdd BLAST112
Compositional biasi688 – 711PolyampholyteSequence analysisAdd BLAST24
Compositional biasi731 – 748PolarSequence analysisAdd BLAST18
Compositional biasi760 – 795PolarSequence analysisAdd BLAST36
Compositional biasi812 – 961PolarSequence analysisAdd BLAST150
Compositional biasi993 – 1015PolyampholyteSequence analysisAdd BLAST23
Compositional biasi1022 – 1043PolarSequence analysisAdd BLAST22
Compositional biasi1051 – 1065PolarSequence analysisAdd BLAST15
Compositional biasi1104 – 1131PolarSequence analysisAdd BLAST28
Compositional biasi1169 – 1183PolarSequence analysisAdd BLAST15
Compositional biasi1334 – 1376PolarSequence analysisAdd BLAST43
Compositional biasi1736 – 1750Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.ARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711, RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28, PTHR13020:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928, SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A6I9LAS3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLVAEPGLE ARCPGSQDTP LPEEWNRELE AKATKDVERN LSRDLVQEEE
60 70 80 90 100
QLMEEKKKKK DDKKKKEAAQ KKATEQKIKV PEQIKPSVSQ PQPANSDNGT
110 120 130 140 150
STATSTNNNA KRATASNQQP PPQQQQQQQQ EQQQQQQQPQ ALPRYPREVP
160 170 180 190 200
PRFRHQEHKQ LLKRGQHFPV IAANLGSAVK VLNSQSESSA VTNQQPQNNG
210 220 230 240 250
EVQNSKNQSD INHNTSGSHY ENCQRGPVSS TSDCSTSSKN AVKDLLEKEA
260 270 280 290 300
WPSAPGSDPE LASECMDADS ASSSESERNI TVMASGNTGG EKDGLRNSTG
310 320 330 340 350
LGSQSKFVVG SSSNNVGHGS STGPWGFPHG AIISTCQVSV DAPESKSESS
360 370 380 390 400
NNRMNAWGTV SSSSNGGLNP STLNSASNHG AWPVLENNGL ALKGPVGSGS
410 420 430 440 450
SGINIQCSTI GQMPNNQSIN SKVSGSSTHG TWGSLQETCE PEVSGTQKVS
460 470 480 490 500
FSGQPQNITT ETTGPNNTTN FMTSSLPNSG SVQNNELPTS NPGAWRVSTM
510 520 530 540 550
NHPQIQAPSV MNGTSLSHLS NGESKTGGSY GTTWGAYGSN YSGDKCAGPN
560 570 580 590 600
GQANGDTVNA TLMQPGMNGP IGTNFQVHTN KGGGVWEPGT TNSQSSPWGS
610 620 630 640 650
GNGANSGGSR RGWGSPAQNT GTSLPSVEWN KLPSNQHSND SANGNGKKFT
660 670 680 690 700
NGWKSTEEED QGSATSQTSE QSSVWAKTGA VESDGSAEST GRLEEKVTGE
710 720 730 740 750
GQSRDRRKID QHTLLQSIVN RTDLDPRVLS NSGWGQTPIK QNTAWDTETS
760 770 780 790 800
PRGERKTDNG TEAWGSSATQ TFNSGACVDK TSPNSNDTSS VSGWGDPKPT
810 820 830 840 850
LRWGDSKGSN CQGGWEDDSA ATGMIKSNQW GNCKEEKSAW NDSQKNKQGW
860 870 880 890 900
GDGQKSSQGW SISASDNWGE TSRSNHWGEA NKKSSSGGSD SDRSVSGWNE
910 920 930 940 950
LGKTSSFTWG NNINPNNSSG WDESSKPSSS QGWGDPPKCN QSLGWGDSSK
960 970 980 990 1000
PVSSPDWNKQ QDIVGSWGIP PATGKPPGTG WLGGPIPAPT KEEEPTGWEE
1010 1020 1030 1040 1050
PSPESIRRKM EIDDGTSAWG DPSKYNYKNV NMWNKNIPDG SGRPDQQAQM
1060 1070 1080 1090 1100
HRLLPSANAV SSKEASGGSG WGEPWGEPST PATTVDNGTS AWGKPIDSGP
1110 1120 1130 1140 1150
SWGEPITAAS SASTWGSSSV GPQSLNKSGP KSMQDGWCGD DMPLPGSRPT
1160 1170 1180 1190 1200
GWEEEEDVEI GMWNSNSSQE LNSSLNWPPY TKKMSSKGLS GKKRRRERGM
1210 1220 1230 1240 1250
MKGGNKQEDA WINPFVKQFS NISFSRDSPE ENVQSNKMDL SGGMLQDKRM
1260 1270 1280 1290 1300
EIDKHSLNIG DYNRTVGKGP GSRPQISKES SMERNPYFDK DGIVADESQN
1310 1320 1330 1340 1350
MQFMSSQSMK LPPSNSALPN QALGSIAGLG TQNLNSVRQN GNPSMFGVGN
1360 1370 1380 1390 1400
TAAQPRGLQQ PPAQPLSSSQ PNLRAQVPPP LLSPQVPVSL LKYAPNNGGL
1410 1420 1430 1440 1450
NPLFGPQQVA MLNQLSQLNQ LSQISQLQRL LAQQQRVQNP RSVPSANRQQ
1460 1470 1480 1490 1500
QDQQGRPLSV QQQMMQQSRQ LDPSLLVKQQ TPPSQQPLHQ PAMKSFLDNV
1510 1520 1530 1540 1550
MPHTTPELQK GPSPVNAFSN FPIGLNSNLN VNMDMNSIKE PQSRLRKWTT
1560 1570 1580 1590 1600
VDSISVNTSL DQNSSKHGAI SSGFRLEESP FVPYDFMNSS TSPASPPGSI
1610 1620 1630 1640 1650
GDGWPRAKSP NGSSSVNWPP EFRPGEPWKG YPNIDPETDP YVTPGSVINS
1660 1670 1680 1690 1700
LSINTVREVD HLRDRNSGSS SSLNTTLPST SAWSSIRASN YNVPLSSTAQ
1710 1720 1730 1740 1750
STSARNSDSK LTWSPGSVTN TSLAHELWKV PLPPKNITAP SRPPPGLTGQ
1760 1770 1780 1790 1800
KPPLSTWDNS PLRVGGGWGN SDARYTPGSS WGESSSGRIT NWLVLKNLTP
1810 1820 1830 1840 1850
QIDGSTLRTL CMQHGPLITF HLNLPHGNAL VRYSSKEEVV KAQKSLHMCV
1860 1870 1880 1890 1900
LGNTTILAEF ASEEEISRFF AQSQSLTPSP GWQSLGSSQS RLGSLDCSHS
1910 1920 1930 1940 1950
FSSRTDLNHW NGAGLSGTNC GDLHGTSLWG TPHYSTSLWG PPSSSDPRGI
1960 1970
SSPSPINAFL SVDHLGGGGE SM
Length:1,972
Mass (Da):211,384
Last modified:October 7, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE17D1082F1DF3F7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A6I9LPQ1A0A6I9LPQ1_PERMB
trinucleotide repeat-containing gen...
Tnrc6a
1,923Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6J0DF29A0A6J0DF29_PERMB
trinucleotide repeat-containing gen...
Tnrc6a
1,961Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6J0DHP6A0A6J0DHP6_PERMB
trinucleotide repeat-containing gen...
Tnrc6a
1,930Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6J0DMY9A0A6J0DMY9_PERMB
trinucleotide repeat-containing gen...
Tnrc6a
1,956Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6J0DH97A0A6J0DH97_PERMB
trinucleotide repeat-containing gen...
Tnrc6a
1,717Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_006980418.2, XM_006980356.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102905691

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_006980418.2, XM_006980356.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi102905691

Family and domain databases

CDDicd12711, RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486, Argonaute_hook_dom
IPR026805, GW182_M_dom
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR032226, TNRC6_PABC-bd
IPR033501, TNRC6A
IPR034924, TNRC6A_RRM
PANTHERiPTHR13020:SF28, PTHR13020:SF28, 1 hit
PfamiView protein in Pfam
PF10427, Ago_hook, 1 hit
PF12938, M_domain, 1 hit
PF16608, TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6I9LAS3_PERMB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6I9LAS3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 7, 2020
Last sequence update: October 7, 2020
Last modified: February 10, 2021
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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