We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - A0A6I8SQB3 (A0A6I8SQB3_XENTR)
Protein
Non-specific serine/threonine protein kinase
Gene
pak4
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 425 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
GO - Biological processi
- intracellular signal transduction Source: GO_Central
- protein phosphorylation Source: GO_Central
- regulation of MAPK cascade Source: GO_Central
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-XTR-9013148, CDC42 GTPase cycle R-XTR-9013149, RAC1 GTPase cycle R-XTR-9013404, RAC2 GTPase cycle R-XTR-9013406, RHOQ GTPase cycle R-XTR-9013407, RHOH GTPase cycle R-XTR-9013409, RHOJ GTPase cycle R-XTR-9013423, RAC3 GTPase cycle R-XTR-9013424, RHOV GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Non-specific serine/threonine protein kinaseARBA annotation (EC:2.7.11.1ARBA annotation) |
Gene namesi | Name:pak4Imported |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-1013749, pak4 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: GO_Central
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 39 | CRIBInterPro annotationAdd BLAST | 14 | |
Domaini | 395 – 646 | Protein kinaseInterPro annotationAdd BLAST | 252 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 114 – 375 | DisorderedSequence analysisAdd BLAST | 262 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 118 – 173 | Basic and acidic residuesSequence analysisAdd BLAST | 56 | |
Compositional biasi | 186 – 241 | Basic and acidic residuesSequence analysisAdd BLAST | 56 | |
Compositional biasi | 262 – 286 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 306 – 328 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 343 – 368 | Polar residuesSequence analysisAdd BLAST | 26 |
Phylogenomic databases
GeneTreei | ENSGT00940000159792 |
OMAi | VCIATMK |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
A0A6I8SQB3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSGITGHDK GSLATMFGKK KKRIEISAPL NFEHRVHTGF DQQEQKFTGL
60 70 80 90 100
PRQWQSLIEE SAKRPKPLVD PSYITTINHV PQKTIVRGSK MSLDGSLAWL
110 120 130 140 150
LDEFDAMSIC RSNSLRRESP PCHPREDRFH QENGMSEVRV RQQREDGQRG
160 170 180 190 200
SERNRSEHSR RERQREEHKA VPQQPRGQEP SNKHRPPPPD YPKDIPEKRG
210 220 230 240 250
TRSHEKGDGR REYPVNDRGY SEPVERVVKR EKGEEKRPKS SYTSAEGSPQ
260 270 280 290 300
SPRDKRPLSG PSIRTPGSSS TEGVVKQTQT GRAFNTYPRA ETDPSRGAPH
310 320 330 340 350
QVPDSHSTVP LDSKSTVSKS SSRPQQGQVK PKLPDKPHPT QLVPHSSDPQ
360 370 380 390 400
LSHPVQTQHP AQPRSPQREP QRVSHEQFRA ALQMVVDPGD PRTYLDNFIK
410 420 430 440 450
IGEGSTGIVC IATIKSSGKL VAVKKMDLRK QQRRELLFNE VVIMRDYQHE
460 470 480 490 500
NVVEMYNSYL VGDELWVIME FLEGGALTDI VTHTRMNEEQ IATVCVSVLK
510 520 530 540 550
ALSVLHAQGV IHRDIKSDSI LLTHDGRVKL SDFGFCAQVN KEVPRRKSLV
560 570 580 590 600
GTPYWMAPEL ISRLPYGPEV DIWSLGIMVI EMVDGEPPYF NEPPLKAMKM
610 620 630 640 650
IRDNLPPKLK NAQKVSPLLK GFLDRLLVRD PSQRASANEL LKHPFLGKAG
660
PPSCIVPLMR QNRLR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6PS80 | F6PS80_XENTR | Non-specific serine/threonine prote... | pak4 | 657 | Annotation score: |
Sequence databases
RefSeqi | XP_012823244.1, XM_012967790.2 |
Genome annotation databases
Ensembli | ENSXETT00000093029; ENSXETP00000100492; ENSXETG00000005314 |
GeneIDi | 100036644 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | XP_012823244.1, XM_012967790.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 100036644 |
Genome annotation databases
Ensembli | ENSXETT00000093029; ENSXETP00000100492; ENSXETG00000005314 |
GeneIDi | 100036644 |
Organism-specific databases
CTDi | 10298 |
Xenbasei | XB-GENE-1013749, pak4 |
Phylogenomic databases
GeneTreei | ENSGT00940000159792 |
OMAi | VCIATMK |
Enzyme and pathway databases
Reactomei | R-XTR-9013148, CDC42 GTPase cycle R-XTR-9013149, RAC1 GTPase cycle R-XTR-9013404, RAC2 GTPase cycle R-XTR-9013406, RHOQ GTPase cycle R-XTR-9013407, RHOH GTPase cycle R-XTR-9013409, RHOJ GTPase cycle R-XTR-9013423, RAC3 GTPase cycle R-XTR-9013424, RHOV GTPase cycle |
Family and domain databases
CDDi | cd01093, CRIB_PAK_like, 1 hit |
Gene3Di | 3.90.810.10, 1 hit |
InterProi | View protein in InterPro IPR000095, CRIB_dom IPR036936, CRIB_dom_sf IPR011009, Kinase-like_dom_sf IPR033923, PAK_BD IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00786, PBD, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A6I8SQB3_XENTR | |
Accessioni | A0A6I8SQB3Primary (citable) accession number: A0A6I8SQB3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | August 12, 2020 |
Last sequence update: | August 12, 2020 | |
Last modified: | January 19, 2022 | |
This is version 8 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |