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UniProtKB - A0A6I8QG99 (A0A6I8QG99_XENTR)

Entry version 8 (25 May 2022)
Sequence version 2 (02 Jun 2021)
Previous versions | rss
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

macf1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...Xenbasei		XB-GENE-494799, macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 173Calponin-homology (CH)InterPro annotationAdd BLAST138
Domaini186 – 290Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini856 – 913SH3InterPro annotationAdd BLAST58
Domaini7021 – 7056EF-handInterPro annotationAdd BLAST36
Domaini7057 – 7092EF-handInterPro annotationAdd BLAST36
Domaini7097 – 7175GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3175 – 3229DisorderedSequence analysisAdd BLAST55
Regioni7212 – 7267DisorderedSequence analysisAdd BLAST56
Regioni7296 – 7416DisorderedSequence analysisAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili20 – 40Sequence analysisAdd BLAST21
Coiled coili237 – 257Sequence analysisAdd BLAST21
Coiled coili469 – 489Sequence analysisAdd BLAST21
Coiled coili710 – 737Sequence analysisAdd BLAST28
Coiled coili809 – 829Sequence analysisAdd BLAST21
Coiled coili1077 – 1104Sequence analysisAdd BLAST28
Coiled coili1299 – 1319Sequence analysisAdd BLAST21
Coiled coili1393 – 1423Sequence analysisAdd BLAST31
Coiled coili1489 – 1516Sequence analysisAdd BLAST28
Coiled coili2991 – 3011Sequence analysisAdd BLAST21
Coiled coili3285 – 3305Sequence analysisAdd BLAST21
Coiled coili3332 – 3352Sequence analysisAdd BLAST21
Coiled coili3402 – 3422Sequence analysisAdd BLAST21
Coiled coili3456 – 3483Sequence analysisAdd BLAST28
Coiled coili3584 – 3604Sequence analysisAdd BLAST21
Coiled coili3719 – 3757Sequence analysisAdd BLAST39
Coiled coili3997 – 4017Sequence analysisAdd BLAST21
Coiled coili4134 – 4161Sequence analysisAdd BLAST28
Coiled coili4174 – 4194Sequence analysisAdd BLAST21
Coiled coili4333 – 4353Sequence analysisAdd BLAST21
Coiled coili4388 – 4415Sequence analysisAdd BLAST28
Coiled coili4495 – 4515Sequence analysisAdd BLAST21
Coiled coili4561 – 4588Sequence analysisAdd BLAST28
Coiled coili4616 – 4636Sequence analysisAdd BLAST21
Coiled coili5106 – 5133Sequence analysisAdd BLAST28
Coiled coili5407 – 5427Sequence analysisAdd BLAST21
Coiled coili6403 – 6423Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3178 – 3194Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3205 – 3229Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi7227 – 7267Polar residuesSequence analysisAdd BLAST41
Compositional biasi7312 – 7336Polar residuesSequence analysisAdd BLAST25
Compositional biasi7364 – 7386Polar residuesSequence analysisAdd BLAST23
Compositional biasi7393 – 7416Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 15 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 13 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6I8QG99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGYIPGQLP ADRSQENEFV RAYEGVLERY KDERDRVQKK TFTKWVNKHL 
        60         70         80         90        100
IKVRKHINDL YEDLRDGHNL ISLLEVLSGI RLNKDPEAPR SLRLSRLPSR 
       110        120        130        140        150
RLLLMREDLE EDPDDAPREK GRMRFHRLQN VQIALDFLKQ RQVKLVNIRN 
       160        170        180        190        200
DDITDGNPKL TLGLIWTIIL HFQISDIYVS GESGDMSAKE KLLLWTQKVT 
       210        220        230        240        250
AGYTGIKCTN FSSCWSDGKM FNAIIHRYRP DLVDMQKVEL QGNRENLEQA 
       260        270        280        290        300
FEIAESLGVT RLLDSEDVDV ASPDEKSVIT YVSSIYDAFP KVPEGAEGIS 
       310        320        330        340        350
ATEVDSRWLE YQERVVCLTQ WIRQHVLLMS DKSFPQNPVE LKALYNQYVH 
       360        370        380        390        400
VKETEIPAKE QEKEQIQKLY QMLQAWIEFG RIKLPPSFHP NDVEEQWGKL 
       410        420        430        440        450
ILSMLEREKI LRPAVERLEL LLQIANRIQN GCLSCEEKLT LARNTLQSDA 
       460        470        480        490        500
ANIECGQTFQ QESEVVQFLQ ESEVLLRQLQ SDVQILRDEK YFQVEELAFR 
       510        520        530        540        550
VLRIQDELLN LKMECTNLYR RGNLITSDLQ PTVSLSNTHQ HSLHTSPSSS 
       560        570        580        590        600
SWFRKPMSRT ELVVLSSSED EGSLRFVYEL LAWVEEMQMK LEISEWGSDL 
       610        620        630        640        650
PSVEAQLESQ RIVHTSVEEL TSSLREARSY EVKMSHNFRS SYSETLSKLE 
       660        670        680        690        700
TQYCKLRETS SSRLHNLQSL HDFVSQATAQ IIWLNQKEEE ELAYDWSDGN 
       710        720        730        740        750
PNIAAKKEYF TELMQELEEK QDVIQALQET AELLSLENHP AKQTVEAYSA 
       760        770        780        790        800
AVVSQWQWVK QLCLCVEQHL KENTAYFQFF NDVRESEVYL NNLQDSIKRK 
       810        820        830        840        850
YSCDRTTSIN RLEDILQDSM DEKEQLIQSR SSVASLVGRS KNIVQLKPRN 
       860        870        880        890        900
PELTLANTLP IKAVCDYRQI EITIGRNEEC VLEDNTQRTK WKVISTTGNE 
       910        920        930        940        950
AMVPSVCFLI PPPNQEAMEM ASRVEQLYQK VMSLWHQLHI NTKSLISWNY 
       960        970        980        990       1000
LRKDVEVVQS WNAEKLKVLP LAERLETLSN LSASLKCHLD EFLEDSKDSQ 
      1010       1020       1030       1040       1050
IFSMTDRLNM EQEVESCRDQ CRQLVDMIVT EDKEESEART YLSELYNIEL 
      1060       1070       1080       1090       1100
QMGHCEQRLV KRIQSPVGTD ADAVHEITIY ISEQERMQEE LNRLKSELSV 
      1110       1120       1130       1140       1150
VSERCDDFVH KSPSGSCTPN LRSQLDLLVG KMDQIYGLSS VFLEKLKTVD 
      1160       1170       1180       1190       1200
VVIRSLQEAE GMVKGFEIKL SQEASLNADT SFIQSQQDLL QQWLTEAADK 
      1210       1220       1230       1240       1250
DSIISALEND IAKSKDVRER LYKMTQERSM DVEHYQERAD KLRERWNAVH 
      1260       1270       1280       1290       1300
SQLETRESEL LGIQESLRNY RGLHDNLIHW IEETKSQQEM MKPGQSEDRR 
      1310       1320       1330       1340       1350
VLSEQLSQQT ALVAEIEKNQ TRLDKCQTIS QQYSNLVKEY ELQLMTYRAC 
      1360       1370       1380       1390       1400
VESQQKSPMK RRRLFSSSDI ITQEFMDLRT RYTALVTLTT QHVKYISDAL 
      1410       1420       1430       1440       1450
RRLEEEEKVL EEEKEKHVEE LKRLTGWVSG LSQGVSLQGP DHADLNKSIS 
      1460       1470       1480       1490       1500
EQKALSEELL SQKEHISEAV KSMQIFLAKN SDRLSAQEKE ELLSQIQELN 
      1510       1520       1530       1540       1550
GKYSHLSEEC DNQVQQLHTK LAQEAEQKVD HAVGGVIDLG SMEIFPIFWA 
      1560       1570       1580       1590       1600
IQRGLIDQDT GLLLLEAQIV LSGLIVPATN ERLNLKEALK HNIIDQRLFQ 
      1610       1620       1630       1640       1650
FLKDLRDASK VVAGAGSKSG KQKLLSVIAA MEDKKIRESD GLKILSIHFA 
      1660       1670       1680       1690       1700
TGGFRLTAEE DVTNLERAAE AGLISRRLCQ KLKSSSKSLV DPNTAKRMSL 
      1710       1720       1730       1740       1750
AEIMQTCIIH ESTGLRLLPV KQLSVGMVCL KSGKKVSIFS AVQEGLIDRQ 
      1760       1770       1780       1790       1800
VAVRLLEAQL FAGGIKDTKT GHRLTVEEAL RQQLMDQDMA IALLKRQLED 
      1810       1820       1830       1840       1850
GGIIDTATGQ IITLGEAVKQ NIVSPKLALL VLESLGSFKG VLIPESGEIL 
      1860       1870       1880       1890       1900
LVADALQLGI ISTEFAINAL GSRQRIQGLY MLEDRRILSW DDTVKCIIMD 
      1910       1920       1930       1940       1950
ENIAKILQSI DIPDTISSLE AGSASMPELG LCPGTLSVNS SPCPLESSEL 
      1960       1970       1980       1990       2000
EMQRGACSEG NRELISHLMN VSYINIHSGK RLLLTNKNEN IVTKLFPGAF 
      2010       2020       2030       2040       2050
LDNSIVVSHN NKEEIHMQHT VEKKLESMAL LANFTAKNTE AVTNLEKNQC 
      2060       2070       2080       2090       2100
LLPREGRLPL DTHHAKLDET LSSLQNNHAS QLQLAAHCGD VEEKMFKHPE 
      2110       2120       2130       2140       2150
ISSFSTEQLL LPAVPENSAN EINDSKTEIS PVNKGLVDIQ VQTLSVNGKL 
      2160       2170       2180       2190       2200
PEITAQSKTN KAFEMSFDPD KVTNKSDLKT ENVDVLNYIP EQQVASSKCL 
      2210       2220       2230       2240       2250
TVNAAYPEKI FCKGKLEDSG GLLDNMHDHY DISSSEQVDN YAHVMEEEDA 
      2260       2270       2280       2290       2300
LNMLSEQLTN GGIVVPNSSQ KLLLNEAANH GIISSHTALK LMERVGLFAG 
      2310       2320       2330       2340       2350
FFDSQTCERL TIQDVIDEGL MDETLLQQVL SSDKTISGIV DTKNKILYSL 
      2360       2370       2380       2390       2400
QDALNVGLVN EDIAKQILEV QVITGGIYDM KRGKRISVTL ATSLNLVPPS 
      2410       2420       2430       2440       2450
SKEDLIKLEK ASKGKKTDQA SMKKLASLQI ETSGITDPLS KKVLPVAQAI 
      2460       2470       2480       2490       2500
EQGFITREEA MQLLTKQIAD GGIIHHSSGM RLSVLDALKH RLIDHTVFDD 
      2510       2520       2530       2540       2550
LTEFEYLTQS GLHKSCEVDS SLSAQGEYLT SNDTNPISQA STKQGDKIQY 
      2560       2570       2580       2590       2600
TDVLKKCAFD VITGQRYMDL NKHKSNFSPD TQKNTFESLD ILQSETLLMQ 
      2610       2620       2630       2640       2650
DNIYDLEHGK SKTCSPAVLC DEGVAVTEKF LDGIKDSMKP MSLMYSMRDT 
      2660       2670       2680       2690       2700
GYSEDSQPQD QHNNKVNEDC FLKLNPQQYS SQNFTNSDSI LFCKQNNTNI 
      2710       2720       2730       2740       2750
LQVDKIKMGK NGAPDVCLEN EKRPFVQGVC FEMEQGVESF TGGQISQVPE 
      2760       2770       2780       2790       2800
SDIRINDGVL MEQTQRNITF TDDFKVHCKP SAAETSVPSF FGEGLLDVNH 
      2810       2820       2830       2840       2850
FDTNMCVDET SLHVTSTKVY SDSQLSESKS TDGETSKLPC ISLNLDKQEL 
      2860       2870       2880       2890       2900
SPEVNCGPIF KNQEVKRLLP DTALFSPVPE KEHFTDRLVN KHSEKITTIT 
      2910       2920       2930       2940       2950
ENVSKDLQKL QNDKQQGQIP ISQCDLPMVS DQKPFTTSNY VPSENLPFSQ 
      2960       2970       2980       2990       3000
DLSQSDMSSV SRIFQKSGNI EFYSEVDMMY FDSQKYVKKY NDKIQQKLSE 
      3010       3020       3030       3040       3050
KELVIEHEQQ REGSCLTQDL YLCALNKSSV QSVINIQQEC ELIQTSGDLT 
      3060       3070       3080       3090       3100
VGKPNKNTVK QPKYLTDAEP KVNTDNPAKE NSEKVTVKPE KDLTAGTIKE 
      3110       3120       3130       3140       3150
GTRKPIKDIK SKQIKEDVVN PATNFKTEIP TEHTVKPSNG VISKEDTVTS 
      3160       3170       3180       3190       3200
VRALTDVRFK QDAIKPTRQL ALVKSKEGTF KPSRKPKEDP VKVDQSLMEG 
      3210       3220       3230       3240       3250
NSKDETVNES NDRKEGPPKK KAEARPIEDT IEPGRDFALE KPKDSYTISI 
      3260       3270       3280       3290       3300
KQTCLEHEEN LVSYLSMLRD IEVRLGPVQP IPPSIKEVEE QLKQAEVLDL 
      3310       3320       3330       3340       3350
ELRQLMSPVS QELDFAKRII SDQPTEVPVQ LLRALEKDAK NLEKSLTSIK 
      3360       3370       3380       3390       3400
GNSELRVKQL QDALKTEKGK ILVEHKELES KLHYLLQWVK ETTDSLDSAK 
      3410       3420       3430       3440       3450
TNDDLRLDAE KLQKELNHAE SLRRPLTDTR QKLDNIAFDI QFFISEKAQD 
      3460       3470       3480       3490       3500
LTPQQSRTLL RLLNELQRSF RELSERLVAW EEVLQLCQKQ TKYNTEFKIL 
      3510       3520       3530       3540       3550
QEQQATCSKE FEELASWAEH TEKALPSLQT FHKTTDLSSL MEQQKAVQVL 
      3560       3570       3580       3590       3600
HKDVQSRGKH FSRVIRAAED FLAENKLKMD PVELESFQKK LQQAKERYHA 
      3610       3620       3630       3640       3650
VLEKTGDTEK QLESAVSTAV LEETKKSETA EELKVNLGKI ESLLSQVRPS 
      3660       3670       3680       3690       3700
YALLKTVPDG SALSNQSMQN RCLPPDETSF MVNELYERKK TQHQEMLEQQ 
      3710       3720       3730       3740       3750
QNFILTIQSA QDFLDKHGNT LCPEERQQLQ NQLAQLKEEY SASMSQAQLQ 
      3760       3770       3780       3790       3800
LKNAQVLRDE MQNFIRDHGE FEHWLIHTEE ELDNMHKGKK DYNALKNLLN 
      3810       3820       3830       3840       3850
QQMNISEDII SHKGDLRYIN LAGQKAIEAE KATADQCKED FEMVAGAMVK 
      3860       3870       3880       3890       3900
NKLEEASKRY STLQSKCSKL GCHLNVVLDR YQQFQEGSDT AVAWLQVTEL 
      3910       3920       3930       3940       3950
EVDRILSEPV ASDPEVLQNQ LAKAKGMQSN FAEHQVQVEK VHKALRMLLE 
      3960       3970       3980       3990       4000
IQDDPIPDCR SVQDIADSID RRFQNLSNQM SSHSDLLQKT VAQSQSVQDA 
      4010       4020       4030       4040       4050
LENLLQWLKE MEKTLAEQKH TRMSSASVEE ALAVNMKLKQ DISSRRGSMD 
      4060       4070       4080       4090       4100
ATGEMVGKFM ETADSAAASA LHSKLSEVTS RFNEVCMQQR LQENALKEIL 
      4110       4120       4130       4140       4150
PKVEKYEQFS NELQDFTVTR SHLLASGNQP ERDITQFSEQ IKELNAEIKQ 
      4160       4170       4180       4190       4200
QEGHLLMVEQ LARELSASPI LTDASEHLQK LATLKKDFAE LREAALARES 
      4210       4220       4230       4240       4250
ETLSCQESLE QFQKLVGVMR KWLKEKEDIV PSAEDSLKTC EMMSRLQQVK 
      4260       4270       4280       4290       4300
DLLSEWEMKS PKMAEIAQKG SELECCIMEI TASACQRKGG SLLMATGSSL 
      4310       4320       4330       4340       4350
GNVNGYHTCQ DLTGIQCDVS ETSQKFENLG LLLHKREEQL SKMLENFEKI 
      4360       4370       4380       4390       4400
KQETNHMLKW LESKEKTMTA VNVSPTKSEV VKAQAKQNKE FLSELEQSTE 
      4410       4420       4430       4440       4450
KVESLKAALR DLLEKHPNSP EAENWKTMLE NLDQQWGRVN QVTAERQHKL 
      4460       4470       4480       4490       4500
EESANQLATF QVAGSQLCPW LKEKELMMSV LGPLSVDPNM LNAQKQQVQF 
      4510       4520       4530       4540       4550
MLKEFEARKA QYEELKLAAY GILTGPGEES PSTCQVEEEF HNISGKWMEL 
      4560       4570       4580       4590       4600
TSRLNSRADQ IDQATIKSSQ YKEVLQRLTD KIKQAGKNLA AQPAVSTQPD 
      4610       4620       4630       4640       4650
AVKQQLQETS GIRSELEQLA KEVTDAQKLC NELSALVMEP YLKDELQKRL 
      4660       4670       4680       4690       4700
DTVALPLKGM EDLAVDRVNR LQTALSSSQQ FQQMFDELRS WLDEKQLQHV 
      4710       4720       4730       4740       4750
KSHPVSAKLE KLQIQLQEQE EFQKSLSQYS GSYEMIVAEG ESLLMSAQPG 
      4760       4770       4780       4790       4800
EEKTTLQNQL VNLKSNWNEL GKQSSERHGK LKDCLQKAQK YVRHVEDMVP 
      4810       4820       4830       4840       4850
WLEDCEIHMK EMEITLDPVQ LEAQLLRAKA LQTDIDKKRS LLEMMNSAAD 
      4860       4870       4880       4890       4900
LLIEAAEIDD RDILEERAKI NQRIDAITEE LHNKSGSFEE MSLRLKELKD 
      4910       4920       4930       4940       4950
SFSNIDKKME GAKHLLEIFT ALGPQACSSK NLESMRSQQD MLLGLDSQIL 
      4960       4970       4980       4990       5000
YLKNLIQGLI ADVPQDSDVS HLVYQAQQVQ HDFEIVKEDV NECCANMETK 
      5010       5020       5030       5040       5050
LQGIGQFHSH VREMFSELAD LDDELDSMGP VGRDIDSLKS QAEVIQKFLE 
      5060       5070       5080       5090       5100
ALLSLKSSIE SSECKCRDML EKEGGPDLIV LMRELGTLNK QCSKLTERGK 
      5110       5120       5130       5140       5150
NRQGQLVATL RRVEEFNMKL KELNHQIVTA EGSSVLQGVV GTEVDTIKQQ 
      5160       5170       5180       5190       5200
LDNFKVFQKE QVDSLQAKLH QVNGIGQGLI QSADKNCDVH GLEHDTEELN 
      5210       5220       5230       5240       5250
IKWNTLNKKV AERVTQLQEA LLHCGKFQDA LEPLLSWLTD TEDLIANQKP 
      5260       5270       5280       5290       5300
PSAEYKVVKA QIQEQKLLQR LLDDRRTTVE MIQAEGVRIA EGADPADGDK 
      5310       5320       5330       5340       5350
ISHQLEILAE RWSLLLQKAQ SRQKQLEDIL VLAKQFHETT EPIFDWLSAT 
      5360       5370       5380       5390       5400
EKKLANSEPI GTQTGKIQQQ IQRHKSLEGD ITVHETDVHQ ANKLGGSLAA 
      5410       5420       5430       5440       5450
LCSNAEQERL SQKLEFLQAR YSEVQDLCSR KGTLLGQALI NARLFGEDEV 
      5460       5470       5480       5490       5500
EVLNWLGDVE DRLNSVCVKD YKPEVLQNQH KQHMALNEDI INRKKNVDQA 
      5510       5520       5530       5540       5550
IKNGQALLKQ TTGEEVLLIQ EKLDGIKTRY SEITASSGKA LKTLEQALQL 
      5560       5570       5580       5590       5600
AGKFQATHDE LTGWLRRAED ELSQSFGQSP SGDMIPQFQQ QQKELKKEAM 
      5610       5620       5630       5640       5650
EYRIVLDTIN EVGSALLELV PWRAREGLDK LVADANEQYR SISDTIGQRV 
      5660       5670       5680       5690       5700
DQIDAAIQRS QQYEQAADAE LAWVAETKRK LLALGSICLE QDQTTAQLQV 
      5710       5720       5730       5740       5750
QKAFSVDIIR HKDSIDELIS TEEEILATCG DEQKSVLQEK TKNLVQHYED 
      5760       5770       5780       5790       5800
ISHLNSERYA RLERAQVLVG QFWETYEELI PWIDEMQVLF SQLPPPAVDH 
      5810       5820       5830       5840       5850
EMLRQQQEEM RQLRESVAEH KPHIDKLLKI GPHLSELNPE EGTAVQEKYR 
      5860       5870       5880       5890       5900
SAEKLYVGIK EEVRKRAMVL DDALAQAAQF HDKIGPMLET LESMASRLRM 
      5910       5920       5930       5940       5950
PPLIPAEVEK IRECISENKN AVMELEKLQP AFQALKHRGE ELISRSQGPD 
      5960       5970       5980       5990       6000
IDPAAKDIQD KLDQLVFFWE DIKARADERE SKFLDVLELA EKFWLDMNTL 
      6010       6020       6030       6040       6050
LTTIKDTHEI VHDLESPGID PSMIKQQIEA ADSIKEETDG LHEELEFIRI 
      6060       6070       6080       6090       6100
LGADLIFACG ETEKPEVKKS IDEMNTAWEN LKRTWAERIE KLRDAMSHAV 
      6110       6120       6130       6140       6150
QYQDSLQAMF DWLDNTVIKL CDMPPVGTDI STVKEQIEEM KEFKVEVYQQ 
      6160       6170       6180       6190       6200
QIEMEKLNHQ GELMLKKAID DTDRDIIQGP LTELKHLWEN LGEKIAHRQQ 
      6210       6220       6230       6240       6250
KLEDSLLALG QFQHALAELM SWLTHTNELL NAQRPICGDP KVIEVELAKH 
      6260       6270       6280       6290       6300
HVLKNDVLAH QSTVQIVNKA GNELLESSAG DDASSLRTRL ETLNQLWEIV 
      6310       6320       6330       6340       6350
LQKTEEREQQ LDMALQQAQG FSGEIEDFIQ WQTNIESQLS AAKPTGGLPE 
      6360       6370       6380       6390       6400
TAREQLQAHM ELFAEIKANE DLYRHLLDKG QLMLISRDDA TGSITEQNVS 
      6410       6420       6430       6440       6450
ILKRKWQAIS NKVEERKAKL EEALTLATDF QNSLQDFINW LTQAEQSLNI 
      6460       6470       6480       6490       6500
APSPSLILDT VLFQIDEHKV FVNEVNIHRE HIIELDKIGN QLKFLSQKQD 
      6510       6520       6530       6540       6550
VVLIKNLLLS VQSRWEKVVQ RSVERGRSLD DARKRAKQFH EAWKKLIDWL 
      6560       6570       6580       6590       6600
EEAENHLDSE LEISNDPDKI KLQLSKHKEF QKTLGSKQPV YDTTVRTGRA 
      6610       6620       6630       6640       6650
LKEKALLSGD VQKLDHLLGE VRDKWDTVCG KSVERQHKLE EALLFSGQFM 
      6660       6670       6680       6690       6700
DALQALVDWL YKVEPQLAED QPLHGDLDLV MNLMDAHKVF QKELGKRTSS 
      6710       6720       6730       6740       6750
VQALKRSARE LLESSREDTT WVKVQLQELS TRWDTVCKLS VSKQTRLEQA 
      6760       6770       6780       6790       6800
LKQAEEFHAA VHMLLEWLSE AEQTLRFRGA LPDDAESLQS LIDIHKEFMR 
      6810       6820       6830       6840       6850
KVEEKQIDVN TAVSMGEEIL TMCHPDCITT IKHWITIIRA RFEEVLTWGN 
      6860       6870       6880       6890       6900
QHQQRLQTAL SELLANSELL DELLSWIQWA ETTLIQRGQD PMPQNIDQVK 
      6910       6920       6930       6940       6950
ALISEHQVFM EEMTQKQPDV DRVTKTYKRK TTDTNHASFN DKTRRKHSVQ 
      6960       6970       6980       6990       7000
NATPVLPVLS QPETKNPRIN QLSARWQQVW LLALERQRKL NDALDRLEEL 
      7010       7020       7030       7040       7050
KEFANFDFDI WRKKYMRWMN HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI 
      7060       7070       7080       7090       7100
LASKFPTTRL EMTAVADIFD RDGDGYIDYY EFVAALHPNK DAYRPTTDAD 
      7110       7120       7130       7140       7150
KIEDEVTRQV AQCKCAKRFQ VEQIGENKYR FFLGNQFGDS QQLRLVRILR 
      7160       7170       7180       7190       7200
STVMVRVGGG WMALDEFLVK NDPCRVHHPG NKLKRTDSIS SIARGRTNLE 
      7210       7220       7230       7240       7250
LREKFILPEG VSQGMTPFRS RGRRSKPSSR TASPTRSSSS ASQSNHSCTS 
      7260       7270       7280       7290       7300
VPSSPATPAS GSKTPQHLSR CYEKPWLVNS KASTPIRCAE YPDFHTPSPE 
      7310       7320       7330       7340       7350
VTPAQGSKLK KAAVHTSRSS LTGDTPTSSS AKSGRADPKK SASRAGSRAG 
      7360       7370       7380       7390       7400
SRASSRRGSD ASDFDLLETQ SACSDTSESS AAGGPGSSRR GLSKPSKIPT 
      7410 
MSKKTASTPK TQGTKR
Length:7,416
Mass (Da):842,735
Last modified:June 2, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F6E2ACCFC731037
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSXETT00000086213; ENSXETP00000071844; ENSXETG00000007367

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSXETT00000086213; ENSXETP00000071844; ENSXETG00000007367

Organism-specific databases

XenbaseiXB-GENE-494799, macf1

Phylogenomic databases

GeneTreeiENSGT00940000155824

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 4 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 15 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 13 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6I8QG99_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6I8QG99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 12, 2020
Last sequence update: June 2, 2021
Last modified: May 25, 2022
This is version 8 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
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