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Entry version 8 (25 May 2022)
Sequence version 2 (02 Jun 2021)
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Protein
Submitted name:

Microtubule actin crosslinking factor 1

Gene

macf1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule actin crosslinking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-494799, macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 173Calponin-homology (CH)InterPro annotationAdd BLAST138
Domaini186 – 290Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini856 – 913SH3InterPro annotationAdd BLAST58
Domaini7021 – 7056EF-handInterPro annotationAdd BLAST36
Domaini7057 – 7092EF-handInterPro annotationAdd BLAST36
Domaini7097 – 7175GARInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3175 – 3229DisorderedSequence analysisAdd BLAST55
Regioni7212 – 7267DisorderedSequence analysisAdd BLAST56
Regioni7296 – 7416DisorderedSequence analysisAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili20 – 40Sequence analysisAdd BLAST21
Coiled coili237 – 257Sequence analysisAdd BLAST21
Coiled coili469 – 489Sequence analysisAdd BLAST21
Coiled coili710 – 737Sequence analysisAdd BLAST28
Coiled coili809 – 829Sequence analysisAdd BLAST21
Coiled coili1077 – 1104Sequence analysisAdd BLAST28
Coiled coili1299 – 1319Sequence analysisAdd BLAST21
Coiled coili1393 – 1423Sequence analysisAdd BLAST31
Coiled coili1489 – 1516Sequence analysisAdd BLAST28
Coiled coili2991 – 3011Sequence analysisAdd BLAST21
Coiled coili3285 – 3305Sequence analysisAdd BLAST21
Coiled coili3332 – 3352Sequence analysisAdd BLAST21
Coiled coili3402 – 3422Sequence analysisAdd BLAST21
Coiled coili3456 – 3483Sequence analysisAdd BLAST28
Coiled coili3584 – 3604Sequence analysisAdd BLAST21
Coiled coili3719 – 3757Sequence analysisAdd BLAST39
Coiled coili3997 – 4017Sequence analysisAdd BLAST21
Coiled coili4134 – 4161Sequence analysisAdd BLAST28
Coiled coili4174 – 4194Sequence analysisAdd BLAST21
Coiled coili4333 – 4353Sequence analysisAdd BLAST21
Coiled coili4388 – 4415Sequence analysisAdd BLAST28
Coiled coili4495 – 4515Sequence analysisAdd BLAST21
Coiled coili4561 – 4588Sequence analysisAdd BLAST28
Coiled coili4616 – 4636Sequence analysisAdd BLAST21
Coiled coili5106 – 5133Sequence analysisAdd BLAST28
Coiled coili5407 – 5427Sequence analysisAdd BLAST21
Coiled coili6403 – 6423Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3178 – 3194Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3205 – 3229Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi7227 – 7267Polar residuesSequence analysisAdd BLAST41
Compositional biasi7312 – 7336Polar residuesSequence analysisAdd BLAST25
Compositional biasi7364 – 7386Polar residuesSequence analysisAdd BLAST23
Compositional biasi7393 – 7416Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 15 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 13 hits
SM00150, SPEC, 34 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6I8QG99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGYIPGQLP ADRSQENEFV RAYEGVLERY KDERDRVQKK TFTKWVNKHL
60 70 80 90 100
IKVRKHINDL YEDLRDGHNL ISLLEVLSGI RLNKDPEAPR SLRLSRLPSR
110 120 130 140 150
RLLLMREDLE EDPDDAPREK GRMRFHRLQN VQIALDFLKQ RQVKLVNIRN
160 170 180 190 200
DDITDGNPKL TLGLIWTIIL HFQISDIYVS GESGDMSAKE KLLLWTQKVT
210 220 230 240 250
AGYTGIKCTN FSSCWSDGKM FNAIIHRYRP DLVDMQKVEL QGNRENLEQA
260 270 280 290 300
FEIAESLGVT RLLDSEDVDV ASPDEKSVIT YVSSIYDAFP KVPEGAEGIS
310 320 330 340 350
ATEVDSRWLE YQERVVCLTQ WIRQHVLLMS DKSFPQNPVE LKALYNQYVH
360 370 380 390 400
VKETEIPAKE QEKEQIQKLY QMLQAWIEFG RIKLPPSFHP NDVEEQWGKL
410 420 430 440 450
ILSMLEREKI LRPAVERLEL LLQIANRIQN GCLSCEEKLT LARNTLQSDA
460 470 480 490 500
ANIECGQTFQ QESEVVQFLQ ESEVLLRQLQ SDVQILRDEK YFQVEELAFR
510 520 530 540 550
VLRIQDELLN LKMECTNLYR RGNLITSDLQ PTVSLSNTHQ HSLHTSPSSS
560 570 580 590 600
SWFRKPMSRT ELVVLSSSED EGSLRFVYEL LAWVEEMQMK LEISEWGSDL
610 620 630 640 650
PSVEAQLESQ RIVHTSVEEL TSSLREARSY EVKMSHNFRS SYSETLSKLE
660 670 680 690 700
TQYCKLRETS SSRLHNLQSL HDFVSQATAQ IIWLNQKEEE ELAYDWSDGN
710 720 730 740 750
PNIAAKKEYF TELMQELEEK QDVIQALQET AELLSLENHP AKQTVEAYSA
760 770 780 790 800
AVVSQWQWVK QLCLCVEQHL KENTAYFQFF NDVRESEVYL NNLQDSIKRK
810 820 830 840 850
YSCDRTTSIN RLEDILQDSM DEKEQLIQSR SSVASLVGRS KNIVQLKPRN
860 870 880 890 900
PELTLANTLP IKAVCDYRQI EITIGRNEEC VLEDNTQRTK WKVISTTGNE
910 920 930 940 950
AMVPSVCFLI PPPNQEAMEM ASRVEQLYQK VMSLWHQLHI NTKSLISWNY
960 970 980 990 1000
LRKDVEVVQS WNAEKLKVLP LAERLETLSN LSASLKCHLD EFLEDSKDSQ
1010 1020 1030 1040 1050
IFSMTDRLNM EQEVESCRDQ CRQLVDMIVT EDKEESEART YLSELYNIEL
1060 1070 1080 1090 1100
QMGHCEQRLV KRIQSPVGTD ADAVHEITIY ISEQERMQEE LNRLKSELSV
1110 1120 1130 1140 1150
VSERCDDFVH KSPSGSCTPN LRSQLDLLVG KMDQIYGLSS VFLEKLKTVD
1160 1170 1180 1190 1200
VVIRSLQEAE GMVKGFEIKL SQEASLNADT SFIQSQQDLL QQWLTEAADK
1210 1220 1230 1240 1250
DSIISALEND IAKSKDVRER LYKMTQERSM DVEHYQERAD KLRERWNAVH
1260 1270 1280 1290 1300
SQLETRESEL LGIQESLRNY RGLHDNLIHW IEETKSQQEM MKPGQSEDRR
1310 1320 1330 1340 1350
VLSEQLSQQT ALVAEIEKNQ TRLDKCQTIS QQYSNLVKEY ELQLMTYRAC
1360 1370 1380 1390 1400
VESQQKSPMK RRRLFSSSDI ITQEFMDLRT RYTALVTLTT QHVKYISDAL
1410 1420 1430 1440 1450
RRLEEEEKVL EEEKEKHVEE LKRLTGWVSG LSQGVSLQGP DHADLNKSIS
1460 1470 1480 1490 1500
EQKALSEELL SQKEHISEAV KSMQIFLAKN SDRLSAQEKE ELLSQIQELN
1510 1520 1530 1540 1550
GKYSHLSEEC DNQVQQLHTK LAQEAEQKVD HAVGGVIDLG SMEIFPIFWA
1560 1570 1580 1590 1600
IQRGLIDQDT GLLLLEAQIV LSGLIVPATN ERLNLKEALK HNIIDQRLFQ
1610 1620 1630 1640 1650
FLKDLRDASK VVAGAGSKSG KQKLLSVIAA MEDKKIRESD GLKILSIHFA
1660 1670 1680 1690 1700
TGGFRLTAEE DVTNLERAAE AGLISRRLCQ KLKSSSKSLV DPNTAKRMSL
1710 1720 1730 1740 1750
AEIMQTCIIH ESTGLRLLPV KQLSVGMVCL KSGKKVSIFS AVQEGLIDRQ
1760 1770 1780 1790 1800
VAVRLLEAQL FAGGIKDTKT GHRLTVEEAL RQQLMDQDMA IALLKRQLED
1810 1820 1830 1840 1850
GGIIDTATGQ IITLGEAVKQ NIVSPKLALL VLESLGSFKG VLIPESGEIL
1860 1870 1880 1890 1900
LVADALQLGI ISTEFAINAL GSRQRIQGLY MLEDRRILSW DDTVKCIIMD
1910 1920 1930 1940 1950
ENIAKILQSI DIPDTISSLE AGSASMPELG LCPGTLSVNS SPCPLESSEL
1960 1970 1980 1990 2000
EMQRGACSEG NRELISHLMN VSYINIHSGK RLLLTNKNEN IVTKLFPGAF
2010 2020 2030 2040 2050
LDNSIVVSHN NKEEIHMQHT VEKKLESMAL LANFTAKNTE AVTNLEKNQC
2060 2070 2080 2090 2100
LLPREGRLPL DTHHAKLDET LSSLQNNHAS QLQLAAHCGD VEEKMFKHPE
2110 2120 2130 2140 2150
ISSFSTEQLL LPAVPENSAN EINDSKTEIS PVNKGLVDIQ VQTLSVNGKL
2160 2170 2180 2190 2200
PEITAQSKTN KAFEMSFDPD KVTNKSDLKT ENVDVLNYIP EQQVASSKCL
2210 2220 2230 2240 2250
TVNAAYPEKI FCKGKLEDSG GLLDNMHDHY DISSSEQVDN YAHVMEEEDA
2260 2270 2280 2290 2300
LNMLSEQLTN GGIVVPNSSQ KLLLNEAANH GIISSHTALK LMERVGLFAG
2310 2320 2330 2340 2350
FFDSQTCERL TIQDVIDEGL MDETLLQQVL SSDKTISGIV DTKNKILYSL
2360 2370 2380 2390 2400
QDALNVGLVN EDIAKQILEV QVITGGIYDM KRGKRISVTL ATSLNLVPPS
2410 2420 2430 2440 2450
SKEDLIKLEK ASKGKKTDQA SMKKLASLQI ETSGITDPLS KKVLPVAQAI
2460 2470 2480 2490 2500
EQGFITREEA MQLLTKQIAD GGIIHHSSGM RLSVLDALKH RLIDHTVFDD
2510 2520 2530 2540 2550
LTEFEYLTQS GLHKSCEVDS SLSAQGEYLT SNDTNPISQA STKQGDKIQY
2560 2570 2580 2590 2600
TDVLKKCAFD VITGQRYMDL NKHKSNFSPD TQKNTFESLD ILQSETLLMQ
2610 2620 2630 2640 2650
DNIYDLEHGK SKTCSPAVLC DEGVAVTEKF LDGIKDSMKP MSLMYSMRDT
2660 2670 2680 2690 2700
GYSEDSQPQD QHNNKVNEDC FLKLNPQQYS SQNFTNSDSI LFCKQNNTNI
2710 2720 2730 2740 2750
LQVDKIKMGK NGAPDVCLEN EKRPFVQGVC FEMEQGVESF TGGQISQVPE
2760 2770 2780 2790 2800
SDIRINDGVL MEQTQRNITF TDDFKVHCKP SAAETSVPSF FGEGLLDVNH
2810 2820 2830 2840 2850
FDTNMCVDET SLHVTSTKVY SDSQLSESKS TDGETSKLPC ISLNLDKQEL
2860 2870 2880 2890 2900
SPEVNCGPIF KNQEVKRLLP DTALFSPVPE KEHFTDRLVN KHSEKITTIT
2910 2920 2930 2940 2950
ENVSKDLQKL QNDKQQGQIP ISQCDLPMVS DQKPFTTSNY VPSENLPFSQ
2960 2970 2980 2990 3000
DLSQSDMSSV SRIFQKSGNI EFYSEVDMMY FDSQKYVKKY NDKIQQKLSE
3010 3020 3030 3040 3050
KELVIEHEQQ REGSCLTQDL YLCALNKSSV QSVINIQQEC ELIQTSGDLT
3060 3070 3080 3090 3100
VGKPNKNTVK QPKYLTDAEP KVNTDNPAKE NSEKVTVKPE KDLTAGTIKE
3110 3120 3130 3140 3150
GTRKPIKDIK SKQIKEDVVN PATNFKTEIP TEHTVKPSNG VISKEDTVTS
3160 3170 3180 3190 3200
VRALTDVRFK QDAIKPTRQL ALVKSKEGTF KPSRKPKEDP VKVDQSLMEG
3210 3220 3230 3240 3250
NSKDETVNES NDRKEGPPKK KAEARPIEDT IEPGRDFALE KPKDSYTISI
3260 3270 3280 3290 3300
KQTCLEHEEN LVSYLSMLRD IEVRLGPVQP IPPSIKEVEE QLKQAEVLDL
3310 3320 3330 3340 3350
ELRQLMSPVS QELDFAKRII SDQPTEVPVQ LLRALEKDAK NLEKSLTSIK
3360 3370 3380 3390 3400
GNSELRVKQL QDALKTEKGK ILVEHKELES KLHYLLQWVK ETTDSLDSAK
3410 3420 3430 3440 3450
TNDDLRLDAE KLQKELNHAE SLRRPLTDTR QKLDNIAFDI QFFISEKAQD
3460 3470 3480 3490 3500
LTPQQSRTLL RLLNELQRSF RELSERLVAW EEVLQLCQKQ TKYNTEFKIL
3510 3520 3530 3540 3550
QEQQATCSKE FEELASWAEH TEKALPSLQT FHKTTDLSSL MEQQKAVQVL
3560 3570 3580 3590 3600
HKDVQSRGKH FSRVIRAAED FLAENKLKMD PVELESFQKK LQQAKERYHA
3610 3620 3630 3640 3650
VLEKTGDTEK QLESAVSTAV LEETKKSETA EELKVNLGKI ESLLSQVRPS
3660 3670 3680 3690 3700
YALLKTVPDG SALSNQSMQN RCLPPDETSF MVNELYERKK TQHQEMLEQQ
3710 3720 3730 3740 3750
QNFILTIQSA QDFLDKHGNT LCPEERQQLQ NQLAQLKEEY SASMSQAQLQ
3760 3770 3780 3790 3800
LKNAQVLRDE MQNFIRDHGE FEHWLIHTEE ELDNMHKGKK DYNALKNLLN
3810 3820 3830 3840 3850
QQMNISEDII SHKGDLRYIN LAGQKAIEAE KATADQCKED FEMVAGAMVK
3860 3870 3880 3890 3900
NKLEEASKRY STLQSKCSKL GCHLNVVLDR YQQFQEGSDT AVAWLQVTEL
3910 3920 3930 3940 3950
EVDRILSEPV ASDPEVLQNQ LAKAKGMQSN FAEHQVQVEK VHKALRMLLE
3960 3970 3980 3990 4000
IQDDPIPDCR SVQDIADSID RRFQNLSNQM SSHSDLLQKT VAQSQSVQDA
4010 4020 4030 4040 4050
LENLLQWLKE MEKTLAEQKH TRMSSASVEE ALAVNMKLKQ DISSRRGSMD
4060 4070 4080 4090 4100
ATGEMVGKFM ETADSAAASA LHSKLSEVTS RFNEVCMQQR LQENALKEIL
4110 4120 4130 4140 4150
PKVEKYEQFS NELQDFTVTR SHLLASGNQP ERDITQFSEQ IKELNAEIKQ
4160 4170 4180 4190 4200
QEGHLLMVEQ LARELSASPI LTDASEHLQK LATLKKDFAE LREAALARES
4210 4220 4230 4240 4250
ETLSCQESLE QFQKLVGVMR KWLKEKEDIV PSAEDSLKTC EMMSRLQQVK
4260 4270 4280 4290 4300
DLLSEWEMKS PKMAEIAQKG SELECCIMEI TASACQRKGG SLLMATGSSL
4310 4320 4330 4340 4350
GNVNGYHTCQ DLTGIQCDVS ETSQKFENLG LLLHKREEQL SKMLENFEKI
4360 4370 4380 4390 4400
KQETNHMLKW LESKEKTMTA VNVSPTKSEV VKAQAKQNKE FLSELEQSTE
4410 4420 4430 4440 4450
KVESLKAALR DLLEKHPNSP EAENWKTMLE NLDQQWGRVN QVTAERQHKL
4460 4470 4480 4490 4500
EESANQLATF QVAGSQLCPW LKEKELMMSV LGPLSVDPNM LNAQKQQVQF
4510 4520 4530 4540 4550
MLKEFEARKA QYEELKLAAY GILTGPGEES PSTCQVEEEF HNISGKWMEL
4560 4570 4580 4590 4600
TSRLNSRADQ IDQATIKSSQ YKEVLQRLTD KIKQAGKNLA AQPAVSTQPD
4610 4620 4630 4640 4650
AVKQQLQETS GIRSELEQLA KEVTDAQKLC NELSALVMEP YLKDELQKRL
4660 4670 4680 4690 4700
DTVALPLKGM EDLAVDRVNR LQTALSSSQQ FQQMFDELRS WLDEKQLQHV
4710 4720 4730 4740 4750
KSHPVSAKLE KLQIQLQEQE EFQKSLSQYS GSYEMIVAEG ESLLMSAQPG
4760 4770 4780 4790 4800
EEKTTLQNQL VNLKSNWNEL GKQSSERHGK LKDCLQKAQK YVRHVEDMVP
4810 4820 4830 4840 4850
WLEDCEIHMK EMEITLDPVQ LEAQLLRAKA LQTDIDKKRS LLEMMNSAAD
4860 4870 4880 4890 4900
LLIEAAEIDD RDILEERAKI NQRIDAITEE LHNKSGSFEE MSLRLKELKD
4910 4920 4930 4940 4950
SFSNIDKKME GAKHLLEIFT ALGPQACSSK NLESMRSQQD MLLGLDSQIL
4960 4970 4980 4990 5000
YLKNLIQGLI ADVPQDSDVS HLVYQAQQVQ HDFEIVKEDV NECCANMETK
5010 5020 5030 5040 5050
LQGIGQFHSH VREMFSELAD LDDELDSMGP VGRDIDSLKS QAEVIQKFLE
5060 5070 5080 5090 5100
ALLSLKSSIE SSECKCRDML EKEGGPDLIV LMRELGTLNK QCSKLTERGK
5110 5120 5130 5140 5150
NRQGQLVATL RRVEEFNMKL KELNHQIVTA EGSSVLQGVV GTEVDTIKQQ
5160 5170 5180 5190 5200
LDNFKVFQKE QVDSLQAKLH QVNGIGQGLI QSADKNCDVH GLEHDTEELN
5210 5220 5230 5240 5250
IKWNTLNKKV AERVTQLQEA LLHCGKFQDA LEPLLSWLTD TEDLIANQKP
5260 5270 5280 5290 5300
PSAEYKVVKA QIQEQKLLQR LLDDRRTTVE MIQAEGVRIA EGADPADGDK
5310 5320 5330 5340 5350
ISHQLEILAE RWSLLLQKAQ SRQKQLEDIL VLAKQFHETT EPIFDWLSAT
5360 5370 5380 5390 5400
EKKLANSEPI GTQTGKIQQQ IQRHKSLEGD ITVHETDVHQ ANKLGGSLAA
5410 5420 5430 5440 5450
LCSNAEQERL SQKLEFLQAR YSEVQDLCSR KGTLLGQALI NARLFGEDEV
5460 5470 5480 5490 5500
EVLNWLGDVE DRLNSVCVKD YKPEVLQNQH KQHMALNEDI INRKKNVDQA
5510 5520 5530 5540 5550
IKNGQALLKQ TTGEEVLLIQ EKLDGIKTRY SEITASSGKA LKTLEQALQL
5560 5570 5580 5590 5600
AGKFQATHDE LTGWLRRAED ELSQSFGQSP SGDMIPQFQQ QQKELKKEAM
5610 5620 5630 5640 5650
EYRIVLDTIN EVGSALLELV PWRAREGLDK LVADANEQYR SISDTIGQRV
5660 5670 5680 5690 5700
DQIDAAIQRS QQYEQAADAE LAWVAETKRK LLALGSICLE QDQTTAQLQV
5710 5720 5730 5740 5750
QKAFSVDIIR HKDSIDELIS TEEEILATCG DEQKSVLQEK TKNLVQHYED
5760 5770 5780 5790 5800
ISHLNSERYA RLERAQVLVG QFWETYEELI PWIDEMQVLF SQLPPPAVDH
5810 5820 5830 5840 5850
EMLRQQQEEM RQLRESVAEH KPHIDKLLKI GPHLSELNPE EGTAVQEKYR
5860 5870 5880 5890 5900
SAEKLYVGIK EEVRKRAMVL DDALAQAAQF HDKIGPMLET LESMASRLRM
5910 5920 5930 5940 5950
PPLIPAEVEK IRECISENKN AVMELEKLQP AFQALKHRGE ELISRSQGPD
5960 5970 5980 5990 6000
IDPAAKDIQD KLDQLVFFWE DIKARADERE SKFLDVLELA EKFWLDMNTL
6010 6020 6030 6040 6050
LTTIKDTHEI VHDLESPGID PSMIKQQIEA ADSIKEETDG LHEELEFIRI
6060 6070 6080 6090 6100
LGADLIFACG ETEKPEVKKS IDEMNTAWEN LKRTWAERIE KLRDAMSHAV
6110 6120 6130 6140 6150
QYQDSLQAMF DWLDNTVIKL CDMPPVGTDI STVKEQIEEM KEFKVEVYQQ
6160 6170 6180 6190 6200
QIEMEKLNHQ GELMLKKAID DTDRDIIQGP LTELKHLWEN LGEKIAHRQQ
6210 6220 6230 6240 6250
KLEDSLLALG QFQHALAELM SWLTHTNELL NAQRPICGDP KVIEVELAKH
6260 6270 6280 6290 6300
HVLKNDVLAH QSTVQIVNKA GNELLESSAG DDASSLRTRL ETLNQLWEIV
6310 6320 6330 6340 6350
LQKTEEREQQ LDMALQQAQG FSGEIEDFIQ WQTNIESQLS AAKPTGGLPE
6360 6370 6380 6390 6400
TAREQLQAHM ELFAEIKANE DLYRHLLDKG QLMLISRDDA TGSITEQNVS
6410 6420 6430 6440 6450
ILKRKWQAIS NKVEERKAKL EEALTLATDF QNSLQDFINW LTQAEQSLNI
6460 6470 6480 6490 6500
APSPSLILDT VLFQIDEHKV FVNEVNIHRE HIIELDKIGN QLKFLSQKQD
6510 6520 6530 6540 6550
VVLIKNLLLS VQSRWEKVVQ RSVERGRSLD DARKRAKQFH EAWKKLIDWL
6560 6570 6580 6590 6600
EEAENHLDSE LEISNDPDKI KLQLSKHKEF QKTLGSKQPV YDTTVRTGRA
6610 6620 6630 6640 6650
LKEKALLSGD VQKLDHLLGE VRDKWDTVCG KSVERQHKLE EALLFSGQFM
6660 6670 6680 6690 6700
DALQALVDWL YKVEPQLAED QPLHGDLDLV MNLMDAHKVF QKELGKRTSS
6710 6720 6730 6740 6750
VQALKRSARE LLESSREDTT WVKVQLQELS TRWDTVCKLS VSKQTRLEQA
6760 6770 6780 6790 6800
LKQAEEFHAA VHMLLEWLSE AEQTLRFRGA LPDDAESLQS LIDIHKEFMR
6810 6820 6830 6840 6850
KVEEKQIDVN TAVSMGEEIL TMCHPDCITT IKHWITIIRA RFEEVLTWGN
6860 6870 6880 6890 6900
QHQQRLQTAL SELLANSELL DELLSWIQWA ETTLIQRGQD PMPQNIDQVK
6910 6920 6930 6940 6950
ALISEHQVFM EEMTQKQPDV DRVTKTYKRK TTDTNHASFN DKTRRKHSVQ
6960 6970 6980 6990 7000
NATPVLPVLS QPETKNPRIN QLSARWQQVW LLALERQRKL NDALDRLEEL
7010 7020 7030 7040 7050
KEFANFDFDI WRKKYMRWMN HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI
7060 7070 7080 7090 7100
LASKFPTTRL EMTAVADIFD RDGDGYIDYY EFVAALHPNK DAYRPTTDAD
7110 7120 7130 7140 7150
KIEDEVTRQV AQCKCAKRFQ VEQIGENKYR FFLGNQFGDS QQLRLVRILR
7160 7170 7180 7190 7200
STVMVRVGGG WMALDEFLVK NDPCRVHHPG NKLKRTDSIS SIARGRTNLE
7210 7220 7230 7240 7250
LREKFILPEG VSQGMTPFRS RGRRSKPSSR TASPTRSSSS ASQSNHSCTS
7260 7270 7280 7290 7300
VPSSPATPAS GSKTPQHLSR CYEKPWLVNS KASTPIRCAE YPDFHTPSPE
7310 7320 7330 7340 7350
VTPAQGSKLK KAAVHTSRSS LTGDTPTSSS AKSGRADPKK SASRAGSRAG
7360 7370 7380 7390 7400
SRASSRRGSD ASDFDLLETQ SACSDTSESS AAGGPGSSRR GLSKPSKIPT
7410
MSKKTASTPK TQGTKR
Length:7,416
Mass (Da):842,735
Last modified:June 2, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F6E2ACCFC731037
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSXETT00000086213; ENSXETP00000071844; ENSXETG00000007367

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSXETT00000086213; ENSXETP00000071844; ENSXETG00000007367

Organism-specific databases

XenbaseiXB-GENE-494799, macf1

Phylogenomic databases

GeneTreeiENSGT00940000155824

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 16 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
3.90.1290.10, 4 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF00681, Plectin, 4 hits
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 15 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00250, PLEC, 13 hits
SM00150, SPEC, 34 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 4 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6I8QG99_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6I8QG99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 12, 2020
Last sequence update: June 2, 2021
Last modified: May 25, 2022
This is version 8 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
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