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Entry version 4 (10 Feb 2021)
Sequence version 1 (12 Aug 2020)
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Protein

3C-like proteinase

Gene

orf1a

Organism
Pangolin coronavirus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
Leader proteinARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Papain-like proteinaseARBA annotation
p65 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orf1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPangolin coronavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2708335 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusSarbecovirusunclassified Sarbecovirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2221 – 2245HelicalSequence analysisAdd BLAST25
Transmembranei2329 – 2351HelicalSequence analysisAdd BLAST23
Transmembranei2357 – 2379HelicalSequence analysisAdd BLAST23
Transmembranei2764 – 2782HelicalSequence analysisAdd BLAST19
Transmembranei3035 – 3057HelicalSequence analysisAdd BLAST23
Transmembranei3069 – 3093HelicalSequence analysisAdd BLAST25
Transmembranei3128 – 3149HelicalSequence analysisAdd BLAST22
Transmembranei3574 – 3597HelicalSequence analysisAdd BLAST24
Transmembranei3603 – 3621HelicalSequence analysisAdd BLAST19
Transmembranei3628 – 3649HelicalSequence analysisAdd BLAST22
Transmembranei3675 – 3693HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1017 – 1183MacroInterPro annotationAdd BLAST167
Domaini1626 – 1890Peptidase C16InterPro annotationAdd BLAST265
Domaini3256 – 3561Peptidase C30InterPro annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni927 – 952DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili968 – 988Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi927 – 941AcidicSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6G9KMG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EARQHLLDGT
60 70 80 90 100
CGIIDVEKGV LPQLEQPYVF VKRSDARTAP HGHVMVELVA ELDGVQYGRS
110 120 130 140 150
GETLGVLVPH VGETPVAYRK ILLRKNGNKG AGGHSFGIDL KSYDLGDELG
160 170 180 190 200
TDPIDDFQVN WNTKHGSGVT RELMRELNGG AYTRYVDNNF CGPDGYPLEC
210 220 230 240 250
IKDLLARAGK SSCSLSEQLD FIDTKRGVYC CREHEHEIVW YTERSDKSYE
260 270 280 290 300
LQIPFEIKLA KKFDNFTGEC PNFVFPLNST IKTIQPRVEK KKLEGFMGRI
310 320 330 340 350
RSVYPVASPN ECNPMHLSTL MKCEHCSETS WQTGDFLKAT CEFCGTENQV
360 370 380 390 400
KEGPTTCGYL PQNAVVKIFC PACHNPEMGP EHSLAEYHNE SGIKTTLRKG
410 420 430 440 450
GRTKAFGGCV FSYVGCHNKC AYWVPRAAAN VGCNHTGVVG EGSESLNDNL
460 470 480 490 500
LEILTKEKVN INIVGDFKLT EEIAIILASF SASTSAFVET VKGLDYKSFK
510 520 530 540 550
QIVESCGNFK VTKGKFKKNA WNIGEPKSIL SPLYAFPSEA ARVVRSIFSR
560 570 580 590 600
TLETAQHSVR VLQKAAITIL DGISQYSLRL IDAMLFTSEL TTDSIVVMAY
610 620 630 640 650
VTGGVVQMTT QWLTNIFGTV YEKLKPILDW LEEKFKEGIE FLKDGWEIVK
660 670 680 690 700
FITTCSCEII GGQLVAFTTE LKDSVKKFFK LVNKFLALCA DSIVIGGAKL
710 720 730 740 750
KALNLGETFV AHSRGLYKKC VKSRGDSGLL MPLKAPKEVI FLDGETLPTE
760 770 780 790 800
VLSEEVILKT GELQPLEEPT AQAVEVPLVG TPVCINGLML LEIKDTEKYC
810 820 830 840 850
ALAPNMMVTN NTFTLKGGAP TKVTFGDDTV IEVQGYKNVN ITFELDERVD
860 870 880 890 900
KVLNEKCSNY TVELGTNIDE LACVVAEAVI KTLQPVSELL TPLGIDLDEW
910 920 930 940 950
GVATYYLFDE SGEYTLSSRM YCSFYPPDED YEEEYSEEEQ PEQPTQYEYG
960 970 980 990 1000
TESDYKGLPL EFGASSVQQQ EEQEEDWLET EAEVVEQEVT PTEQEEELPI
1010 1020 1030 1040 1050
TEIVPAVEQT TIVELECDNF TGYLKLTDNV SIKNVDIVSE AKNVKPTIVV
1060 1070 1080 1090 1100
NAANVHLKHG GGVAGALNKA TNNAMQIESD DYIARNGPLN VGGSCLLNGH
1110 1120 1130 1140 1150
NLAKNCLHVV GPNLNKGEDI QLLKVAYENF NHHEKLLAPL LSAGIFGAQP
1160 1170 1180 1190 1200
IQSLKVCIET VRTQVFLAVF DKDLYEELVA SFLEMKSETK VQDHFDVVET
1210 1220 1230 1240 1250
KVEITPEESA SSEKPTKEEP KKVKPCIEEV TTTLEETKFL TENLLLYADI
1260 1270 1280 1290 1300
NGNLYPDSTS LVEXVDVTFL KKDAPYIVGD IITSGNLTTV VIPTKKAGGT
1310 1320 1330 1340 1350
TEMLAKALRK VPTDHYITTY PGQGCVGYTI EEAKTALKKS KSAYYVLPSI
1360 1370 1380 1390 1400
IPNKKEEILG TVSWNLREML THAEETRKLM PICMDTKAIM STVQRKYKGI
1410 1420 1430 1440 1450
KIQEGVVDYG VRFYFYTSKT PVATLIATLN SLGETLVTMP LGYVTHGLNL
1460 1470 1480 1490 1500
EEAARYMRSL KVPATVSVSS PDAVTAYNGY LTSSSKTPEE HFIETISLAG
1510 1520 1530 1540 1550
SYKDWSYSGQ ATELGIEFLK RGDKVVYHTT SKPITFHMDG EVINIDSLKT
1560 1570 1580 1590 1600
LLALREVKTI KVFTTVDNIN LHTQVVDMSM TYGQQFGPTY LDGADVTKIK
1610 1620 1630 1640 1650
PHASHDSKTF YVLPNDDTLR SEAFEYYHTT DESFLGRYMS ALNHTKKWKF
1660 1670 1680 1690 1700
PQVNGLTSIK WADNNCYLAT ALLTLQQIEL KFNPPALQDA YYRARAGDAA
1710 1720 1730 1740 1750
NFCALILAYC NKTVGELGDV RETMSHLFQH ANLDSCKRVL NVVCKTCGQQ
1760 1770 1780 1790 1800
QTTLKGVEAV MYMGTLSYEQ LKRGVTVPCV CGRQATQYLV QQESSFVMMS
1810 1820 1830 1840 1850
APPAEYKLKH GTFLCASEYT GNYQCGHYKH ITSKETLYVI DGALLSKTSE
1860 1870 1880 1890 1900
YKGPVTDVFY KENSYTTTIK PIVYKLDGVV CTEIDPKLDG YYKKDNAYFT
1910 1920 1930 1940 1950
EQPIDLVPTQ PYPNSNFDNF KFVCDNTKFA DDLNQMSGYK KPASRELKIT
1960 1970 1980 1990 2000
FFPDLNGDVV AIDYKHYTPS FKKGAKLLHK PIVWHVNNTI NKATFKPNTW
2010 2020 2030 2040 2050
CLRCLWSTKP VETSNIFDVL QSEDTQGMET LACEDTKLVT EEVVETPTIQ
2060 2070 2080 2090 2100
KDIVECDVKT TEVVGDVILK PVQDGVKITE EVGHEDLMAA YVDNTSLTIK
2110 2120 2130 2140 2150
KPNELSVMLG LKTLKIHGLA AVNSVPWDTI VTYAKPFLNK VTSVAASGVA
2160 2170 2180 2190 2200
RCLNRICVNY MPYVLTLLLQ FCTFTRSTNS RIKASMPTTI AKNTVKSVGK
2210 2220 2230 2240 2250
FCLEASFNYL KSPNFSKLIT IIVWFLLLSV CLGSLIYSSA ALGVLMSNLG
2260 2270 2280 2290 2300
MPSYCTSYRD GYLNSTNVTT TAYCTGSIPC SVCLSGMDSL DAYPALETIQ
2310 2320 2330 2340 2350
VTIXSFKWDL TAFGIIAEWC LAYILFTRFF YVLGLAAIMQ LFFGYFAVHF
2360 2370 2380 2390 2400
ISNSWLMWLI INLVQMAPIS AMVRMYIFFA SFYYVWKSYI HVVDGCTSST
2410 2420 2430 2440 2450
CMMCYKRNRA TRVECTTIVN GVRRSFYVYA NGGKGFCKLH NWNCVNCDTF
2460 2470 2480 2490 2500
CAGSTFISDE VARDLSLQFK RPINPTDQSS YVVDSVAVKN GSLHLYFDKA
2510 2520 2530 2540 2550
GQKTYERHSL SHFVNLDNLR ANNTKGSIPI NVIVFDGKSK CDESSARAAS
2560 2570 2580 2590 2600
VYYSQLMCQP ILLLDQALVS DVGDSAEVAV KMFDAYVNTF SSTFNVPMDK
2610 2620 2630 2640 2650
LKTLIATAET ELAKNVSLDN VLSTFISAAR QGFVDSDVDT KDVVECLKIS
2660 2670 2680 2690 2700
HQSDIEVTGD SCNNYMLTYN KVENMTPRDL GACIDCSARH INAQVAKSHN
2710 2720 2730 2740 2750
ISLIWNIKDF MSLSEQLRKQ IRSAAKKNNL PFKLTCATTR QVVNVVTTKI
2760 2770 2780 2790 2800
ALKGGKFVTN WFKYLLKATL VCVVIACVFY FITPVHVLTK HGDFADEIIG
2810 2820 2830 2840 2850
YKAIEDGVTR DISSNDNCFA NKHVGFDSWF SQRGGSYTND KTCPIVAAVI
2860 2870 2880 2890 2900
TRDVGFVVPG LPGTIFRTLS GDFLHFLPRV FSAVGNICYT PSKLIEYTDF
2910 2920 2930 2940 2950
ATSACVLAAE CTIFKDAAGK PVPYCYDTNV LEGSVPYESL RPDTRYVLMD
2960 2970 2980 2990 3000
GSIIQFPNTY LEGSVRVVTT FDSEYCRHGT CEKSEAGICV STSGRWVLNN
3010 3020 3030 3040 3050
DYYRSLPGVF CGVDSVNLLT NMFTPLIQPI GALDISASIV AGGLVAIFVT
3060 3070 3080 3090 3100
CLAYYFMRFR RAFGEYSHVV AFNTLLFLMS FTVLCLTPVY SFLPGVYSVF
3110 3120 3130 3140 3150
YLYLTFYLTN DVSFLAHVQW MVMFTPLVPF WITIVYVICI STKHCYWFFS
3160 3170 3180 3190 3200
NYLRRRVVFN GTSFSTFEEA ALCTFLLNKE MYLKLRSETL LPLTQYNRYL
3210 3220 3230 3240 3250
ALYNKYKYFS GAMDTTSYRE AACCHLAKAL NDFSNSGSDV LYQPPQTSIT
3260 3270 3280 3290 3300
SAVLQSGFRK MAFPSGKVEG CMVQVTCGTT TLNGLWLDDV VYCPRHVICT
3310 3320 3330 3340 3350
AEDMLNPNYE DLLIRKSNHN FLVQAGNVHL RVIGHSMQNC VLKLKVDAAN
3360 3370 3380 3390 3400
PKTPKYKFVR IQPGQTFSVL ACYNGSPSGV YQCAMRPNFT IKGSFLNGSC
3410 3420 3430 3440 3450
GSVGFNIDYD CVSFCYMHHM ELPTGVHAGT DLEGTFYGPF VDRQTAQAAG
3460 3470 3480 3490 3500
TDTVITINVL AWLYAAVING DRWFLNRYTT TLNDFNLVAM KFNYEPLTQD
3510 3520 3530 3540 3550
HVDILGPLSA QTGIAVLDMC ASLKELLQNG VNGRTILGSA ILEDEFTPFD
3560 3570 3580 3590 3600
VVRQCSGVTF QSAIKRTVKG THHWLLLTIL TSLLVLVQST QWSLFFFVYE
3610 3620 3630 3640 3650
NAFLPFALGI IAMSAFAMMF VKHKHAFLCL FLLPSLATVA YFNMVYMPAS
3660 3670 3680 3690 3700
WVMRIMTWLD MVDTSLSGYK LKDCIMYASA IILLILMTAR TVYDDGARRV
3710 3720 3730 3740 3750
WTLMNVLTLV YKVYYGNALD QAISMWALII SVTSNYSGVV TTVMFLARGI
3760 3770 3780 3790 3800
VFMCVEYCPI LFITGNTLQC IMLVYCFLGY FCTCYFGLFC LLNRYFRLTL
3810 3820 3830 3840 3850
GVYDYLVSTQ EFRYMNSQGL LPPKNSIDAF KLNVKLLGIG GKPCIKVATV
3860 3870 3880 3890 3900
QSKMSDVKCT SVVLLSVLQQ LRVESSSKLW AQCVQLHNDI LLAKDTTEAF
3910 3920 3930 3940 3950
EKXVSLLSVL LSMQGAVDIN KLCEEMLDNR ATLQAIASEF SSLPSYAAFA
3960 3970 3980 3990 4000
TAQEAYEQAV ANGDSEVVLK KLKKSLNVAK SEFDRDAAMQ RKLEKMADQA
4010 4020 4030 4040 4050
MTQMYKQARS EDKRAKVTSA MQTMLFTMLR KLDNDALNNI INNARDGCVP
4060 4070 4080 4090 4100
LNIIPLTTAA KLMVVVPDYN TYKNTCEGST FTYASALWEI QQVVDADSKI
4110 4120 4130 4140 4150
VQLSEITMDN SPNIAWPLIV TALRANSAVK LQNNELSPVA LRQMSCAAGT
4160 4170 4180 4190 4200
TQTACNEDNA LAYYNTSKGG RFVLALLSDL QDLKWARFPK SDGTGTIYTE
4210 4220 4230 4240 4250
LEPPCRFVTD TPKGPKVKYL YFIKGLNNLN RGMVLGSLAA TVRLQAGNAT
4260 4270 4280 4290 4300
EVPANSTVLS FCAFAVDASK AYRDYLASGG QPITNCVKML CTHTGTGQAI
4310 4320 4330 4340 4350
TVTPEANMDQ ESFGGASCCL YCRCHIDHPN PKGYCELKGK YVQIPTTCAN
4360 4370 4380 4390
DPVGFTLKNT VCTVCGMWKG YGCSCDQLRE PMLQSADAQS FLNGFAV
Length:4,397
Mass (Da):489,117
Last modified:August 12, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA218754E28829DA
GO

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
MT072864 Genomic RNA Translation: QIQ54046.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MT072864 Genomic RNA Translation: QIQ54046.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6G9KMG9_9BETC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6G9KMG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 12, 2020
Last sequence update: August 12, 2020
Last modified: February 10, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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