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UniProtKB - A0A6G9KMG9 (A0A6G9KMG9_9BETC)

Entry version 4 (10 Feb 2021)
Sequence version 1 (12 Aug 2020)
Previous versions | rss
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Protein

3C-like proteinase

Gene

orf1a

Organism
Pangolin coronavirus
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, RNA-bindingARBA annotation, Thiol proteaseARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3C-like proteinaseARBA annotation (EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation)
Alternative name(s):
Growth factor-like peptideARBA annotation
Leader proteinARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
Papain-like proteinaseARBA annotation
p65 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orf1aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPangolin coronavirusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2708335 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Sarbecovirus › unclassified Sarbecovirus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2221 – 2245HelicalSequence analysisAdd BLAST25
Transmembranei2329 – 2351HelicalSequence analysisAdd BLAST23
Transmembranei2357 – 2379HelicalSequence analysisAdd BLAST23
Transmembranei2764 – 2782HelicalSequence analysisAdd BLAST19
Transmembranei3035 – 3057HelicalSequence analysisAdd BLAST23
Transmembranei3069 – 3093HelicalSequence analysisAdd BLAST25
Transmembranei3128 – 3149HelicalSequence analysisAdd BLAST22
Transmembranei3574 – 3597HelicalSequence analysisAdd BLAST24
Transmembranei3603 – 3621HelicalSequence analysisAdd BLAST19
Transmembranei3628 – 3649HelicalSequence analysisAdd BLAST22
Transmembranei3675 – 3693HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1017 – 1183MacroInterPro annotationAdd BLAST167
Domaini1626 – 1890Peptidase C16InterPro annotationAdd BLAST265
Domaini3256 – 3561Peptidase C30InterPro annotationAdd BLAST306

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni927 – 952DisorderedSequence analysisAdd BLAST26

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili968 – 988Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi927 – 941AcidicSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6G9KMG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EARQHLLDGT 
        60         70         80         90        100
CGIIDVEKGV LPQLEQPYVF VKRSDARTAP HGHVMVELVA ELDGVQYGRS 
       110        120        130        140        150
GETLGVLVPH VGETPVAYRK ILLRKNGNKG AGGHSFGIDL KSYDLGDELG 
       160        170        180        190        200
TDPIDDFQVN WNTKHGSGVT RELMRELNGG AYTRYVDNNF CGPDGYPLEC 
       210        220        230        240        250
IKDLLARAGK SSCSLSEQLD FIDTKRGVYC CREHEHEIVW YTERSDKSYE 
       260        270        280        290        300
LQIPFEIKLA KKFDNFTGEC PNFVFPLNST IKTIQPRVEK KKLEGFMGRI 
       310        320        330        340        350
RSVYPVASPN ECNPMHLSTL MKCEHCSETS WQTGDFLKAT CEFCGTENQV 
       360        370        380        390        400
KEGPTTCGYL PQNAVVKIFC PACHNPEMGP EHSLAEYHNE SGIKTTLRKG 
       410        420        430        440        450
GRTKAFGGCV FSYVGCHNKC AYWVPRAAAN VGCNHTGVVG EGSESLNDNL 
       460        470        480        490        500
LEILTKEKVN INIVGDFKLT EEIAIILASF SASTSAFVET VKGLDYKSFK 
       510        520        530        540        550
QIVESCGNFK VTKGKFKKNA WNIGEPKSIL SPLYAFPSEA ARVVRSIFSR 
       560        570        580        590        600
TLETAQHSVR VLQKAAITIL DGISQYSLRL IDAMLFTSEL TTDSIVVMAY 
       610        620        630        640        650
VTGGVVQMTT QWLTNIFGTV YEKLKPILDW LEEKFKEGIE FLKDGWEIVK 
       660        670        680        690        700
FITTCSCEII GGQLVAFTTE LKDSVKKFFK LVNKFLALCA DSIVIGGAKL 
       710        720        730        740        750
KALNLGETFV AHSRGLYKKC VKSRGDSGLL MPLKAPKEVI FLDGETLPTE 
       760        770        780        790        800
VLSEEVILKT GELQPLEEPT AQAVEVPLVG TPVCINGLML LEIKDTEKYC 
       810        820        830        840        850
ALAPNMMVTN NTFTLKGGAP TKVTFGDDTV IEVQGYKNVN ITFELDERVD 
       860        870        880        890        900
KVLNEKCSNY TVELGTNIDE LACVVAEAVI KTLQPVSELL TPLGIDLDEW 
       910        920        930        940        950
GVATYYLFDE SGEYTLSSRM YCSFYPPDED YEEEYSEEEQ PEQPTQYEYG 
       960        970        980        990       1000
TESDYKGLPL EFGASSVQQQ EEQEEDWLET EAEVVEQEVT PTEQEEELPI 
      1010       1020       1030       1040       1050
TEIVPAVEQT TIVELECDNF TGYLKLTDNV SIKNVDIVSE AKNVKPTIVV 
      1060       1070       1080       1090       1100
NAANVHLKHG GGVAGALNKA TNNAMQIESD DYIARNGPLN VGGSCLLNGH 
      1110       1120       1130       1140       1150
NLAKNCLHVV GPNLNKGEDI QLLKVAYENF NHHEKLLAPL LSAGIFGAQP 
      1160       1170       1180       1190       1200
IQSLKVCIET VRTQVFLAVF DKDLYEELVA SFLEMKSETK VQDHFDVVET 
      1210       1220       1230       1240       1250
KVEITPEESA SSEKPTKEEP KKVKPCIEEV TTTLEETKFL TENLLLYADI 
      1260       1270       1280       1290       1300
NGNLYPDSTS LVEXVDVTFL KKDAPYIVGD IITSGNLTTV VIPTKKAGGT 
      1310       1320       1330       1340       1350
TEMLAKALRK VPTDHYITTY PGQGCVGYTI EEAKTALKKS KSAYYVLPSI 
      1360       1370       1380       1390       1400
IPNKKEEILG TVSWNLREML THAEETRKLM PICMDTKAIM STVQRKYKGI 
      1410       1420       1430       1440       1450
KIQEGVVDYG VRFYFYTSKT PVATLIATLN SLGETLVTMP LGYVTHGLNL 
      1460       1470       1480       1490       1500
EEAARYMRSL KVPATVSVSS PDAVTAYNGY LTSSSKTPEE HFIETISLAG 
      1510       1520       1530       1540       1550
SYKDWSYSGQ ATELGIEFLK RGDKVVYHTT SKPITFHMDG EVINIDSLKT 
      1560       1570       1580       1590       1600
LLALREVKTI KVFTTVDNIN LHTQVVDMSM TYGQQFGPTY LDGADVTKIK 
      1610       1620       1630       1640       1650
PHASHDSKTF YVLPNDDTLR SEAFEYYHTT DESFLGRYMS ALNHTKKWKF 
      1660       1670       1680       1690       1700
PQVNGLTSIK WADNNCYLAT ALLTLQQIEL KFNPPALQDA YYRARAGDAA 
      1710       1720       1730       1740       1750
NFCALILAYC NKTVGELGDV RETMSHLFQH ANLDSCKRVL NVVCKTCGQQ 
      1760       1770       1780       1790       1800
QTTLKGVEAV MYMGTLSYEQ LKRGVTVPCV CGRQATQYLV QQESSFVMMS 
      1810       1820       1830       1840       1850
APPAEYKLKH GTFLCASEYT GNYQCGHYKH ITSKETLYVI DGALLSKTSE 
      1860       1870       1880       1890       1900
YKGPVTDVFY KENSYTTTIK PIVYKLDGVV CTEIDPKLDG YYKKDNAYFT 
      1910       1920       1930       1940       1950
EQPIDLVPTQ PYPNSNFDNF KFVCDNTKFA DDLNQMSGYK KPASRELKIT 
      1960       1970       1980       1990       2000
FFPDLNGDVV AIDYKHYTPS FKKGAKLLHK PIVWHVNNTI NKATFKPNTW 
      2010       2020       2030       2040       2050
CLRCLWSTKP VETSNIFDVL QSEDTQGMET LACEDTKLVT EEVVETPTIQ 
      2060       2070       2080       2090       2100
KDIVECDVKT TEVVGDVILK PVQDGVKITE EVGHEDLMAA YVDNTSLTIK 
      2110       2120       2130       2140       2150
KPNELSVMLG LKTLKIHGLA AVNSVPWDTI VTYAKPFLNK VTSVAASGVA 
      2160       2170       2180       2190       2200
RCLNRICVNY MPYVLTLLLQ FCTFTRSTNS RIKASMPTTI AKNTVKSVGK 
      2210       2220       2230       2240       2250
FCLEASFNYL KSPNFSKLIT IIVWFLLLSV CLGSLIYSSA ALGVLMSNLG 
      2260       2270       2280       2290       2300
MPSYCTSYRD GYLNSTNVTT TAYCTGSIPC SVCLSGMDSL DAYPALETIQ 
      2310       2320       2330       2340       2350
VTIXSFKWDL TAFGIIAEWC LAYILFTRFF YVLGLAAIMQ LFFGYFAVHF 
      2360       2370       2380       2390       2400
ISNSWLMWLI INLVQMAPIS AMVRMYIFFA SFYYVWKSYI HVVDGCTSST 
      2410       2420       2430       2440       2450
CMMCYKRNRA TRVECTTIVN GVRRSFYVYA NGGKGFCKLH NWNCVNCDTF 
      2460       2470       2480       2490       2500
CAGSTFISDE VARDLSLQFK RPINPTDQSS YVVDSVAVKN GSLHLYFDKA 
      2510       2520       2530       2540       2550
GQKTYERHSL SHFVNLDNLR ANNTKGSIPI NVIVFDGKSK CDESSARAAS 
      2560       2570       2580       2590       2600
VYYSQLMCQP ILLLDQALVS DVGDSAEVAV KMFDAYVNTF SSTFNVPMDK 
      2610       2620       2630       2640       2650
LKTLIATAET ELAKNVSLDN VLSTFISAAR QGFVDSDVDT KDVVECLKIS 
      2660       2670       2680       2690       2700
HQSDIEVTGD SCNNYMLTYN KVENMTPRDL GACIDCSARH INAQVAKSHN 
      2710       2720       2730       2740       2750
ISLIWNIKDF MSLSEQLRKQ IRSAAKKNNL PFKLTCATTR QVVNVVTTKI 
      2760       2770       2780       2790       2800
ALKGGKFVTN WFKYLLKATL VCVVIACVFY FITPVHVLTK HGDFADEIIG 
      2810       2820       2830       2840       2850
YKAIEDGVTR DISSNDNCFA NKHVGFDSWF SQRGGSYTND KTCPIVAAVI 
      2860       2870       2880       2890       2900
TRDVGFVVPG LPGTIFRTLS GDFLHFLPRV FSAVGNICYT PSKLIEYTDF 
      2910       2920       2930       2940       2950
ATSACVLAAE CTIFKDAAGK PVPYCYDTNV LEGSVPYESL RPDTRYVLMD 
      2960       2970       2980       2990       3000
GSIIQFPNTY LEGSVRVVTT FDSEYCRHGT CEKSEAGICV STSGRWVLNN 
      3010       3020       3030       3040       3050
DYYRSLPGVF CGVDSVNLLT NMFTPLIQPI GALDISASIV AGGLVAIFVT 
      3060       3070       3080       3090       3100
CLAYYFMRFR RAFGEYSHVV AFNTLLFLMS FTVLCLTPVY SFLPGVYSVF 
      3110       3120       3130       3140       3150
YLYLTFYLTN DVSFLAHVQW MVMFTPLVPF WITIVYVICI STKHCYWFFS 
      3160       3170       3180       3190       3200
NYLRRRVVFN GTSFSTFEEA ALCTFLLNKE MYLKLRSETL LPLTQYNRYL 
      3210       3220       3230       3240       3250
ALYNKYKYFS GAMDTTSYRE AACCHLAKAL NDFSNSGSDV LYQPPQTSIT 
      3260       3270       3280       3290       3300
SAVLQSGFRK MAFPSGKVEG CMVQVTCGTT TLNGLWLDDV VYCPRHVICT 
      3310       3320       3330       3340       3350
AEDMLNPNYE DLLIRKSNHN FLVQAGNVHL RVIGHSMQNC VLKLKVDAAN 
      3360       3370       3380       3390       3400
PKTPKYKFVR IQPGQTFSVL ACYNGSPSGV YQCAMRPNFT IKGSFLNGSC 
      3410       3420       3430       3440       3450
GSVGFNIDYD CVSFCYMHHM ELPTGVHAGT DLEGTFYGPF VDRQTAQAAG 
      3460       3470       3480       3490       3500
TDTVITINVL AWLYAAVING DRWFLNRYTT TLNDFNLVAM KFNYEPLTQD 
      3510       3520       3530       3540       3550
HVDILGPLSA QTGIAVLDMC ASLKELLQNG VNGRTILGSA ILEDEFTPFD 
      3560       3570       3580       3590       3600
VVRQCSGVTF QSAIKRTVKG THHWLLLTIL TSLLVLVQST QWSLFFFVYE 
      3610       3620       3630       3640       3650
NAFLPFALGI IAMSAFAMMF VKHKHAFLCL FLLPSLATVA YFNMVYMPAS 
      3660       3670       3680       3690       3700
WVMRIMTWLD MVDTSLSGYK LKDCIMYASA IILLILMTAR TVYDDGARRV 
      3710       3720       3730       3740       3750
WTLMNVLTLV YKVYYGNALD QAISMWALII SVTSNYSGVV TTVMFLARGI 
      3760       3770       3780       3790       3800
VFMCVEYCPI LFITGNTLQC IMLVYCFLGY FCTCYFGLFC LLNRYFRLTL 
      3810       3820       3830       3840       3850
GVYDYLVSTQ EFRYMNSQGL LPPKNSIDAF KLNVKLLGIG GKPCIKVATV 
      3860       3870       3880       3890       3900
QSKMSDVKCT SVVLLSVLQQ LRVESSSKLW AQCVQLHNDI LLAKDTTEAF 
      3910       3920       3930       3940       3950
EKXVSLLSVL LSMQGAVDIN KLCEEMLDNR ATLQAIASEF SSLPSYAAFA 
      3960       3970       3980       3990       4000
TAQEAYEQAV ANGDSEVVLK KLKKSLNVAK SEFDRDAAMQ RKLEKMADQA 
      4010       4020       4030       4040       4050
MTQMYKQARS EDKRAKVTSA MQTMLFTMLR KLDNDALNNI INNARDGCVP 
      4060       4070       4080       4090       4100
LNIIPLTTAA KLMVVVPDYN TYKNTCEGST FTYASALWEI QQVVDADSKI 
      4110       4120       4130       4140       4150
VQLSEITMDN SPNIAWPLIV TALRANSAVK LQNNELSPVA LRQMSCAAGT 
      4160       4170       4180       4190       4200
TQTACNEDNA LAYYNTSKGG RFVLALLSDL QDLKWARFPK SDGTGTIYTE 
      4210       4220       4230       4240       4250
LEPPCRFVTD TPKGPKVKYL YFIKGLNNLN RGMVLGSLAA TVRLQAGNAT 
      4260       4270       4280       4290       4300
EVPANSTVLS FCAFAVDASK AYRDYLASGG QPITNCVKML CTHTGTGQAI 
      4310       4320       4330       4340       4350
TVTPEANMDQ ESFGGASCCL YCRCHIDHPN PKGYCELKGK YVQIPTTCAN 
      4360       4370       4380       4390 
DPVGFTLKNT VCTVCGMWKG YGCSCDQLRE PMLQSADAQS FLNGFAV
Length:4,397
Mass (Da):489,117
Last modified:August 12, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA218754E28829DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
MT072864 Genomic RNA Translation: QIQ54046.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MT072864 Genomic RNA Translation: QIQ54046.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR043613, CoV_NSP2_C
IPR043615, CoV_NSP2_N
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043610, CoV_NSP6
IPR022733, DPUP_SUD_C_bCoV
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR042570, NAR_sf
IPR036333, NSP10_sf_CoV
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR018995, RNA_synth_NSP10_CoV
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52949, SSF52949, 1 hit
PROSITEiView protein in PROSITE
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6G9KMG9_9BETC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6G9KMG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 12, 2020
Last sequence update: August 12, 2020
Last modified: February 10, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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