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UniProtKB - A0A6D2XY77 (A0A6D2XY77_PONAB)

Entry version 4 (02 Dec 2020)
Sequence version 1 (17 Jun 2020)
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Protein
Submitted name:

BIRC2 isoform 10

Gene

CR201_G0025482

Organism
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BIRC2 isoform 10Imported
Submitted name:
BIRC2 isoform 12Imported
Submitted name:
BIRC2 isoform 6Imported
Submitted name:
BIRC2 isoform 7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CR201_G0025482Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9601 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pongo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000236516 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini432 – 522CARDInterPro annotationAdd BLAST91
Domaini550 – 585RING-typeInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili406 – 435Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IAP family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		FQRLTCV

Database of Orthologous Groups

More...OrthoDBi		1340284at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6D2XY77-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDSTILSDW TNSNKQKMKY DFSCELYRMS TYSTFPAGVP VSERSLARAG 
        60         70         80         90        100
FYYTGVNDKV KCFCCGLMLD NWKLGDSPIQ KHKQLYPSCS FIQNLVSASL 
       110        120        130        140        150
GSTSKNTSPM RNSFAHSLSP TLEHSSLFSG SYSSLSPNPL NSRAVEDFSS 
       160        170        180        190        200
SRTNPYSYAM STEEARFLTY HMWPLTFLSP SELARAGFYY IGPGDRVACF 
       210        220        230        240        250
ACGGKLSNWE PKDDAMSEHR RHFPNCPFLE NSLETLRFSI SNLSMQTHAA 
       260        270        280        290        300
RMRTFMYWPS SVPVQPEQLA SAGFYYVGRN DDVKCFCCDG GLRCWESGDD 
       310        320        330        340        350
PWVEHAKWFP RCEFLIRMKG QEFVDEIQGR YPHLLEQLLS TSDTTGEENA 
       360        370        380        390        400
DPPIIHFGPG ESSSEDAVMM NTPVVKSALE MGFNRDLVKQ TVQSKILTTG 
       410        420        430        440        450
ENYKTVNDIV SALLNAEDEK REEEKEKQAE EMASDDLSLI RKNRMALFQQ 
       460        470        480        490        500
LTCVLPILDN LLKANVINKQ EHDIIKQKTQ IPLQARELID TILVKGNAAA 
       510        520        530        540        550
NIFKNCLKEI DSTLYKNLFV DKNMKYIPTE DVSGLSLEEQ LRRLQEERTC 
       560        570        580        590 
KVCMDKEVSI VFIPCGHLVV CQECAPSLRK CPICRGIIKG TVRTFLS
Length:597
Mass (Da):67,562
Last modified:June 17, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i318E81FD3C51786E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
NDHI03003296 Genomic DNA Translation: PNJ86585.1
NDHI03003296 Genomic DNA Translation: PNJ86586.1
NDHI03003296 Genomic DNA Translation: PNJ86589.1
NDHI03003296 Genomic DNA Translation: PNJ86590.1

NCBI Reference Sequences

More...RefSeqi		XP_009245268.1, XM_009246993.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100457858

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		pon:100457858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NDHI03003296 Genomic DNA Translation: PNJ86585.1
NDHI03003296 Genomic DNA Translation: PNJ86586.1
NDHI03003296 Genomic DNA Translation: PNJ86589.1
NDHI03003296 Genomic DNA Translation: PNJ86590.1
RefSeqiXP_009245268.1, XM_009246993.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi100457858
KEGGipon:100457858

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		329

Phylogenomic databases

OMAiFQRLTCV
OrthoDBi1340284at2759

Family and domain databases

CDDicd00022, BIR, 3 hits
cd14394, UBA_BIRC2_3, 1 hit
InterProiView protein in InterPro
IPR001370, BIR_rpt
IPR041933, BIRC2/BIRC3_UBA
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR001841, Znf_RING
PfamiView protein in Pfam
PF00653, BIR, 3 hits
PF00619, CARD, 1 hit
SMARTiView protein in SMART
SM00238, BIR, 3 hits
SM00114, CARD, 1 hit
SM00184, RING, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS01282, BIR_REPEAT_1, 3 hits
PS50143, BIR_REPEAT_2, 3 hits
PS50209, CARD, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6D2XY77_PONAB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6D2XY77
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 17, 2020
Last sequence update: June 17, 2020
Last modified: December 2, 2020
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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