NFKBIA isoform 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• NF-kappaB binding Source: Ensembl
• nuclear localization sequence binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• cytoplasmic sequestering of NF-kappaB Source: Ensembl
• I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• lipopolysaccharide-mediated signaling pathway Source: Ensembl
• negative regulation of lipid storage Source: Ensembl
• negative regulation of macrophage derived foam cell differentiation Source: Ensembl
• negative regulation of myeloid cell differentiation Source: Ensembl
• negative regulation of Notch signaling pathway Source: Ensembl
• nucleotide-binding oligomerization domain containing 1 signaling pathway Source: Ensembl
• nucleotide-binding oligomerization domain containing 2 signaling pathway Source: Ensembl
• positive regulation of cellular protein metabolic process Source: Ensembl
• positive regulation of cholesterol efflux Source: Ensembl
• positive regulation of inflammatory response Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: Ensembl
• protein import into nucleus Source: Ensembl
• regulation of cell population proliferation Source: Ensembl
• response to exogenous dsRNA Source: Ensembl
• response to muramyl dipeptide Source: Ensembl
• response to muscle stretch Source: Ensembl
• toll-like receptor 4 signaling pathway Source: Ensembl
• tumor necrosis factor-mediated signaling pathway Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• NF-kappaB binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFQAAERPQE WAMEGPRDGL KKERLLDDRH DSGLDSMKDE EYEQMVKELQ 
        60         70         80         90        100
EIRLEPQEVP RGAEPWKQQL TEDGDSFLHL AIIHEEKALT MEVIRQVKGD 
       110        120        130        140        150
LAFLNFQNNL QQTPLHLAVI TNQPEIAEAL LGAGCDPELR DFRGNTPLHL 
       160        170        180        190        200
ACEQGCLASV GVLTQSCTTP HLHSILKATN YNGHTCLHLA SIHGYLGIVE 
       210        220        230        240        250
LLVSLGADVN AQEPCNGRTA LHLAVDLQNP DLVSLLLKCG ADVNRVTYQG 
       260        270        280        290        300
YSPYQLTWGR PSTRIQQQLG QLTLENLQML PESEDEESYD TESEFTEFTE 
       310 
DELPYDDCVF GGQRLTL                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ