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UniProtKB - A0A6C6YVG1 (A0A6C6YVG1_BURM7)

Entry version 7 (29 Sep 2021)
Sequence version 1 (17 Jun 2020)
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Protein
Submitted name:

PTS system, N-acetylglucosamine-specific IIBC component

Gene

nagE

Organism
Burkholderia mallei (strain NCTC 10247)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei416Phosphocysteine intermediate; for EIIB activityPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, Transferase
Biological processPhosphotransferase systemARBA annotation, Sugar transportARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PTS system, N-acetylglucosamine-specific IIBC componentImported (EC:2.7.1.69Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nagEImported
Ordered Locus Names:BMA10247_2874Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBurkholderia mallei (strain NCTC 10247)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri320389 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002284 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 30HelicalSequence analysisAdd BLAST19
Transmembranei42 – 66HelicalSequence analysisAdd BLAST25
Transmembranei73 – 90HelicalSequence analysisAdd BLAST18
Transmembranei96 – 114HelicalSequence analysisAdd BLAST19
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei198 – 216HelicalSequence analysisAdd BLAST19
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Transmembranei260 – 278HelicalSequence analysisAdd BLAST19
Transmembranei284 – 308HelicalSequence analysisAdd BLAST25
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 370PTS EIIC type-1InterPro annotationAdd BLAST368
Domaini394 – 476PTS EIIB type-1InterPro annotationAdd BLAST83

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		IVHCARP

Family and domain databases

Conserved Domains Database

More...CDDi		cd00212, PTS_IIB_glc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1360.60, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR010974, PTS_IIBC_nag

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00367, PTS_EIIB, 2 hits
PF02378, PTS_EIIC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55604, SSF55604, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00826, EIIB_glc, 1 hit
TIGR01998, PTS-II-BC-nag, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6C6YVG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGNPFLKIQ SLGRALMLPI AVLPVAGILL RLGQQDVLNI KMIADAGGAI 
        60         70         80         90        100
FENLPLLFAI GVAVGFAKDN NGVAALAGAI GYLIEVAIMK DIDPKLNMGV 
       110        120        130        140        150
LSGIIAGVVA GLLYNRYKDI KLPDYLAFFG GKRFVPIITG LACVVLGIVF 
       160        170        180        190        200
GYVWQPVQHA IDAVGQWLLT AGAIGTFVYG FLNRLLLVTG LHHIINSLVW 
       210        220        230        240        250
FVFGTFTPAG GAAVTGDLHR FFAGDPSAGG FMAGFFPIMM FGLPAACLAM 
       260        270        280        290        300
FHEAPKARRA IVGGLLFSMA LTSFLTGVTE PIEFSFMFLA PVLYVIHAVL 
       310        320        330        340        350
TGLSLAICQL LGVKLGFTFS AGAIDYVLNY GLSTKGWIAI PLGLAYGLAY 
       360        370        380        390        400
YGLFRFFIRK FNMATPGREP AGADAQAQSF ASGGFVAPTA GASVPRAQRY 
       410        420        430        440        450
IAALGGAANL SVVDACTTRL RLSVVDPEKV SEADLRTIGA RGVLKRGGSS 
       460        470        480        490        500
VQVIIGPEAD LIADEIRATL GSGAAAPAAA AAAAPAAAAT ATAAGAQSGP 
       510        520        530        540        550
LDPEPTRWLA VFGGATNVAS LDAVAATRLR VVVRDPSAVD RQRLATLDVA 
       560        570        580 
WVASDTFHIV CGQSAPRYAQ QLAARLPSSD GGTAAQPA
Length:588
Mass (Da):61,010
Last modified:June 17, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD226D8A4F8FB101D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CP000548 Genomic DNA Translation: ABO06973.1

NCBI Reference Sequences

More...RefSeqi		WP_004195339.1, NZ_CP007802.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56593864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		bmaz:BM44_467
bmn:BMA10247_2874

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000548 Genomic DNA Translation: ABO06973.1
RefSeqiWP_004195339.1, NZ_CP007802.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi56593864
KEGGibmaz:BM44_467
bmn:BMA10247_2874

Phylogenomic databases

OMAiIVHCARP

Family and domain databases

CDDicd00212, PTS_IIB_glc, 1 hit
Gene3Di3.30.1360.60, 2 hits
InterProiView protein in InterPro
IPR036878, Glu_permease_IIB
IPR018113, PTrfase_EIIB_Cys
IPR003352, PTS_EIIC
IPR013013, PTS_EIIC_1
IPR001996, PTS_IIB_1
IPR010974, PTS_IIBC_nag
PfamiView protein in Pfam
PF00367, PTS_EIIB, 2 hits
PF02378, PTS_EIIC, 1 hit
SUPFAMiSSF55604, SSF55604, 2 hits
TIGRFAMsiTIGR00826, EIIB_glc, 1 hit
TIGR01998, PTS-II-BC-nag, 1 hit
PROSITEiView protein in PROSITE
PS51098, PTS_EIIB_TYPE_1, 1 hit
PS01035, PTS_EIIB_TYPE_1_CYS, 1 hit
PS51103, PTS_EIIC_TYPE_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6C6YVG1_BURM7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6C6YVG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 17, 2020
Last sequence update: June 17, 2020
Last modified: September 29, 2021
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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