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Entry version 4 (02 Jun 2021)
Sequence version 1 (02 Dec 2020)
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Protein

2'-O-methyltransferase

Gene

orf1ab

Organism
Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

ARBA annotation

Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.

ARBA annotation

May participate in viral replication by acting as a ssRNA-binding protein.

ARBA annotation

May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.

ARBA annotation

Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.

ARBA annotation

Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.

ARBA annotation

Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.

ARBA annotation

Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.

ARBA annotation

Responsible for replication and transcription of the viral RNA genome.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseARBA annotation, ExonucleaseARBA annotation, HelicaseARBA annotation, Hydrolase, MethyltransferaseARBA annotation, Nuclease, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Thiol proteaseARBA annotation, Transferase
Biological processActivation of host autophagy by virusARBA annotation, Decay of host mRNAs by virusARBA annotation, Eukaryotic host gene expression shutoff by virus, Eukaryotic host translation shutoff by virusARBA annotation, Host gene expression shutoff by virus, Host mRNA suppression by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virusARBA annotation, Inhibition of host NF-kappa-B by virusARBA annotation, Modulation of host ubiquitin pathway by viral deubiquitinaseARBA annotation, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathwayARBA annotation, Viral immunoevasion, Viral RNA replicationARBA annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2'-O-methyltransferaseARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.19.12ARBA annotation, EC:3.4.22.69ARBA annotation, EC:3.6.4.12ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
3C-like proteinaseARBA annotation
Growth factor-like peptideARBA annotation
Guanine-N7 methyltransferaseARBA annotation
HelicaseARBA annotation
Host translation inhibitor nsp1ARBA annotation
Leader proteinARBA annotation
NendoUARBA annotation
Non-structural protein 10ARBA annotation
Non-structural protein 2ARBA annotation
Non-structural protein 3ARBA annotation
Non-structural protein 4ARBA annotation
Non-structural protein 6ARBA annotation
Non-structural protein 7ARBA annotation
Non-structural protein 8ARBA annotation
Non-structural protein 9ARBA annotation
ORF1ab polyproteinARBA annotation
Papain-like proteinaseARBA annotation
RNA-directed RNA polymeraseARBA annotation
Replicase polyprotein 1abARBA annotation
Uridylate-specific endoribonucleaseARBA annotation
p65 homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:orf1abImported
Synonyms:ORF1abImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSevere acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2697049 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesNidoviralesCornidovirineaeCoronaviridaeOrthocoronavirinaeBetacoronavirusSarbecovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2229 – 2253HelicalSequence analysisAdd BLAST25
Transmembranei2328 – 2351HelicalSequence analysisAdd BLAST24
Transmembranei2363 – 2387HelicalSequence analysisAdd BLAST25
Transmembranei2773 – 2790HelicalSequence analysisAdd BLAST18
Transmembranei3043 – 3065HelicalSequence analysisAdd BLAST23
Transmembranei3077 – 3098HelicalSequence analysisAdd BLAST22
Transmembranei3104 – 3124HelicalSequence analysisAdd BLAST21
Transmembranei3136 – 3154HelicalSequence analysisAdd BLAST19
Transmembranei3582 – 3605HelicalSequence analysisAdd BLAST24
Transmembranei3611 – 3629HelicalSequence analysisAdd BLAST19
Transmembranei3636 – 3657HelicalSequence analysisAdd BLAST22
Transmembranei3683 – 3701HelicalSequence analysisAdd BLAST19
Transmembranei3731 – 3755HelicalSequence analysisAdd BLAST25
Transmembranei3767 – 3789HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Host cytoplasmARBA annotation, Host membraneARBA annotation, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1025 – 1194MacroInterPro annotationAdd BLAST170
Domaini1634 – 1898Peptidase C16InterPro annotationAdd BLAST265
Domaini3264 – 3569Peptidase C30InterPro annotationAdd BLAST306
Domaini5004 – 5166RdRp catalyticInterPro annotationAdd BLAST163
Domaini5325 – 5408CV ZBDInterPro annotationAdd BLAST84
Domaini5581 – 5932(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST352

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni926 – 999DisorderedSequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi927 – 947Acidic residuesSequence analysisAdd BLAST21
Compositional biasi984 – 999Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.ARBA annotation

Keywords - Domaini

RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21516, cv_beta_Nsp2_SARS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21591, SARS-CoV-like_RdRp, 1 hit
cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR043615, NSP2_N_CoV
IPR044389, NSP2_SARS-CoV-like
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044351, RdRp_SARS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506, A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6B9V049-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLVPGFNE KTHVQLSLPV LQVRDVLVRG FGDSVEEVLS EARQHLKDGT
60 70 80 90 100
CGLVEVEKGV LPQLEQPYVF IKRSDARTAP HGHVMVELVA ELEGIQYGRS
110 120 130 140 150
GETLGVLVPH VGEIPVAYRK VLLRKNGNKG AGGHSYGADL KSFDLGDELG
160 170 180 190 200
TDPYEDFQEN WNTKHSSGVT RELMRELNGG AYTRYVDNNF CGPDGYPLEC
210 220 230 240 250
IKDLLARAGK ASCTLSEQLD FIDTKRGVYC CREHEHEIAW YTERSEKSYE
260 270 280 290 300
LQTPFEIKLA KKFDTFNGEC PNFVFPLNSI IKTIQPRVEK KKLDGFMGRI
310 320 330 340 350
RSVYPVASPN ECNQMCLSTL MKCDHCGETS WQTGDFVKAT CEFCGTENLT
360 370 380 390 400
KEGATTCGYL PQNAVVKIYC PACHNSEVGP EHSLAEYHNE SGLKTILRKG
410 420 430 440 450
GRTIAFGGCV FSYVGCHNKC AYWVPRASAN IGCNHTGVVG EGSEGLNDNL
460 470 480 490 500
LEILQKEKVN INIVGDFKLN EEIAIILASF SASTSAFVET VKGLDYKAFK
510 520 530 540 550
QIVESCGNFK VTKGKAKKGA WNIGEQKSIL SPLYAFASEA ARVVRSIFSR
560 570 580 590 600
TLETAQNSVR VLQKAAITIL DGISQYSLRL IDAMMFTSDL ATNNLVVMAY
610 620 630 640 650
ITGGVVQLTS QWLTNIFGTV YEKLKPVLDW LEEKFKEGVE FLRDGWEIVK
660 670 680 690 700
FISTCACEIV GGQIVTCAKE IKESVQTFFK LVNKFLALCA DSIIIGGAKL
710 720 730 740 750
KALNLGETFV THSKGLYRKC VKSREETGLL MPLKAPKEII FLEGETLPTE
760 770 780 790 800
VLTEEVVLKT GDLQPLEQPT SEAVEAPLVG TPVCINGLML LEIKDTEKYC
810 820 830 840 850
ALAPNMMVTN NTFTLKGGAP TKVTFGDDTV IEVQGYKSVN ITFELDERID
860 870 880 890 900
KVLNEKCSAY TVELGTEVNE FACVVADAVI KTLQPVSELL TPLGIDLDEW
910 920 930 940 950
SMATYYLFDE SGEFKLASHM YCSFYPPDED EEEGDCEEEE FEPSTQYEYG
960 970 980 990 1000
TEDDYQGKPL EFGATSAALQ PEEEQEEDWL DDDSQQTVGQ QDGSEDNQTT
1010 1020 1030 1040 1050
TIQTIVEVQP QLEMELTPVV QTIEVNSFSG YLKLTDNVYI KNADIVEEAK
1060 1070 1080 1090 1100
KVKPTVVVNA ANVYLKHGGG VAGALNKATN NAMQVESDDY IATNGPLKVG
1110 1120 1130 1140 1150
GSCVLSGHNL AKHCLHVVGP NVNKGEDIQL LKSAYENFNQ HEVLLAPLLS
1160 1170 1180 1190 1200
AGIFGADPIH SLRVCVDTVR TNVYLAVFDK NLYDKLVSSF LEMKSEKQVE
1210 1220 1230 1240 1250
QKIAEIPKEE VKPFITESKP SVEQRKQDDK KIKACVEEVT TTLEETKFLT
1260 1270 1280 1290 1300
ENLLLYIDIN GNLHPDSATL VSDIDITFLK KDAPYIVGDV VQEGVLTAVV
1310 1320 1330 1340 1350
IPTKKAGGTT EMLAKALRKV PTDNYITTYP GQGLNGYTVE EAKTVLKKCK
1360 1370 1380 1390 1400
SAFYILPSII SNEKQEILGT VSWNLREMLA HAEETRKLMP VCVETKAIVS
1410 1420 1430 1440 1450
TIQRKYKGIK IQEGVVDYGA RFYFYTSKTT VASLINTLND LNETLVTMPL
1460 1470 1480 1490 1500
GYVTHGLNLE EAARYMRSLK VPATVSVSSP DAVTAYNGYL TSSSKTPEEH
1510 1520 1530 1540 1550
FIETISLAGS YKDWSYSGQS TQLGIEFLKR GDKSVYYTSN PTTFHLDGEV
1560 1570 1580 1590 1600
ITFDNLKTLL SLREVRTIKV FTTVDNINLH TQVVDMSMTY GQQFGPTYLD
1610 1620 1630 1640 1650
GADVTKIKPH NSHEGKTFYV LPNDDTLRVE AFEYYHTTDP SFLGRYMSAL
1660 1670 1680 1690 1700
NHTKKWKYPQ VNGLTSIKWA DNNCYLATAL LTLQQIELKF NPPALQDAYY
1710 1720 1730 1740 1750
RARAGEAANF CALILAYCNK TVGELGDVRE TMSYLFQHAN LDSCKRVLNV
1760 1770 1780 1790 1800
VCKTCGQQQT TLKGVEAVMY MGTLSYEQFK KGVQIPCTCG KQATKYLVQQ
1810 1820 1830 1840 1850
ESPFVMMSAP PAQYELKHGT FTCASEYTGN YQCGHYKHIT SKETLYCIDG
1860 1870 1880 1890 1900
ALLTKSSEYK GPITDVFYKE NSYTTTIKPV TYKLDGVVCT EIDPKLDNYY
1910 1920 1930 1940 1950
KKDNSYFTEQ PIDLVPNQPY PNASFDNFKF VCDNIKFADD LNQLTGYKKP
1960 1970 1980 1990 2000
ASRELKVTFF PDLNGDVVAI DYKHYTPSFK KGAKLLHKPI VWHVNNATNK
2010 2020 2030 2040 2050
ATYKPNTWCI RCLWSTKPVE TSNSFDVLKS EDAQGMDNLA CEDLKPVSEE
2060 2070 2080 2090 2100
VVENPTIQKD VLECNVKTTE VVGDIILKPA NNSLKITEEV GHTDLMAAYV
2110 2120 2130 2140 2150
DNSSLTIKKP NELSRVLGLK TLATHGLAAV NSVPWDTIAN YAKPFLNKVV
2160 2170 2180 2190 2200
STTTNIVTRC LNRVCTNYMP YFFTLLLQLC TFTRSTNSRI KASMPTTIAK
2210 2220 2230 2240 2250
NTVKSVGKFC LEASFNYLKS PNFSKLINII IWFLLLSVCL GSLIYSTAAL
2260 2270 2280 2290 2300
GVLMSNLGMP SYCTGYREGY LNSTNVTIAT YCTGSIPCSV CLSGLDSLDT
2310 2320 2330 2340 2350
YPSLETIQIT ISSFKWDLTA FGLVAEWFLA YILFTRFFYV LGLAAIMQLF
2360 2370 2380 2390 2400
FSYFAVHFIS NSWLMWLIIN LVQMAPISAM VRMYIFFASF YYVWKSYVHV
2410 2420 2430 2440 2450
VDGCNSSTCM MCYKRNRATR VECTTIVNGV RRSFYVYANG GKGFCKLHNW
2460 2470 2480 2490 2500
NCVNCDTFCA GSTFISDEVA RDLSLQFKRP INPTDQSSYI VDSVTVKNGS
2510 2520 2530 2540 2550
IHLYFDKAGQ KTYERHSLSH FVNLDNLRAN NTKGSLPINV IVFDGKSKCE
2560 2570 2580 2590 2600
ESSAKSASVY YSQLMCQPIL LLDQALVSDV GDSAEVAVKM FDAYVNTFSS
2610 2620 2630 2640 2650
TFNVPMEKLK TLVATAEAEL AKNVSLDNVL STFISAARQG FVDSDVETKD
2660 2670 2680 2690 2700
VVECLKLSHQ SDIEVTGDSC NNYMLTYNKV ENMTPRDLGA CIDCSARHIN
2710 2720 2730 2740 2750
AQVAKSHNIA LIWNVKDFMS LSEQLRKQIR SAAKKNNLPF KLTCATTRQV
2760 2770 2780 2790 2800
VNVVTTKIAL KGGKIVNNWL KQLIKVTLVF LFVAAIFYLI TPVHVMSKHT
2810 2820 2830 2840 2850
DFSSEIIGYK AIDGGVTRDI ASTDTCFANK HADFDTWFSQ RGGSYTNDKA
2860 2870 2880 2890 2900
CPLIAAVITR EVGFVVPGLP GTILRTTNGD FLHFLPRVFS AVGNICYTPS
2910 2920 2930 2940 2950
KLIEYTDFAT SACVLAAECT IFKDASGKPV PYCYDTNVLE GSVAYESLRP
2960 2970 2980 2990 3000
DTRYVLMDGS IIQFPNTYLE GSVRVVTTFD SEYCRHGTCE RSEAGVCVST
3010 3020 3030 3040 3050
SGRWVLNNDY YRSLPGVFCG VDAVNLLTNM FTPLIQPIGA LDISASIVAG
3060 3070 3080 3090 3100
GIVAIVVTCL AYYFMRFRRA FGEYSHVVAF NTLLFLMSFT VLCLTPVYSF
3110 3120 3130 3140 3150
LPGVYSVIYL YLTFYLTNDV SFLAHIQWMV MFTPLVPFWI TIAYIICIST
3160 3170 3180 3190 3200
KHFYWFFSNY LKRRVVFNGV SFSTFEEAAL CTFLLNKEMY LKLRSDVLLP
3210 3220 3230 3240 3250
LTQYNRYLAL YNKYKYFSGA MDTTSYREAA CCHLAKALND FSNSGSDVLY
3260 3270 3280 3290 3300
QPPQTSITSA VLQSGFRKMA FPSGKVEGCM VQVTCGTTTL NGLWLDDVVY
3310 3320 3330 3340 3350
CPRHVICTSE DMLNPNYEDL LIRKSNHNFL VQAGNVQLRV IGHSMQNCVL
3360 3370 3380 3390 3400
KLKVDTANPK TPKYKFVRIQ PGQTFSVLAC YNGSPSGVYQ CAMRPNFTIK
3410 3420 3430 3440 3450
GSFLNGSCGS VGFNIDYDCV SFCYMHHMEL PTGVHAGTDL EGNFYGPFVD
3460 3470 3480 3490 3500
RQTAQAAGTD TTITVNVLAW LYAAVINGDR WFLNRFTTTL NDFNLVAMKY
3510 3520 3530 3540 3550
NYEPLTQDHV DILGPLSAQT GIAVLDMCAS LKELLQNGMN GRTILGSALL
3560 3570 3580 3590 3600
EDEFTPFDVV RQCSGVTFQS AVKRTIKGTH HWLLLTILTS LLVLVQSTQW
3610 3620 3630 3640 3650
SLFFFLYENA FLPFAMGIIA MSAFAMMFVK HKHAFLCLFL LPSLATVAYF
3660 3670 3680 3690 3700
NMVYMPASWV MRIMTWLDMV DTSLSGFKLK DCVMYASAVV LLILMTARTV
3710 3720 3730 3740 3750
YDDGARRVWT LMNVLTLVYK VYYGNALDQA ISMWALIISV TSNYSGVVTT
3760 3770 3780 3790 3800
VMFLARGIVF MCVEYCPIFF ITGNTLQCIM LVYCFLGYFC TCYFGLFCLL
3810 3820 3830 3840 3850
NRYFRLTLGV YDYLVSTQEF RYMNSQGLLP PKNSIDAFKL NIKLLGVGGK
3860 3870 3880 3890 3900
PCIKVATVQS KMSDVKCTSV VLLSVLQQLR VESSSKLWAQ CVQLHNDILL
3910 3920 3930 3940 3950
AKDTTEAFEK MVSLLSVLLS MQGAVDINKL CEEMLDNRAT LQAIASEFSS
3960 3970 3980 3990 4000
LPSYAAFATA QEAYEQAVAN GDSEVVLKKL KKSLNVAKSE FDRDAAMQRK
4010 4020 4030 4040 4050
LEKMADQAMT QMYKQARSED KRAKVTSAMQ TMLFTMLRKL DNDALNNIIN
4060 4070 4080 4090 4100
NARDGCVPLN IIPLTTAAKL MVVIPDYNTY KNTCDGTTFT YASALWEIQQ
4110 4120 4130 4140 4150
VVDADSKIVQ LSEISMDNSP NLAWPLIVTA LRANSAVKLQ NNELSPVALR
4160 4170 4180 4190 4200
QMSCAAGTTQ TACTDDNALA YYNTTKGGRF VLALLSDLQD LKWARFPKSD
4210 4220 4230 4240 4250
GTGTIYTELE PPCRFVTDTP KGPKVKYLYF IKGLNNLNRG MVLGSLAATV
4260 4270 4280 4290 4300
RLQAGNATEV PANSTVLSFC AFAVDAAKAY KDYLASGGQP ITNCVKMLCT
4310 4320 4330 4340 4350
HTGTGQAITV TPEANMDQES FGGASCCLYC RCHIDHPNPK GFCDLKGKYV
4360 4370 4380 4390 4400
QIPTTCANDP VGFTLKNTVC TVCGMWKGYG CSCDQLREPM LQSADAQSFL
4410 4420 4430 4440 4450
NRVCGVSAAR LTPCGTGTST DVVYRAFDIY NDKVAGFAKF LKTNCCRFQE
4460 4470 4480 4490 4500
KDEDDNLIDS YFVVKRHTFS NYQHEETIYN LLKDCPAVAK HDFFKFRIDG
4510 4520 4530 4540 4550
DMVPHISRQR LTKYTMADLV YALRHFDEGN CDTLKEILVT YNCCDDDYFN
4560 4570 4580 4590 4600
KKDWYDFVEN PDILRVYANL GERVRQALLK TVQFCDAMRN AGIVGVLTLD
4610 4620 4630 4640 4650
NQDLNGNWYD FGDFIQTTPG SGVPVVDSYY SLLMPILTLT RALTAESHVD
4660 4670 4680 4690 4700
TDLTKPYIKW DLLKYDFTEE RLKLFDRYFK YWDQTYHPNC VNCLDDRCIL
4710 4720 4730 4740 4750
HCANFNVLFS TVFPPTSFGP LVRKIFVDGV PFVVSTGYHF RELGVVHNQD
4760 4770 4780 4790 4800
VNLHSSRLSF KELLVYAADP AMHAASGNLL LDKRTTCFSV AALTNNVAFQ
4810 4820 4830 4840 4850
TVKPGNFNKD FYDFAVSKGF FKEGSSVELK HFFFAQDGNA AISDYDYYRY
4860 4870 4880 4890 4900
NLPTMCDIRQ LLFVVEVVDK YFDCYDGGCI NANQVIVNNL DKSAGFPFNK
4910 4920 4930 4940 4950
WGKARLYYDS MSYEDQDALF AYTKRNVIPT ITQMNLKYAI SAKNRARTVA
4960 4970 4980 4990 5000
GVSICSTMTN RQFHQKLLKS IAATRGATVV IGTSKFYGGW HNMLKTVYSD
5010 5020 5030 5040 5050
VENPHLMGWD YPKCDRAMPN MLRIMASLVL ARKHTTCCSL SHRFYRLANE
5060 5070 5080 5090 5100
CAQVLSEMVM CGGSLYVKPG GTSSGDATTA YANSVFNICQ AVTANVNALL
5110 5120 5130 5140 5150
STDGNKIADK YVRNLQHRLY ECLYRNRDVD TDFVNEFYAY LRKHFSMMIL
5160 5170 5180 5190 5200
SDDAVVCFNS TYASQGLVAS IKNFKSVLYY QNNVFMSEAK CWTETDLTKG
5210 5220 5230 5240 5250
PHEFCSQHTM LVKQGDDYVY LPYPDPSRIL GAGCFVDDIV KTDGTLMIER
5260 5270 5280 5290 5300
FVSLAIDAYP LTKHPNQEYA DVFHLYLQYI RKLHDELTGH MLDMYSVMLT
5310 5320 5330 5340 5350
NDNTSRYWEP EFYEAMYTPH TVLQAVGACV LCNSQTSLRC GACIRRPFLC
5360 5370 5380 5390 5400
CKCCYDHVIS TSHKLVLSVN PYVCNAPGCD VTDVTQLYLG GMSYYCKSHK
5410 5420 5430 5440 5450
PPISFPLCAN GQVFGLYKNT CVGSDNVTDF NAIATCDWTN AGDYILANTC
5460 5470 5480 5490 5500
TERLKLFAAE TLKATEETFK LSYGIATVRE VLSDRELHLS WEVGKPRPPL
5510 5520 5530 5540 5550
NRNYVFTGYR VTKNSKVQIG EYTFEKGDYG DAVVYRGTTT YKLNVGDYFV
5560 5570 5580 5590 5600
LTSHTVMPLS APTLVPQEHY VRITGLYPTL NISDEFSSNV ANYQKVGMQK
5610 5620 5630 5640 5650
YSTLQGPPGT GKSHFAIGLA LYYPSARIVY TACSHAAVDA LCEKALKYLP
5660 5670 5680 5690 5700
IDKCSRIIPA RARVECFDKF KVNSTLEQYV FCTVNALPET TADIVVFDEI
5710 5720 5730 5740 5750
SMATNYDLSV VNARLRAKHY VYIGDPAQLP APRTLLTKGT LEPEYFNSVC
5760 5770 5780 5790 5800
RLMKTIGPDM FLGTCRRCPA EIVDTVSALV YDNKLKAHKD KSAQCFKMFY
5810 5820 5830 5840 5850
KGVITHDVSS AINRPQIGVV REFLTRNPAW RKAVFISPYN SQNAVASKIL
5860 5870 5880 5890 5900
GLPTQTVDSS QGSEYDYVIF TQTTETAHSC NVNRFNVAIT RAKVGILCIM
5910 5920 5930 5940 5950
SDRDLYDKLQ FTSLEIPRRN VATLQAENVT GLFKDCSKVI TGLHPTQAPT
5960 5970 5980 5990 6000
HLSVDTKFKT EGLCVDIPGI PKDMTYRRLI SMMGFKMNYQ VNGYPNMFIT
6010 6020 6030 6040 6050
REEAIRHVRA WIGFDVEGCH ATREAVGTNL PLQLGFSTGV NLVAVPTGYV
6060 6070 6080 6090 6100
DTPNNTDFSR VSAKPPPGDQ FKHLIPLMYK GLPWNVVRIK IVQMLSDTLK
6110 6120 6130 6140 6150
NLSDRVVFVL WAHGFELTSM KYFVKIGPER TCCLCDRRAT CFSTASDTYA
6160 6170 6180 6190 6200
CWHHSIGFDY VYNPFMIDVQ QWGFTGNLQS NHDLYCQVHG NAHVASCDAI
6210 6220 6230 6240 6250
MTRCLAVHEC FVKRVDWTIE YPIIGDELKI NAACRKVQHM VVKAALLADK
6260 6270 6280 6290 6300
FPVLHDIGNP KAIKCVPQAD VEWKFYDAQP CSDKAYKIEE LFYSYATHSD
6310 6320 6330 6340 6350
KFTDGVCLFW NCNVDRYPAN SIVCRFDTRV LSNLNLPGCD GGSLYVNKHA
6360 6370 6380 6390 6400
FHTPAFDKSA FVNLKQLPFF YYSDSPCESH GKQVVSDIDY VPLKSATCIT
6410 6420 6430 6440 6450
RCNLGGAVCR HHANEYRLYL DAYNMMISAG FSLWVYKQFD TYNLWNTFTR
6460 6470 6480 6490 6500
LQSLENVAFN VVNKGHFDGQ QGEVPVSIIN NTVYTKVDGV DVELFENKTT
6510 6520 6530 6540 6550
LPVNVAFELW AKRNIKPVPE VKILNNLGVD IAANTVIWDY KRDAPAHIST
6560 6570 6580 6590 6600
IGVCSMTDIA KKPTETICAP LTVFFDGRVD GQVDLFRNAR NGVLITEGSV
6610 6620 6630 6640 6650
KGLQPSVGPK QASLNGVTLI GEAVKTQFNY YKKVDGVVQQ LPETYFTQSR
6660 6670 6680 6690 6700
NLQEFKPRSQ MEIDFLELAM DEFIERYKLE GYAFEHIVYG DFSHSQLGGL
6710 6720 6730 6740 6750
HLLIGLAKRF KESPFELEDF IPMDSTVKNY FITDAQTGSS KCVCSVIDLL
6760 6770 6780 6790 6800
LDDFVEIIKS QDLSVVSKVV KVTIDYTEIS FMLWCKDGHV ETFYPKLQSS
6810 6820 6830 6840 6850
QAWQPGVAMP NLYKMQRMLL EKCDLQNYGD SATLPKGIMM NVAKYTQLCQ
6860 6870 6880 6890 6900
YLNTLTLAVP YNMRVIHFGA GSDKGVAPGT AVLRQWLPTG TLLVDSDLND
6910 6920 6930 6940 6950
FVSDADSTLI GDCATVHTAN KWDLIISDMY DPKTKNVTKE NDSKEGFFTY
6960 6970 6980 6990 7000
ICGFIQQKLA LGGSVAIKIT EHSWNADLYK LMGHFAWWTA FVTNVNASSS
7010 7020 7030 7040 7050
EAFLIGCNYL GKPREQIDGY VMHANYIFWR NTNPIQLSSY SLFDMSKFPL
7060 7070 7080 7090
KLRGTAVMSL KEGQINDMIL SLLSKGRLII RENNRVVISS DVLVNN
Length:7,096
Mass (Da):794,058
Last modified:December 2, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4E62D97150BB8CC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
MN938384 Genomic RNA Translation: QHN73794.1
MN985325 Genomic RNA Translation: QHO60603.1
MN988668 Genomic RNA Translation: QHO62106.1
MN988669 Genomic RNA Translation: QHO62111.1
MN996528 Genomic RNA Translation: QHR63259.1
MN996530 Genomic RNA Translation: QHR63279.1
MT007544 Genomic RNA Translation: QHR84448.1
MT019530 Genomic RNA Translation: QHU36833.1
MT019532 Genomic RNA Translation: QHU36853.1
MT020880 Genomic RNA Translation: QHU79193.1
MT020881 Genomic RNA Translation: QHU79203.1
MT039873 Genomic RNA Translation: QHZ00357.1
MT066175 Genomic RNA Translation: QIA98595.1
MT072688 Genomic RNA Translation: QIB84672.1
MT093631 Genomic RNA Translation: QIC53222.1
MT106052 Genomic RNA Translation: QID21047.1
MT106053 Genomic RNA Translation: QID21057.1
MT123290 Genomic RNA Translation: QIE07450.1
MT192759 Genomic RNA Translation: QIK50416.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingARBA annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
MN938384 Genomic RNA Translation: QHN73794.1
MN985325 Genomic RNA Translation: QHO60603.1
MN988668 Genomic RNA Translation: QHO62106.1
MN988669 Genomic RNA Translation: QHO62111.1
MN996528 Genomic RNA Translation: QHR63259.1
MN996530 Genomic RNA Translation: QHR63279.1
MT007544 Genomic RNA Translation: QHR84448.1
MT019530 Genomic RNA Translation: QHU36833.1
MT019532 Genomic RNA Translation: QHU36853.1
MT020880 Genomic RNA Translation: QHU79193.1
MT020881 Genomic RNA Translation: QHU79203.1
MT039873 Genomic RNA Translation: QHZ00357.1
MT066175 Genomic RNA Translation: QIA98595.1
MT072688 Genomic RNA Translation: QIB84672.1
MT093631 Genomic RNA Translation: QIC53222.1
MT106052 Genomic RNA Translation: QID21047.1
MT106053 Genomic RNA Translation: QID21057.1
MT123290 Genomic RNA Translation: QIE07450.1
MT192759 Genomic RNA Translation: QIK50416.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd21409, 1B_cv_Nsp13-like, 1 hit
cd21560, betaCoV-Nsp6, 1 hit
cd21659, betaCoV_Nsp14, 1 hit
cd21666, betaCoV_Nsp5_Mpro, 1 hit
cd20762, capping_2-OMTase_Nidovirales, 1 hit
cd21516, cv_beta_Nsp2_SARS-like, 1 hit
cd21473, cv_Nsp4_TM, 1 hit
cd21167, M_alpha_beta_cv_Nsp15-like, 1 hit
cd21563, Macro_cv_SUD-M_Nsp3-like, 1 hit
cd21557, Macro_X_Nsp3-like, 1 hit
cd21161, NendoU_cv_Nsp15-like, 1 hit
cd21171, NTD_alpha_beta_cv_Nsp15-like, 1 hit
cd21591, SARS-CoV-like_RdRp, 1 hit
cd21525, SUD_C_SARS-CoV_Nsp3, 1 hit
cd21467, Ubl1_cv_Nsp3_N-like, 1 hit
cd21466, Ubl2_cv_PLpro_N_Nsp3-like, 1 hit
cd21401, ZBD_cv_Nsp13-like, 1 hit
Gene3Di1.10.150.420, 1 hit
1.10.1840.10, 1 hit
1.10.8.1190, 1 hit
1.10.8.370, 1 hit
2.20.25.360, 1 hit
2.30.30.590, 1 hit
2.40.10.10, 2 hits
2.40.10.250, 1 hit
2.40.10.290, 1 hit
3.10.20.350, 1 hit
3.10.20.540, 1 hit
3.40.220.10, 1 hit
3.40.220.20, 1 hit
3.40.220.30, 1 hit
3.40.50.11020, 1 hit
3.40.50.11580, 1 hit
3.90.70.90, 1 hit
InterProiView protein in InterPro
IPR027351, (+)RNA_virus_helicase_core_dom
IPR043608, CoV_NSP15_M
IPR043606, CoV_NSP15_N
IPR043613, CoV_NSP2_C
IPR043611, CoV_NSP3_C
IPR043612, CoV_NSP4_N
IPR043502, DNA/RNA_pol_sf
IPR022733, DPUP_SUD_C_bCoV
IPR037227, EndoU-like
IPR002589, Macro_dom
IPR043472, Macro_dom-like
IPR044371, Macro_X_NSP3-like
IPR042570, NAR_sf
IPR043609, NendoU_nidovirus
IPR036333, NSP10_sf_CoV
IPR044343, NSP13_1B_dom_CoV
IPR027352, NSP13_ZBD_CoV-like
IPR044315, NSP14_betaCoV
IPR009466, NSP14_CoV
IPR044330, NSP15_alpha_betaCoV_N
IPR044322, NSP15_M_alpha_beta_CoV
IPR043174, NSP15_middle_sf
IPR042515, NSP15_N_CoV
IPR044401, NSP15_NendoU_CoV
IPR009461, NSP16_CoV-like
IPR021590, NSP1_bCoV
IPR038030, NSP1_sf_bCoV
IPR043615, NSP2_N_CoV
IPR044389, NSP2_SARS-CoV-like
IPR024375, NSP3_bCoV
IPR024358, NSP3_N_bCoV
IPR032592, NSP3_NAR_bCoV
IPR038166, NSP3_PL2pro_sf_CoV
IPR038400, NSP3_SUD-M_sf_bCoV
IPR043478, NSP3_SUD-N_bCoV
IPR044357, NSP3_Ubl1_dom_CoV
IPR044353, Nsp3_Ubl2_dom_CoV
IPR038083, NSP3A-like
IPR032505, NSP4_C_CoV
IPR038123, NSP4_C_sf_CoV
IPR044367, NSP6_betaCoV
IPR043610, NSP6_CoV
IPR014828, NSP7_CoV
IPR037204, NSP7_sf_CoV
IPR014829, NSP8_CoV-like
IPR037230, NSP8_sf_CoV
IPR014822, NSP9_CoV
IPR036499, NSP9_sf_CoV
IPR027417, P-loop_NTPase
IPR013016, Peptidase_C16_CoV
IPR008740, Peptidase_C30_CoV
IPR043477, Peptidase_C30_dom3_CoV
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR043177, PLpro_N_sf_CoV
IPR043503, PLpro_palm_finger_dom_CoV
IPR043178, PLpro_thumb_sf_CoV
IPR044351, RdRp_SARS-CoV-like
IPR001205, RNA-dir_pol_C
IPR007094, RNA-dir_pol_PSvirus
IPR009469, RNA_pol_N_coronovir
IPR018995, RNA_synth_NSP10_CoV
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF16251, bCoV_NAR, 1 hit
PF11501, bCoV_NSP1, 1 hit
PF12379, bCoV_NSP3_N, 1 hit
PF12124, bCoV_SUD_C, 1 hit
PF11633, bCoV_SUD_M, 1 hit
PF06471, CoV_Methyltr_1, 1 hit
PF06460, CoV_Methyltr_2, 1 hit
PF09401, CoV_NSP10, 1 hit
PF19215, CoV_NSP15_C, 1 hit
PF19216, CoV_NSP15_M, 1 hit
PF19219, CoV_NSP15_N, 1 hit
PF19212, CoV_NSP2_C, 1 hit
PF19211, CoV_NSP2_N, 1 hit
PF19218, CoV_NSP3_C, 1 hit
PF16348, CoV_NSP4_C, 1 hit
PF19217, CoV_NSP4_N, 1 hit
PF19213, CoV_NSP6, 1 hit
PF08716, CoV_NSP7, 1 hit
PF08717, CoV_NSP8, 1 hit
PF08710, CoV_NSP9, 1 hit
PF08715, CoV_peptidase, 1 hit
PF06478, CoV_RPol_N, 1 hit
PF01661, Macro, 1 hit
PF05409, Peptidase_C30, 1 hit
PF00680, RdRP_1, 1 hit
PF01443, Viral_helicase1, 1 hit
SMARTiView protein in SMART
SM00506, A1pp, 1 hit
SUPFAMiSSF101816, SSF101816, 1 hit
SSF140367, SSF140367, 1 hit
SSF142877, SSF142877, 1 hit
SSF143076, SSF143076, 1 hit
SSF144246, SSF144246, 1 hit
SSF159936, SSF159936, 1 hit
SSF160099, SSF160099, 1 hit
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 1 hit
SSF52949, SSF52949, 1 hit
SSF53335, SSF53335, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51653, CV_ZBD, 1 hit
PS51442, M_PRO, 1 hit
PS51154, MACRO, 1 hit
PS51124, PEPTIDASE_C16, 1 hit
PS51657, PSRV_HELICASE, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6B9V049_SARS2
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6B9V049
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 2, 2020
Last sequence update: December 2, 2020
Last modified: June 2, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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