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Entry version 7 (29 Sep 2021)
Sequence version 1 (17 Jun 2020)
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Protein
Submitted name:

Uncharacterized protein

Gene

E5288_WYG014040

Organism
Bos mutus (wild yak)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi403 – 410ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
Biological processCilium biogenesis/degradationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:E5288_WYG014040Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos mutus (wild yak)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri72004 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000322234 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

MethylationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 111LisHInterPro annotationAdd BLAST33
Domaini256 – 306Myosin N-terminal SH3-likeInterPro annotationAdd BLAST51
Domaini310 – 1008Myosin motorInterPro annotationAdd BLAST699

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni155 – 209DisorderedSequence analysisAdd BLAST55
Regioni886 – 908Actin-bindingPROSITE-ProRule annotationAdd BLAST23
Regioni1082 – 1107DisorderedSequence analysisAdd BLAST26
Regioni1968 – 2027DisorderedSequence analysisAdd BLAST60
Regioni2094 – 2174DisorderedSequence analysisAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1405 – 1527Sequence analysisAdd BLAST123
Coiled coili1535 – 1604Sequence analysisAdd BLAST70
Coiled coili1612 – 1944Sequence analysisAdd BLAST333

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 173Polar residuesSequence analysisAdd BLAST19
Compositional biasi1981 – 2012Polar residuesSequence analysisAdd BLAST32
Compositional biasi2013 – 2027Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2094 – 2117Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi2147 – 2174Basic and acidic residuesSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP43 family.ARBA annotation
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018993, FOP_dimerisation-dom_N
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR006594, LisH
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09398, FOP_dimer, 1 hit
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 1 hit
SM00667, LisH, 1 hit
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 1 hit
PS50896, LISH, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A6B0RRP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRKEGPRNT KVNLSQGRSV ASGPVEHPAG VAAAARAPGV LKDTLEKRGV
60 70 80 90 100
LGHLKARIRA EVFNALDDES EPRPSLSHEN FLINELIREY LEFNKYKYTA
110 120 130 140 150
SVLIAESGQP VVPLDRQFLI HELNAFEDSK DNTIPLLYGI LAHFLHGTKD
160 170 180 190 200
DNQNTFLKGS SLPPANPNLG RQPSGRKQME EHLRQEQARG SNAENLHTSP
210 220 230 240 250
TIFPKAASPK VANEKYSLGG DQPGTMAQKD QLSEDEKFLF VDKNFINNPV
260 270 280 290 300
AQADWAAKKL VWVPSEKQGF EAASIKEEKG DEVIVELVEN GKKVTVGKDD
310 320 330 340 350
IQKMNPPKFS KVEDMAELTC LNEASVLHNL RERYFSGLIY TYSGLFCVVV
360 370 380 390 400
NPYKQLPIYS EKIIEMYKGK KRHEMPPHIY AIADTAYRSM LQDREDQSIL
410 420 430 440 450
CTGESGAGKT ENTKKVIQYL AMVASSHKGK KDTSITGELE KQLLQANPIL
460 470 480 490 500
EAFGNAKTVK NDNSSRFGKF IRINFDVTGY IVGANIETYL LEKSRAIRQA
510 520 530 540 550
RDERTFHIFY YLIAGAKEKM RNDLLLEGFN NYTFLSNGFV PIPAAQDDEM
560 570 580 590 600
FNETVEAMAI MGFTEEEQLS ILRVVSSVLQ LGNIVFKKER NTDQASMPDN
610 620 630 640 650
TAAQKVCHLM GINVTDFTRS ILTPRIKVGR DVVQKAQTKE QADFAVEALA
660 670 680 690 700
KATYERLFRW ILTRVNKALD KTHRQGASFL GILDIAGFEI FEVNSFEQLC
710 720 730 740 750
INYTNEKLQQ LFNHTMFILE QEEYQREGIE WNFIDFGLDL QPCIELIERP
760 770 780 790 800
TNPPGVLALL DEECWFPKAT DKSFVEKLCT EQGSHPKFQK PKQLKDKTEF
810 820 830 840 850
SIIHYAGKVD YNASAWLTKN MDPLNDNVTS LLNASSDKFM ADLWKDVDRI
860 870 880 890 900
VGLDQMAKMT ESSLPSASKT KKGMFRTVGQ LYKEQLGKLM TTLRNTTPNF
910 920 930 940 950
VRCIIPNHEK RSGKLDAFLV LEQLRCNGVL EGIRICRQGF PNRIVFQEFR
960 970 980 990 1000
QRYEILAANA IPKGFMDGKQ ACILMIKALE LDPNLYRIGQ SKIFFRTGVL
1010 1020 1030 1040 1050
AHLEEERDLK ITDVIMAFQA MCRGYLARKA FAKRQQQLTA MKVIQRNCAA
1060 1070 1080 1090 1100
YLKLRNWQWW RLFTKVKPLL QVTRQEEEMQ AKEDELQKTK ERQQKAESEL
1110 1120 1130 1140 1150
KELEQKHSQL TEEKNLLQEQ LQAETELYAE AEEMRVRLAA KKQELEEILH
1160 1170 1180 1190 1200
EMEARLEEEE DRSQQLQAER KKMAQQMLDL EEQLEEEEAA RQKLQLEKVT
1210 1220 1230 1240 1250
AEAKIKKLED DILVMDDQNN KLSKERKLLE ERISDLTTNL AEEEEKAKNL
1260 1270 1280 1290 1300
TKLKNKHESM ISELEVRLKK EEKSRQELEK LKRKLDGEAS DLHEQIAELQ
1310 1320 1330 1340 1350
AQIAELKMQL AKKEEELQAA LGRLDDEMAQ KNNALKKIRE LEGHISDLQE
1360 1370 1380 1390 1400
DLDSERAARN KAEKQKRDLG EELEALKTEL EDTLDSTATQ QELRAKREQE
1410 1420 1430 1440 1450
VTMLKKALDE ETRSHESQVQ EMRQKHTQVV EELTEQLEQF KRAKANLDKN
1460 1470 1480 1490 1500
KQALEKENAE LAGELRVLSQ AKQEVEHKKK KLEVQLQELQ SKYSDGEKVR
1510 1520 1530 1540 1550
AELNDKVHKL QNEVESVTGM LNEAEGKAIK LAKDVASLGS QLQDTQELLQ
1560 1570 1580 1590 1600
EETRQKLNVS TKLRQLEDER NSLQEQLDEE MEAKQNLERH ISTLNIQLSD
1610 1620 1630 1640 1650
SKKKLQDFAS TVELLEEGKK KFQKEIESLT QQYEEKAAAY DKLEKTKNRL
1660 1670 1680 1690 1700
QQELDDLVVD LDNQRQLVSN LEKKQKKFDQ LLAEEKNISS KYADERDRAE
1710 1720 1730 1740 1750
AEAREKETKA LSLARALEEA LEAKEELERT NKMLKAEMED LVSSKDDVGK
1760 1770 1780 1790 1800
NVHELEKSKR ALETQMEEMK TQLEELEDEL QATEDAKLRL EVNMQALKVQ
1810 1820 1830 1840 1850
FERDLQARDE QNEEKRRQLQ RQLHEYETEL EDERKQRALA VAAKKKLEGD
1860 1870 1880 1890 1900
LKDLELQADS AIKGREEAIK QLRKLQAQMK DFQRELEDAR ASRDEIFATA
1910 1920 1930 1940 1950
KENEKKAKSL EADLMQLQED LAAAERARKQ ADLEKDELAE ELASSVSGRN
1960 1970 1980 1990 2000
ALQDEKRRLE ARIAQLEEEL EEEQGNTEAM SERVRKATQQ AEQLSNELAT
2010 2020 2030 2040 2050
ERSAAQKNEN ARQQLERQNK ELRSKLQEME GAVKSKFKST IAALEAKIAQ
2060 2070 2080 2090 2100
LEEQVEQEAR EKQATAKALK QKDKKLKEAL LQVEDERKMA EQYKEQRINA
2110 2120 2130 2140 2150
NRRKLQRELD EATESNEAMG REVTALKSKL RRGNETSFVP TRRSGGRRVI
2160 2170
ENADGSEEEM DARDADFNGT KASE
Length:2,174
Mass (Da):249,633
Last modified:June 17, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45FC3162FBED18A1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
VBQZ03000060 Genomic DNA Translation: MXQ90053.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
VBQZ03000060 Genomic DNA Translation: MXQ90053.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR018993, FOP_dimerisation-dom_N
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR006594, LisH
IPR001609, Myosin_head_motor_dom
IPR004009, Myosin_N
IPR008989, Myosin_S1_N
IPR002928, Myosin_tail
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF09398, FOP_dimer, 1 hit
PF00063, Myosin_head, 1 hit
PF02736, Myosin_N, 1 hit
PF01576, Myosin_tail_1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00015, IQ, 1 hit
SM00667, LisH, 1 hit
SM00242, MYSc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 1 hit
PS50896, LISH, 1 hit
PS51456, MYOSIN_MOTOR, 1 hit
PS51844, SH3_LIKE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A6B0RRP8_9CETA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A6B0RRP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 17, 2020
Last sequence update: June 17, 2020
Last modified: September 29, 2021
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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