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UniProtKB - A0A673LP99 (A0A673LP99_9TELE)
Protein
Large proline-rich protein BAG6
Gene
LOC107745707
Organism
Sinocyclocheilus rhinocerous
Status
Functioni
Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).
ARBA annotationGO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- immune system process Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulatorARBA annotation |
Biological process | ApoptosisARBA annotation, Differentiation, ImmunityARBA annotation, SpermatogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Large proline-rich protein BAG6ARBA annotationAlternative name(s): BCL2-associated athanogene 6ARBA annotation HLA-B-associated transcript 3ARBA annotation |
Gene namesi | Name:LOC107745707Imported |
Organismi | Sinocyclocheilus rhinocerousImported |
Taxonomic identifieri | 307959 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Cyprininae › Sinocyclocheilus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular exosome ARBA annotation
Nucleus
- Nucleus ARBA annotation
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 68 | Ubiquitin-likeInterPro annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 77 – 119 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 345 – 388 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 459 – 499 | DisorderedSequence analysisAdd BLAST | 41 | |
Regioni | 514 – 581 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 624 – 667 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 1054 – 1082 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 78 – 119 | Polar residuesSequence analysisAdd BLAST | 42 | |
Compositional biasi | 345 – 366 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 459 – 477 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 514 – 577 | Polar residuesSequence analysisAdd BLAST | 64 | |
Compositional biasi | 630 – 644 | Pro residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 645 – 661 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
RepeatARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
A0A673LP99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEPGAIEVT VKTLDSQSRT FTVRGEWTVK QFKEHIASAV EIPVDKQRLI
60 70 80 90 100
YQGKVLQDES TLTEYNVDGK VIHLVERAPP QSSQSGDGRC GVSGSSGTTD
110 120 130 140 150
GGSTSSQSST FPGTPHDRNA NNYVMLGTFN LPMLAGVGEM GRNVRVSTST
160 170 180 190 200
GSSGSVDVHI NVDQSVQSEP RMRLQLADSL LRETQALIHR LEVQNKYLHP
210 220 230 240 250
TNKTIFLDFL IIYQMTFATH SGPNHPSPLE LVEVLSEVRR VEERLRPFME
260 270 280 290 300
RTHSILGAAN SADYNNNTQE REEDQRTLNL IGESLHLLGN TLVALSDLRC
310 320 330 340 350
NLSAQPPRHL HVVRPMSHYT SPVVLQSGPP HIPIPMNLGS TMTMTANSRQ
360 370 380 390 400
TSEGQAQTSQ PSNQSEPQGQ APPPPPNGAS QQTGHGQGTP RVIRITHQTM
410 420 430 440 450
EPVVMMQMNL DGMSPTRPIR TAGETGTTAP IHVPGLPPEF MQAIIHQISQ
460 470 480 490 500
QAVAMATAAS AGHQGQQQGT AGTGAQSADS PAPPPPQARG NPMTSSPLTQ
510 520 530 540 550
MVSGLVGQLL MPLHTGDQTS TTSSSHSFSF STSTATPSSS SISSSTAPPS
560 570 580 590 600
STNTSGQTST HTTSTASMGQ SQEGGPGDNL AQLLGSLLGG FAGAGGGVSG
610 620 630 640 650
GPPSITVTVP GVPAFIQGLS EFIQSGQPVF PPPNQQPPPS QATPSAPSGA
660 670 680 690 700
AHTTAPQPPS GGGETLSPEL FTGIVQGVLS TMMGSLGAGQ GNTESIAQFI
710 720 730 740 750
QRLSQTSNLF TPGTGDAVGF FGDLLSLVCQ SFSMVDMVLL LHGNPQPLSR
760 770 780 790 800
VQPQLTAFFT EHYLQGLEPT DANIASAAED LINGLEEYIA ESFSTVTVRL
810 820 830 840 850
GVDIIQTNIS FLRQQFTRMA THILRCTDNT FGQRLLHMCT QGLFECLALN
860 870 880 890 900
LYCLRGEQRA LTTVINHRIR RMSAEVNPSL VNWLTSMMSM RLHVILEHNP
910 920 930 940 950
VSEDQIQHYV LYTQVFTLTS GFTPKLNHRI LKSICFYYVF HVQSESSQRI
960 970 980 990 1000
ESDAHASQQS DNMSVEEWVP IIRHDMLTQR KMKAQPPLSD AYLHGMPAKR
1010 1020 1030 1040 1050
RKTTQGEGPH LSLSEAVSRA ARTAGVRPVT APDSLQGELE ASELQEAYTQ
1060 1070 1080
QVKSDIKKRL SDDPDYNHQR FPNTHRAFSE DS
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A673LNY7 | A0A673LNY7_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,198 | Annotation score: | ||
A0A673LW12 | A0A673LW12_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,178 | Annotation score: | ||
A0A673LP24 | A0A673LP24_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,172 | Annotation score: | ||
A0A673LRM5 | A0A673LRM5_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,162 | Annotation score: | ||
A0A673LW31 | A0A673LW31_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,134 | Annotation score: | ||
A0A673LWD5 | A0A673LWD5_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,077 | Annotation score: | ||
A0A673LWN9 | A0A673LWN9_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,053 | Annotation score: | ||
A0A673LYW0 | A0A673LYW0_9TELE | Large proline-rich protein BAG6 | LOC107745707 | 1,068 | Annotation score: |
Genome annotation databases
Ensembli | ENSSRHT00000083298; ENSSRHP00000081102; ENSSRHG00000039228 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSSRHT00000083298; ENSSRHP00000081102; ENSSRHG00000039228 |
Family and domain databases
InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A673LP99_9TELE | |
Accessioni | A0A673LP99Primary (citable) accession number: A0A673LP99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 17, 2020 |
Last sequence update: | June 17, 2020 | |
Last modified: | May 25, 2022 | |
This is version 8 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |