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UniProtKB - A0A663DDU4 (A0A663DDU4_PANTR)

Entry version 8 (19 Jan 2022)
Sequence version 1 (22 Apr 2020)
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Protein

BK channel

Gene

CK820_G0007780

Organism
Pan troglodytes (Chimpanzee)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channelARBA annotation
Biological processIon transport, Potassium transport, Transport
LigandMagnesiumARBA annotation, Potassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BK channelARBA annotation
Alternative name(s):
BKCA alphaARBA annotation
Calcium-activated potassium channel subunit alpha-1ARBA annotation
Calcium-activated potassium channel, subfamily M subunit alpha-1ARBA annotation
K(VCA)alphaARBA annotation
KCa1.1ARBA annotation
Maxi K channelARBA annotation
Slo-alphaARBA annotation
Slo1ARBA annotation
Slowpoke homologARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CK820_G0007780Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPan troglodytes (Chimpanzee)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9598 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Pan
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000236370 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei84 – 106HelicalSequence analysisAdd BLAST23
Transmembranei177 – 195HelicalSequence analysisAdd BLAST19
Transmembranei215 – 233HelicalSequence analysisAdd BLAST19
Transmembranei298 – 319HelicalSequence analysisAdd BLAST22
Transmembranei334 – 353HelicalSequence analysisAdd BLAST20
Transmembranei365 – 383HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini180 – 389Ion_transInterPro annotationAdd BLAST210
Domaini544 – 631BK_channel_aInterPro annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 59DisorderedSequence analysisAdd BLAST59
Regioni699 – 727DisorderedSequence analysisAdd BLAST29
Regioni1167 – 1217DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 59Polar residuesSequence analysisAdd BLAST42
Compositional biasi706 – 724Polar residuesSequence analysisAdd BLAST19
Compositional biasi1167 – 1198Polar residuesSequence analysisAdd BLAST32
Compositional biasi1199 – 1217Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. [View classification]ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...OMAi		MEMYTES

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024939, Ca-act_K_channel_Slo-1
IPR005821, Ion_trans_dom
IPR003929, K_chnl_BK_asu
IPR036291, NAD(P)-bd_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR10027:SF28, PTHR10027:SF28, 3 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03493, BK_channel_a, 1 hit
PF00520, Ion_trans, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A663DDU4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANGGGGGGG SSGGGGGGGS SLRMSSNIHA NHLSLDASSS SSSSSSSSSS 
        60         70         80         90        100
SSSSSSSSVH EPKMDALIIP VTMEVPCDSR GQRMWWAFLA SSMVTFFGGL 
       110        120        130        140        150
FIILLWRTLK YLWTVCCHCG GKTKEAQKIN NGSSQADGTL KPVDEKEEAV 
       160        170        180        190        200
AAEVGWMTSV KDWAGVMISA QTLTGRVLVV LVFALSIGAL VIYFIDSSNP 
       210        220        230        240        250
IESCQNFYKD FTLQIDMAFN VFFLLYFGLR FIAANDKLWF WLEVNSVVDF 
       260        270        280        290        300
FTVPPVFVSV YLNRSWLGLR FLRALRLIQF SEILQFLNIL KTSNSIKLVN 
       310        320        330        340        350
LLSIFISTWL TAAGFIHLVE NSGDPWENFQ NNQALTYWEC VYLLMVTMST 
       360        370        380        390        400
VGYGDVYAKT TLGRLFMVFF ILGGLAMFAS YVPEIIELIG NRKKYGGSYS 
       410        420        430        440        450
AVSGRKHIVV CGHITLESVS NFLKDFLHKD RDDVNVEIVF LHNISPNLEL 
       460        470        480        490        500
EALFKRHFTQ VEFYQGSVLN PHDLARVKIE SADACLILAN KYCADPDAED 
       510        520        530        540        550
ASNIMRVISI KNYHPKIRII TQMLQYHNKA HLLNIPSWNW KEGDDAICLA 
       560        570        580        590        600
ELKLGFIAQS CLAQGLSTML ANLFSMRSFI KIEEDTWQKY YLEGVSNEMY 
       610        620        630        640        650
TEYLSSAFVG LSFPTVCELC FVKLKLLMIA IEYKSANRES RILINPGNHL 
       660        670        680        690        700
KIQEGTLGFF IASDAKEVKR AFFYCKACHD DITDPKRIKK CGCKRLEDEQ 
       710        720        730        740        750
PSTLSPKKKQ RNGGMRNSPN TSPKLMRHDP LLIPGNDQID NMDSNVKKYD 
       760        770        780        790        800
STGMFHWCAP KEIEKVILVT GWMPYLGPRV LMTCLDIGVV CMPTDIQSTS 
       810        820        830        840        850
PASIKKFKET RSEAAMTVLS GHVVVCIFGD VSSALIGLRN LVMPLRASNF 
       860        870        880        890        900
HYHELKHIVF VGSIEYLKRE WETLHNFPKV SILPGTPLSR ADLRAVNINL 
       910        920        930        940        950
CDMCVILSAN QNNIDDTSLQ DKECILASLN IKSMQFDDSI GVLQANSQGF 
       960        970        980        990       1000
TPPGMDRSSP DNSPVHGMLR QPSITTGVNI PIITELVNDT NVQFLDQDDD 
      1010       1020       1030       1040       1050
DDPDTELYLT QPFACGTAFA VSVLDSLMSA TYFNDNILTL IRTLVTGGAT 
      1060       1070       1080       1090       1100
PELEALIAEE NALRGGYSTP QTLANRDRCR VAQLALLDGP FADLGDGGCY 
      1110       1120       1130       1140       1150
GDLFCKALKT YNMLCFGIYR LRDAHLSTPS QCTKRYVITN PPYEFELVPT 
      1160       1170       1180       1190       1200
DLIFCLMQFD HNAGQSRASL SHSSHSSQSS SKKSSSVHSI PSTANRQNRP 
      1210 
KSRESRDKQK YVQEERL
Length:1,217
Mass (Da):135,351
Last modified:April 22, 2020 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8667A6C5AFF87788
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
NBAG03000223 Genomic DNA Translation: PNI75257.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
NBAG03000223 Genomic DNA Translation: PNI75257.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Phylogenomic databases

OMAiMEMYTES

Family and domain databases

InterProiView protein in InterPro
IPR024939, Ca-act_K_channel_Slo-1
IPR005821, Ion_trans_dom
IPR003929, K_chnl_BK_asu
IPR036291, NAD(P)-bd_dom_sf
PANTHERiPTHR10027:SF28, PTHR10027:SF28, 3 hits
PfamiView protein in Pfam
PF03493, BK_channel_a, 1 hit
PF00520, Ion_trans, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A663DDU4_PANTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A663DDU4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 22, 2020
Last sequence update: April 22, 2020
Last modified: January 19, 2022
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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