CK820_G0048139

Functionⁱ

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functionⁱ

coreceptor activity Source: InterPro
interleukin-16 binding Source: Ensembl
interleukin-16 receptor activity Source: Ensembl
MHC class II protein binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
zinc ion binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion Source: InterPro
cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
cytokine production Source: Ensembl
defense response to Gram-negative bacterium Source: Ensembl
helper T cell enhancement of adaptive immune response Source: Ensembl
immune response Source: InterPro
induction by virus of host cell-cell fusion Source: Ensembl
interleukin-15-mediated signaling pathway Source: Ensembl
macrophage differentiation Source: Ensembl
maintenance of protein location in cell Source: Ensembl
positive regulation of calcium-mediated signaling Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of monocyte differentiation Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of protein kinase activity Source: Ensembl
positive regulation of T cell activation Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
positive regulation of viral entry into host cell Source: Ensembl
regulation of calcium ion transport Source: Ensembl
T cell selection Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ImmunityARBA annotation

Biological process

ImmunityARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: CD4 isoform 1Imported Submitted name: CD4 isoform 2Imported
Gene namesⁱ	ORF Names:CK820_G0048139Imported
Organismⁱ	Pan troglodytes (Chimpanzee)Imported
Taxonomic identifierⁱ	9598 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Pan
Proteomesⁱ	UP000236370 Componentⁱ: Unassembled WGS sequence

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	397 – 420	HelicalSequence analysisAdd BLAST		24

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_5024698819	26 – 458	Sequence analysisAdd BLAST		433

Keywords - PTMⁱ

PhosphoproteinARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

interleukin-16 binding Source: Ensembl
MHC class II protein binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein tyrosine kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A663D762
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	26 – 123	IGInterPro annotationAdd BLAST	98
Domainⁱ	32 – 116	IGc2InterPro annotationAdd BLAST	85
Domainⁱ	36 – 111	IGvInterPro annotationAdd BLAST	76
Domainⁱ	128 – 202	IGInterPro annotationAdd BLAST	75
Domainⁱ	134 – 191	IGc2InterPro annotationAdd BLAST	58
Domainⁱ	208 – 317	IGInterPro annotationAdd BLAST	110

Keywords - Domainⁱ

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups More...OrthoDBⁱ	652984at2759

OrthoDBⁱ

652984at2759

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR000973, CD4 IPR015274, CD4-extracel IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin IPR021963, Tcell_CD4_Cterm
PANTHERⁱ	PTHR11422:SF0, PTHR11422:SF0, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05790, C2-set, 2 hits PF09191, CD4-extracel, 1 hit PF00047, ig, 1 hit PF12104, Tcell_CD4_C, 1 hit
PRINTSⁱ	PR00692, CD4TCANTIGEN
SMARTⁱ	View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A663D762-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ 
        60         70         80         90        100
FHWKNSNQTK ILGNQGSFLT KGPSKLNDRV DSRRSLWDQG NFTLIIKNLK 
       110        120        130        140        150
IEDSDTYICE VGDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS 
       160        170        180        190        200
PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV 
       210        220        230        240        250
VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS 
       260        270        280        290        300
WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA 
       310        320        330        340        350
LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK 
       360        370        380        390        400
VSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI 
       410        420        430        440        450
VLGGVAGLLL FIGLGIFFCV RCRHRRRQAQ RMSQIKRLLS EKKTCQCPHR 

FQKTCSPI

Length:458

Mass (Da):51,057

Last modified:April 22, 2020 - v1

Checksum:ⁱA7C3AC8A5257D3AD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	NBAG03000464 Genomic DNA Translation: PNI21209.1 NBAG03000464 Genomic DNA Translation: PNI21210.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001009043.1, NM_001009043.1 XP_016777999.1, XM_016922510.1 XP_016778000.1, XM_016922511.1

Genome annotation databases

GeneIDⁱ	450124
KEGGⁱ	ptr:450124

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A663D762	T-cell surface glycoprotein CD4		PANTR		458	UniRef100_P16004
T-cell surface antigen T4/Leu-3		Pan troglodytes verus		458
T-cell surface antigen T4/Leu-3		Pan troglodytes troglodytes		458
T-cell surface antigen T4/Leu-3		PANTR		458
+1

Protein	Similar proteins		Species	Score	Length	Source
A0A663D762	T-cell surface glycoprotein CD4	)	HUMAN		458	UniRef90_P01730
T-cell surface glycoprotein CD4	)	MACMU		458
T-cell surface glycoprotein CD4		MACFA		458
T-cell surface glycoprotein CD4		MACNE		458
T-cell surface glycoprotein CD4		PANTR		458
+104

Protein	Similar proteins		Species	Score	Length	Source
A0A663D762	T-cell surface glycoprotein CD4	)	HUMAN		458	UniRef50_P01730
T-cell surface glycoprotein CD4	)	MACMU		458
T-cell surface glycoprotein CD4		MACNE		458
T-cell surface glycoprotein CD4		MACFU		458
T-cell surface glycoprotein CD4		PANTR		458
+227

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	NBAG03000464 Genomic DNA Translation: PNI21209.1 NBAG03000464 Genomic DNA Translation: PNI21210.1
RefSeqⁱ	NP_001009043.1, NM_001009043.1 XP_016777999.1, XM_016922510.1 XP_016778000.1, XM_016922511.1

3D structure databases

SMRⁱ	A0A663D762
ModBaseⁱ	Search...

Genome annotation databases

GeneIDⁱ	450124
KEGGⁱ	ptr:450124

Organism-specific databases

CTDⁱ	920

CTDⁱ

920

Phylogenomic databases

OrthoDBⁱ	652984at2759

OrthoDBⁱ

652984at2759

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR000973, CD4 IPR015274, CD4-extracel IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set IPR013151, Immunoglobulin IPR021963, Tcell_CD4_Cterm
PANTHERⁱ	PTHR11422:SF0, PTHR11422:SF0, 1 hit
Pfamⁱ	View protein in Pfam PF05790, C2-set, 2 hits PF09191, CD4-extracel, 1 hit PF00047, ig, 1 hit PF12104, Tcell_CD4_C, 1 hit
PRINTSⁱ	PR00692, CD4TCANTIGEN
SMARTⁱ	View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 2 hits SM00406, IGv, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 4 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A663D762_PANTR
Accessionⁱ	A0A663D762Primary (citable) accession number: A0A663D762
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 22, 2020
	Last sequence update:	April 22, 2020
	Last modified:	February 10, 2021
	This is version 6 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - A0A663D762 (A0A663D762_PANTR)

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CD4 isoform 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ