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Entry version 7 (10 Feb 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Spectrin alpha

Gene

DEA37_0010677

Organism
Paragonimus westermani
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2289 – 2300PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2332 – 2343PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin cappingARBA annotation, Actin-bindingARBA annotation, Calmodulin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotationARBA annotation, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spectrin alphaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DEA37_0010677Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiParagonimus westermaniImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34504 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaTroglotremataTroglotrematidaeParagonimus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000324629 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini980 – 1039SH3InterPro annotationAdd BLAST60
Domaini2276 – 2311EF-handInterPro annotationAdd BLAST36
Domaini2319 – 2354EF-handInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili197 – 228Sequence analysisAdd BLAST32
Coiled coili303 – 337Sequence analysisAdd BLAST35
Coiled coili515 – 535Sequence analysisAdd BLAST21
Coiled coili733 – 753Sequence analysisAdd BLAST21
Coiled coili1160 – 1187Sequence analysisAdd BLAST28
Coiled coili1227 – 1254Sequence analysisAdd BLAST28
Coiled coili1658 – 1685Sequence analysisAdd BLAST28
Coiled coili1864 – 1891Sequence analysisAdd BLAST28
Coiled coili1903 – 1923Sequence analysisAdd BLAST21
Coiled coili2208 – 2228Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A5J4P2W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSELPLKVKI LETPEDIQER REQVLSRYSA FKEATEYRRY KLEQAKRYQY
60 70 80 90 100
FKRDADELES WILEKLQTYS NEDFKELNNL QAKKQKHQAF ELEVTAHAET
110 120 130 140 150
LASLDRSGEE MIQDDHYASE IIKVRRRYLI LTLQNRLDEL HALWNKLMAM
160 170 180 190 200
LGEKSRLLNL TLKFVQFLRQ ADDLLFWIRE KETYVTSEDY GNDLEHVEVL
210 220 230 240 250
QKKFEEFLKD LEYQEQRAQD VYEKEEELLK EEFPEDALVI AKAGEVREAL
260 270 280 290 300
KRLNDLADHR RHKLFEAHEI QRFFRDTDKA ISWVNEKSIP LTVEDCGRDL
310 320 330 340 350
ASVQALQRKH ETLERDLAAL KDKLVQIGLD AEELAEKHPD SRDTIHGKHQ
360 370 380 390 400
TLLAAWEKLK AQADLRSSKL DEAFKLQRFL ADWRDISVWI ADMKALIEAD
410 420 430 440 450
ELAKDVAGAE AHVERHNEHK AEIASREDSY LSCVQEGQNL IDLGIADSAD
460 470 480 490 500
IATKLSELER ERDALLNLWE TRRVQFEQCM DLQLFYRDAE QAESWISKQE
510 520 530 540 550
ALLENKDVGD SLDSVEALIR KHEDFEKSLA AQEEKMRHID DFATKLIENN
560 570 580 590 600
HYAAPEVAQL QTLLSDRRSA LRDKAGDHRK RLEDSHRYQM FDRDADEMQL
610 620 630 640 650
WIIEKLRSAT DDSHKDPTNL QTKVQKHQNF EAEVQANQSR VDGIKKMGQD
660 670 680 690 700
LIQAGHYNSP EIGARIEQLD DTWSRLIDAM TIKKTNLDQA NRQQQFVRNV
710 720 730 740 750
DDVELWLGEV EAQLASDELG RDLNGVINVQ KKHNLLEADV QAHRDRIEAF
760 770 780 790 800
KAQVDTFAAE GHFDAPIIAE KYSQLSQRYL AMEEPIRLRR EKLRDAYRLH
810 820 830 840 850
QFFRDVEDEQ DWIHEKEPIA GSTNVGRDLI GVQNLIKKHQ AVSAEVTGHH
860 870 880 890 900
PRIQDVVQEG NAMIAAQHYA ADDIAKRIKE LEDDWKSLCN KTDRRHQLLE
910 920 930 940 950
DSLQAQQYFA DASEAESWMR EKEPLVGSSE FGRDEDSTEA LLKKHNALMA
960 970 980 990 1000
DIEAYGSTID ALGNQASACR MQEAPISDIL GKDVVMALYD YQEKSPREVS
1010 1020 1030 1040 1050
MRKGEILTLL ASNHKDWWKV EVNDRQGFVP AAYVKKIDAP LSDSQNDLME
1060 1070 1080 1090 1100
KPLTVASQQQ RLEEQYQYLL QLGRDRRERL QDSLEAYHLV REANDLHQWV
1110 1120 1130 1140 1150
IEKELVAVTE TIVPGKLEEV ESARKKVDDF VVEQKEREAR VTELCAKADR
1160 1170 1180 1190 1200
LKRGGQTEAV EKIEGIIMQL QKKYEQLEEV TTKKMKDLED IDAVQRYHRE
1210 1220 1230 1240 1250
CDEAKEWVDE KQARLMTDDL GTDLTSVQRL IRKHDALERD LVALGDRVKQ
1260 1270 1280 1290 1300
LDTKAADLVQ IHPQDADAIF DHQQDLNQSW NALAESAEQR KAKLLDSLDL
1310 1320 1330 1340 1350
QKFLADARDL QSWIATMDGL VTSDELAKDV TSAEALLERH RDYRTEIDTR
1360 1370 1380 1390 1400
SPAFTNLEMF GKELLDHGHY AAPVVQEQLQ KLAEARAVLD NDWCDRNKKL
1410 1420 1430 1440 1450
EQCLEMQLFL RDCEQAEDWM GMRESSLAGD DVDGNKVDAL IRKHEDFNRA
1460 1470 1480 1490 1500
LNLQEAKIQS LQVGAEKLLD MDHYDSEAIK GKLQEVLGRW KELKDAMIEN
1510 1520 1530 1540 1550
RSKLRDVQTF QAFIRDADEM ELWITKKMQL TMDESYKDPK INVQAKHQKH
1560 1570 1580 1590 1600
QAFEAELAAN AERLQSIIGA GQRLIQNDQC KGQEDIVQER IEKLANQWDH
1610 1620 1630 1640 1650
LVNRSKEKSE KLQEANRQAA YDAGIKDIEF WLGEMETTLA SPDYGKDSAS
1660 1670 1680 1690 1700
VDSLMSKHQV LATDIQAHED RIRELDARAD EFIHSGAGDA ETILERKKLI
1710 1720 1730 1740 1750
NERYEKIRAL SENRAVTLGK AKRLHDFYRN IDDEEAWIRE KKIIVSSEDY
1760 1770 1780 1790 1800
GRDLIGVRNL HKKHQRIEAE VASHEPAIRQ TLEQGEELMV GTLLTDPEVV
1810 1820 1830 1840 1850
RSRMQQLDNA WDELQSLTAL RRQKLEESLA YQDFLDSVEE EEAWILEKQH
1860 1870 1880 1890 1900
LLSSEDYGST LAAVQGLQKK HEAFEADLKI HEDKCDNLCA EGAGLIRTGN
1910 1920 1930 1940 1950
HNCPAIEQRR EGLREKLETL KRAALRRKSC LTDNSAFLQF MWKTDVVESW
1960 1970 1980 1990 2000
IADRETQVRS EDYARDLSSV QTLLTKHETF DTALESFRNE GIQTITTLYE
2010 2020 2030 2040 2050
QLIEAKHAQT PTIQSRFTTL MDRWNRLCRD SDRRKADLLQ LQEQYKKVEE
2060 2070 2080 2090 2100
LYLAFAKRAS TFNSWFENAE EDLTDPVRCN SLDEVRALCD AQEQFKASLK
2110 2120 2130 2140 2150
AAEVDFQKLG QLDHEIKSYG VGMNPYTWFT MEALVETWRN LQKIILERDT
2160 2170 2180 2190 2200
ELRRETARQE QNDQLRQEFA AVANSFHQWL QNVRTSMMEA SGSLEEQLEA
2210 2220 2230 2240 2250
TRIKATEVNA RRNDLREIEE LGARLEERLI LDNRYTEHST VGLSQAWDQL
2260 2270 2280 2290 2300
NQLAMRMQHN LEQQIQARNV SGVSEEALRE FSMMFKHFDK DKSGRLDHRE
2310 2320 2330 2340 2350
FKSCLRALGH DLHEVGEGQV DEEFEAILNA VDPNRDGFVT LQEFMAFMIS
2360 2370 2380 2390 2400
RETENVQSRD EVEEAFKALT KDGKEYLKDG KEYITKEQLY ANLSKEQAEY
2410 2420 2430
CCRVMPPYYT KGGQPIPDAY DYHAFTRQLF QN
Length:2,432
Mass (Da):282,214
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CA936DD44B7C14C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
QNGE01000034 Genomic DNA Translation: KAA3682296.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
QNGE01000034 Genomic DNA Translation: KAA3682296.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit
InterProiView protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5J4P2W7_9TREM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5J4P2W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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