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Entry version 10 (29 Sep 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Dystrophin

Gene

DMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingUniRule annotationARBA annotation
LigandCalciumARBA annotation, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DystrophinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DMDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2928, DMD

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198947

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationARBA annotation, Cytoplasm, CytoskeletonUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotationARBA annotation, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000198947

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A5H1ZRP8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A5H1ZRP8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 115Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini130 – 236Calponin-homology (CH)InterPro annotationAdd BLAST107
Domaini3051 – 3084WWInterPro annotationAdd BLAST34
Domaini3303 – 3350ZZ-typeInterPro annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3524 – 3550DisorderedSequence analysisAdd BLAST27
Regioni3599 – 3681DisorderedSequence analysisAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili453 – 473Sequence analysisAdd BLAST21
Coiled coili479 – 502Sequence analysisAdd BLAST24
Coiled coili752 – 779Sequence analysisAdd BLAST28
Coiled coili968 – 988Sequence analysisAdd BLAST21
Coiled coili1029 – 1056Sequence analysisAdd BLAST28
Coiled coili1186 – 1216Sequence analysisAdd BLAST31
Coiled coili1295 – 1315Sequence analysisAdd BLAST21
Coiled coili1351 – 1371Sequence analysisAdd BLAST21
Coiled coili1820 – 1840Sequence analysisAdd BLAST21
Coiled coili1908 – 1935Sequence analysisAdd BLAST28
Coiled coili2185 – 2215Sequence analysisAdd BLAST31
Coiled coili2312 – 2339Sequence analysisAdd BLAST28
Coiled coili2399 – 2419Sequence analysisAdd BLAST21
Coiled coili2499 – 2543Sequence analysisAdd BLAST45
Coiled coili2550 – 2570Sequence analysisAdd BLAST21
Coiled coili2585 – 2605Sequence analysisAdd BLAST21
Coiled coili2918 – 2952Sequence analysisAdd BLAST35
Coiled coili3565 – 3599Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3599 – 3669Polar residuesSequence analysisAdd BLAST71

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154342

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.60.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 17 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002341, Dystrophin/utrophin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 22 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 36 potential isoforms that are computationally mapped.Show allAlign All

A0A5H1ZRP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEVSSDERE DVQKKTFTKW VNAQFSKFGK QHIENLFSDL QDGRRLLDLL
60 70 80 90 100
EGLTGQKLPK EKGSTRVHAL NNVNKALRVL QNNNVDLVNI GSTDIVDGNH
110 120 130 140 150
KLTLGLIWNI ILHWQVKNVM KNIMAGLQQT NSEKILLSWV RQSTRNYPQV
160 170 180 190 200
NVINFTTSWS DGLALNALIH SHRPDLFDWN SVVCQQSATQ RLEHAFNIAR
210 220 230 240 250
YQLGIEKLLD PEDVDTTYPD KKSILMYITS LFQVLPQQVS IEAIQEVEML
260 270 280 290 300
PRPPKVTKEE HFQLHHQMHY SQQITVSLAQ GYERTSSPKP RFKSYAYTQA
310 320 330 340 350
AYVTTSDPTR SPFPSQHLEA PEDKSFGSSL MESEVNLDRY QTALEEVLSW
360 370 380 390 400
LLSAEDTLQA QGEISNDVEV VKDQFHTHEG YMMDLTAHQG RVGNILQLGS
410 420 430 440 450
KLIGTGKLSE DEETEVQEQM NLLNSRWECL RVASMEKQSN LHRVLMDLQN
460 470 480 490 500
QKLKELNDWL TKTEERTRKM EEEPLGPDLE DLKRQVQQHK VLQEDLEQEQ
510 520 530 540 550
VRVNSLTHMV VVVDESSGDH ATAALEEQLK VLGDRWANIC RWTEDRWVLL
560 570 580 590 600
QDILLKWQRL TEEQCLFSAW LSEKEDAVNK IHTTGFKDQN EMLSSLQKLA
610 620 630 640 650
VLKADLEKKK QSMGKLYSLK QDLLSTLKNK SVTQKTEAWL DNFARCWDNL
660 670 680 690 700
VQKLEKSTAQ ISQAVTTTQP SLTQTTVMET VTTVTTREQI LVKHAQEELP
710 720 730 740 750
PPPPQKKRQI TVDSEIRKRL DVDITELHSW ITRSEAVLQS PEFAIFRKEG
760 770 780 790 800
NFSDLKEKVN AIEREKAEKF RKLQDASRSA QALVEQMVNE GVNADSIKQA
810 820 830 840 850
SEQLNSRWIE FCQLLSERLN WLEYQNNIIA FYNQLQQLEQ MTTTAENWLK
860 870 880 890 900
IQPTTPSEPT AIKSQLKICK DEVNRLSDLQ PQIERLKIQS IALKEKGQGP
910 920 930 940 950
MFLDADFVAF TNHFKQVFSD VQAREKELQT IFDTLPPMRY QETMSAIRTW
960 970 980 990 1000
VQQSETKLSI PQLSVTDYEI MEQRLGELQA LQSSLQEQQS GLYYLSTTVK
1010 1020 1030 1040 1050
EMSKKAPSEI SRKYQSEFEE IEGRWKKLSS QLVEHCQKLE EQMNKLRKIQ
1060 1070 1080 1090 1100
NHIQTLKKWM AEVDVFLKEE WPALGDSEIL KKQLKQCRLL VSDIQTIQPS
1110 1120 1130 1140 1150
LNSVNEGGQK IKNEAEPEFA SRLETELKEL NTQWDHMCQQ VYARKEALKG
1160 1170 1180 1190 1200
GLEKTVSLQK DLSEMHEWMT QAEEEYLERD FEYKTPDELQ KAVEEMKRAK
1210 1220 1230 1240 1250
EEAQQKEAKV KLLTESVNSV IAQAPPVAQE ALKKELETLT TNYQWLCTRL
1260 1270 1280 1290 1300
NGKCKTLEEV WACWHELLSY LEKANKWLNE VEFKLKTTEN IPGGAEEISE
1310 1320 1330 1340 1350
VLDSLENLMR HSEDNPNQIR ILAQTLTDGG VMDELINEEL ETFNSRWREL
1360 1370 1380 1390 1400
HEEAVRRQKL LEQSIQSAQE TEKSLHLIQE SLTFIDKQLA AYIADKVDAA
1410 1420 1430 1440 1450
QMPQEAQKIQ SDLTSHEISL EEMKKHNQGK EAAQRVLSQI DVAQKKLQDV
1460 1470 1480 1490 1500
SMKFRLFQKP ANFEQRLQES KMILDEVKMH LPALETKSVE QEVVQSQLNH
1510 1520 1530 1540 1550
CVNLYKSLSE VKSEVEMVIK TGRQIVQKKQ TENPKELDER VTALKLHYNE
1560 1570 1580 1590 1600
LGAKVTERKQ QLEKCLKLSR KMRKEMNVLT EWLAATDMEL TKRSAVEGMP
1610 1620 1630 1640 1650
SNLDSEVAWG KATQKEIEKQ KVHLKSITEV GEALKTVLGK KETLVEDKLS
1660 1670 1680 1690 1700
LLNSNWIAVT SRAEEWLNLL LEYQKHMETF DQNVDHITKW IIQADTLLDE
1710 1720 1730 1740 1750
SEKKKPQQKE DVLKRLKAEL NDIRPKVDST RDQAANLMAN RGDHCRKLVE
1760 1770 1780 1790 1800
PQISELNHRF AAISHRIKTG KASIPLKELE QFNSDIQKLL EPLEAEIQQG
1810 1820 1830 1840 1850
VNLKEEDFNK DMNEDNEGTV KELLQRGDNL QQRITDERKR EEIKIKQQLL
1860 1870 1880 1890 1900
QTKHNALKDL RSQRRKKALE ISHQWYQYKR QADDLLKCLD DIEKKLASLP
1910 1920 1930 1940 1950
EPRDERKIKE IDRELQKKKE ELNAVRRQAE GLSEDGAAMA VEPTQIQLSK
1960 1970 1980 1990 2000
RWREIESKFA QFRRLNFAQI HTVREETMMV MTEDMPLEIS YVPSTYLTEI
2010 2020 2030 2040 2050
THVSQALLEV EQLLNAPDLC AKDFEDLFKQ EESLKNIKDS LQQSSGRIDI
2060 2070 2080 2090 2100
IHSKKTAALQ SATPVERVKL QEALSQLDFQ WEKVNKMYKD RQGRFDRSVE
2110 2120 2130 2140 2150
KWRRFHYDIK IFNQWLTEAE QFLRKTQIPE NWEHAKYKWY LKELQDGIGQ
2160 2170 2180 2190 2200
RQTVVRTLNA TGEEIIQQSS KTDASILQEK LGSLNLRWQE VCKQLSDRKK
2210 2220 2230 2240 2250
RLEEQKNILS EFQRDLNEFV LWLEEADNIA SIPLEPGKEQ QLKEKLEQVK
2260 2270 2280 2290 2300
LLVEELPLRQ GILKQLNETG GPVLVSAPIS PEEQDKLENK LKQTNLQWIK
2310 2320 2330 2340 2350
VSRALPEKQG EIEAQIKDLG QLEKKLEDLE EQLNHLLLWL SPIRNQLEIY
2360 2370 2380 2390 2400
NQPNQEGPFD VKETEIAVQA KQPDVEEILS KGQHLYKEKP ATQPVKRKLE
2410 2420 2430 2440 2450
DLSSEWKAVN RLLQELRAKQ PDLAPGLTTI GASPTQTVTL VTQPVVTKET
2460 2470 2480 2490 2500
AISKLEMPSS LMLEVPALAD FNRAWTELTD WLSLLDQVIK SQRVMVGDLE
2510 2520 2530 2540 2550
DINEMIIKQK ATMQDLEQRR PQLEELITAA QNLKNKTSNQ EARTIITDRI
2560 2570 2580 2590 2600
ERIQNQWDEV QEHLQNRRQQ LNEMLKDSTQ WLEAKEEAEQ VLGQARAKLE
2610 2620 2630 2640 2650
SWKEGPYTVD AIQKKITETK QLAKDLRQWQ TNVDVANDLA LKLLRDYSAD
2660 2670 2680 2690 2700
DTRKVHMITE NINASWRSIH KRVSEREAAL EETHRLLQQF PLDLEKFLAW
2710 2720 2730 2740 2750
LTEAETTANV LQDATRKERL LEDSKGVKEL MKQWQDLQGE IEAHTDVYHN
2760 2770 2780 2790 2800
LDENSQKILR SLEGSDDAVL LQRRLDNMNF KWSELRKKSL NIRSHLEASS
2810 2820 2830 2840 2850
DQWKRLHLSL QELLVWLQLK DDELSRQAPI GGDFPAVQKQ NDVHRAFKRE
2860 2870 2880 2890 2900
LKTKEPVIMS TLETVRIFLT EQPLEGLEKL YQEPRELPPE ERAQNVTRLL
2910 2920 2930 2940 2950
RKQAEEVNTE WEKLNLHSAD WQRKIDETLE RLRELQEATD ELDLKLRQAE
2960 2970 2980 2990 3000
VIKGSWQPVG DLLIDSLQDH LEKVKALRGE IAPLKENVSH VNDLARQLTT
3010 3020 3030 3040 3050
LGIQLSPYNL STLEDLNTRW KLLQVAVEDR VRQLHEAHRD FGPASQHFLS
3060 3070 3080 3090 3100
TSVQGPWERA ISPNKVPYYI NHETQTTCWD HPKMTELYQS LADLNNVRFS
3110 3120 3130 3140 3150
AYRTAMKLRR LQKALCLDLL SLSAACDALD QHNLKQNDQP MDILQIINCL
3160 3170 3180 3190 3200
TTIYDRLEQE HNNLVNVPLC VDMCLNWLLN VYDTGRTGRI RVLSFKTGII
3210 3220 3230 3240 3250
SLCKAHLEDK YRYLFKQVAS STGFCDQRRL GLLLHDSIQI PRQLGEVASF
3260 3270 3280 3290 3300
GGSNIEPSVR SCFQFANNKP EIEAALFLDW MRLEPQSMVW LPVLHRVAAA
3310 3320 3330 3340 3350
ETAKHQAKCN ICKECPIIGF RYRSLKHFNY DICQSCFFSG RVAKGHKMHY
3360 3370 3380 3390 3400
PMVEYCTPTT SGEDVRDFAK VLKNKFRTKR YFAKHPRMGY LPVQTVLEGD
3410 3420 3430 3440 3450
NMETPVTLIN FWPVDSAPAS SPQLSHDDTH SRIEHYASRL AEMENSNGSY
3460 3470 3480 3490 3500
LNDSISPNES IDDEHLLIQH YCQSLNQDSP LSQPRSPAQI LISLESEERG
3510 3520 3530 3540 3550
ELERILADLE EENRNLQAEY DRLKQQHEHK GLSPLPSPPE MMPTSPQSPR
3560 3570 3580 3590 3600
DAELIAEAKL LRQHKGRLEA RMQILEDHNK QLESQLHRLR QLLEQPQAEA
3610 3620 3630 3640 3650
KVNGTTVSSP STSLQRSDSS QPMLLRVVGS QTSDSMGEED LLSPPQDTST
3660 3670 3680
GLEEVMEQLN NSFPSSRGRN TPGKPMREDT M
Length:3,681
Mass (Da):426,029
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD04A9DF144AF0EB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 36 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P11532DMD_HUMAN
Dystrophin
DMD
3,685Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6G3A0A075B6G3_HUMAN
Dystrophin
DMD
3,685Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WV90A0A087WV90_HUMAN
Dystrophin
DMD
2,341Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WTU7A0A087WTU7_HUMAN
Dystrophin
DMD
1,154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRQ1A0A5H1ZRQ1_HUMAN
Dystrophin
DMD
1,225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRP7A0A5H1ZRP7_HUMAN
Dystrophin
DMD
970Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRR9A0A5H1ZRR9_HUMAN
Dystrophin
DMD
1,115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y304H0Y304_HUMAN
Dystrophin
DMD
1,386Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRP9A0A5H1ZRP9_HUMAN
Dystrophin
DMD
1,230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5H1ZRQ8A0A5H1ZRQ8_HUMAN
Dystrophin
DMD
1,243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006061 Genomic DNA No translation available.
AC078957 Genomic DNA No translation available.
AC078958 Genomic DNA No translation available.
AC079143 Genomic DNA No translation available.
AC079175 Genomic DNA No translation available.
AC079177 Genomic DNA No translation available.
AC079864 Genomic DNA No translation available.
AC090632 Genomic DNA No translation available.
AC093167 Genomic DNA No translation available.
AC093193 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378677; ENSP00000367948; ENSG00000198947

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006061 Genomic DNA No translation available.
AC078957 Genomic DNA No translation available.
AC078958 Genomic DNA No translation available.
AC079143 Genomic DNA No translation available.
AC079175 Genomic DNA No translation available.
AC079177 Genomic DNA No translation available.
AC079864 Genomic DNA No translation available.
AC090632 Genomic DNA No translation available.
AC093167 Genomic DNA No translation available.
AC093193 Genomic DNA No translation available.

3D structure databases

SMRiA0A5H1ZRP8
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5H1ZRP8

Genome annotation databases

EnsembliENST00000378677; ENSP00000367948; ENSG00000198947

Organism-specific databases

HGNCiHGNC:2928, DMD
OpenTargetsiENSG00000198947
VEuPathDBiHostDB:ENSG00000198947

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154342

Family and domain databases

CDDicd00014, CH, 2 hits
cd00201, WW, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.60.90, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR035436, Dystrophin/utrophin
IPR011992, EF-hand-dom_pair
IPR015153, EF-hand_dom_typ1
IPR015154, EF-hand_dom_typ2
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
IPR001202, WW_dom
IPR036020, WW_dom_sf
IPR000433, Znf_ZZ
IPR043145, Znf_ZZ_sf
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF09068, EF-hand_2, 1 hit
PF09069, EF-hand_3, 1 hit
PF00435, Spectrin, 17 hits
PF00397, WW, 1 hit
PF00569, ZZ, 1 hit
PIRSFiPIRSF002341, Dystrophin/utrophin, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00150, SPEC, 22 hits
SM00456, WW, 1 hit
SM00291, ZnF_ZZ, 1 hit
SUPFAMiSSF47473, SSF47473, 2 hits
SSF47576, SSF47576, 1 hit
SSF51045, SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 1 hit
PS01357, ZF_ZZ_1, 1 hit
PS50135, ZF_ZZ_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5H1ZRP8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5H1ZRP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: September 29, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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