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UniProtKB - A0A5F9ZI73 (A0A5F9ZI73_HUMAN)
Protein
Submitted name:
Ankyrin-2
Gene
ANK2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Ankyrin-2Imported |
Gene namesi | Name:ANK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
VEuPathDBi | HostDB:ENSG00000145362 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- Membrane ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 42 – 74 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 75 – 107 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 108 – 140 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 203 – 235 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 236 – 268 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 269 – 301 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 302 – 334 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 335 – 367 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 368 – 400 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 401 – 433 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 434 – 466 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 467 – 499 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 500 – 532 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 533 – 565 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 566 – 598 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 599 – 631 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 632 – 664 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 665 – 697 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 698 – 730 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 731 – 763 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 951 – 1106 | ZU5InterPro annotationAdd BLAST | 156 | |
Domaini | 1108 – 1254 | ZU5InterPro annotationAdd BLAST | 147 | |
Domaini | 1434 – 1518 | DeathInterPro annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1408 – 1432 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1642 – 1723 | DisorderedSequence analysisAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1642 – 1665 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1674 – 1688 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1694 – 1708 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All
A0A5F9ZI73-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKSGFTPLHI AAHYGNVNVA TLLLNRGAAV DFTARNGITP LHVASKRGNT
260 270 280 290 300
NMVKLLLDRG GQIDAKTRDG LTPLHCAARS GHDQVVELLL ERGAPLLART
310 320 330 340 350
KNGLSPLHMA AQGDHVECVK HLLQHKAPVD DVTLDYLTAL HVAAHCGHYR
360 370 380 390 400
VTKLLLDKRA NPNARALNGF TPLHIACKKN RIKVMELLVK YGASIQAITE
410 420 430 440 450
SGLTPIHVAA FMGHLNIVLL LLQNGASPDV TNIRGETALH MAARAGQVEV
460 470 480 490 500
VRCLLRNGAL VDARAREEQT PLHIASRLGK TEIVQLLLQH MAHPDAATTN
510 520 530 540 550
GYTPLHISAR EGQVDVASVL LEAGAAHSLA TKKGFTPLHV AAKYGSLDVA
560 570 580 590 600
KLLLQRRAAA DSAGKNGLTP LHVAAHYDNQ KVALLLLEKG ASPHATAKNG
610 620 630 640 650
YTPLHIAAKK NQMQIASTLL NYGAETNIVT KQGVTPLHLA SQEGHTDMVT
660 670 680 690 700
LLLDKGANIH MSTKSGLTSL HLAAQEDKVN VADILTKHGA DQDAHTKLGY
710 720 730 740 750
TPLIVACHYG NVKMVNFLLK QGANVNAKTK NGYTPLHQAA QQGHTHIINV
760 770 780 790 800
LLQHGAKPNA TTANGNTALA IAKRLGYISV VDTLKVVTEE VTTTTTTITE
810 820 830 840 850
KHKLNVPETM TEVLDVSDEE GDDTMTGDGG EYLRPEDLKE LGDDSLPSSQ
860 870 880 890 900
FLDGMNYLRY SLEGGRSDSL RSFSSDRSHT LSHASYLRDS AVMDDSVVIP
910 920 930 940 950
SHQVSTLAKE AERNSYRLSW GTENLDNVAL SSSPIHSGRA SPCLERDNSS
960 970 980 990 1000
FLVSFMVDAR GGAMRGCRHN GLRIIIPPRK CTAPTRVTCR LVKRHRLATM
1010 1020 1030 1040 1050
PPMVEGEGLA SRLIEVGPSG AQFLGPVIVE IPHFAALRGK ERELVVLRSE
1060 1070 1080 1090 1100
NGDSWKEHFC DYTEDELNEI LNGMDEVLDS PEDLEKKRIC RIITRDFPQY
1110 1120 1130 1140 1150
FAVVSRIKQD SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP
1160 1170 1180 1190 1200
MHSELVKKIL GNKATFSPIV TLEPRRRKFH KPITMTIPVP KASSDVMLNG
1210 1220 1230 1240 1250
FGGDAPTLRL LCSITGGTTP AQWEDITGTT PLTFVNECVS FTTNVSARFW
1260 1270 1280 1290 1300
LIDCRQIQES VTFASQVYRE IICVPYMAKF VVFAKSHDPI EARLRCFCMT
1310 1320 1330 1340 1350
DDKVDKTLEQ QENFAEVARS RDVEVLEGKP IYVDCFGNLV PLTKSGQHHI
1360 1370 1380 1390 1400
FSFFAFKENR LPLFVKVRDT TQEPCGRLSF MKEPKSTRGL VHQAICNLNI
1410 1420 1430 1440 1450
TLPIYTKESE SDQEQEEEID MTSEKNPQDE QERIEERLAY IADHLGFSWT
1460 1470 1480 1490 1500
ELARELDFTE EQIHQIRIEN PNSLQDQSHA LLKYWLERDG KHATDTNLVE
1510 1520 1530 1540 1550
CLTKINRMDI VHLMETNTEP LQERISHSYA EIEQTITLDH SEGFSVLQEE
1560 1570 1580 1590 1600
LCTAQHKQKE EQAVSKESET CDHPPIVSEE DISVGYSTFQ DGVPKTEGDS
1610 1620 1630 1640 1650
SATALFPQTH KEQVQQDFSG KMQDLPEESS LEYQQEYFVT TPGTETSETQ
1660 1670 1680 1690 1700
KAMIVPSSPS KTPEEVSTPA EEEKLYLQTP TSSERGGSPI IQEPEEPSEH
1710 1720 1730 1740 1750
REESSPRKTS LVIVESADNQ PETCERLDED AAFEKGDDMP EIPPETVTEE
1760 1770 1780 1790 1800
EYIDEHGHTV VKKVTRKIIR RYVSSEGTEK EEIMVQGMPQ EPVNIEEGDG
1810 1820
YSKVIKRVVL KSDTEQSEDN NE
Computationally mapped potential isoform sequencesi
There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ01484 | ANK2_HUMAN | Ankyrin-2 | ANK2 ANKB | 3,957 | Annotation score: | ||
I6L894 | I6L894_HUMAN | Ankyrin-2 | ANK2 | 3,924 | Annotation score: | ||
D6RHE1 | D6RHE1_HUMAN | Ankyrin-2 | ANK2 | 3,961 | Annotation score: | ||
A0A5F9ZH30 | A0A5F9ZH30_HUMAN | Ankyrin-2 | ANK2 | 3,995 | Annotation score: | ||
A0A5F9ZGX3 | A0A5F9ZGX3_HUMAN | Ankyrin-2 | ANK2 | 3,972 | Annotation score: | ||
A0A5F9ZGY3 | A0A5F9ZGY3_HUMAN | Ankyrin-2 | ANK2 | 3,934 | Annotation score: | ||
A0A5F9ZGY4 | A0A5F9ZGY4_HUMAN | Ankyrin-2 | ANK2 | 3,848 | Annotation score: | ||
A0A5F9ZGZ5 | A0A5F9ZGZ5_HUMAN | Ankyrin-2 | ANK2 | 3,874 | Annotation score: | ||
A0A5F9ZH19 | A0A5F9ZH19_HUMAN | Ankyrin-2 | ANK2 | 3,895 | Annotation score: | ||
A0A5F9ZHD2 | A0A5F9ZHD2_HUMAN | Ankyrin 2, neuronal, isoform CRA_b | ANK2 hCG_22680 | 3,936 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000672177; ENSP00000500918; ENSG00000145362 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A5F9ZI73 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A5F9ZI73 |
Genome annotation databases
Ensembli | ENST00000672177; ENSP00000500918; ENSG00000145362 |
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
OpenTargetsi | ENSG00000145362 |
VEuPathDBi | HostDB:ENSG00000145362 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A5F9ZI73_HUMAN | |
Accessioni | A0A5F9ZI73Primary (citable) accession number: A0A5F9ZI73 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | January 19, 2022 | |
This is version 9 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |