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UniProtKB - A0A5F9ZI45 (A0A5F9ZI45_HUMAN)
Protein
Submitted name:
Ankyrin-2
Gene
ANK2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Ankyrin-2Imported |
Gene namesi | Name:ANK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
VEuPathDBi | HostDB:ENSG00000145362 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 42 – 74 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 75 – 107 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 108 – 140 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 211 – 243 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 244 – 276 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 277 – 309 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 310 – 342 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 343 – 375 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 376 – 408 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 409 – 441 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 442 – 474 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 475 – 507 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 508 – 540 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 541 – 573 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 574 – 606 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 607 – 639 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 640 – 672 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 673 – 705 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 706 – 738 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 739 – 771 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 947 – 1102 | ZU5InterPro annotationAdd BLAST | 156 | |
Domaini | 1104 – 1250 | ZU5InterPro annotationAdd BLAST | 147 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS51145, ZU5, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All
A0A5F9ZI45-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF TARNGITPLH
260 270 280 290 300
VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER
310 320 330 340 350
GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV
360 370 380 390 400
AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG
410 420 430 440 450
ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA
460 470 480 490 500
ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA
510 520 530 540 550
HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK KGFTPLHVAA
560 570 580 590 600
KYGSLDVAKL LLQRRAAADS AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS
610 620 630 640 650
PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNIVTKQ GVTPLHLASQ
660 670 680 690 700
EGHTDMVTLL LDKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ
710 720 730 740 750
DAHTKLGYTP LIVACHYGNV KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ
760 770 780 790 800
GHTHIINVLL QHGAKPNATT ANGNTALAIA KRLGYISVVD TLKVVTEEVT
810 820 830 840 850
TTTTTITEKH KLNVPETMTE VLDVSDEEGD DTMTGDGGEY LRPEDLKELG
860 870 880 890 900
DDSLPSSQFL DGMNYLRYSL EGGRSDSLRS FSSDRSHTLS HASYLRDSAV
910 920 930 940 950
MDDSVVIPSH QVSTLAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGFLVS
960 970 980 990 1000
FMVDARGGAM RGCRHNGLRI IIPPRKCTAP TRVTCRLVKR HRLATMPPMV
1010 1020 1030 1040 1050
EGEGLASRLI EVGPSGAQFL GPVIVEIPHF AALRGKEREL VVLRSENGDS
1060 1070 1080 1090 1100
WKEHFCDYTE DELNEILNGM DEVLDSPEDL EKKRICRIIT RDFPQYFAVV
1110 1120 1130 1140 1150
SRIKQDSNLI GPEGGVLSST VVPQVQAVFP EGALTKRIRV GLQAQPMHSE
1160 1170 1180 1190 1200
LVKKILGNKA TFSPIVTLEP RRRKFHKPIT MTIPVPKASS DVMLNGFGGD
1210 1220 1230 1240 1250
APTLRLLCSI TGGTTPAQWE DITGTTPLTF VNECVSFTTN VSARFWLIDC
1260 1270 1280 1290 1300
RQIQESVTFA SQVYREIICV PYMAKFVVFA KSHDPIEARL RCFCMTDDKV
1310 1320 1330 1340 1350
DKTLEQQENF AEVARSRDVE VLEGKPIYVD CFGNLVPLTK SGQHHIFSFF
1360 1370 1380 1390 1400
AFKENRLPLF VKVRDTTQEP CGRLSFMKEP KSTRGLVHQA ICNLNITLPI
1410 1420 1430 1440
YTKESESDQE QEEEIHRMSR NGSRKGWLIL LITLASAGQN
Computationally mapped potential isoform sequencesi
There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ01484 | ANK2_HUMAN | Ankyrin-2 | ANK2 ANKB | 3,957 | Annotation score: | ||
I6L894 | I6L894_HUMAN | Ankyrin-2 | ANK2 | 3,924 | Annotation score: | ||
D6RHE1 | D6RHE1_HUMAN | Ankyrin-2 | ANK2 | 3,961 | Annotation score: | ||
A0A5F9ZH30 | A0A5F9ZH30_HUMAN | Ankyrin-2 | ANK2 | 3,995 | Annotation score: | ||
A0A5F9ZGX3 | A0A5F9ZGX3_HUMAN | Ankyrin-2 | ANK2 | 3,972 | Annotation score: | ||
A0A5F9ZGY3 | A0A5F9ZGY3_HUMAN | Ankyrin-2 | ANK2 | 3,934 | Annotation score: | ||
A0A5F9ZGY4 | A0A5F9ZGY4_HUMAN | Ankyrin-2 | ANK2 | 3,848 | Annotation score: | ||
A0A5F9ZGZ5 | A0A5F9ZGZ5_HUMAN | Ankyrin-2 | ANK2 | 3,874 | Annotation score: | ||
A0A5F9ZH19 | A0A5F9ZH19_HUMAN | Ankyrin-2 | ANK2 | 3,895 | Annotation score: | ||
A0A5F9ZHD2 | A0A5F9ZHD2_HUMAN | Ankyrin 2, neuronal, isoform CRA_b | ANK2 hCG_22680 | 3,936 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000671863; ENSP00000500855; ENSG00000145362 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A5F9ZI45 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A5F9ZI45 |
Genome annotation databases
Ensembli | ENST00000671863; ENSP00000500855; ENSG00000145362 |
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
OpenTargetsi | ENSG00000145362 |
VEuPathDBi | HostDB:ENSG00000145362 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00218, ZU5, 1 hit |
SUPFAMi | SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS51145, ZU5, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A5F9ZI45_HUMAN | |
Accessioni | A0A5F9ZI45Primary (citable) accession number: A0A5F9ZI45 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | January 19, 2022 | |
This is version 8 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |