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Entry version 8 (29 Sep 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:493, ANK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000145362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A5F9ZI40

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A5F9ZI40

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 74ANKPROSITE-ProRule annotationAdd BLAST33
Repeati75 – 107ANKPROSITE-ProRule annotationAdd BLAST33
Repeati108 – 140ANKPROSITE-ProRule annotationAdd BLAST33
Repeati211 – 243ANKPROSITE-ProRule annotationAdd BLAST33
Repeati244 – 276ANKPROSITE-ProRule annotationAdd BLAST33
Repeati277 – 309ANKPROSITE-ProRule annotationAdd BLAST33
Repeati310 – 342ANKPROSITE-ProRule annotationAdd BLAST33
Repeati343 – 375ANKPROSITE-ProRule annotationAdd BLAST33
Repeati376 – 408ANKPROSITE-ProRule annotationAdd BLAST33
Repeati409 – 441ANKPROSITE-ProRule annotationAdd BLAST33
Repeati442 – 474ANKPROSITE-ProRule annotationAdd BLAST33
Repeati475 – 507ANKPROSITE-ProRule annotationAdd BLAST33
Repeati508 – 540ANKPROSITE-ProRule annotationAdd BLAST33
Repeati541 – 573ANKPROSITE-ProRule annotationAdd BLAST33
Repeati574 – 606ANKPROSITE-ProRule annotationAdd BLAST33
Repeati607 – 639ANKPROSITE-ProRule annotationAdd BLAST33
Repeati640 – 672ANKPROSITE-ProRule annotationAdd BLAST33
Repeati673 – 705ANKPROSITE-ProRule annotationAdd BLAST33
Repeati706 – 738ANKPROSITE-ProRule annotationAdd BLAST33
Repeati739 – 771ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini959 – 1114ZU5InterPro annotationAdd BLAST156
Domaini1116 – 1262ZU5InterPro annotationAdd BLAST147
Domaini3527 – 3611DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1415 – 1444DisorderedSequence analysisAdd BLAST30
Regioni1628 – 2095DisorderedSequence analysisAdd BLAST468
Regioni2155 – 2369DisorderedSequence analysisAdd BLAST215
Regioni2388 – 2442DisorderedSequence analysisAdd BLAST55
Regioni2465 – 2544DisorderedSequence analysisAdd BLAST80
Regioni2562 – 2810DisorderedSequence analysisAdd BLAST249
Regioni2822 – 2862DisorderedSequence analysisAdd BLAST41
Regioni2881 – 2909DisorderedSequence analysisAdd BLAST29
Regioni2945 – 2974DisorderedSequence analysisAdd BLAST30
Regioni3027 – 3057DisorderedSequence analysisAdd BLAST31
Regioni3094 – 3420DisorderedSequence analysisAdd BLAST327
Regioni3735 – 3816DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3436 – 3456Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1628 – 1646Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1668 – 1694Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1722 – 1761Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1783 – 1861Polar residuesSequence analysisAdd BLAST79
Compositional biasi1927 – 1941Polar residuesSequence analysisAdd BLAST15
Compositional biasi1964 – 1997Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1998 – 2013Polar residuesSequence analysisAdd BLAST16
Compositional biasi2028 – 2083Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2213 – 2244Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2257 – 2276Polar residuesSequence analysisAdd BLAST20
Compositional biasi2314 – 2337Polar residuesSequence analysisAdd BLAST24
Compositional biasi2478 – 2516Polar residuesSequence analysisAdd BLAST39
Compositional biasi2523 – 2544Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2562 – 2581Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2612 – 2627Polar residuesSequence analysisAdd BLAST16
Compositional biasi2652 – 2679Polar residuesSequence analysisAdd BLAST28
Compositional biasi2680 – 2730Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi2741 – 2756Polar residuesSequence analysisAdd BLAST16
Compositional biasi2772 – 2790Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2794 – 2810Polar residuesSequence analysisAdd BLAST17
Compositional biasi2846 – 2862Polar residuesSequence analysisAdd BLAST17
Compositional biasi2884 – 2909Polar residuesSequence analysisAdd BLAST26
Compositional biasi3029 – 3057Polar residuesSequence analysisAdd BLAST29
Compositional biasi3135 – 3150Acidic residuesSequence analysisAdd BLAST16
Compositional biasi3154 – 3175Polar residuesSequence analysisAdd BLAST22
Compositional biasi3199 – 3225Polar residuesSequence analysisAdd BLAST27
Compositional biasi3262 – 3288Polar residuesSequence analysisAdd BLAST27
Compositional biasi3289 – 3305Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3317 – 3348Polar residuesSequence analysisAdd BLAST32
Compositional biasi3363 – 3392Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3400 – 3416Polar residuesSequence analysisAdd BLAST17
Compositional biasi3735 – 3758Polar residuesSequence analysisAdd BLAST24
Compositional biasi3767 – 3781Polar residuesSequence analysisAdd BLAST15
Compositional biasi3787 – 3801Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationARBA annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All

A0A5F9ZI40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKMMVNRTTE SGFTPLHIAA HYGNVNVATL LLNRGAAVDF TARNGITPLH
260 270 280 290 300
VASKRGNTNM VKLLLDRGGQ IDAKTRDGLT PLHCAARSGH DQVVELLLER
310 320 330 340 350
GAPLLARTKN GLSPLHMAAQ GDHVECVKHL LQHKAPVDDV TLDYLTALHV
360 370 380 390 400
AAHCGHYRVT KLLLDKRANP NARALNGFTP LHIACKKNRI KVMELLVKYG
410 420 430 440 450
ASIQAITESG LTPIHVAAFM GHLNIVLLLL QNGASPDVTN IRGETALHMA
460 470 480 490 500
ARAGQVEVVR CLLRNGALVD ARAREEQTPL HIASRLGKTE IVQLLLQHMA
510 520 530 540 550
HPDAATTNGY TPLHISAREG QVDVASVLLE AGAAHSLATK KGFTPLHVAA
560 570 580 590 600
KYGSLDVAKL LLQRRAAADS AGKNGLTPLH VAAHYDNQKV ALLLLEKGAS
610 620 630 640 650
PHATAKNGYT PLHIAAKKNQ MQIASTLLNY GAETNIVTKQ GVTPLHLASQ
660 670 680 690 700
EGHTDMVTLL LDKGANIHMS TKSGLTSLHL AAQEDKVNVA DILTKHGADQ
710 720 730 740 750
DAHTKLGYTP LIVACHYGNV KMVNFLLKQG ANVNAKTKNG YTPLHQAAQQ
760 770 780 790 800
GHTHIINVLL QHGAKPNATT ANGNTALAIA KRLGYISVVD TLKVVTEEVT
810 820 830 840 850
TTTTTITEKH KLNVPETMTE VLDVSDEEGD DTMTGDGGEY LRPEDLKELG
860 870 880 890 900
DDSLPSSQFL DGMNYLRYSL EGGRSDSLRS FSSDRSHTLS HASYLRDSAV
910 920 930 940 950
MDDSVVIPSH QVSTLAKEAE RNSYRLSWGT ENLDNVALSS SPIHSGRASP
960 970 980 990 1000
CLERDNSSFL VSFMVDARGG AMRGCRHNGL RIIIPPRKCT APTRVTCRLV
1010 1020 1030 1040 1050
KRHRLATMPP MVEGEGLASR LIEVGPSGAQ FLGPVIVEIP HFAALRGKER
1060 1070 1080 1090 1100
ELVVLRSENG DSWKEHFCDY TEDELNEILN GMDEVLDSPE DLEKKRICRI
1110 1120 1130 1140 1150
ITRDFPQYFA VVSRIKQDSN LIGPEGGVLS STVVPQVQAV FPEGALTKRI
1160 1170 1180 1190 1200
RVGLQAQPMH SELVKKILGN KATFSPIVTL EPRRRKFHKP ITMTIPVPKA
1210 1220 1230 1240 1250
SSDVMLNGFG GDAPTLRLLC SITGGTTPAQ WEDITGTTPL TFVNECVSFT
1260 1270 1280 1290 1300
TNVSARFWLI DCRQIQESVT FASQVYREII CVPYMAKFVV FAKSHDPIEA
1310 1320 1330 1340 1350
RLRCFCMTDD KVDKTLEQQE NFAEVARSRD VEVLEGKPIY VDCFGNLVPL
1360 1370 1380 1390 1400
TKSGQHHIFS FFAFKENRLP LFVKVRDTTQ EPCGRLSFMK EPKSTRGLVH
1410 1420 1430 1440 1450
QAICNLNITL PIYTKESESD QEQEEEIDMT SEKNDETEST ETSVLKSHLV
1460 1470 1480 1490 1500
NEVPVLASPD LLSEVSEMKQ DLIKMTAILT TDVSDKAGSI KVKELVKAAE
1510 1520 1530 1540 1550
EEPGEPFEIV ERVKEDLEKV NEILRSGTCT RDESSVQSSR SERGLVEEEW
1560 1570 1580 1590 1600
VIVSDEEIEE ARQKAPLEIT EYPCVEVRID KEIKGKVEKD STGLVNYLTD
1610 1620 1630 1640 1650
DLNTCVPLPK EQLQTVQDKA GKKCEALAVG RSSEKEGKDI PPDETQSTQK
1660 1670 1680 1690 1700
QHKPSLGIKK PVRRKLKEKQ KQKEEGLQAS AEKAELKKGS SEESLGEDPG
1710 1720 1730 1740 1750
LAPEPLPTVK ATSPLIEETP IGSIKDKVKA LQKRVEDEQK GRSKLPIRVK
1760 1770 1780 1790 1800
GKEDVPKKTT HRPHPAASPS LKSERHAPGS PSPKTERHST LSSSAKTERH
1810 1820 1830 1840 1850
PPVSPSSKTE KHSPVSPSAK TERHSPASSS SKTEKHSPVS PSTKTERHSP
1860 1870 1880 1890 1900
VSSTKTERHP PVSPSGKTDK RPPVSPSGRT EKHPPVSPGR TEKRLPVSPS
1910 1920 1930 1940 1950
GRTDKHQPVS TAGKTEKHLP VSPSGKTEKQ PPVSPTSKTE RIEETMSVRE
1960 1970 1980 1990 2000
LMKAFQSGQD PSKHKTGLFE HKSAKQKQPQ EKGKVRVEKE KGPILTQREA
2010 2020 2030 2040 2050
QKTENQTIKR GQRLPVTGTA ESKRGVRVSS IGVKKEDAAG GKEKVLSHKI
2060 2070 2080 2090 2100
PEPVQSVPEE ESHRESEVPK EKMADEQGDM DLQISPDRKT STDFSEVIKQ
2110 2120 2130 2140 2150
ELEDNDKYQQ FRLSEETEKA QLHLDQVLTS PFNTTFPLDY MKDEFLPALS
2160 2170 2180 2190 2200
LQSGALDGSS ESLKNEGVAG SPCGSLMEGT PQISSEESYK HEGLAETPET
2210 2220 2230 2240 2250
SPESLSFSPK KSEEQTGETK ESTKTETTTE IRSEKEHPTT KDITGGSEER
2260 2270 2280 2290 2300
GATVTEDSET STESFQKEAT LGSPKDTSPK RQDDCTGSCS VALAKETPTG
2310 2320 2330 2340 2350
LTEEAACDEG QRTFGSSAHK TQTDSEVQES TATSDETKAL PLPEASVKTD
2360 2370 2380 2390 2400
TGTESKPQGV IRSPQGLELA LPSRDSEVLS AVADDSLAVS HKDSLEASPV
2410 2420 2430 2440 2450
LEDNSSHKTP DSLEPSPLKE SPCRDSLESS PVEPKMKAGI FPSHFPLPAA
2460 2470 2480 2490 2500
VAKTELLTEV ASVRSRLLRD PDGSAEDDSL EQTSLMESSG KSPLSPDTPS
2510 2520 2530 2540 2550
SEEVSYEVTP KTTDVSTPKP AVIHECAEED DSENGEKKRF TPEEEMFKMV
2560 2570 2580 2590 2600
TKIKMFDELE QEAKQKRDYK KEPKQEESSS SSDPDADCSV DVDEPKHTGS
2610 2620 2630 2640 2650
GEDESGVPVL VTSESRKVSS SSESEPELAQ LKKGADSGLL PEPVIRVQPP
2660 2670 2680 2690 2700
SPLPSSMDSN SSPEEVQFQP VVSKQYTFKM NEDTQEEPGK SEEEKDSESH
2710 2720 2730 2740 2750
LAEDRHAVST EAEDRSYDKL NRDTDQPKIC DGHGCEAMSP SSSAAPVSSG
2760 2770 2780 2790 2800
LQSPTGDDVD EQPVIYKESL ALQGTHEKDT EGEELDVSRA ESPQADCPSE
2810 2820 2830 2840 2850
SFSSSSSLPH CLVSEGKELD EDISATSSIQ KTEVTKTDET FENLPKDCPS
2860 2870 2880 2890 2900
QDSSITTQTD RFSMDVPVSD LAENDEIYDP QITSPYENVP SQSFFSSEES
2910 2920 2930 2940 2950
KTQTDANHTT SFHSSEVYSV TITSPVEDVV VASSSSGTVL SKESNFEGQD
2960 2970 2980 2990 3000
IKMESQQEST LWEMQSDSVS SSFEPTMSAT TTVVGEQISK VIITKTDVDS
3010 3020 3030 3040 3050
DSWSEIREDD EAFEARVKEE EQKIFGLMVD RQSQGTTPDT TPARTPTEEG
3060 3070 3080 3090 3100
TPTSEQNPFL FQEGKLFEMT RSGAIDMTKR SYADESFHFF QIGQESREET
3110 3120 3130 3140 3150
LSEDVKEGAT GADPLPLETS AESLALSESK ETVDDEADLL PDDVSEEVEE
3160 3170 3180 3190 3200
IPASDAQLNS QMGISASTET PTKEAVSVGT KDLPTVQTGD IPPLSGVKQI
3210 3220 3230 3240 3250
SCPDSSEPAV QVQLDFSTLT RSVYSDRGDD SPDSSPEEQK SVIEIPTAPM
3260 3270 3280 3290 3300
ENVPFTESKS KIPVRTMPTS TPAPPSAEYE SSVSEDFLSS VDEENKADEA
3310 3320 3330 3340 3350
KPKSKLPVKV PLQRVEQQLS DLDTSVQKTV APQGQDMASI APDNRSKSES
3360 3370 3380 3390 3400
DASSLDSKTK CPVKTRSYTE TETESRERAE ELELESEEGA TRPKILTSRL
3410 3420 3430 3440 3450
PVKSRSTTSS CRGGTSPTKE SKEHFFDLYR NSIEFFEEIS DEASKLVDRL
3460 3470 3480 3490 3500
TQSEREQEIV SDDESSSALE VSVIENLPPV ETEHSVPEDI FDTRPIWDES
3510 3520 3530 3540 3550
IETLIERIPD ENGHDHAEDP QDEQERIEER LAYIADHLGF SWTELARELD
3560 3570 3580 3590 3600
FTEEQIHQIR IENPNSLQDQ SHALLKYWLE RDGKHATDTN LVECLTKINR
3610 3620 3630 3640 3650
MDIVHLMETN TEPLQERISH SYAEIEQTIT LDHSEGFSVL QEELCTAQHK
3660 3670 3680 3690 3700
QKEEQAVSKE SETCDHPPIV SEEDISVGYS TFQDGVPKTE GDSSATALFP
3710 3720 3730 3740 3750
QTHKEQVQQD FSGKMQDLPE ESSLEYQQEY FVTTPGTETS ETQKAMIVPS
3760 3770 3780 3790 3800
SPSKTPEEVS TPAEEEKLYL QTPTSSERGG SPIIQEPEEP SEHREESSPR
3810 3820 3830 3840 3850
KTSLVIVESA DNQPETCERL DEDAAFEKGD DMPEIPPETV TEEEYIDEHG
3860 3870 3880 3890 3900
HTVVKKVTRK IIRRYVSSEG TEKEEIMVQG MPQEPVNIEE GDGYSKVIKR
3910
VVLKSDTEQS EDNNE
Length:3,915
Mass (Da):429,211
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95AA43BAA8F40EA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01484ANK2_HUMAN
Ankyrin-2
ANK2 ANKB
3,957Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
3,961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHD2A0A5F9ZHD2_HUMAN
Ankyrin 2, neuronal, isoform CRA_b
ANK2 hCG_22680
3,936Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH30A0A5F9ZH30_HUMAN
Ankyrin-2
ANK2
3,995Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX3A0A5F9ZGX3_HUMAN
Ankyrin-2
ANK2
3,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY3A0A5F9ZGY3_HUMAN
Ankyrin-2
ANK2
3,934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY4A0A5F9ZGY4_HUMAN
Ankyrin-2
ANK2
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ5A0A5F9ZGZ5_HUMAN
Ankyrin-2
ANK2
3,874Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH19A0A5F9ZH19_HUMAN
Ankyrin-2
ANK2
3,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000671809; ENSP00000500872; ENSG00000145362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

3D structure databases

SMRiA0A5F9ZI40
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5F9ZI40

Genome annotation databases

EnsembliENST00000671809; ENSP00000500872; ENSG00000145362

Organism-specific databases

HGNCiHGNC:493, ANK2
OpenTargetsiENSG00000145362
VEuPathDBiHostDB:ENSG00000145362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F9ZI40_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F9ZI40
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: September 29, 2021
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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