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UniProtKB - A0A5F9ZHS1 (A0A5F9ZHS1_HUMAN)

Entry version 9 (19 Jan 2022)
Sequence version 1 (11 Dec 2019)
Previous versions | rss
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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:493, ANK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000145362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000145362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A0A5F9ZHS1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A5F9ZHS1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Repeati775 – 807ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini995 – 1183ZU5InterPro annotationAdd BLAST189
Domaini1185 – 1331ZU5InterPro annotationAdd BLAST147
Domaini3596 – 3680DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1484 – 1513DisorderedSequence analysisAdd BLAST30
Regioni1697 – 2164DisorderedSequence analysisAdd BLAST468
Regioni2224 – 2438DisorderedSequence analysisAdd BLAST215
Regioni2457 – 2511DisorderedSequence analysisAdd BLAST55
Regioni2534 – 2613DisorderedSequence analysisAdd BLAST80
Regioni2631 – 2879DisorderedSequence analysisAdd BLAST249
Regioni2891 – 2931DisorderedSequence analysisAdd BLAST41
Regioni2950 – 2978DisorderedSequence analysisAdd BLAST29
Regioni3014 – 3043DisorderedSequence analysisAdd BLAST30
Regioni3096 – 3126DisorderedSequence analysisAdd BLAST31
Regioni3163 – 3489DisorderedSequence analysisAdd BLAST327
Regioni3804 – 3885DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3505 – 3525Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi1697 – 1715Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1737 – 1763Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1791 – 1830Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1852 – 1930Polar residuesSequence analysisAdd BLAST79
Compositional biasi1996 – 2010Polar residuesSequence analysisAdd BLAST15
Compositional biasi2033 – 2066Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi2067 – 2082Polar residuesSequence analysisAdd BLAST16
Compositional biasi2097 – 2152Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2282 – 2313Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2326 – 2345Polar residuesSequence analysisAdd BLAST20
Compositional biasi2383 – 2406Polar residuesSequence analysisAdd BLAST24
Compositional biasi2547 – 2585Polar residuesSequence analysisAdd BLAST39
Compositional biasi2592 – 2613Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2631 – 2650Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2681 – 2696Polar residuesSequence analysisAdd BLAST16
Compositional biasi2721 – 2748Polar residuesSequence analysisAdd BLAST28
Compositional biasi2749 – 2799Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi2810 – 2825Polar residuesSequence analysisAdd BLAST16
Compositional biasi2841 – 2859Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2863 – 2879Polar residuesSequence analysisAdd BLAST17
Compositional biasi2915 – 2931Polar residuesSequence analysisAdd BLAST17
Compositional biasi2953 – 2978Polar residuesSequence analysisAdd BLAST26
Compositional biasi3098 – 3126Polar residuesSequence analysisAdd BLAST29
Compositional biasi3204 – 3219Acidic residuesSequence analysisAdd BLAST16
Compositional biasi3223 – 3244Polar residuesSequence analysisAdd BLAST22
Compositional biasi3268 – 3294Polar residuesSequence analysisAdd BLAST27
Compositional biasi3331 – 3357Polar residuesSequence analysisAdd BLAST27
Compositional biasi3358 – 3374Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3386 – 3417Polar residuesSequence analysisAdd BLAST32
Compositional biasi3432 – 3461Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3469 – 3485Polar residuesSequence analysisAdd BLAST17
Compositional biasi3804 – 3827Polar residuesSequence analysisAdd BLAST24
Compositional biasi3836 – 3850Polar residuesSequence analysisAdd BLAST15
Compositional biasi3856 – 3870Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All

A0A5F9ZHS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREADLDEKE KNLERDRKKQ RKIPRERMER KRKSDSNASF 
        60         70         80         90        100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG 
       110        120        130        140        150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY 
       160        170        180        190        200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN 
       210        220        230        240        250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT 
       260        270        280        290        300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL 
       310        320        330        340        350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP 
       360        370        380        390        400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL 
       410        420        430        440        450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI 
       460        470        480        490        500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR 
       510        520        530        540        550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH 
       560        570        580        590        600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR 
       610        620        630        640        650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI 
       660        670        680        690        700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG 
       710        720        730        740        750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KHGADQDAHT KLGYTPLIVA 
       760        770        780        790        800
CHYGNVKMVN FLLKQGANVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA 
       810        820        830        840        850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV 
       860        870        880        890        900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN 
       910        920        930        940        950
YLRYSLEGGR SDSLRSFSSD RSHTLSHASY LRDSAVMDDS VVIPSHQVST 
       960        970        980        990       1000
LAKEAERNSY RLSWGTENLD NVALSSSPIH SGRASPCLER DNSSFLVSFM 
      1010       1020       1030       1040       1050
VDARGGAMRG CRHNGLRIII PPRKCTAPTR VTCRLVKRHR LATMPPMVEG 
      1060       1070       1080       1090       1100
EGLASRLIEV GPSGAQFLGK LHLPTAPPPL NEGESLVSRI LQLGPPGTKF 
      1110       1120       1130       1140       1150
LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHFCDYT EDELNEILNG 
      1160       1170       1180       1190       1200
MDEVLDSPED LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS 
      1210       1220       1230       1240       1250
TVVPQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE 
      1260       1270       1280       1290       1300
PRRRKFHKPI TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW 
      1310       1320       1330       1340       1350
EDITGTTPLT FVNECVSFTT NVSARFWLID CRQIQESVTF ASQVYREIIC 
      1360       1370       1380       1390       1400
VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK VDKTLEQQEN FAEVARSRDV 
      1410       1420       1430       1440       1450
EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL FVKVRDTTQE 
      1460       1470       1480       1490       1500
PCGRLSFMKE PKSTRGLVHQ AICNLNITLP IYTKESESDQ EQEEEIDMTS 
      1510       1520       1530       1540       1550
EKNDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT 
      1560       1570       1580       1590       1600
DVSDKAGSIK VKELVKAAEE EPGEPFEIVE RVKEDLEKVN EILRSGTCTR 
      1610       1620       1630       1640       1650
DESSVQSSRS ERGLVEEEWV IVSDEEIEEA RQKAPLEITE YPCVEVRIDK 
      1660       1670       1680       1690       1700
EIKGKVEKDS TGLVNYLTDD LNTCVPLPKE QLQTVQDKAG KKCEALAVGR 
      1710       1720       1730       1740       1750
SSEKEGKDIP PDETQSTQKQ HKPSLGIKKP VRRKLKEKQK QKEEGLQASA 
      1760       1770       1780       1790       1800
EKAELKKGSS EESLGEDPGL APEPLPTVKA TSPLIEETPI GSIKDKVKAL 
      1810       1820       1830       1840       1850
QKRVEDEQKG RSKLPIRVKG KEDVPKKTTH RPHPAASPSL KSERHAPGSP 
      1860       1870       1880       1890       1900
SPKTERHSTL SSSAKTERHP PVSPSSKTEK HSPVSPSAKT ERHSPASSSS 
      1910       1920       1930       1940       1950
KTEKHSPVSP STKTERHSPV SSTKTERHPP VSPSGKTDKR PPVSPSGRTE 
      1960       1970       1980       1990       2000
KHPPVSPGRT EKRLPVSPSG RTDKHQPVST AGKTEKHLPV SPSGKTEKQP 
      2010       2020       2030       2040       2050
PVSPTSKTER IEETMSVREL MKAFQSGQDP SKHKTGLFEH KSAKQKQPQE 
      2060       2070       2080       2090       2100
KGKVRVEKEK GPILTQREAQ KTENQTIKRG QRLPVTGTAE SKRGVRVSSI 
      2110       2120       2130       2140       2150
GVKKEDAAGG KEKVLSHKIP EPVQSVPEEE SHRESEVPKE KMADEQGDMD 
      2160       2170       2180       2190       2200
LQISPDRKTS TDFSEVIKQE LEDNDKYQQF RLSEETEKAQ LHLDQVLTSP 
      2210       2220       2230       2240       2250
FNTTFPLDYM KDEFLPALSL QSGALDGSSE SLKNEGVAGS PCGSLMEGTP 
      2260       2270       2280       2290       2300
QISSEESYKH EGLAETPETS PESLSFSPKK SEEQTGETKE STKTETTTEI 
      2310       2320       2330       2340       2350
RSEKEHPTTK DITGGSEERG ATVTEDSETS TESFQKEATL GSPKDTSPKR 
      2360       2370       2380       2390       2400
QDDCTGSCSV ALAKETPTGL TEEAACDEGQ RTFGSSAHKT QTDSEVQEST 
      2410       2420       2430       2440       2450
ATSDETKALP LPEASVKTDT GTESKPQGVI RSPQGLELAL PSRDSEVLSA 
      2460       2470       2480       2490       2500
VADDSLAVSH KDSLEASPVL EDNSSHKTPD SLEPSPLKES PCRDSLESSP 
      2510       2520       2530       2540       2550
VEPKMKAGIF PSHFPLPAAV AKTELLTEVA SVRSRLLRDP DGSAEDDSLE 
      2560       2570       2580       2590       2600
QTSLMESSGK SPLSPDTPSS EEVSYEVTPK TTDVSTPKPA VIHECAEEDD 
      2610       2620       2630       2640       2650
SENGEKKRFT PEEEMFKMVT KIKMFDELEQ EAKQKRDYKK EPKQEESSSS 
      2660       2670       2680       2690       2700
SDPDADCSVD VDEPKHTGSG EDESGVPVLV TSESRKVSSS SESEPELAQL 
      2710       2720       2730       2740       2750
KKGADSGLLP EPVIRVQPPS PLPSSMDSNS SPEEVQFQPV VSKQYTFKMN 
      2760       2770       2780       2790       2800
EDTQEEPGKS EEEKDSESHL AEDRHAVSTE AEDRSYDKLN RDTDQPKICD 
      2810       2820       2830       2840       2850
GHGCEAMSPS SSAAPVSSGL QSPTGDDVDE QPVIYKESLA LQGTHEKDTE 
      2860       2870       2880       2890       2900
GEELDVSRAE SPQADCPSES FSSSSSLPHC LVSEGKELDE DISATSSIQK 
      2910       2920       2930       2940       2950
TEVTKTDETF ENLPKDCPSQ DSSITTQTDR FSMDVPVSDL AENDEIYDPQ 
      2960       2970       2980       2990       3000
ITSPYENVPS QSFFSSEESK TQTDANHTTS FHSSEVYSVT ITSPVEDVVV 
      3010       3020       3030       3040       3050
ASSSSGTVLS KESNFEGQDI KMESQQESTL WEMQSDSVSS SFEPTMSATT 
      3060       3070       3080       3090       3100
TVVGEQISKV IITKTDVDSD SWSEIREDDE AFEARVKEEE QKIFGLMVDR 
      3110       3120       3130       3140       3150
QSQGTTPDTT PARTPTEEGT PTSEQNPFLF QEGKLFEMTR SGAIDMTKRS 
      3160       3170       3180       3190       3200
YADESFHFFQ IGQESREETL SEDVKEGATG ADPLPLETSA ESLALSESKE 
      3210       3220       3230       3240       3250
TVDDEADLLP DDVSEEVEEI PASDAQLNSQ MGISASTETP TKEAVSVGTK 
      3260       3270       3280       3290       3300
DLPTVQTGDI PPLSGVKQIS CPDSSEPAVQ VQLDFSTLTR SVYSDRGDDS 
      3310       3320       3330       3340       3350
PDSSPEEQKS VIEIPTAPME NVPFTESKSK IPVRTMPTST PAPPSAEYES 
      3360       3370       3380       3390       3400
SVSEDFLSSV DEENKADEAK PKSKLPVKVP LQRVEQQLSD LDTSVQKTVA 
      3410       3420       3430       3440       3450
PQGQDMASIA PDNRSKSESD ASSLDSKTKC PVKTRSYTET ETESRERAEE 
      3460       3470       3480       3490       3500
LELESEEGAT RPKILTSRLP VKSRSTTSSC RGGTSPTKES KEHFFDLYRN 
      3510       3520       3530       3540       3550
SIEFFEEISD EASKLVDRLT QSEREQEIVS DDESSSALEV SVIENLPPVE 
      3560       3570       3580       3590       3600
TEHSVPEDIF DTRPIWDESI ETLIERIPDE NGHDHAEDPQ DEQERIEERL 
      3610       3620       3630       3640       3650
AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER 
      3660       3670       3680       3690       3700
DGKHATDTNL VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL 
      3710       3720       3730       3740       3750
DHSEGFSVLQ EELCTAQHKQ KEEQAVSKES ETCDHPPIVS EEDISVGYST 
      3760       3770       3780       3790       3800
FQDGVPKTEG DSSATALFPQ THKEQVQQDF SGKMQDLPEE SSLEYQQEYF 
      3810       3820       3830       3840       3850
VTTPGTETSE TQKAMIVPSS PSKTPEEVST PAEEEKLYLQ TPTSSERGGS 
      3860       3870       3880       3890       3900
PIIQEPEEPS EHREESSPRK TSLVIVESAD NQPETCERLD EDAAFEKGDD 
      3910       3920       3930       3940       3950
MPEIPPETVT EEEYIDEHGH TVVKKVTRKI IRRYVSSEGT EKEEIMVQGM 
      3960       3970       3980 
PQEPVNIEEG DGYSKVIKRV VLKSDTEQSE DNNE
Length:3,984
Mass (Da):437,094
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA6D0CD765FF89E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01484ANK2_HUMAN
Ankyrin-2
ANK2 ANKB
3,957Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
3,961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH30A0A5F9ZH30_HUMAN
Ankyrin-2
ANK2
3,995Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX3A0A5F9ZGX3_HUMAN
Ankyrin-2
ANK2
3,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY3A0A5F9ZGY3_HUMAN
Ankyrin-2
ANK2
3,934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY4A0A5F9ZGY4_HUMAN
Ankyrin-2
ANK2
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ5A0A5F9ZGZ5_HUMAN
Ankyrin-2
ANK2
3,874Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH19A0A5F9ZH19_HUMAN
Ankyrin-2
ANK2
3,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHD2A0A5F9ZHD2_HUMAN
Ankyrin 2, neuronal, isoform CRA_b
ANK2 hCG_22680
3,936Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000672240; ENSP00000500548; ENSG00000145362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

3D structure databases

SMRiA0A5F9ZHS1
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5F9ZHS1

Genome annotation databases

EnsembliENST00000672240; ENSP00000500548; ENSG00000145362

Organism-specific databases

HGNCiHGNC:493, ANK2
OpenTargetsiENSG00000145362
VEuPathDBiHostDB:ENSG00000145362

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F9ZHS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F9ZHS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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