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Entry version 9 (19 Jan 2022)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:493, ANK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000145362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A5F9ZHS1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A5F9ZHS1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Repeati775 – 807ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini995 – 1183ZU5InterPro annotationAdd BLAST189
Domaini1185 – 1331ZU5InterPro annotationAdd BLAST147
Domaini3596 – 3680DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1484 – 1513DisorderedSequence analysisAdd BLAST30
Regioni1697 – 2164DisorderedSequence analysisAdd BLAST468
Regioni2224 – 2438DisorderedSequence analysisAdd BLAST215
Regioni2457 – 2511DisorderedSequence analysisAdd BLAST55
Regioni2534 – 2613DisorderedSequence analysisAdd BLAST80
Regioni2631 – 2879DisorderedSequence analysisAdd BLAST249
Regioni2891 – 2931DisorderedSequence analysisAdd BLAST41
Regioni2950 – 2978DisorderedSequence analysisAdd BLAST29
Regioni3014 – 3043DisorderedSequence analysisAdd BLAST30
Regioni3096 – 3126DisorderedSequence analysisAdd BLAST31
Regioni3163 – 3489DisorderedSequence analysisAdd BLAST327
Regioni3804 – 3885DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3505 – 3525Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi1697 – 1715Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1737 – 1763Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1791 – 1830Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1852 – 1930Polar residuesSequence analysisAdd BLAST79
Compositional biasi1996 – 2010Polar residuesSequence analysisAdd BLAST15
Compositional biasi2033 – 2066Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi2067 – 2082Polar residuesSequence analysisAdd BLAST16
Compositional biasi2097 – 2152Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2282 – 2313Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2326 – 2345Polar residuesSequence analysisAdd BLAST20
Compositional biasi2383 – 2406Polar residuesSequence analysisAdd BLAST24
Compositional biasi2547 – 2585Polar residuesSequence analysisAdd BLAST39
Compositional biasi2592 – 2613Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2631 – 2650Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2681 – 2696Polar residuesSequence analysisAdd BLAST16
Compositional biasi2721 – 2748Polar residuesSequence analysisAdd BLAST28
Compositional biasi2749 – 2799Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi2810 – 2825Polar residuesSequence analysisAdd BLAST16
Compositional biasi2841 – 2859Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2863 – 2879Polar residuesSequence analysisAdd BLAST17
Compositional biasi2915 – 2931Polar residuesSequence analysisAdd BLAST17
Compositional biasi2953 – 2978Polar residuesSequence analysisAdd BLAST26
Compositional biasi3098 – 3126Polar residuesSequence analysisAdd BLAST29
Compositional biasi3204 – 3219Acidic residuesSequence analysisAdd BLAST16
Compositional biasi3223 – 3244Polar residuesSequence analysisAdd BLAST22
Compositional biasi3268 – 3294Polar residuesSequence analysisAdd BLAST27
Compositional biasi3331 – 3357Polar residuesSequence analysisAdd BLAST27
Compositional biasi3358 – 3374Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3386 – 3417Polar residuesSequence analysisAdd BLAST32
Compositional biasi3432 – 3461Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3469 – 3485Polar residuesSequence analysisAdd BLAST17
Compositional biasi3804 – 3827Polar residuesSequence analysisAdd BLAST24
Compositional biasi3836 – 3850Polar residuesSequence analysisAdd BLAST15
Compositional biasi3856 – 3870Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All

A0A5F9ZHS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREADLDEKE KNLERDRKKQ RKIPRERMER KRKSDSNASF
60 70 80 90 100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG
110 120 130 140 150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY
160 170 180 190 200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN
210 220 230 240 250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT
260 270 280 290 300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
310 320 330 340 350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP
360 370 380 390 400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL
410 420 430 440 450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI
460 470 480 490 500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR
510 520 530 540 550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH
560 570 580 590 600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
610 620 630 640 650
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI
660 670 680 690 700
AAKKNQMQIA STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG
710 720 730 740 750
ANIHMSTKSG LTSLHLAAQE DKVNVADILT KHGADQDAHT KLGYTPLIVA
760 770 780 790 800
CHYGNVKMVN FLLKQGANVN AKTKNGYTPL HQAAQQGHTH IINVLLQHGA
810 820 830 840 850
KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT TITEKHKLNV
860 870 880 890 900
PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
910 920 930 940 950
YLRYSLEGGR SDSLRSFSSD RSHTLSHASY LRDSAVMDDS VVIPSHQVST
960 970 980 990 1000
LAKEAERNSY RLSWGTENLD NVALSSSPIH SGRASPCLER DNSSFLVSFM
1010 1020 1030 1040 1050
VDARGGAMRG CRHNGLRIII PPRKCTAPTR VTCRLVKRHR LATMPPMVEG
1060 1070 1080 1090 1100
EGLASRLIEV GPSGAQFLGK LHLPTAPPPL NEGESLVSRI LQLGPPGTKF
1110 1120 1130 1140 1150
LGPVIVEIPH FAALRGKERE LVVLRSENGD SWKEHFCDYT EDELNEILNG
1160 1170 1180 1190 1200
MDEVLDSPED LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS
1210 1220 1230 1240 1250
TVVPQVQAVF PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE
1260 1270 1280 1290 1300
PRRRKFHKPI TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW
1310 1320 1330 1340 1350
EDITGTTPLT FVNECVSFTT NVSARFWLID CRQIQESVTF ASQVYREIIC
1360 1370 1380 1390 1400
VPYMAKFVVF AKSHDPIEAR LRCFCMTDDK VDKTLEQQEN FAEVARSRDV
1410 1420 1430 1440 1450
EVLEGKPIYV DCFGNLVPLT KSGQHHIFSF FAFKENRLPL FVKVRDTTQE
1460 1470 1480 1490 1500
PCGRLSFMKE PKSTRGLVHQ AICNLNITLP IYTKESESDQ EQEEEIDMTS
1510 1520 1530 1540 1550
EKNDETESTE TSVLKSHLVN EVPVLASPDL LSEVSEMKQD LIKMTAILTT
1560 1570 1580 1590 1600
DVSDKAGSIK VKELVKAAEE EPGEPFEIVE RVKEDLEKVN EILRSGTCTR
1610 1620 1630 1640 1650
DESSVQSSRS ERGLVEEEWV IVSDEEIEEA RQKAPLEITE YPCVEVRIDK
1660 1670 1680 1690 1700
EIKGKVEKDS TGLVNYLTDD LNTCVPLPKE QLQTVQDKAG KKCEALAVGR
1710 1720 1730 1740 1750
SSEKEGKDIP PDETQSTQKQ HKPSLGIKKP VRRKLKEKQK QKEEGLQASA
1760 1770 1780 1790 1800
EKAELKKGSS EESLGEDPGL APEPLPTVKA TSPLIEETPI GSIKDKVKAL
1810 1820 1830 1840 1850
QKRVEDEQKG RSKLPIRVKG KEDVPKKTTH RPHPAASPSL KSERHAPGSP
1860 1870 1880 1890 1900
SPKTERHSTL SSSAKTERHP PVSPSSKTEK HSPVSPSAKT ERHSPASSSS
1910 1920 1930 1940 1950
KTEKHSPVSP STKTERHSPV SSTKTERHPP VSPSGKTDKR PPVSPSGRTE
1960 1970 1980 1990 2000
KHPPVSPGRT EKRLPVSPSG RTDKHQPVST AGKTEKHLPV SPSGKTEKQP
2010 2020 2030 2040 2050
PVSPTSKTER IEETMSVREL MKAFQSGQDP SKHKTGLFEH KSAKQKQPQE
2060 2070 2080 2090 2100
KGKVRVEKEK GPILTQREAQ KTENQTIKRG QRLPVTGTAE SKRGVRVSSI
2110 2120 2130 2140 2150
GVKKEDAAGG KEKVLSHKIP EPVQSVPEEE SHRESEVPKE KMADEQGDMD
2160 2170 2180 2190 2200
LQISPDRKTS TDFSEVIKQE LEDNDKYQQF RLSEETEKAQ LHLDQVLTSP
2210 2220 2230 2240 2250
FNTTFPLDYM KDEFLPALSL QSGALDGSSE SLKNEGVAGS PCGSLMEGTP
2260 2270 2280 2290 2300
QISSEESYKH EGLAETPETS PESLSFSPKK SEEQTGETKE STKTETTTEI
2310 2320 2330 2340 2350
RSEKEHPTTK DITGGSEERG ATVTEDSETS TESFQKEATL GSPKDTSPKR
2360 2370 2380 2390 2400
QDDCTGSCSV ALAKETPTGL TEEAACDEGQ RTFGSSAHKT QTDSEVQEST
2410 2420 2430 2440 2450
ATSDETKALP LPEASVKTDT GTESKPQGVI RSPQGLELAL PSRDSEVLSA
2460 2470 2480 2490 2500
VADDSLAVSH KDSLEASPVL EDNSSHKTPD SLEPSPLKES PCRDSLESSP
2510 2520 2530 2540 2550
VEPKMKAGIF PSHFPLPAAV AKTELLTEVA SVRSRLLRDP DGSAEDDSLE
2560 2570 2580 2590 2600
QTSLMESSGK SPLSPDTPSS EEVSYEVTPK TTDVSTPKPA VIHECAEEDD
2610 2620 2630 2640 2650
SENGEKKRFT PEEEMFKMVT KIKMFDELEQ EAKQKRDYKK EPKQEESSSS
2660 2670 2680 2690 2700
SDPDADCSVD VDEPKHTGSG EDESGVPVLV TSESRKVSSS SESEPELAQL
2710 2720 2730 2740 2750
KKGADSGLLP EPVIRVQPPS PLPSSMDSNS SPEEVQFQPV VSKQYTFKMN
2760 2770 2780 2790 2800
EDTQEEPGKS EEEKDSESHL AEDRHAVSTE AEDRSYDKLN RDTDQPKICD
2810 2820 2830 2840 2850
GHGCEAMSPS SSAAPVSSGL QSPTGDDVDE QPVIYKESLA LQGTHEKDTE
2860 2870 2880 2890 2900
GEELDVSRAE SPQADCPSES FSSSSSLPHC LVSEGKELDE DISATSSIQK
2910 2920 2930 2940 2950
TEVTKTDETF ENLPKDCPSQ DSSITTQTDR FSMDVPVSDL AENDEIYDPQ
2960 2970 2980 2990 3000
ITSPYENVPS QSFFSSEESK TQTDANHTTS FHSSEVYSVT ITSPVEDVVV
3010 3020 3030 3040 3050
ASSSSGTVLS KESNFEGQDI KMESQQESTL WEMQSDSVSS SFEPTMSATT
3060 3070 3080 3090 3100
TVVGEQISKV IITKTDVDSD SWSEIREDDE AFEARVKEEE QKIFGLMVDR
3110 3120 3130 3140 3150
QSQGTTPDTT PARTPTEEGT PTSEQNPFLF QEGKLFEMTR SGAIDMTKRS
3160 3170 3180 3190 3200
YADESFHFFQ IGQESREETL SEDVKEGATG ADPLPLETSA ESLALSESKE
3210 3220 3230 3240 3250
TVDDEADLLP DDVSEEVEEI PASDAQLNSQ MGISASTETP TKEAVSVGTK
3260 3270 3280 3290 3300
DLPTVQTGDI PPLSGVKQIS CPDSSEPAVQ VQLDFSTLTR SVYSDRGDDS
3310 3320 3330 3340 3350
PDSSPEEQKS VIEIPTAPME NVPFTESKSK IPVRTMPTST PAPPSAEYES
3360 3370 3380 3390 3400
SVSEDFLSSV DEENKADEAK PKSKLPVKVP LQRVEQQLSD LDTSVQKTVA
3410 3420 3430 3440 3450
PQGQDMASIA PDNRSKSESD ASSLDSKTKC PVKTRSYTET ETESRERAEE
3460 3470 3480 3490 3500
LELESEEGAT RPKILTSRLP VKSRSTTSSC RGGTSPTKES KEHFFDLYRN
3510 3520 3530 3540 3550
SIEFFEEISD EASKLVDRLT QSEREQEIVS DDESSSALEV SVIENLPPVE
3560 3570 3580 3590 3600
TEHSVPEDIF DTRPIWDESI ETLIERIPDE NGHDHAEDPQ DEQERIEERL
3610 3620 3630 3640 3650
AYIADHLGFS WTELARELDF TEEQIHQIRI ENPNSLQDQS HALLKYWLER
3660 3670 3680 3690 3700
DGKHATDTNL VECLTKINRM DIVHLMETNT EPLQERISHS YAEIEQTITL
3710 3720 3730 3740 3750
DHSEGFSVLQ EELCTAQHKQ KEEQAVSKES ETCDHPPIVS EEDISVGYST
3760 3770 3780 3790 3800
FQDGVPKTEG DSSATALFPQ THKEQVQQDF SGKMQDLPEE SSLEYQQEYF
3810 3820 3830 3840 3850
VTTPGTETSE TQKAMIVPSS PSKTPEEVST PAEEEKLYLQ TPTSSERGGS
3860 3870 3880 3890 3900
PIIQEPEEPS EHREESSPRK TSLVIVESAD NQPETCERLD EDAAFEKGDD
3910 3920 3930 3940 3950
MPEIPPETVT EEEYIDEHGH TVVKKVTRKI IRRYVSSEGT EKEEIMVQGM
3960 3970 3980
PQEPVNIEEG DGYSKVIKRV VLKSDTEQSE DNNE
Length:3,984
Mass (Da):437,094
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA6D0CD765FF89E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01484ANK2_HUMAN
Ankyrin-2
ANK2 ANKB
3,957Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
3,961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH30A0A5F9ZH30_HUMAN
Ankyrin-2
ANK2
3,995Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX3A0A5F9ZGX3_HUMAN
Ankyrin-2
ANK2
3,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY3A0A5F9ZGY3_HUMAN
Ankyrin-2
ANK2
3,934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY4A0A5F9ZGY4_HUMAN
Ankyrin-2
ANK2
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ5A0A5F9ZGZ5_HUMAN
Ankyrin-2
ANK2
3,874Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH19A0A5F9ZH19_HUMAN
Ankyrin-2
ANK2
3,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHD2A0A5F9ZHD2_HUMAN
Ankyrin 2, neuronal, isoform CRA_b
ANK2 hCG_22680
3,936Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000672240; ENSP00000500548; ENSG00000145362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

3D structure databases

SMRiA0A5F9ZHS1
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5F9ZHS1

Genome annotation databases

EnsembliENST00000672240; ENSP00000500548; ENSG00000145362

Organism-specific databases

HGNCiHGNC:493, ANK2
OpenTargetsiENSG00000145362
VEuPathDBiHostDB:ENSG00000145362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 1 hit
PF12796, Ank_2, 7 hits
PF13637, Ank_4, 2 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 2 hits
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F9ZHS1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F9ZHS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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