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UniProtKB - A0A5F9ZHF7 (A0A5F9ZHF7_HUMAN)

Entry version 9 (19 Jan 2022)
Sequence version 1 (11 Dec 2019)
Previous versions | rss
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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:493, ANK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000145362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000145362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A0A5F9ZHF7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A5F9ZHF7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 74ANKPROSITE-ProRule annotationAdd BLAST33
Repeati75 – 107ANKPROSITE-ProRule annotationAdd BLAST33
Repeati108 – 140ANKPROSITE-ProRule annotationAdd BLAST33
Repeati203 – 235ANKPROSITE-ProRule annotationAdd BLAST33
Repeati236 – 268ANKPROSITE-ProRule annotationAdd BLAST33
Repeati269 – 301ANKPROSITE-ProRule annotationAdd BLAST33
Repeati302 – 334ANKPROSITE-ProRule annotationAdd BLAST33
Repeati335 – 367ANKPROSITE-ProRule annotationAdd BLAST33
Repeati368 – 400ANKPROSITE-ProRule annotationAdd BLAST33
Repeati401 – 433ANKPROSITE-ProRule annotationAdd BLAST33
Repeati434 – 466ANKPROSITE-ProRule annotationAdd BLAST33
Repeati467 – 499ANKPROSITE-ProRule annotationAdd BLAST33
Repeati500 – 532ANKPROSITE-ProRule annotationAdd BLAST33
Repeati533 – 565ANKPROSITE-ProRule annotationAdd BLAST33
Repeati566 – 598ANKPROSITE-ProRule annotationAdd BLAST33
Repeati599 – 631ANKPROSITE-ProRule annotationAdd BLAST33
Repeati632 – 664ANKPROSITE-ProRule annotationAdd BLAST33
Repeati665 – 697ANKPROSITE-ProRule annotationAdd BLAST33
Repeati698 – 730ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini906 – 1061ZU5InterPro annotationAdd BLAST156
Domaini1063 – 1209ZU5InterPro annotationAdd BLAST147
Domaini3474 – 3558DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1362 – 1391DisorderedSequence analysisAdd BLAST30
Regioni1575 – 2041DisorderedSequence analysisAdd BLAST467
Regioni2102 – 2316DisorderedSequence analysisAdd BLAST215
Regioni2335 – 2389DisorderedSequence analysisAdd BLAST55
Regioni2412 – 2491DisorderedSequence analysisAdd BLAST80
Regioni2509 – 2757DisorderedSequence analysisAdd BLAST249
Regioni2769 – 2809DisorderedSequence analysisAdd BLAST41
Regioni2828 – 2856DisorderedSequence analysisAdd BLAST29
Regioni2892 – 2921DisorderedSequence analysisAdd BLAST30
Regioni2974 – 3004DisorderedSequence analysisAdd BLAST31
Regioni3041 – 3367DisorderedSequence analysisAdd BLAST327
Regioni3682 – 3763DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3383 – 3403Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1575 – 1593Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1615 – 1641Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1669 – 1708Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1730 – 1808Polar residuesSequence analysisAdd BLAST79
Compositional biasi1874 – 1888Polar residuesSequence analysisAdd BLAST15
Compositional biasi1911 – 1944Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1945 – 1960Polar residuesSequence analysisAdd BLAST16
Compositional biasi1975 – 2030Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2160 – 2191Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2204 – 2223Polar residuesSequence analysisAdd BLAST20
Compositional biasi2261 – 2284Polar residuesSequence analysisAdd BLAST24
Compositional biasi2425 – 2463Polar residuesSequence analysisAdd BLAST39
Compositional biasi2470 – 2491Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2509 – 2528Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2559 – 2574Polar residuesSequence analysisAdd BLAST16
Compositional biasi2599 – 2626Polar residuesSequence analysisAdd BLAST28
Compositional biasi2627 – 2677Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi2688 – 2703Polar residuesSequence analysisAdd BLAST16
Compositional biasi2719 – 2737Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2741 – 2757Polar residuesSequence analysisAdd BLAST17
Compositional biasi2793 – 2809Polar residuesSequence analysisAdd BLAST17
Compositional biasi2831 – 2856Polar residuesSequence analysisAdd BLAST26
Compositional biasi2976 – 3004Polar residuesSequence analysisAdd BLAST29
Compositional biasi3082 – 3097Acidic residuesSequence analysisAdd BLAST16
Compositional biasi3101 – 3122Polar residuesSequence analysisAdd BLAST22
Compositional biasi3146 – 3172Polar residuesSequence analysisAdd BLAST27
Compositional biasi3209 – 3235Polar residuesSequence analysisAdd BLAST27
Compositional biasi3236 – 3252Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3264 – 3295Polar residuesSequence analysisAdd BLAST32
Compositional biasi3310 – 3339Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3347 – 3363Polar residuesSequence analysisAdd BLAST17
Compositional biasi3682 – 3705Polar residuesSequence analysisAdd BLAST24
Compositional biasi3714 – 3728Polar residuesSequence analysisAdd BLAST15
Compositional biasi3734 – 3748Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF13637, Ank_4, 3 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All

A0A5F9ZHF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA 
        60         70         80         90        100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA 
       110        120        130        140        150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL 
       160        170        180        190        200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ 
       210        220        230        240        250
SKSGFTPLHI AAHYGNVNVA TLLLNRGAAV DFTARNGITP LHVASKRGNT 
       260        270        280        290        300
NMVKLLLDRG GQIDAKTRDG LTPLHCAARS GHDQVVELLL ERGAPLLART 
       310        320        330        340        350
KNGLSPLHMA AQGDHVECVK HLLQHKAPVD DVTLDYLTAL HVAAHCGHYR 
       360        370        380        390        400
VTKLLLDKRA NPNARALNGF TPLHIACKKN RIKVMELLVK YGASIQAITE 
       410        420        430        440        450
SGLTPIHVAA FMGHLNIVLL LLQNGASPDV TNIRGETALH MAARAGQVEV 
       460        470        480        490        500
VRCLLRNGAL VDARAREEQT PLHIASRLGK TEIVQLLLQH MAHPDAATTN 
       510        520        530        540        550
GYTPLHISAR EGQVDVASVL LEAGAAHSLA TKKGFTPLHV AAKYGSLDVA 
       560        570        580        590        600
KLLLQRRAAA DSAGKNGYTP LHIAAKKNQM QIASTLLNYG AETNIVTKQG 
       610        620        630        640        650
VTPLHLASQE GHTDMVTLLL DKGANIHMST KSGLTSLHLA AQEDKVNVAD 
       660        670        680        690        700
ILTKHGADQD AHTKLGYTPL IVACHYGNVK MVNFLLKQGA NVNAKTKNGY 
       710        720        730        740        750
TPLHQAAQQG HTHIINVLLQ HGAKPNATTA NGNTALAIAK RLGYISVVDT 
       760        770        780        790        800
LKVVTEEVTT TTTTITEKHK LNVPETMTEV LDVSDEEGDD TMTGDGGEYL 
       810        820        830        840        850
RPEDLKELGD DSLPSSQFLD GMNYLRYSLE GGRSDSLRSF SSDRSHTLSH 
       860        870        880        890        900
ASYLRDSAVM DDSVVIPSHQ VSTLAKEAER NSYRLSWGTE NLDNVALSSS 
       910        920        930        940        950
PIHSGFLVSF MVDARGGAMR GCRHNGLRII IPPRKCTAPT RVTCRLVKRH 
       960        970        980        990       1000
RLATMPPMVE GEGLASRLIE VGPSGAQFLG PVIVEIPHFA ALRGKERELV 
      1010       1020       1030       1040       1050
VLRSENGDSW KEHFCDYTED ELNEILNGMD EVLDSPEDLE KKRICRIITR 
      1060       1070       1080       1090       1100
DFPQYFAVVS RIKQDSNLIG PEGGVLSSTV VPQVQAVFPE GALTKRIRVG 
      1110       1120       1130       1140       1150
LQAQPMHSEL VKKILGNKAT FSPIVTLEPR RRKFHKPITM TIPVPKASSD 
      1160       1170       1180       1190       1200
VMLNGFGGDA PTLRLLCSIT GGTTPAQWED ITGTTPLTFV NECVSFTTNV 
      1210       1220       1230       1240       1250
SARFWLIDCR QIQESVTFAS QVYREIICVP YMAKFVVFAK SHDPIEARLR 
      1260       1270       1280       1290       1300
CFCMTDDKVD KTLEQQENFA EVARSRDVEV LEGKPIYVDC FGNLVPLTKS 
      1310       1320       1330       1340       1350
GQHHIFSFFA FKENRLPLFV KVRDTTQEPC GRLSFMKEPK STRGLVHQAI 
      1360       1370       1380       1390       1400
CNLNITLPIY TKESESDQEQ EEEIDMTSEK NDETESTETS VLKSHLVNEV 
      1410       1420       1430       1440       1450
PVLASPDLLS EVSEMKQDLI KMTAILTTDV SDKAGSIKVK ELVKAAEEEP 
      1460       1470       1480       1490       1500
GEPFEIVERV KEDLEKVNEI LRSGTCTRDE SSVQSSRSER GLVEEEWVIV 
      1510       1520       1530       1540       1550
SDEEIEEARQ KAPLEITEYP CVEVRIDKEI KGKVEKDSTG LVNYLTDDLN 
      1560       1570       1580       1590       1600
TCVPLPKEQL QTVQDKAGKK CEALAVGRSS EKEGKDIPPD ETQSTQKQHK 
      1610       1620       1630       1640       1650
PSLGIKKPVR RKLKEKQKQK EEGLQASAEK AELKKGSSEE SLGEDPGLAP 
      1660       1670       1680       1690       1700
EPLPTVKATS PLIEETPIGS IKDKVKALQK RVEDEQKGRS KLPIRVKGKE 
      1710       1720       1730       1740       1750
DVPKKTTHRP HPAASPSLKS ERHAPGSPSP KTERHSTLSS SAKTERHPPV 
      1760       1770       1780       1790       1800
SPSSKTEKHS PVSPSAKTER HSPASSSSKT EKHSPVSPST KTERHSPVSS 
      1810       1820       1830       1840       1850
TKTERHPPVS PSGKTDKRPP VSPSGRTEKH PPVSPGRTEK RLPVSPSGRT 
      1860       1870       1880       1890       1900
DKHQPVSTAG KTEKHLPVSP SGKTEKQPPV SPTSKTERIE ETMSVRELMK 
      1910       1920       1930       1940       1950
AFQSGQDPSK HKTGLFEHKS AKQKQPQEKG KVRVEKEKGP ILTQREAQKT 
      1960       1970       1980       1990       2000
ENQTIKRGQR LPVTGTAESK RGVRVSSIGV KKEDAAGGKE KVLSHKIPEP 
      2010       2020       2030       2040       2050
VQSVPEEESH RESEVPKEKM ADEQGDMDLQ ISPDRKTSTD FSEVIKQELE 
      2060       2070       2080       2090       2100
DNDKYQQFRL SEETEKAQLH LDQVLTSPFN TTFPLDYMKD EFLPALSLQS 
      2110       2120       2130       2140       2150
GALDGSSESL KNEGVAGSPC GSLMEGTPQI SSEESYKHEG LAETPETSPE 
      2160       2170       2180       2190       2200
SLSFSPKKSE EQTGETKEST KTETTTEIRS EKEHPTTKDI TGGSEERGAT 
      2210       2220       2230       2240       2250
VTEDSETSTE SFQKEATLGS PKDTSPKRQD DCTGSCSVAL AKETPTGLTE 
      2260       2270       2280       2290       2300
EAACDEGQRT FGSSAHKTQT DSEVQESTAT SDETKALPLP EASVKTDTGT 
      2310       2320       2330       2340       2350
ESKPQGVIRS PQGLELALPS RDSEVLSAVA DDSLAVSHKD SLEASPVLED 
      2360       2370       2380       2390       2400
NSSHKTPDSL EPSPLKESPC RDSLESSPVE PKMKAGIFPS HFPLPAAVAK 
      2410       2420       2430       2440       2450
TELLTEVASV RSRLLRDPDG SAEDDSLEQT SLMESSGKSP LSPDTPSSEE 
      2460       2470       2480       2490       2500
VSYEVTPKTT DVSTPKPAVI HECAEEDDSE NGEKKRFTPE EEMFKMVTKI 
      2510       2520       2530       2540       2550
KMFDELEQEA KQKRDYKKEP KQEESSSSSD PDADCSVDVD EPKHTGSGED 
      2560       2570       2580       2590       2600
ESGVPVLVTS ESRKVSSSSE SEPELAQLKK GADSGLLPEP VIRVQPPSPL 
      2610       2620       2630       2640       2650
PSSMDSNSSP EEVQFQPVVS KQYTFKMNED TQEEPGKSEE EKDSESHLAE 
      2660       2670       2680       2690       2700
DRHAVSTEAE DRSYDKLNRD TDQPKICDGH GCEAMSPSSS AAPVSSGLQS 
      2710       2720       2730       2740       2750
PTGDDVDEQP VIYKESLALQ GTHEKDTEGE ELDVSRAESP QADCPSESFS 
      2760       2770       2780       2790       2800
SSSSLPHCLV SEGKELDEDI SATSSIQKTE VTKTDETFEN LPKDCPSQDS 
      2810       2820       2830       2840       2850
SITTQTDRFS MDVPVSDLAE NDEIYDPQIT SPYENVPSQS FFSSEESKTQ 
      2860       2870       2880       2890       2900
TDANHTTSFH SSEVYSVTIT SPVEDVVVAS SSSGTVLSKE SNFEGQDIKM 
      2910       2920       2930       2940       2950
ESQQESTLWE MQSDSVSSSF EPTMSATTTV VGEQISKVII TKTDVDSDSW 
      2960       2970       2980       2990       3000
SEIREDDEAF EARVKEEEQK IFGLMVDRQS QGTTPDTTPA RTPTEEGTPT 
      3010       3020       3030       3040       3050
SEQNPFLFQE GKLFEMTRSG AIDMTKRSYA DESFHFFQIG QESREETLSE 
      3060       3070       3080       3090       3100
DVKEGATGAD PLPLETSAES LALSESKETV DDEADLLPDD VSEEVEEIPA 
      3110       3120       3130       3140       3150
SDAQLNSQMG ISASTETPTK EAVSVGTKDL PTVQTGDIPP LSGVKQISCP 
      3160       3170       3180       3190       3200
DSSEPAVQVQ LDFSTLTRSV YSDRGDDSPD SSPEEQKSVI EIPTAPMENV 
      3210       3220       3230       3240       3250
PFTESKSKIP VRTMPTSTPA PPSAEYESSV SEDFLSSVDE ENKADEAKPK 
      3260       3270       3280       3290       3300
SKLPVKVPLQ RVEQQLSDLD TSVQKTVAPQ GQDMASIAPD NRSKSESDAS 
      3310       3320       3330       3340       3350
SLDSKTKCPV KTRSYTETET ESRERAEELE LESEEGATRP KILTSRLPVK 
      3360       3370       3380       3390       3400
SRSTTSSCRG GTSPTKESKE HFFDLYRNSI EFFEEISDEA SKLVDRLTQS 
      3410       3420       3430       3440       3450
EREQEIVSDD ESSSALEVSV IENLPPVETE HSVPEDIFDT RPIWDESIET 
      3460       3470       3480       3490       3500
LIERIPDENG HDHAEDPQDE QERIEERLAY IADHLGFSWT ELARELDFTE 
      3510       3520       3530       3540       3550
EQIHQIRIEN PNSLQDQSHA LLKYWLERDG KHATDTNLVE CLTKINRMDI 
      3560       3570       3580       3590       3600
VHLMETNTEP LQERISHSYA EIEQTITLDH SEGFSVLQEE LCTAQHKQKE 
      3610       3620       3630       3640       3650
EQAVSKESET CDHPPIVSEE DISVGYSTFQ DGVPKTEGDS SATALFPQTH 
      3660       3670       3680       3690       3700
KEQVQQDFSG KMQDLPEESS LEYQQEYFVT TPGTETSETQ KAMIVPSSPS 
      3710       3720       3730       3740       3750
KTPEEVSTPA EEEKLYLQTP TSSERGGSPI IQEPEEPSEH REESSPRKTS 
      3760       3770       3780       3790       3800
LVIVESADNQ PETCERLDED AAFEKGDDMP EIPPETVTEE EYIDEHGHTV 
      3810       3820       3830       3840       3850
VKKVTRKIIR RYVSSEGTEK EEIMVQGMPQ EPVNIEEGDG YSKVIKRVVL 
      3860 
KSDTEQSEDN NE
Length:3,862
Mass (Da):423,471
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DE19E6C398DC615
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01484ANK2_HUMAN
Ankyrin-2
ANK2 ANKB
3,957Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
3,961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH30A0A5F9ZH30_HUMAN
Ankyrin-2
ANK2
3,995Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX3A0A5F9ZGX3_HUMAN
Ankyrin-2
ANK2
3,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY3A0A5F9ZGY3_HUMAN
Ankyrin-2
ANK2
3,934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY4A0A5F9ZGY4_HUMAN
Ankyrin-2
ANK2
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ5A0A5F9ZGZ5_HUMAN
Ankyrin-2
ANK2
3,874Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH19A0A5F9ZH19_HUMAN
Ankyrin-2
ANK2
3,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHD2A0A5F9ZHD2_HUMAN
Ankyrin 2, neuronal, isoform CRA_b
ANK2 hCG_22680
3,936Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000673109; ENSP00000500265; ENSG00000145362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

3D structure databases

SMRiA0A5F9ZHF7
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5F9ZHF7

Genome annotation databases

EnsembliENST00000673109; ENSP00000500265; ENSG00000145362

Organism-specific databases

HGNCiHGNC:493, ANK2
OpenTargetsiENSG00000145362
VEuPathDBiHostDB:ENSG00000145362

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF13637, Ank_4, 3 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F9ZHF7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F9ZHF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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