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Entry version 9 (19 Jan 2022)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Ankyrin-2

Gene

ANK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ankyrin-2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:493, ANK2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000145362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A5F9ZHF7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A5F9ZHF7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati42 – 74ANKPROSITE-ProRule annotationAdd BLAST33
Repeati75 – 107ANKPROSITE-ProRule annotationAdd BLAST33
Repeati108 – 140ANKPROSITE-ProRule annotationAdd BLAST33
Repeati203 – 235ANKPROSITE-ProRule annotationAdd BLAST33
Repeati236 – 268ANKPROSITE-ProRule annotationAdd BLAST33
Repeati269 – 301ANKPROSITE-ProRule annotationAdd BLAST33
Repeati302 – 334ANKPROSITE-ProRule annotationAdd BLAST33
Repeati335 – 367ANKPROSITE-ProRule annotationAdd BLAST33
Repeati368 – 400ANKPROSITE-ProRule annotationAdd BLAST33
Repeati401 – 433ANKPROSITE-ProRule annotationAdd BLAST33
Repeati434 – 466ANKPROSITE-ProRule annotationAdd BLAST33
Repeati467 – 499ANKPROSITE-ProRule annotationAdd BLAST33
Repeati500 – 532ANKPROSITE-ProRule annotationAdd BLAST33
Repeati533 – 565ANKPROSITE-ProRule annotationAdd BLAST33
Repeati566 – 598ANKPROSITE-ProRule annotationAdd BLAST33
Repeati599 – 631ANKPROSITE-ProRule annotationAdd BLAST33
Repeati632 – 664ANKPROSITE-ProRule annotationAdd BLAST33
Repeati665 – 697ANKPROSITE-ProRule annotationAdd BLAST33
Repeati698 – 730ANKPROSITE-ProRule annotationAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini906 – 1061ZU5InterPro annotationAdd BLAST156
Domaini1063 – 1209ZU5InterPro annotationAdd BLAST147
Domaini3474 – 3558DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1362 – 1391DisorderedSequence analysisAdd BLAST30
Regioni1575 – 2041DisorderedSequence analysisAdd BLAST467
Regioni2102 – 2316DisorderedSequence analysisAdd BLAST215
Regioni2335 – 2389DisorderedSequence analysisAdd BLAST55
Regioni2412 – 2491DisorderedSequence analysisAdd BLAST80
Regioni2509 – 2757DisorderedSequence analysisAdd BLAST249
Regioni2769 – 2809DisorderedSequence analysisAdd BLAST41
Regioni2828 – 2856DisorderedSequence analysisAdd BLAST29
Regioni2892 – 2921DisorderedSequence analysisAdd BLAST30
Regioni2974 – 3004DisorderedSequence analysisAdd BLAST31
Regioni3041 – 3367DisorderedSequence analysisAdd BLAST327
Regioni3682 – 3763DisorderedSequence analysisAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3383 – 3403Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1575 – 1593Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1615 – 1641Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi1669 – 1708Basic and acidic residuesSequence analysisAdd BLAST40
Compositional biasi1730 – 1808Polar residuesSequence analysisAdd BLAST79
Compositional biasi1874 – 1888Polar residuesSequence analysisAdd BLAST15
Compositional biasi1911 – 1944Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1945 – 1960Polar residuesSequence analysisAdd BLAST16
Compositional biasi1975 – 2030Basic and acidic residuesSequence analysisAdd BLAST56
Compositional biasi2160 – 2191Basic and acidic residuesSequence analysisAdd BLAST32
Compositional biasi2204 – 2223Polar residuesSequence analysisAdd BLAST20
Compositional biasi2261 – 2284Polar residuesSequence analysisAdd BLAST24
Compositional biasi2425 – 2463Polar residuesSequence analysisAdd BLAST39
Compositional biasi2470 – 2491Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi2509 – 2528Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi2559 – 2574Polar residuesSequence analysisAdd BLAST16
Compositional biasi2599 – 2626Polar residuesSequence analysisAdd BLAST28
Compositional biasi2627 – 2677Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi2688 – 2703Polar residuesSequence analysisAdd BLAST16
Compositional biasi2719 – 2737Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi2741 – 2757Polar residuesSequence analysisAdd BLAST17
Compositional biasi2793 – 2809Polar residuesSequence analysisAdd BLAST17
Compositional biasi2831 – 2856Polar residuesSequence analysisAdd BLAST26
Compositional biasi2976 – 3004Polar residuesSequence analysisAdd BLAST29
Compositional biasi3082 – 3097Acidic residuesSequence analysisAdd BLAST16
Compositional biasi3101 – 3122Polar residuesSequence analysisAdd BLAST22
Compositional biasi3146 – 3172Polar residuesSequence analysisAdd BLAST27
Compositional biasi3209 – 3235Polar residuesSequence analysisAdd BLAST27
Compositional biasi3236 – 3252Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi3264 – 3295Polar residuesSequence analysisAdd BLAST32
Compositional biasi3310 – 3339Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi3347 – 3363Polar residuesSequence analysisAdd BLAST17
Compositional biasi3682 – 3705Polar residuesSequence analysisAdd BLAST24
Compositional biasi3714 – 3728Polar residuesSequence analysisAdd BLAST15
Compositional biasi3734 – 3748Basic and acidic residuesSequence analysisAdd BLAST15

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.533.10, 1 hit
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF13637, Ank_4, 3 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All

A0A5F9ZHF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTMLQKSDS NASFLRAARA GNLDKVVEYL KGGIDINTCN QNGLNALHLA
60 70 80 90 100
AKEGHVGLVQ ELLGRGSSVD SATKKGNTAL HIASLAGQAE VVKVLVKEGA
110 120 130 140 150
NINAQSQNGF TPLYMAAQEN HIDVVKYLLE NGANQSTATE DGFTPLAVAL
160 170 180 190 200
QQGHNQAVAI LLENDTKGKV RLPALHIAAR KDDTKSAALL LQNDHNADVQ
210 220 230 240 250
SKSGFTPLHI AAHYGNVNVA TLLLNRGAAV DFTARNGITP LHVASKRGNT
260 270 280 290 300
NMVKLLLDRG GQIDAKTRDG LTPLHCAARS GHDQVVELLL ERGAPLLART
310 320 330 340 350
KNGLSPLHMA AQGDHVECVK HLLQHKAPVD DVTLDYLTAL HVAAHCGHYR
360 370 380 390 400
VTKLLLDKRA NPNARALNGF TPLHIACKKN RIKVMELLVK YGASIQAITE
410 420 430 440 450
SGLTPIHVAA FMGHLNIVLL LLQNGASPDV TNIRGETALH MAARAGQVEV
460 470 480 490 500
VRCLLRNGAL VDARAREEQT PLHIASRLGK TEIVQLLLQH MAHPDAATTN
510 520 530 540 550
GYTPLHISAR EGQVDVASVL LEAGAAHSLA TKKGFTPLHV AAKYGSLDVA
560 570 580 590 600
KLLLQRRAAA DSAGKNGYTP LHIAAKKNQM QIASTLLNYG AETNIVTKQG
610 620 630 640 650
VTPLHLASQE GHTDMVTLLL DKGANIHMST KSGLTSLHLA AQEDKVNVAD
660 670 680 690 700
ILTKHGADQD AHTKLGYTPL IVACHYGNVK MVNFLLKQGA NVNAKTKNGY
710 720 730 740 750
TPLHQAAQQG HTHIINVLLQ HGAKPNATTA NGNTALAIAK RLGYISVVDT
760 770 780 790 800
LKVVTEEVTT TTTTITEKHK LNVPETMTEV LDVSDEEGDD TMTGDGGEYL
810 820 830 840 850
RPEDLKELGD DSLPSSQFLD GMNYLRYSLE GGRSDSLRSF SSDRSHTLSH
860 870 880 890 900
ASYLRDSAVM DDSVVIPSHQ VSTLAKEAER NSYRLSWGTE NLDNVALSSS
910 920 930 940 950
PIHSGFLVSF MVDARGGAMR GCRHNGLRII IPPRKCTAPT RVTCRLVKRH
960 970 980 990 1000
RLATMPPMVE GEGLASRLIE VGPSGAQFLG PVIVEIPHFA ALRGKERELV
1010 1020 1030 1040 1050
VLRSENGDSW KEHFCDYTED ELNEILNGMD EVLDSPEDLE KKRICRIITR
1060 1070 1080 1090 1100
DFPQYFAVVS RIKQDSNLIG PEGGVLSSTV VPQVQAVFPE GALTKRIRVG
1110 1120 1130 1140 1150
LQAQPMHSEL VKKILGNKAT FSPIVTLEPR RRKFHKPITM TIPVPKASSD
1160 1170 1180 1190 1200
VMLNGFGGDA PTLRLLCSIT GGTTPAQWED ITGTTPLTFV NECVSFTTNV
1210 1220 1230 1240 1250
SARFWLIDCR QIQESVTFAS QVYREIICVP YMAKFVVFAK SHDPIEARLR
1260 1270 1280 1290 1300
CFCMTDDKVD KTLEQQENFA EVARSRDVEV LEGKPIYVDC FGNLVPLTKS
1310 1320 1330 1340 1350
GQHHIFSFFA FKENRLPLFV KVRDTTQEPC GRLSFMKEPK STRGLVHQAI
1360 1370 1380 1390 1400
CNLNITLPIY TKESESDQEQ EEEIDMTSEK NDETESTETS VLKSHLVNEV
1410 1420 1430 1440 1450
PVLASPDLLS EVSEMKQDLI KMTAILTTDV SDKAGSIKVK ELVKAAEEEP
1460 1470 1480 1490 1500
GEPFEIVERV KEDLEKVNEI LRSGTCTRDE SSVQSSRSER GLVEEEWVIV
1510 1520 1530 1540 1550
SDEEIEEARQ KAPLEITEYP CVEVRIDKEI KGKVEKDSTG LVNYLTDDLN
1560 1570 1580 1590 1600
TCVPLPKEQL QTVQDKAGKK CEALAVGRSS EKEGKDIPPD ETQSTQKQHK
1610 1620 1630 1640 1650
PSLGIKKPVR RKLKEKQKQK EEGLQASAEK AELKKGSSEE SLGEDPGLAP
1660 1670 1680 1690 1700
EPLPTVKATS PLIEETPIGS IKDKVKALQK RVEDEQKGRS KLPIRVKGKE
1710 1720 1730 1740 1750
DVPKKTTHRP HPAASPSLKS ERHAPGSPSP KTERHSTLSS SAKTERHPPV
1760 1770 1780 1790 1800
SPSSKTEKHS PVSPSAKTER HSPASSSSKT EKHSPVSPST KTERHSPVSS
1810 1820 1830 1840 1850
TKTERHPPVS PSGKTDKRPP VSPSGRTEKH PPVSPGRTEK RLPVSPSGRT
1860 1870 1880 1890 1900
DKHQPVSTAG KTEKHLPVSP SGKTEKQPPV SPTSKTERIE ETMSVRELMK
1910 1920 1930 1940 1950
AFQSGQDPSK HKTGLFEHKS AKQKQPQEKG KVRVEKEKGP ILTQREAQKT
1960 1970 1980 1990 2000
ENQTIKRGQR LPVTGTAESK RGVRVSSIGV KKEDAAGGKE KVLSHKIPEP
2010 2020 2030 2040 2050
VQSVPEEESH RESEVPKEKM ADEQGDMDLQ ISPDRKTSTD FSEVIKQELE
2060 2070 2080 2090 2100
DNDKYQQFRL SEETEKAQLH LDQVLTSPFN TTFPLDYMKD EFLPALSLQS
2110 2120 2130 2140 2150
GALDGSSESL KNEGVAGSPC GSLMEGTPQI SSEESYKHEG LAETPETSPE
2160 2170 2180 2190 2200
SLSFSPKKSE EQTGETKEST KTETTTEIRS EKEHPTTKDI TGGSEERGAT
2210 2220 2230 2240 2250
VTEDSETSTE SFQKEATLGS PKDTSPKRQD DCTGSCSVAL AKETPTGLTE
2260 2270 2280 2290 2300
EAACDEGQRT FGSSAHKTQT DSEVQESTAT SDETKALPLP EASVKTDTGT
2310 2320 2330 2340 2350
ESKPQGVIRS PQGLELALPS RDSEVLSAVA DDSLAVSHKD SLEASPVLED
2360 2370 2380 2390 2400
NSSHKTPDSL EPSPLKESPC RDSLESSPVE PKMKAGIFPS HFPLPAAVAK
2410 2420 2430 2440 2450
TELLTEVASV RSRLLRDPDG SAEDDSLEQT SLMESSGKSP LSPDTPSSEE
2460 2470 2480 2490 2500
VSYEVTPKTT DVSTPKPAVI HECAEEDDSE NGEKKRFTPE EEMFKMVTKI
2510 2520 2530 2540 2550
KMFDELEQEA KQKRDYKKEP KQEESSSSSD PDADCSVDVD EPKHTGSGED
2560 2570 2580 2590 2600
ESGVPVLVTS ESRKVSSSSE SEPELAQLKK GADSGLLPEP VIRVQPPSPL
2610 2620 2630 2640 2650
PSSMDSNSSP EEVQFQPVVS KQYTFKMNED TQEEPGKSEE EKDSESHLAE
2660 2670 2680 2690 2700
DRHAVSTEAE DRSYDKLNRD TDQPKICDGH GCEAMSPSSS AAPVSSGLQS
2710 2720 2730 2740 2750
PTGDDVDEQP VIYKESLALQ GTHEKDTEGE ELDVSRAESP QADCPSESFS
2760 2770 2780 2790 2800
SSSSLPHCLV SEGKELDEDI SATSSIQKTE VTKTDETFEN LPKDCPSQDS
2810 2820 2830 2840 2850
SITTQTDRFS MDVPVSDLAE NDEIYDPQIT SPYENVPSQS FFSSEESKTQ
2860 2870 2880 2890 2900
TDANHTTSFH SSEVYSVTIT SPVEDVVVAS SSSGTVLSKE SNFEGQDIKM
2910 2920 2930 2940 2950
ESQQESTLWE MQSDSVSSSF EPTMSATTTV VGEQISKVII TKTDVDSDSW
2960 2970 2980 2990 3000
SEIREDDEAF EARVKEEEQK IFGLMVDRQS QGTTPDTTPA RTPTEEGTPT
3010 3020 3030 3040 3050
SEQNPFLFQE GKLFEMTRSG AIDMTKRSYA DESFHFFQIG QESREETLSE
3060 3070 3080 3090 3100
DVKEGATGAD PLPLETSAES LALSESKETV DDEADLLPDD VSEEVEEIPA
3110 3120 3130 3140 3150
SDAQLNSQMG ISASTETPTK EAVSVGTKDL PTVQTGDIPP LSGVKQISCP
3160 3170 3180 3190 3200
DSSEPAVQVQ LDFSTLTRSV YSDRGDDSPD SSPEEQKSVI EIPTAPMENV
3210 3220 3230 3240 3250
PFTESKSKIP VRTMPTSTPA PPSAEYESSV SEDFLSSVDE ENKADEAKPK
3260 3270 3280 3290 3300
SKLPVKVPLQ RVEQQLSDLD TSVQKTVAPQ GQDMASIAPD NRSKSESDAS
3310 3320 3330 3340 3350
SLDSKTKCPV KTRSYTETET ESRERAEELE LESEEGATRP KILTSRLPVK
3360 3370 3380 3390 3400
SRSTTSSCRG GTSPTKESKE HFFDLYRNSI EFFEEISDEA SKLVDRLTQS
3410 3420 3430 3440 3450
EREQEIVSDD ESSSALEVSV IENLPPVETE HSVPEDIFDT RPIWDESIET
3460 3470 3480 3490 3500
LIERIPDENG HDHAEDPQDE QERIEERLAY IADHLGFSWT ELARELDFTE
3510 3520 3530 3540 3550
EQIHQIRIEN PNSLQDQSHA LLKYWLERDG KHATDTNLVE CLTKINRMDI
3560 3570 3580 3590 3600
VHLMETNTEP LQERISHSYA EIEQTITLDH SEGFSVLQEE LCTAQHKQKE
3610 3620 3630 3640 3650
EQAVSKESET CDHPPIVSEE DISVGYSTFQ DGVPKTEGDS SATALFPQTH
3660 3670 3680 3690 3700
KEQVQQDFSG KMQDLPEESS LEYQQEYFVT TPGTETSETQ KAMIVPSSPS
3710 3720 3730 3740 3750
KTPEEVSTPA EEEKLYLQTP TSSERGGSPI IQEPEEPSEH REESSPRKTS
3760 3770 3780 3790 3800
LVIVESADNQ PETCERLDED AAFEKGDDMP EIPPETVTEE EYIDEHGHTV
3810 3820 3830 3840 3850
VKKVTRKIIR RYVSSEGTEK EEIMVQGMPQ EPVNIEEGDG YSKVIKRVVL
3860
KSDTEQSEDN NE
Length:3,862
Mass (Da):423,471
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DE19E6C398DC615
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01484ANK2_HUMAN
Ankyrin-2
ANK2 ANKB
3,957Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I6L894I6L894_HUMAN
Ankyrin-2
ANK2
3,924Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHE1D6RHE1_HUMAN
Ankyrin-2
ANK2
3,961Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH30A0A5F9ZH30_HUMAN
Ankyrin-2
ANK2
3,995Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX3A0A5F9ZGX3_HUMAN
Ankyrin-2
ANK2
3,972Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY3A0A5F9ZGY3_HUMAN
Ankyrin-2
ANK2
3,934Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY4A0A5F9ZGY4_HUMAN
Ankyrin-2
ANK2
3,848Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ5A0A5F9ZGZ5_HUMAN
Ankyrin-2
ANK2
3,874Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZH19A0A5F9ZH19_HUMAN
Ankyrin-2
ANK2
3,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHD2A0A5F9ZHD2_HUMAN
Ankyrin 2, neuronal, isoform CRA_b
ANK2 hCG_22680
3,936Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000673109; ENSP00000500265; ENSG00000145362

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004057 Genomic DNA No translation available.
AC017007 Genomic DNA No translation available.
AC093617 Genomic DNA No translation available.
AC093879 Genomic DNA No translation available.
AC093900 Genomic DNA No translation available.
AC108042 Genomic DNA No translation available.

3D structure databases

SMRiA0A5F9ZHF7
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A5F9ZHF7

Genome annotation databases

EnsembliENST00000673109; ENSP00000500265; ENSG00000145362

Organism-specific databases

HGNCiHGNC:493, ANK2
OpenTargetsiENSG00000145362
VEuPathDBiHostDB:ENSG00000145362

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155279

Family and domain databases

Gene3Di1.10.533.10, 1 hit
1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF13637, Ank_4, 3 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F9ZHF7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F9ZHF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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