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UniProtKB - A0A5F9ZH70 (A0A5F9ZH70_HUMAN)
Protein
Submitted name:
Ankyrin-2
Gene
ANK2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Ankyrin-2Imported |
Gene namesi | Name:ANK2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
VEuPathDBi | HostDB:ENSG00000145362 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Other locations
- Membrane ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 63 – 95 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 96 – 128 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 129 – 161 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 232 – 264 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 265 – 297 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 298 – 330 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 331 – 363 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 364 – 396 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 397 – 429 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 430 – 462 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 463 – 495 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 496 – 528 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 529 – 561 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 562 – 594 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 595 – 627 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 628 – 660 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 661 – 693 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 694 – 726 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 727 – 759 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 760 – 792 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 968 – 1123 | ZU5InterPro annotationAdd BLAST | 156 | |
Domaini | 1125 – 1271 | ZU5InterPro annotationAdd BLAST | 147 | |
Domaini | 1451 – 1535 | DeathInterPro annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 1425 – 1449 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1659 – 1741 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 1906 – 1931 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 31 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1659 – 1682 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1691 – 1705 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 1711 – 1725 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationPhylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 78 potential isoforms that are computationally mapped.Show allAlign All
A0A5F9ZH70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMNEDAAQKS DSGEKFNGSS QRRKRPKKSD SNASFLRAAR AGNLDKVVEY
60 70 80 90 100
LKGGIDINTC NQNGLNALHL AAKEGHVGLV QELLGRGSSV DSATKKGNTA
110 120 130 140 150
LHIASLAGQA EVVKVLVKEG ANINAQSQNG FTPLYMAAQE NHIDVVKYLL
160 170 180 190 200
ENGANQSTAT EDGFTPLAVA LQQGHNQAVA ILLENDTKGK VRLPALHIAA
210 220 230 240 250
RKDDTKSAAL LLQNDHNADV QSKMMVNRTT ESGFTPLHIA AHYGNVNVAT
260 270 280 290 300
LLLNRGAAVD FTARNGITPL HVASKRGNTN MVKLLLDRGG QIDAKTRDGL
310 320 330 340 350
TPLHCAARSG HDQVVELLLE RGAPLLARTK NGLSPLHMAA QGDHVECVKH
360 370 380 390 400
LLQHKAPVDD VTLDYLTALH VAAHCGHYRV TKLLLDKRAN PNARALNGFT
410 420 430 440 450
PLHIACKKNR IKVMELLVKY GASIQAITES GLTPIHVAAF MGHLNIVLLL
460 470 480 490 500
LQNGASPDVT NIRGETALHM AARAGQVEVV RCLLRNGALV DARAREEQTP
510 520 530 540 550
LHIASRLGKT EIVQLLLQHM AHPDAATTNG YTPLHISARE GQVDVASVLL
560 570 580 590 600
EAGAAHSLAT KKGFTPLHVA AKYGSLDVAK LLLQRRAAAD SAGKNGLTPL
610 620 630 640 650
HVAAHYDNQK VALLLLEKGA SPHATAKNGY TPLHIAAKKN QMQIASTLLN
660 670 680 690 700
YGAETNIVTK QGVTPLHLAS QEGHTDMVTL LLDKGANIHM STKSGLTSLH
710 720 730 740 750
LAAQEDKVNV ADILTKHGAD QDAHTKLGYT PLIVACHYGN VKMVNFLLKQ
760 770 780 790 800
GANVNAKTKN GYTPLHQAAQ QGHTHIINVL LQHGAKPNAT TANGNTALAI
810 820 830 840 850
AKRLGYISVV DTLKVVTEEV TTTTTTITEK HKLNVPETMT EVLDVSDEEG
860 870 880 890 900
DDTMTGDGGE YLRPEDLKEL GDDSLPSSQF LDGMNYLRYS LEGGRSDSLR
910 920 930 940 950
SFSSDRSHTL SHASYLRDSA VMDDSVVIPS HQVSTLAKEA ERNSYRLSWG
960 970 980 990 1000
TENLDNVALS SSPIHSGFLV SFMVDARGGA MRGCRHNGLR IIIPPRKCTA
1010 1020 1030 1040 1050
PTRVTCRLVK RHRLATMPPM VEGEGLASRL IEVGPSGAQF LGPVIVEIPH
1060 1070 1080 1090 1100
FAALRGKERE LVVLRSENGD SWKEHFCDYT EDELNEILNG MDEVLDSPED
1110 1120 1130 1140 1150
LEKKRICRII TRDFPQYFAV VSRIKQDSNL IGPEGGVLSS TVVPQVQAVF
1160 1170 1180 1190 1200
PEGALTKRIR VGLQAQPMHS ELVKKILGNK ATFSPIVTLE PRRRKFHKPI
1210 1220 1230 1240 1250
TMTIPVPKAS SDVMLNGFGG DAPTLRLLCS ITGGTTPAQW EDITGTTPLT
1260 1270 1280 1290 1300
FVNECVSFTT NVSARFWLID CRQIQESVTF ASQVYREIIC VPYMAKFVVF
1310 1320 1330 1340 1350
AKSHDPIEAR LRCFCMTDDK VDKTLEQQEN FAEVARSRDV EVLEGKPIYV
1360 1370 1380 1390 1400
DCFGNLVPLT KSGQHHIFSF FAFKENRLPL FVKVRDTTQE PCGRLSFMKE
1410 1420 1430 1440 1450
PKSTRGLVHQ AICNLNITLP IYTKESESDQ EQEEEIDMTS EKNPQDEQER
1460 1470 1480 1490 1500
IEERLAYIAD HLGFSWTELA RELDFTEEQI HQIRIENPNS LQDQSHALLK
1510 1520 1530 1540 1550
YWLERDGKHA TDTNLVECLT KINRMDIVHL METNTEPLQE RISHSYAEIE
1560 1570 1580 1590 1600
QTITLDHSEG FSVLQEELCT AQHKQKEEQA VSKESETCDH PPIVSEEDIS
1610 1620 1630 1640 1650
VGYSTFQDGV PKTEGDSSAT ALFPQTHKEQ VQQDFSGKMQ DLPEESSLEY
1660 1670 1680 1690 1700
QQEYFVTTPG TETSETQKAM IVPSSPSKTP EEVSTPAEEE KLYLQTPTSS
1710 1720 1730 1740 1750
ERGGSPIIQE PEEPSEHREE SSPRKTSLVI VESADNQPET CERLDEDAAF
1760 1770 1780 1790 1800
EKELTEELGE LEASSDEEAM VTTRVVRRRV IIQGDDMPEI PPETVTEEEY
1810 1820 1830 1840 1850
IDEHGHTVVK KVTRKIIRRY VSSEGTEKEE IMVQGMPQEP VNIEEGDGYS
1860 1870 1880 1890 1900
KVIKRVVLKS DTEQSEVTLC EPSILSSTSQ FQAEPVEGRR VSKVVKTTVV
1910 1920 1930
LGERMEKHLG DSSLATDLPS AKDDFEEDNN E
Computationally mapped potential isoform sequencesi
There are 78 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ01484 | ANK2_HUMAN | Ankyrin-2 | ANK2 ANKB | 3,957 | Annotation score: | ||
I6L894 | I6L894_HUMAN | Ankyrin-2 | ANK2 | 3,924 | Annotation score: | ||
D6RHE1 | D6RHE1_HUMAN | Ankyrin-2 | ANK2 | 3,961 | Annotation score: | ||
A0A5F9ZH30 | A0A5F9ZH30_HUMAN | Ankyrin-2 | ANK2 | 3,995 | Annotation score: | ||
A0A5F9ZGX3 | A0A5F9ZGX3_HUMAN | Ankyrin-2 | ANK2 | 3,972 | Annotation score: | ||
A0A5F9ZGY3 | A0A5F9ZGY3_HUMAN | Ankyrin-2 | ANK2 | 3,934 | Annotation score: | ||
A0A5F9ZGY4 | A0A5F9ZGY4_HUMAN | Ankyrin-2 | ANK2 | 3,848 | Annotation score: | ||
A0A5F9ZGZ5 | A0A5F9ZGZ5_HUMAN | Ankyrin-2 | ANK2 | 3,874 | Annotation score: | ||
A0A5F9ZH19 | A0A5F9ZH19_HUMAN | Ankyrin-2 | ANK2 | 3,895 | Annotation score: | ||
A0A5F9ZHD2 | A0A5F9ZHD2_HUMAN | Ankyrin 2, neuronal, isoform CRA_b | ANK2 hCG_22680 | 3,936 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
RefSeqi | XP_016863570.1, XM_017008081.1 |
Genome annotation databases
Ensembli | ENST00000671727; ENSP00000500102; ENSG00000145362 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004057 Genomic DNA No translation available. AC017007 Genomic DNA No translation available. AC093617 Genomic DNA No translation available. AC093879 Genomic DNA No translation available. AC093900 Genomic DNA No translation available. AC108042 Genomic DNA No translation available. |
RefSeqi | XP_016863570.1, XM_017008081.1 |
3D structure databases
SMRi | A0A5F9ZH70 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A5F9ZH70 |
Genome annotation databases
Ensembli | ENST00000671727; ENSP00000500102; ENSG00000145362 |
Organism-specific databases
HGNCi | HGNC:493, ANK2 |
OpenTargetsi | ENSG00000145362 |
VEuPathDBi | HostDB:ENSG00000145362 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155279 |
Family and domain databases
Gene3Di | 1.10.533.10, 1 hit 1.25.40.20, 3 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR040745, Ankyrin_UPA IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR000906, ZU5_dom |
Pfami | View protein in Pfam PF00023, Ank, 1 hit PF12796, Ank_2, 7 hits PF13637, Ank_4, 2 hits PF00531, Death, 1 hit PF17809, UPA_2, 1 hit PF00791, ZU5, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 23 hits SM00005, DEATH, 1 hit SM00218, ZU5, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF48403, SSF48403, 3 hits |
PROSITEi | View protein in PROSITE PS50088, ANK_REPEAT, 20 hits PS50017, DEATH_DOMAIN, 1 hit PS51145, ZU5, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A5F9ZH70_HUMAN | |
Accessioni | A0A5F9ZH70Primary (citable) accession number: A0A5F9ZH70 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 11, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | January 19, 2022 | |
This is version 9 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |