HSP90AA1

Functionⁱ

GO - Molecular functionⁱ

ATPase activity Source: Ensembl
ATP binding Source: UniProtKB-KW
disordered domain specific binding Source: Ensembl
DNA polymerase binding Source: Ensembl
GTPase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
nitric-oxide synthase regulator activity Source: Ensembl
protein homodimerization activity Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
tau protein binding Source: Ensembl
TPR domain binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl
unfolded protein binding Source: InterPro

GO - Biological processⁱ

chaperone-mediated protein complex assembly Source: Ensembl
positive regulation of cellular protein catabolic process Source: Ensembl
positive regulation of protein polymerization Source: Ensembl
positive regulation of tau-protein kinase activity Source: Ensembl
positive regulation of telomerase activity Source: Ensembl
protein folding Source: InterPro
protein insertion into mitochondrial outer membrane Source: Ensembl
protein stabilization Source: Ensembl
regulation of protein ubiquitination Source: Ensembl
telomerase holoenzyme complex assembly Source: Ensembl
telomere maintenance via telomerase Source: Ensembl

Keywordsⁱ

Molecular function	ChaperoneARBA annotation
Ligand	ATP-bindingARBA annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HATPase_c domain-containing proteinInterPro annotation
Gene namesⁱ	Name:HSP90AA1Imported
Organismⁱ	Macaca mulatta (Rhesus macaque)Imported
Taxonomic identifierⁱ	9544 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca
Proteomesⁱ	UP000006718 Componentⁱ: Chromosome 7

PTM / Processingⁱ

Keywords - PTMⁱ

AcetylationARBA annotation

Interactionⁱ

GO - Molecular functionⁱ

disordered domain specific binding Source: Ensembl
DNA polymerase binding Source: Ensembl
GTPase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
protein homodimerization activity Source: Ensembl
protein tyrosine kinase binding Source: Ensembl
scaffold protein binding Source: Ensembl
tau protein binding Source: Ensembl
TPR domain binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl
unfolded protein binding Source: InterPro

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A5F8ARZ4
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	40 – 194	HATPase_cInterPro annotationAdd BLAST		155

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	225 – 279	DisorderedSequence analysisAdd BLAST		55
Regionⁱ	701 – 733	DisorderedSequence analysisAdd BLAST		33

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	552 – 572	Sequence analysisAdd BLAST		21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	243 – 257	PolyampholyteSequence analysisAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the heat shock protein 90 family.ARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000182747

GeneTreeⁱ

ENSGT00950000182747

Family and domain databases

Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505, HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528, PTHR11528, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit
PIRSFⁱ	PIRSF002583, Hsp90, 1 hit
PRINTSⁱ	PR00775, HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387, HATPase_c, 1 hit
SUPFAMⁱ	SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS00298, HSP90, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A5F8ARZ4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS 
        60         70         80         90        100
NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK 
       110        120        130        140        150
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV 
       160        170        180        190        200
ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYLEE 
       210        220        230        240        250
RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK 
       260        270        280        290        300
ESEDKPEIED VGSDEEEEEK KDGDKKKKKK IKEKYIDQEE LNKTKPIWTR 
       310        320        330        340        350
NPDDITNEEY GEFYKSLTND WEDHLAVKHF SVEGQLEFRA LLFVPRRAPF 
       360        370        380        390        400
DLFENRKKKN NIKLYVRRVF IMDNCEELIP EYLNFIRGVV DSEDLPLNIS 
       410        420        430        440        450
REMLQQSKIL KVIRKNLVKK CLELFTELAE DKENYKKFYE QFSKNIKLGI 
       460        470        480        490        500
HEDSQNRKKL SELLRYYTSA SGDEMVSLKD YCTRMKENQK HIYYITGETK 
       510        520        530        540        550
DQVANSAFVE RLRKHGLEVI YMIEPIDEYC VQQLKEFEGK TLVSVTKEGL 
       560        570        580        590        600
ELPEDEEEKK KQEEKKTKFE NLCKIMKDIL EKKVEKVVVS NRLVTSPCCI 
       610        620        630        640        650
VTSTYGWTAN MERIMKAQAL RDNSTMGYMA AKKHLEINPD HSIIETLRQK 
       660        670        680        690        700
AEADKNDKSV KDLVILLYET ALLSSGFSLE DPQTHANRIY RMIKLGLGID 
       710        720        730 
EDDPTADDTS AAVTEEMPPL EGDDDTSRME EVD

Length:733

Mass (Da):84,789

Last modified:December 11, 2019 - v1

Checksum:ⁱ4DF7F56B0EA460C5

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	NP_001182596.1, NM_001195667.1

RefSeqⁱ

NP_001182596.1, NM_001195667.1

Genome annotation databases

Ensemblⁱ	ENSMMUT00000102753; ENSMMUP00000080725; ENSMMUG00000054990
GeneIDⁱ	708431
KEGGⁱ	mcc:708431

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A5F8ARZ4	Heat shock protein HSP 90-alpha		MACFA		733	UniRef100_Q4R4P1
HSP90AA1 isoform 2		PANTR		855
Uncharacterized protein		PONAB		615
HATPase_c domain-containing protein		CALJA		733
HATPase_c domain-containing protein		CERAT		733
+5

Protein	Similar proteins		Species	Score	Length	Source
A0A5F8ARZ4	Heat shock protein HSP 90-alpha	)	HUMAN		732	UniRef90_P07900
Heat shock protein HSP 90-alpha		MACFA		733
Heat shock protein 83		Heterotrigona itama		732
Heat shock protein HSP 90-alpha		PANTR		855
Uncharacterized protein		NOMLE		119
+53

Protein	Similar proteins		Species	Score	Length	Source
A0A5F8ARZ4	Heat shock protein HSP 90-alpha	)	HUMAN		732	UniRef50_P07900
Heat shock protein HSP 90-alpha		MACFA		733
Heat shock protein 83		Heterotrigona itama		732
Heat shock protein HSP 90-alpha		PANTR		855
Uncharacterized protein		NOMLE		119
+92

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	NP_001182596.1, NM_001195667.1

RefSeqⁱ

NP_001182596.1, NM_001195667.1

3D structure databases

SMRⁱ	A0A5F8ARZ4
ModBaseⁱ	Search...

Genome annotation databases

Ensemblⁱ	ENSMMUT00000102753; ENSMMUP00000080725; ENSMMUG00000054990
GeneIDⁱ	708431
KEGGⁱ	mcc:708431

Organism-specific databases

CTDⁱ	3320

CTDⁱ

3320

Phylogenomic databases

GeneTreeⁱ	ENSGT00950000182747

GeneTreeⁱ

ENSGT00950000182747

Family and domain databases

Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505, HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528, PTHR11528, 1 hit
Pfamⁱ	View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit
PIRSFⁱ	PIRSF002583, Hsp90, 1 hit
PRINTSⁱ	PR00775, HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387, HATPase_c, 1 hit
SUPFAMⁱ	SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS00298, HSP90, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A5F8ARZ4_MACMU
Accessionⁱ	A0A5F8ARZ4Primary (citable) accession number: A0A5F8ARZ4
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 11, 2019
	Last sequence update:	December 11, 2019
	Last modified:	February 10, 2021
	This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A5F8ARZ4 (A0A5F8ARZ4_MACMU)

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HATPase_c domain-containing protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Mitochondrion

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ