Paired box 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: Ensembl
• co-SMAD binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• HMG box domain binding Source: Ensembl
• protein kinase binding Source: Ensembl
• RNA binding Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
• RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• transcription coregulator binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

GO - Biological processⁱ

• astrocyte differentiation Source: Ensembl
• axon guidance Source: Ensembl
• blood vessel development Source: Ensembl
• cell fate determination Source: Ensembl
• cellular response to leukemia inhibitory factor Source: Ensembl
• cerebral cortex regionalization Source: Ensembl
• commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
• cornea development in camera-type eye Source: Ensembl
• dorsal/ventral axis specification Source: Ensembl
• embryonic camera-type eye morphogenesis Source: Ensembl
• establishment of mitotic spindle orientation Source: Ensembl
• eye photoreceptor cell development Source: Ensembl
• forebrain dorsal/ventral pattern formation Source: Ensembl
• forebrain-midbrain boundary formation Source: Ensembl
• gene expression Source: Ensembl
• glucose homeostasis Source: Ensembl
• habenula development Source: Ensembl
• iris morphogenesis Source: Ensembl
• keratinocyte differentiation Source: Ensembl
• lacrimal gland development Source: Ensembl
• lens development in camera-type eye Source: Ensembl
• negative regulation of epithelial cell proliferation Source: Ensembl
• negative regulation of neural precursor cell proliferation Source: Ensembl
• negative regulation of neuron differentiation Source: Ensembl
• negative regulation of protein phosphorylation Source: Ensembl
• neuron migration Source: Ensembl
• oligodendrocyte cell fate specification Source: Ensembl
• pancreatic A cell development Source: Ensembl
• pituitary gland development Source: Ensembl
• positive regulation of core promoter binding Source: Ensembl
• positive regulation of epithelial cell differentiation Source: Ensembl
• positive regulation of gene expression Source: Ensembl
• positive regulation of neuroblast proliferation Source: Ensembl
• protein localization to organelle Source: Ensembl
• regulation of asymmetric cell division Source: Ensembl
• regulation of cell migration Source: Ensembl
• regulation of timing of cell differentiation Source: Ensembl
• response to wounding Source: Ensembl
• retina development in camera-type eye Source: Ensembl
• salivary gland morphogenesis Source: Ensembl
• signal transduction involved in regulation of gene expression Source: Ensembl
• smoothened signaling pathway Source: Ensembl
• type B pancreatic cell differentiation Source: Ensembl
• ventral spinal cord development Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• co-SMAD binding Source: Ensembl
• histone acetyltransferase binding Source: Ensembl
• HMG box domain binding Source: Ensembl
• protein kinase binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• transcription coregulator binding Source: Ensembl
• ubiquitin protein ligase binding Source: Ensembl

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
APAPAPAPAR AELAGRRETP GAAAAAAPGP IVAQCSRPAG KDEEALWCPR 
        60         70         80         90        100
PWNGRREQPL PAALSSPRPS ERAESGRSEE SPREPACRVS SLPPTLGLCA 
       110        120        130        140        150
ALGSGAEESA CTPAPRGHRA RHQPERSQSA RQPHAGGRRK SELARAGKEA 
       160        170        180        190        200
TRPRRWDARS EGAQSRAGGL VSFHPAPGLL PPTPLERGAR NLKTLCSPGF 
       210        220        230        240        250
PRLSSPSPCG GWGSSLSSGP LRLVSNGCVS KILGRYYETG SIRPRAIGGS 
       260        270        280        290        300
KPRVATPEVV SKIAQYKREC PSIFAWEIRD RLLSEGVCTN DNIPSVSSIN 
       310        320        330        340        350
RVLRNLASEK QQMGADGMYD KLRMLNGQTG SWGTRPGWYP GTSVPGQPTQ 
       360        370        380        390        400
DGCQQQEGGG ENTNSISSNG EDSDEAQMRL QLKRKLQRNR TSFTQEQIEA 
       410        420        430        440        450
LEKEFERTHY PDVFARERLA AKIDLPEARI QVWFSNRRAK WRREEKLRNQ 
       460        470        480        490        500
RRQASNTPSH IPISSSFSTS VYQPIPQPTT PVSSFTSGSM LGRTDTALTN 
       510        520        530        540        550
TYSALPPMPS FTMANNLPMQ PPVPSQTSSY SCMLPTSPSV NGRSYDTYTP 
       560        570        580        590 
PHMQTHMNSQ PMGTSGTTST GLISPGVSVP VQVPGSEPDM SQYWPRLQ   

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ