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Entry version 6 (02 Jun 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene

TCOF1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCOF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:78294, TCOF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 396DisorderedSequence analysisAdd BLAST340
Regioni446 – 645DisorderedSequence analysisAdd BLAST200
Regioni726 – 1017DisorderedSequence analysisAdd BLAST292
Regioni1032 – 1491DisorderedSequence analysisAdd BLAST460
Regioni1526 – 1652DisorderedSequence analysisAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi102 – 116Polar residuesSequence analysisAdd BLAST15
Compositional biasi140 – 174Polar residuesSequence analysisAdd BLAST35
Compositional biasi283 – 300Polar residuesSequence analysisAdd BLAST18
Compositional biasi500 – 517Polar residuesSequence analysisAdd BLAST18
Compositional biasi768 – 782Polar residuesSequence analysisAdd BLAST15
Compositional biasi791 – 805Polar residuesSequence analysisAdd BLAST15
Compositional biasi900 – 914Polar residuesSequence analysisAdd BLAST15
Compositional biasi1039 – 1056Polar residuesSequence analysisAdd BLAST18
Compositional biasi1087 – 1128Polar residuesSequence analysisAdd BLAST42
Compositional biasi1137 – 1151Polar residuesSequence analysisAdd BLAST15
Compositional biasi1178 – 1198Polar residuesSequence analysisAdd BLAST21
Compositional biasi1255 – 1272Polar residuesSequence analysisAdd BLAST18
Compositional biasi1301 – 1323Polar residuesSequence analysisAdd BLAST23
Compositional biasi1338 – 1361Polar residuesSequence analysisAdd BLAST24
Compositional biasi1373 – 1387Polar residuesSequence analysisAdd BLAST15
Compositional biasi1396 – 1438Polar residuesSequence analysisAdd BLAST43
Compositional biasi1526 – 1556Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1588 – 1629Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1636 – 1652Basic and acidic residuesSequence analysisAdd BLAST17

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A5F8AIZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS LKEKAKAETE KAGKTGNSMP HPATGKTVTN
160 170 180 190 200
LLSGKSPRKS AEPSANTTLV SETEEEGSVP AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP APGKVGDVTP
260 270 280 290 300
QVRGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTPSQ VKTSEKILQV
310 320 330 340 350
RAASTAAKGT PGKGATPAHP GKAGAVAFQT KAGKPEEDSE SSSEESSDSE
360 370 380 390 400
EETPAAKALL QVKPEEGDPM QSGPPQKASQ DLFSHSVSEP GACLRPQPLT
410 420 430 440 450
PLSLCGVICP IWSSLPGVLC LLTHPSPGLS PLILFLQAKA SGKTPQVGAA
460 470 480 490 500
SAPAKESPRK GAAPAPPGKT GPAVAKAQTG KQEEDSQSSS EESDSEEEAP
510 520 530 540 550
VQTKPSGKTS QVRAASASAK ESPRKGAAPA PPRKTGPAAT QAQAGKQEED
560 570 580 590 600
SGSSSEESDS DREAPAAMNA AQVKPLGKNP QVKPASTMGT GPLGKGPGPV
610 620 630 640 650
LPGKAGPTTP SAQVGKWEDS DSSSEESSDS DDGEVPTAVA PAQVRPLPVG
660 670 680 690 700
SFLPLRVEPP MASHWDSVYH LGLLMSVHTY SGLPLLILCI SLQEKSLGKV
710 720 730 740 750
LQAKPASGPA KGPPQKAGPV AIQVKAEKPM EDSESSEESS DSADSEETPA
760 770 780 790 800
AMTAAQAKPA LKIPQTKACP KKTNTASAKV TPVRVGTQAP RKAGTVTSPV
810 820 830 840 850
GSSPAVAGGT QRPAEDSSSS EESDSEEEKT GPAVTMGQAK SVGKGLQVKA
860 870 880 890 900
ASVPVKGSLG QGTAPVLPGK TGPTVTQVKA EMQEDSESSE EESDSEEAAA
910 920 930 940 950
PSAQVKTSVK KTQAKANPAA VRASPAKGTI SAPGKVVTAA AQAKQRSPAK
960 970 980 990 1000
AKPPVRNLQN STALVRGPAS VPPVGKAVAA AAQVQTGPEE DSGSSEEESD
1010 1020 1030 1040 1050
SEEETETPAQ VRGREWRTSP TWDVTLLPHP ALVSSHVHPP GSLPSSCFSL
1060 1070 1080 1090 1100
QAKPSEKTPQ VRAALAPAKE SPRKGAAPAP PGKTGPSATQ AGKQDGSGSS
1110 1120 1130 1140 1150
SEESNSDGEA PAAATSAQKD SNSKPARSKT LAPAPPEGNT EGSSESSEEE
1160 1170 1180 1190 1200
LPLTQVIKPP LIFVDPNRSP AGPAATPVQA QAASTPRKSR ASESTARSSS
1210 1220 1230 1240 1250
SESEDEDVIP ATQCLTPGIR TNVVTVPTAH PRIAPKASMT GASSSKESSR
1260 1270 1280 1290 1300
ISDGKKQEGP ATQVSKKNPA SLPLTQAALK VLAQKASEAQ PPVARTQRSR
1310 1320 1330 1340 1350
GADSAVGTLP ATSPQSTPVQ AKGTNKLRKP KLPEGQQATK APGSSDDSED
1360 1370 1380 1390 1400
SSNSSSGSEE DAEGPQVAKS AHTLVGPTPS RTETLVEETA AESSEDDVVA
1410 1420 1430 1440 1450
PSQSLLSGYV TPGLTPANSQ ASKATPKPYS SPSVSSTLAA KDDPDGKQEA
1460 1470 1480 1490 1500
KPQQAAGMLS PKTGGKEAVS GTTPQKSRKP KKGAGNPQAS TLALQSNITQ
1510 1520 1530 1540 1550
CLLGQPWPLN EAQVQASVVK VLTELLEQER KKVVDATKES SRKGWESRKR
1560 1570 1580 1590 1600
KLSGDQPAAR TPRSKKKKKL GAGEGGEAFV SPEKTSTTSK GKAKRDKASD
1610 1620 1630 1640 1650
DVKEKKGKGS LGSQGAKDEP EKELQKGIGK VEGGDQSNPK SKKEKKKSDK

SE
Length:1,652
Mass (Da):169,666
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4FCA0AB4144417D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5R7L3A0A1D5R7L3_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7E9S9F7E9S9_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5QVN6A0A1D5QVN6_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,523Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F7ZC16A0A5F7ZC16_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F7ZQN6A0A5F7ZQN6_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8A6X8A0A5F8A6X8_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,614Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8ADV2A0A5F8ADV2_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,546Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RKQ9A0A1D5RKQ9_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000095071; ENSMMUP00000077362; ENSMMUG00000009111

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMMUT00000095071; ENSMMUP00000077362; ENSMMUG00000009111

Organism-specific databases

VGNCiVGNC:78294, TCOF1

Phylogenomic databases

GeneTreeiENSGT00730000111382

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 4 hits
PfamiView protein in Pfam
PF03546, Treacle, 5 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F8AIZ1_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F8AIZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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