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Entry version 4 (02 Jun 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene

TCOF1

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCOF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:78294, TCOF1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni57 – 858DisorderedSequence analysisAdd BLAST802
Regioni896 – 1347DisorderedSequence analysisAdd BLAST452
Regioni1382 – 1546DisorderedSequence analysisAdd BLAST165

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi102 – 116Polar residuesSequence analysisAdd BLAST15
Compositional biasi140 – 174Polar residuesSequence analysisAdd BLAST35
Compositional biasi283 – 300Polar residuesSequence analysisAdd BLAST18
Compositional biasi424 – 441Polar residuesSequence analysisAdd BLAST18
Compositional biasi642 – 656Polar residuesSequence analysisAdd BLAST15
Compositional biasi665 – 679Polar residuesSequence analysisAdd BLAST15
Compositional biasi774 – 788Polar residuesSequence analysisAdd BLAST15
Compositional biasi982 – 1023Polar residuesSequence analysisAdd BLAST42
Compositional biasi1032 – 1046Polar residuesSequence analysisAdd BLAST15
Compositional biasi1073 – 1093Polar residuesSequence analysisAdd BLAST21
Compositional biasi1158 – 1180Polar residuesSequence analysisAdd BLAST23
Compositional biasi1195 – 1218Polar residuesSequence analysisAdd BLAST24
Compositional biasi1229 – 1243Polar residuesSequence analysisAdd BLAST15
Compositional biasi1252 – 1294Polar residuesSequence analysisAdd BLAST43
Compositional biasi1382 – 1412Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1444 – 1485Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi1500 – 1516Basic residuesSequence analysisAdd BLAST17
Compositional biasi1517 – 1531Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1532 – 1546Basic residuesSequence analysisAdd BLAST15

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A5F8ADV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYHHLLR AGYVRAAREV KEQSGQKCFL AQPVTLLDIY
60 70 80 90 100
THWQQTSELG RKRKAEEDAA LQAKKTRVSD PISTSESSEE EEEAEAETAK
110 120 130 140 150
ATPRLASTNS SVLGADLPSS LKEKAKAETE KAGKTGNSMP HPATGKTVTN
160 170 180 190 200
LLSGKSPRKS AEPSANTTLV SETEEEGSVP AFGAAAKPGM VSAGQADSSS
210 220 230 240 250
EDTSSSSDET DVEGKPSVKP AQVKASSVST KESPARKAAP APGKVGDVTP
260 270 280 290 300
QVRGGALPPA KRAKKPEEES ESSEEGSESE EEAPAGTPSQ VKTSEKILQV
310 320 330 340 350
RAASTAAKGT PGKGATPAHP GKAGAVAFQT KAGKPEEDSE SSSEESSDSE
360 370 380 390 400
EETPAAKALL QAKASGKTPQ VGAASAPAKE SPRKGAAPAP PGKTGPAVAK
410 420 430 440 450
AQTGKQEEDS QSSSEESDSE EEAPVQTKPS GKTSQVRAAS ASAKESPRKG
460 470 480 490 500
AAPAPPRKTG PAATQAQAGK QEEDSGSSSE ESDSDREAPA AMNAAQVKPL
510 520 530 540 550
GKNPQVKPAS TMGTGPLGKG PGPVLPGKAG PTTPSAQVGK WEDSDSSSEE
560 570 580 590 600
SSDSDDGEVP TAVAPAQEKS LGKVLQAKPA SGPAKGPPQK AGPVAIQVKA
610 620 630 640 650
EKPMEDSESS EESSDSADSE ETPAAMTAAQ AKPALKIPQT KACPKKTNTA
660 670 680 690 700
SAKVTPVRVG TQAPRKAGTV TSPVGSSPAV AGGTQRPAED SSSSEESDSE
710 720 730 740 750
EEKTGPAVTM GQAKSVGKGL QVKAASVPVK GSLGQGTAPV LPGKTGPTVT
760 770 780 790 800
QVKAEMQEDS ESSEEESDSE EAAAPSAQVK TSVKKTQAKA NPAAVRASPA
810 820 830 840 850
KGTISAPGKV VTAAAQAKQR SPAKASGARS HRRCGGLEQR GGPLTEPSLE
860 870 880 890 900
KAPAWAGHPP RVVPWWKVGP ERNHFRLQSC YPPAIQAKPP VRNLQNSTAL
910 920 930 940 950
VRGPASVPPV GKAVAAAAQV QTGPEEDSGS SEEESDSEEE TETPAQAKPS
960 970 980 990 1000
EKTPQVRAAL APAKESPRKG AAPAPPGKTG PSATQAGKQD GSGSSSEESN
1010 1020 1030 1040 1050
SDGEAPAAAT SAQKDSNSKP ARSKTLAPAP PEGNTEGSSE SSEEELPLTQ
1060 1070 1080 1090 1100
VIKPPLIFVD PNRSPAGPAA TPVQAQAAST PRKSRASEST ARSSSSESED
1110 1120 1130 1140 1150
EDVIPATQCL TPGIRTNVVT VPTAHPRIAP KASMTGASSS KESSRISDGK
1160 1170 1180 1190 1200
KQEGPATQAD SAVGTLPATS PQSTPVQAKG TNKLRKPKLP EGQQATKAPG
1210 1220 1230 1240 1250
SSDDSEDSSN SSSGSEEDAE GPQVAKSAHT LGPTPSRTET LVEETAAESS
1260 1270 1280 1290 1300
EDDVVAPSQS LLSGYVTPGL TPANSQASKA TPKPYSSPSV SSTLAAKDDP
1310 1320 1330 1340 1350
DGKQEAKPQQ AAGMLSPKTG GKEAVSGTTP QKSRKPKKGA GNPQASTLAL
1360 1370 1380 1390 1400
QSNITQCLLG QPWPLNEAQV QASVVKVLTE LLEQERKKVV DATKESSRKG
1410 1420 1430 1440 1450
WESRKRKLSG DQPAARTPRS KKKKKLGAGE GGEAFVSPEK TSTTSKGKAK
1460 1470 1480 1490 1500
RDKASDDVKE KKGKGSLGSQ GAKDEPEKEL QKGIGKVEGG DQSNPKSKKE
1510 1520 1530 1540
KKKSDKRKKD KEKKEKKKAK KSSTKDSESP SQKKKKKKKK TAEQTV
Length:1,546
Mass (Da):158,854
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49E5993A48FD8333
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8AIZ1A0A5F8AIZ1_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,652Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5R7L3A0A1D5R7L3_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7E9S9F7E9S9_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5QVN6A0A1D5QVN6_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,523Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F7ZC16A0A5F7ZC16_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,381Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F7ZQN6A0A5F7ZQN6_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F8A6X8A0A5F8A6X8_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,614Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5RKQ9A0A1D5RKQ9_MACMU
Treacle ribosome biogenesis factor ...
TCOF1
1,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMMUT00000087052; ENSMMUP00000075119; ENSMMUG00000009111

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMMUT00000087052; ENSMMUP00000075119; ENSMMUG00000009111

Organism-specific databases

VGNCiVGNC:78294, TCOF1

Phylogenomic databases

GeneTreeiENSGT00730000111382

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 3 hits
PfamiView protein in Pfam
PF03546, Treacle, 5 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F8ADV2_MACMU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F8ADV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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